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Donor-derived CD 19 CAR-T Cells versus Chemotherapy Plus Donor Lymphocyte Infusion for Treatment of Recurrent CD 19-positive B-ALL after Allogeneic Hematopoietic Stem Cell Transplantation

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当代医学科学(英文) 2023年第4期43卷 733-740页

作者： Xu TAN xiao-qi WANG Cheng ZHANG xian-lan ZHAO Han YAO Guo CHEN Ying-ying MA Qin WEN Lei GAO Li GAO Pei-yan KONG Yan SHEN xi ZHANG Shi-feng LOU department of Hematology the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Medical Center of Hematology Xinqiao HospitalState Key Laboratory of TraumaBurns and Cobmined InjuryArmy Medical UniversityChongqing 400037China Jinfeng laboratory Chongqing 401329China

Objective:This study aimed to compare the efficacy of anti-CD19 chimeric antigen receptor T cells(CAR-T cells)versus chemotherapy plus donor lymphocyte infusion(chemo-DLI)for treating relapsed CD 19-positive B-cell acute lymphoblastic leukemia(B-ALL)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods:Clinical data of 43.patients with B-ALL who relapsed after allo-HSCT were retrospectively ***-two patients were treated with CAR-T cells(CAR-T group),and 21 with chemotherapy plus DLI(chemo-DLI group).The complete remission(CR)and minimal residual disease(MRD)-negative CR rates,leukemia-free survival(LFS)rate,overall survival(OS)rate,and incidence of acute graft-versus-host disease(aGVHD),cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS)were compared between the two ***:The CR and MRD-negative CR rates in the CAR-T group(77.3.and 61.5%)were significantly higher than those in the chemo-DLI group(3..1%and 23.8%)(P=0.008 and P=0.003..The 1-and 2-year LFS rates in the CAR-T group were superior to those in the chemo-DLI group:54.5%and 50.0%vs.9.5%and 4.8%(P=0.0001 and P=0.00004).The 1-and 2-year OS rates in the CAR-T versus chemo-DLI group were 59.1%and 54.5%vs.19%and 9.5%(P=0.011 and P=0.003..Six patients(28.6%)with grade 2-4 aGVHD were identified in the chemo-DLI *** patients(9.1%)in the CAR-T group developed grade 1-2 *** patients(86.4%)developed CRS in the CAR-T group,comprising grade 1-2 CRS in 13.patients(59.1%)and grade 3.CRS in 6 patients(27.3.).Two patients(9.1%)developed grade 1-2 ***:Donor-derived anti-CD19 CAR-T-cell therapy may be better,safer,and more effective than chemo-DLI for B-ALL patients who relapse after allo-HSCT.

关键词： CD19-positive B-cell acute lymphoblastic leukemia relapse donor-derived CD19 chimeric antigen receptor T cells chemo-donor lymphocyte infusion

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Real-time phase measurement and correction of dynamic multimode beam using a single spatial light modulator

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Chinese Optics Letters 2020年第1期18卷 54-58页

作者： Kun xie Wenguang Liu Qiong Zhou Zongfu Jiang Fengjie xi xiaojun Xu College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China state Key laboratory of Pulsed Power Laser Technology Changsha 410073China Hunan Provincial Key laboratory of High Energy Laser Technology Changsha 410073China

In this Letter,a novel system for adaptively correcting the phase of a dynamic multimode beam is *** using merely one spatial light modulator,the phase measurement of the first-order diffraction pattern and the correction of the zeroth diffraction order are simultaneously *** real-time experimental result is obtained at a control rate of 10 *** power-in-the-bucket value is improved from 3..5%to 61.8%,even with fundamental mode content that is consistently below 3.%.To the best of our knowledge,this is the first implementation of real-time adaptive correction of the entire multimode beam.

关键词： fiber laser mode decomposition adaptive optics phase correction

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高饱和磁化强度铁基非晶纳米晶软磁合金发展概况

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工程科学学报 2018年第10期40卷 1158-1167页

作者：惠希东吕旷斯佳佳杜晨曦王荣山北京科技大学新金属材料国家重点实验室北京100083 苏州热工研究院有限公司苏州215004

概括了铁基非晶软磁合金和纳米晶合金的发展历史和现状,分别详述了高饱和磁化强度（Bs）铁基块体和薄带非晶以及纳米晶合金近年来的研究成果.主要内容包括：高饱和磁化强度块体铁基非晶软磁合金成分和性能,高饱和磁化强度铁基非晶薄带... 详细信息

概括了铁基非晶软磁合金和纳米晶合金的发展历史和现状,分别详述了高饱和磁化强度（Bs）铁基块体和薄带非晶以及纳米晶合金近年来的研究成果.主要内容包括：高饱和磁化强度块体铁基非晶软磁合金成分和性能,高饱和磁化强度铁基非晶薄带软磁合金的成分和性能,高饱和磁化强度铁基纳米晶合金的组织、结构和性能,各类元素对合金磁性能的影响.为进一步研究高饱和磁化强度的铁基软磁材料提供了有价值的参考.

