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High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer Sabine Gerum Falk Roeder stefan münch Stephanie E Combs Alexander B Philipp Enrico N De Toni martha m Kirstein Arndt Vogel Carolin mogler Bernhard Haller Jens Neumann Rickmer F Braren marcus R makowski Philipp Paprottka markus Guba Fabian Geisler Roland m Schmid Andreas Umgelter Ursula Ehmer Internal medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation Oncology University of SalzburgSalzburg 5020Austria Department of Radiation Oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation Oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver *** explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and mann-Whitney-U *** Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests th

关键词： Hepatocellular carcinoma Transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation

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数据完整性的关键清单

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流程工业 2021年第4期 48-50页

作者： stefan münch Christian Wölbeling 柯尔柏集团

数据完整性并不属于新鲜事物——早在20多年前监管机构就提出了这一概念。但在过去的几年中,数据完整性为何得到了如此多的关注?本文将解释数据完整性的重要性,阐明相关因素(如风险和实现合规性的控制),并详细说明数据管治和生命周期管... 详细信息

数据完整性并不属于新鲜事物——早在20多年前监管机构就提出了这一概念。但在过去的几年中,数据完整性为何得到了如此多的关注?本文将解释数据完整性的重要性,阐明相关因素(如风险和实现合规性的控制),并详细说明数据管治和生命周期管理的方法与意义。

关键词：数据完整性生命周期管理合规性监管机构重要性

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Experimental investigation on slip conditions during thread rolling with flat dies

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Friction 2024年第1期12卷 136-143页

作者： stefan VOLZ Peter GROCHE Institute for Production Engineering and Forming machines Technical University DarmstadtOtto-Berndt Straße 2Darmstadt 64287Germany

The process design of flat die rolling operations can be a tedious and costly process due to the challenges posed by small process *** this work,an effort is made to closely investigate and understand the process limits caused by excessive slippage of the *** measurements are carried out to capture the characteristics of excessive slippage and the influence of the stroke rate and the tribological system on this process *** differences in slippage were observed,depending on the tribological *** systems with polymer based lubricants showed excessive slippage at low stroke rates,systems using oil or no lubricant endured higher stroke rates before process limits were *** optical measurements revealed three major forms of slippage:successful rolling without slippage,failure due to excessive slippage at process start,and failure due to excessive slippage at around one workpiece rotation.

关键词： rolling incremental forming thread rolling slippage profile rolling

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O'Hare Airport roadway traffic prediction via data fusion and Gaussian process regression

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 721-732页

作者： Damola m.Akinlana Arindam Fadikar stefan m.Wild Natalia Zuniga-Garcia Joshua Auld Department of mathematics and Statistics University of South FloridaTampaFL 33620USA Decision and Infrastructure Sciences Division Argonne National LaboratoryLemontIL 60439USA Applied mathematics and Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Industrial Engineering and management Sciences Northwestern UniversityEvanstonIL 60208USA Argonne National Laboratory Energy SystemsLemontIL 60439USA

This study proposes an approach of leveraging information gathered from multiple traffic data sources at different resolutions to obtain approximate inference on the traffic distribution of Chicago's O'Hare Airport ***,it proposes the ingestion of traffic datasets at different resolutions to build spatiotemporal models for predicting the distribution of traffic volume on the road *** to its good adaptability and flexibility for spatiotemporal data,the Gaussian process(GP)regression was employed to provide short-term forecasts using data collected by loop detectors(sensors)and supplemented by telematics *** GP regression is used to make predictions of the distribution of the proportion of sensor data traffic volume represented by the telematics data for each location of the ***,the fitted GP model can be used to determine the approximate traffic distribution for a testing location outside of the training *** in the transportation sector can find the results of this work helpful for making informed decisions relating to current and future transportation conditions in the area.

