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smoking prevalence in the area of responsibility of the German Ministry of Defense——results of the employee survey in the context of occupational health management

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Military Medical Research 2020年第3期7卷 343-349页

作者： stefan sammito Annika Claus Dirk-Matthias Rose Department I 3 Research&Development Air Force Centre of Aerospace MedicineCologneGermany Occupational Medicine Faculty of MedicineOtto-von-Guericke-University of MagdeburgMagdeburgGermany Institute for Teachers’Health Institute of OccupationalSocial and Environmental Medicine of the Johannes-Gutenberg University MainzMainzGermany

Background:Tobacco use,correlated with reduced physical fitness,is one of the leading causes of avoidable death *** increases the risk of dementia and can shorten the lifespan by 10 *** the German Armed Forces(Bundeswehr),figures on smoking behavior have not been comprehensively *** study analyzes current data in a large sample from this ***:Based on an employee survey as part of the Occupational Health Management system,data on smoking behavior from 13,326 participants were analyzed in relation to age,gender,professional status,education level and membership in military operational units versus other ***:smoking behavior varied significantly(Polder),gender,professional status,military agency membership status,and education level(the lower the education level,the higher the smoking rates).With the exception of the downward trend in smoking behavior with increasing age among civilian employees,these results were all significant(Psions:This data analysis shows that smoking prevalence among personnel in the area of responsibility of the Federal Ministry of Defense is comparable to the current data from corresponding surveys of the German *** on gender,they generally show values that are slightly above those of the German *** well-known trend in the general population of decreasing smoking prevalence with increasing age is also seen in this ***,there are considerable differences in the smoking prevalence among individual subgroups(professional status,agency,gender,education level).The data show that particular young soldiers in the armed forces should be the target group for further preventive measures.

关键词： Prevention smoking Military Health promotion

The AiiDA-KKR plugin and its application to highthroughput impurity embedding into a topological insulator

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npj Computational Materials 2021年第1期7卷 108-116页

作者： Philipp Rüßmann Fabian Bertoldoand stefan Blügel Peter Grünberg Institut and Institute for Advanced simulation Forschungszentrum Jülich and JARAD-52425 JülichGermany

The ever increasing availability of supercomputing resources led computer-based materials science into a new era of highthroughput ***,Pizzi et *** the AiiDA framework that provides a way to automate calculations while allowing to store the full provenance of complex workflows in a *** present the development of the AiiDA-KKR plugin that allows to perform a large number of ab initio impurity embedding calculations based on the relativistic full-potential Korringa-Kohn-Rostoker Green function *** capabilities of the AiiDA-KKR plugin are demonstrated with the calculation of several thousand impurities embedded into the prototypical topological insulator *** results are collected in the JuDiT database which we use to investigate chemical trends as well as Fermi level and layer dependence of physical properties of *** includes the study of spin moments,the impurity’s tendency to form in-gap states or its effect on the charge doping of the *** properties depend on the detailed electronic structure of the impurity embedded into the host crystal which highlights the need for ab initio calculations in order to get accurate predictions.

关键词： method topological embedding

synthesis, structural and spectroscopic studies on GdBO_3:Yb^(3+)/Tb^(3+)@siO_2 core-shell nanostructures

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Journal of Rare Earths 2015年第11期33卷 1148-1154页

作者： Konrad Kubasiewicz Marcin Runowski stefan Lis Agata szczeszak Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

The presented study concerned up-converting core/shell type nanomaterials based on lanthanide（Ⅲ） ions, Ln（Ⅲ）, doped orthoborates. The system studied composed of the GdBO3 doped with Yb^3＋/Tb^3＋ luminescent core ensured an effective cooperative sensitization up-conversion, resulting in a bright green luminescence. The silica coating process was performed by a modified st？ber method, which resulted in the formation of core-shell nanostructures, making them suitable for bioapplications. The nanophosphors and nanocomposites were obtained by various methods, such as co-precipitation in the presence of Triton X-100 and micelle synthesis with ethylenediaminetetraacetic acid（EDTA） as organic modifiers/surfactants. The synthesized nanomaterials were characterized with the use of powder X-ray diffraction（XRD）, infrared light absorption with Fourier transform FT-IR spectra, transmission electron microscopy（TEM）, up-conversion emission spectra under IR light, as well as excitation spectra, emission spectra and fluorescence lifetimes under UV light, and their photophysical properties were compared.

关键词： Ln(Ⅲ) ions GdB O3 silica coating core-shell nanocomposites up-conversion cooperative sensitization rare earths

surgery for obstructed defecation syndrome-is there an ideal technique

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World Journal of Gastroenterology 2015年第1期21卷 1-5页

作者： stefan Riss Anton stift Department of General surgery Medical University of ViennaA-1090 ViennaAustria

Obstructive defecation syndrome(ODs) is a common disorder with a considerable impact on the quality of life of affected *** for ODs remains a challenging *** exists a great variety of operative techniques to treat patients with *** to the surgeon's preference the approach can be transanal,transvaginal,transperineal or *** techniques have its advantages and ***,high evidence based studies are significantly lacking in literature,thus making accurate assessments *** patient's selection is crucial to achieveoptimal functional *** is mandatory to assess not only defecation disorders but also evaluate overall pelvic floor symptoms,such as fecal incontinence and urinary disorders for choosing an appropriate and tailored *** investigation is essential but may not explain complaints of every patient.

