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Impact of field strength and RF excitation on abdominal diffusion-weighted magnetic resonance imaging

World Journal of Radiology 2013年第9期5卷 334-344页

作者： Philipp Riffel Raghuram K Rao stefan Haneder Mathias Meyer stefan o schoenberg Henrik J Michaely Department of Clinical Radiology and Nuclear Medicine University Medical Center Mannheim Medical Faculty Mannheim-Heidelberg University the Russel H. Morgan Department of Radiology and Radiologic Science the Johns Hopkins Hospital

AIM:To retrospectively and prospectively compare diffusion-weighted(DW)images in the abdomen in a1.5T system and 3.0T systems with and without twochannel functionality for ***:DW images of the abdomen were obtained on 1.5T and 3.0T(with and without two-channel functionality for B1shimming)scanners on 150 patients(retrospective study population)and 10 volunteers(prospective study population).Eight regions were selected for clinical significance or artifact susceptibility(at higher field strengths).objective grading quantified signal-to-noise ratio(SNR),and subjective evaluation qualified image quality,ghosting artifacts,anddiagnostic *** significance was calculated usingχ2tests(categorical variables)and independent two-sided t tests or Mann-Whitney U tests(continuous variables).RESULTS:The 3.0T using dual-source parallel transmit(dpTX 3.0T)provided the significantly highest SNRs in nearly all *** regions susceptible to artifacts at higher field strengths(left lobe of liver,head of pancreas),the SNR was better or similar to the 1.5T ***,both dpTX 3.0T and 1.5T systems provided higher image quality,diagnostic value,and less ghosting artifact(Post values)compared to the 3.0T system without dual-source parallel transmit(non-dpTX 3.0T).CoNCLUSIoN:The dpTX 3.0T scanner provided the highest *** image quality,lack of ghosting,and diagnostic value were equal to or outperformed most currently used systems.

关键词： Abdominal imaging Diffusion weighted 3.0T Radiofrequency excitation Signal-to-noise ratio

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Evaluation of a handheld creatinine measurement device for real-time determination of serum creatinine in radiology departments

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World Journal of Radiology 2012年第7期4卷 328-334页

作者： stefan Haneder Alexandra Gutfleisch Claudia Meier Joachim Brade Dieter Hannak stefan o schoenberg Christoph R Becker Henrik J Michaely Institute of Clinical Radiology and Nuclear Medicine University Medical Centre Mannheim University of Heidelberg 68167 Mannheim Germany Institute for Clinical Statistics University Medical Centre Mannheim University of Heidelberg 68167 Mannheim Germany Institute of Clinical Chemistry University Medical Centre Mannheim University of Heidelberg 68167 Mannheim Germany Institute of Clinical Radiology Hospital Munich-Grosshadern University of Munich 81377 Munich Germany

AIM: To assess the feasibility/accuracy of a commercial handheld device in the context of increased demand for point-of-care serum creatinine (SCr) determination. METHoDS: In this institutional review board-approved, prospective study, 401 patients referred for contrastenhanced computed tomography were included at two centres. Capillary (c)SCr was determined using two devices A+B and venous (v)SCr was determined in the centre's laboratory. Method comparison statistics for both centres and for vSCr1.2 mg/dL, receiver operating characteristic analysis, negative predictive values (NPV), sensitivity and specificity were calculated pre-/ post-curve offset correction with vSCr. RESULTS: Pearson's coefficients for cSCr vs vSCr were: centre 1-A:0.93/B:0.92; centre 2-A:0.85/B:0.82 (all P overall correlation was better for vSCr > 1.2 mg/dL. The area under the receiver operating characteristic curves showed a high accuracy for cSCr, but the device underestimated SCr, which was confirmed by Bland-Altman plot. Addition of the offset correction factor to the original data from centre 1 resulted in an improvement in sensitivity for detecting patients at risk (> 1.2 mg/dL), whilst maintaining acceptable specificity and improving NPV. CoNCLUSIoN: This study showed the feasibility of SCr determination using the evaluated handheld device in a routine clinical setting. The device showed high sensitivity and high NPV, but may significantly underestimate SCr without offset correction to local laboratories.

关键词： Contrast-medium-induced nephropathy Nephrogenic systemic fibrosis Point of care testing Serum creatinine determination StatSensor

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Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI

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World Journal of Radiology 2013年第5期5卷 202-207页

作者： Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser stefan o schoenberg Ulrike I Attenberger Institute of Clinical Radiology and Nuclear Medicine University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityD-68167 MannheimGermany Computer Assisted Clinical Medicine Medical Faculty MannheimHeidelberg UniversityD-68167 MannheimGermany

AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHoDS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion *** parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine *** readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 *** areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 *** differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P o linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CoNCLUSIoN:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI.

关键词： Dual-energy computed tomography Timeresolved magnetic resonance imaging Pulmonary perfusion Iodine maps

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Feasibility study of computed vs measured high b-value(1400 s/mm2) diffusion-weighted MR images of the prostate

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World Journal of Radiology 2014年第6期6卷 374-380页

作者： Leonardo K Bittencourt Ulrike I Attenberger Daniel Lima Ralph Strecker Andre de oliveira stefan o schoenberg Emerson L Gasparetto Daniel Hausmann CDPI Ressonancia Magnética Avenida das Américas 4666 Barra da Tijuca RJ 22631-000 Brazil Institute of Clinical Radiology and Nuclear Medicine University of Heidelberg University Hospital Mannheim The-odor-Kutzer-Ufer 1-3 68167 Mannheim Germany Siemens Healthcare Brazil Avenida Mutinga 3800 Jardim Santo Elias SP 05110-902 Brazil Siemens AG Healthcare Sector Henkestrasse127 D-91052 Erlangen Germany

AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFoV). METHoDS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR *** DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P omparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CoNCLUSIoN: Combination of a high b-value extrap-olation and sFoV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting.

关键词： Prostate cancer Magnetic resonance imag-ing Diffusion-weighted imaging Ultra-high b-values Extrapolated b-values

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肿瘤18F-FDG PET/MRI全身显像专家共识(德国)

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中华核医学与分子影像杂志 2020年第9期40卷 549-555页

作者：王洋洋杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes stefan Grueneisen Christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.o.schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.Neumann D.Vorwerk 青岛大学附属医院核医学科PET/CT中心 266100 Department of Diagnostic and Interventional Radiology and Neuroradiology University-Hospital EssenGermany QIMP Group Centre for Medical Imaging and Biomedical EngineeringMedical University of ViennaAustria Department of Nuclear Medicine University-Hospital EssenGermany High-Field-and Hybrid-MR-Imaging University-Hospital EssenGermany Joint Department of Medical Imaging University of TorontoCanada Department of Nuclear Medicine Klinikum rechts der IsarTechnical University of MunichGermany Department of Nuclear Medicine University of LeipzigGermany Department of Diagnostic and Interventional Radiology University DüsseldorfMedical FacultyDüsseldorfGermany Department of Diagnostic and Interventional Radiology University-Hospital TübingenGermany Department of Nuclear Medicine University Medical Center RostockGermany Department of Clinical Radiology and Nuclear Medicine University Medical Center MannheimGermany Deutsche Röntgengesellschaft BerlinGermany Division of Nuclear Medicine Department of Biomedical Imaging and Image-guided TherapyMedical University ViennaAustria Department of Nuclear Medicine University Hospital MarburgGermany Department of Radiology Klinikum IngolstadtGermany

PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机... 详细信息

PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。

关键词： PET/MRI 肿瘤全身显像专家共识

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