关键词： Spatio-temporal Data fusion Gaussian process multimodal data Airport traffic O'Hare Airport

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Improved Quantile Convolutional and Recurrent Neural Networks for Electric Vehicle Battery Temperature Prediction

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Big Data mining and Analytics 2024年第2期7卷 512-530页

作者： Andreas m.Billert Runyao Yu stefan Erschen michael Frey Frank Gauterin Karlsruhe Institute of Technology(KIT) Institute of Vehicle System TechnologyKarlsruhe 76131Germanyand also with Bayerische Motoren Werke(BMW)AGMunich 80788Germany Technical University of munich(TUm) Munich 80333Germany BmW AG Munich 80788Germany KIT Institute of Vehicle System TechnologyKarlsruhe 76131Germany

The battery thermal management of electric vehicles can be improved using neural networks predicting quantile sequences of the battery *** work extends a method for the development of Quantile Convolutional and Quantile Recurrent Neural Networks(namely Q*NN).Fleet data of 225629 drives are clustered and balanced,simulation data from 971 simulations are augmented before they are combined for training and *** Q*NN hyperparameters are optimized using an efficient Bayesian optimization,before the Q*NN models are compared with regression and quantile regression models for four *** analysis of point-forecast and quantile-related metrics shows the superior performance of the novel Q*NN *** median predictions of the best performing model achieve an average RmSE of 0.66°C and R^(2) of *** predicted 0.99 quantile covers 98.87%of the true values in the test *** conclusion,this work proposes an extended development and comparison of Q*NN models for accurate battery temperature prediction.

关键词： deep learning battery temperature convolutional and recurrent neural network quantile forecasting

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CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin Fleiß Juraj Priscak martin Hammerschmid Josef Fuchs stefan müller Hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

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The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond

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Neural Regeneration Research 2024年第8期19卷 1647-1648页

作者： Sven marcel stefan muhammad Rafehi Drug Development and Chemical Biology Lübeck Institute of Experimental Dermatology(LIED)University of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany Department of Pathology Section of NeuropathologyTranslational Neurodegeneration Research and Neuropathology LabUniversity of Oslo and Oslo University HospitalOsloNorway School of medical Sciences Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Institute of Clinical Pharmacology University Medical Center GöttingenGöttingenGermany Department of medical Education Augsburg University MedicineAugsburgGermany

Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug ***,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted ***,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.

关键词： translation beyond likely

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Implementation and validation of a bonded particle model to predict rheological properties of viscoelastic materials

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Particuology 2024年第6期89卷 198-210页

作者： michael mascara Arno mayrhofer stefan Radl Christoph Kloss Institute of Process and Particle Engineering Graz University of TechnologyInffeldgasse 13Graz8010Austria DCS Computing GmbH Industriezeile 35Linz4020Austria

This work focuses on implementing a particle-based method able to characterize viscoelastic materials whose rheological properties,such as storage modulus G′and loss modulus G″,are *** is based on the bonded particle model,with the elastic constitutive relation here substituted with a viscoelastic one to capture time-scale *** Burgers model,vastly used in literature to model viscoelastic systems,is discretized and *** test case used for calibration comprises of a cubic lattice,sheared with a periodic motion,to mimic the effect of a shear *** appropriate filtering of the stress response,the rheological properties are obtained,highlighting the effect of the lattice geometry,as well as the particle size,on the accuracy of the ***,the Burgers parameters are calibrated by analytically fitting the experimental dataset,showing the limitation of the Burgers *** micro-contact parameters are obtained from the macro parameters through appropriate *** completing a frequency sweep,the simulated G′and G″show a relatively large error,around 25%for G’for *** this reason,a more robust model,namely the generalized maxwell model,has been *** calibration procedure is performed in the same fashion as for the Burgers ***,the tangential micro-contact parameters are scaled *** normal *** scaling parameter,calledα,is calibrated by minimizing the root mean square error between simulation and experimental data,giving errors below 10%in both G′and G″for a large ***,a full ring plate-plate rheometer setup is simulated,and the simulation is compared with the given experimental dataset,again finding a good agreement.

关键词： DEm Rheology Numerical modeling Viscoelasticity

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz J.T.Huber stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced materials(EAm) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

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Artificial intelligence analysis of videos to augment clinical assessment:an overview

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Neural Regeneration Research 2024年第4期19卷 717-718页

作者： David C.Wong stefan Williams University of Leeds Leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

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