关键词： Obstructive defecation syndrome Defecatory disorde

Actuation of Liquid Flow by Guided Acoustic Waves on Punched steel Tapes with Protruding Loops

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Journal of Bionic Engineering 2021年第3期18卷 534-547页

作者： Alexander Backer Johannes Landskron Klaus stefan Drese Gerhard Lindner Institute of sensor and Actuator Technology Coburg University of Applied Sciences and Arts96450 CoburgGermany

In a biomimetic approach the feasibility of liquid flow actuation by vibrating protruding structures excited via guided acoustic waves is *** by periodically beating cilia the loop part of a punched metallic hook-and-loop tape with tilted protruding loops was used as a waveguide for plate waves in *** waves were excited in the frequency range of 110 Hz to 220 Hz by directly coupling the tape to a loudspeaker membrane.A flow generated in the tilt direction of the loops with velocities up to 60 mm s 1 was visualized by ink droplets deposited on the *** phenomenon persisted,when the protruding length of the loops was reduced by decreasing the protrusion ***,after closing the punch holes near the loops with sticking tape streaming could not be observed any *** same happened with open punch holes when the ink was replaced by ***-frequency acoustic streaming around vibrating sharp edges is proposed as an explanation for the observed *** are expected with respect to the modification of flow profiles and the enhancement of transport processes along and across liquid-solid boundaries.

关键词： bio-inspired guided acoustic waves metallic hook-and-loop tape artificial cilia liquid propulsion Copyright

World Literature and Decolonization

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Journal of Foreign Languages and Cultures 2024年第1期8卷 55-67页

作者： stefan HELGEssON stockholm University

With remarkable force,"decolonization"re-entered the academic agenda some ten years *** been an ambivalent historical experience undergirding postcolonial studies in its emergence in the 1980s,"decolonization"today is wielded as a concept and a rallying *** of its rhetorical purposes is to set up an opposition between morally objectionable and morally progressive ways of constructing and sharing knowledge,yet the content of the term is often *** this context,world literature has much to contribute,both methodologically and ***,on the one hand,there is a decolonizing potential in the very ambition to make the world's literary cultures visible,the critical dimension of world literature scholarship makes us aware of its colonial *** Mazisi Kunene's epic poem from south Africa,Emperor shaka the Great,as its key example,this article discusses how the dual potential of world literature might contribute to a"decolonized"'mode of literary reading.

关键词： decolonization ecologies epic world literature Mazisi Kunene Emperor shaka the Great

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo sánchez Tala Alakhras Barbara schreier Michael Gekle stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

Cases with parietal and occipital lobe epilepsies

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Acta Epileptologica 2019年第1期1卷 31-36页

作者： Hermann stefan Department of Neurology-Biomagnetism University Hospital10Schwabachanlage91054 ErlangenGermany

Background:For seizures emerging from the posterior cortex it can be a challenge to differentiate if they belong to temporal,parietal or occipital *** auras like visual phenomena may occur in all of these focal *** signs may mimic non-epileptic *** presentations:Case 1:Patient suffering from a pharmacoresistent focal *** seizures with sudden visual disturbance,later during the seizure epigastric aura,vertigo-nausea,involvement to bilateral tonic-clonic *** detected interictal spikes,source localization indicated focal epileptic activity parietal *** 2:Patient with focal pharmacoresistent epilepsy,semiology with focal unaware seizures,feeling that something like a coat is imposed from behind on him,then feeling cold over the whole body,goose bumbs from both arms to head,then block of motoric activity,later focal unaware seizures with stare gaze,blinking of eyes,clouding of consciousness,elevation of arms and legs,sometimes tonic-clonic ***/MEG source localization and MRI detected an epileptogenic lesion parietal *** 3:Patient with pharmacoresistent focal epilepsy,focal aware seizures,a dark spot occurring in the left visual field,sometimes anxiety during seizures(leading to the suspicion of non-epileptic psychogenic pseudo seizures).MRI demonstrated an atrophy occipito-temporal right after sinus vein *** video-EEG showed a focal seizure onset occipital ***:Contribution of noninvasive and/or invasive confirmation of the localization of the underlying focal epileptic activity in posterior cortex is *** of posterior cortex epilepsies are ventilated.

关键词： Parietal-occipital lobe epilepsy Posterior cortex Diagnosis and treatment

Omicron:Master of immune evasion maintains robust ACE2 binding

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signal Transduction and Targeted Therapy 2022年第5期7卷 1360-1362页

作者： Markus Hoffmann Lu Zhang stefan Pohlmann Infection Biology Unit German Primate Center—Leibniz Institute for Primate ResearchGöttingenGermany Georg-August-University Göttingen GöttingenGermany

The spike(s)protein of the sARs-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear.A recent study published in science by Mannar et *** shows that these mutations are compatible with robust ACE2 binding and allow for efficient evasion of neutralizing *** emergence of sARs-CoV-2 variants has become a hallmark of the COVID-19 *** of concern(VOC)harbor mutations in the viral s protein that can increase transmissibility,potentially by promoting s protein binding to the cellular receptor ACE2.

关键词： ACE2 maintain