关键词：铁基非晶合金纳米晶合金高饱和磁化强度成分组织

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Efficacy of telbivudine in HBeAg-positive chronic hepatitis B patients with high baseline ALT levels

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World Journal of Gastroenterology 2010年第32期16卷 4095-4099页

作者： Guo-Cai Lv Wen-Jiang Ma Lin-Jung Ying xi Jin Lin Zheng Yi-Da Yang state Key laboratory for Diagnosis and Treatment of Infectious Diseases department of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang {3. Hangzhou 310003 Zhejiang ProvinceChina

AIM:To evaluate the efficacy and safety of telbivudine(LDT) in hepatitis B e antigen(HBeAg)-positive chronic hepatitis B(CHB) patients who have high baseline alanine aminotransferase(ALT) levels between 10 and 20 times the upper limit of ***:Forty HBeAg-positive CHB patients with high baseline ALT levels between 10 and 20 times the upper limit of normal were enrolled and received LDT monotherapy for 52 *** forty patients with baseline ALT levels between 2 and 10 times the upper limit of normal were included as *** compared the virological,biochemical,serological and side effect profiles between the two groups at 52 ***:By week 52,the mean decrease in hepatitis B virus(HBV) DNA level compared with baseline was 7.03.log10 copies/mL in the high baseline ALT group and 6.17 log10 copies/mL in the control group,respectively(P 3..5% of those in the high baseline group and 22.5% of controls,respectively,had HBeAg seroconversion(P 3.7.5%) of them seroconverted(became HBsAg-positive).Only 1 patient in the control group became HBsAg-negative,but had no *** ALT normalization rate,viral breakthrough,genotypic resistance to LDT,and elevations in creatine kinase levels were similar in the two groups over the 52 ***:High baseline ALT level is a strong predictor for optimal results during LDT treatment.

关键词： Chronic hepatitis B Hepatitis B e antigen Serum alanine aminotransferase level Telbivudine

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天津市医护人员愤怒情绪下的行为特征调查

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医学与社会 2018年第6期31卷 68-70页

作者：王熙朱琳天津中医药大学中医学院天津300193 天津中医药大学马克思主义学院天津300193

目的:调查愤怒情绪下医护人员的行为特征并提出针对性的解决措施。方法:对天津市3.医院43.医护人员进行问卷调查,分析愤怒情绪下医护人员的行为特征。结果:不同职称的医护人员在愤怒气质耐心维度有显著差异(P<0.05)。主任医师、副主... 详细信息

目的:调查愤怒情绪下医护人员的行为特征并提出针对性的解决措施。方法:对天津市3.医院43.医护人员进行问卷调查,分析愤怒情绪下医护人员的行为特征。结果:不同职称的医护人员在愤怒气质耐心维度有显著差异(P<0.05)。主任医师、副主任医师、护士愤怒气质耐心维度得分较低,主治医师、住院医师得分较高,实习医师和其他居中。状态怒总分与特质怒总分、愤怒表达总分、人际侵犯动机总分之间存在显著相关性。愤怒表达总分与特质怒总分、人际动机侵犯总分之间存在显著相关性,且均呈正相关。结论:医护人员愤怒状态虽倾向于愤怒发泄,但是在具体表达愤怒情绪时更多选择克制。医护人员的愤怒情绪会降低医疗质量,威胁医患双方人身安全。

关键词：愤怒情绪医护人员行为特征天津

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The MKK3.MPK7 cascade phosphorylates ERF4 and promotes its rapid degradation to release seed dormancy in Arabidopsis

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Molecular Plant 2023年第11期16卷 1743-1758页

作者： xi Chen Qiujia Li Ling Ding Shengnan Zhang Siyao Shan xiong xiong Wenhui Jiang Bo Zhao Liying Zhang Ying Luo Yiming Lian xiuqin Kong xiali Ding Jun Zhang Chunli Li Wim J.J.Soppe Yong xiang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Center for Crop Science College of AgronomyQingdao Agricultural UniversityQingdao 266109China School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Hou Ji laboratory in Shanxi Province Academy of AgronomyShanxi Agricultural UniversityTaiyuan 030031China state Key laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400715China Rijk Zwaan 2678 ZG De Lierthe Netherlands

Seeds establish dormancy to delay germination until the arrival of a favorable growing *** this study,we identify a fate switch comprised of the MKK3.MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to *** show that dormancy-breaking factors activate the MKK3.MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed ***,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon *** activated MKK3.MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these ***,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions.

关键词： seed dormancy dormancy breaking seed germination MKK3 MPK7 ERF4 phosphorylation protein degradation DNA binding

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管理层激励对企业数字化转型的影响研究

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技术经济与管理研究 2023年第5期 47-52页

作者：李瑞茜中国劳动关系学院经济管理学院北京100048

以2013.2020年A股制造业上市公司数据为样本,采用Heckman两阶段模型,从管理层特质和公司治理的视角探讨了管理层激励对企业数字化转型决策和规模的影响、异质性及作用渠道。研究发现,管理层激励能够提升企业数字化转型的可能性和规模,... 详细信息

以2013.2020年A股制造业上市公司数据为样本,采用Heckman两阶段模型,从管理层特质和公司治理的视角探讨了管理层激励对企业数字化转型决策和规模的影响、异质性及作用渠道。研究发现,管理层激励能够提升企业数字化转型的可能性和规模,且薪酬激励的效果优于股权激励的效果,这一效应主要体现在非国有企业、大型企业及环境不确定性较高的企业;随着薪酬激励增多,中小企业数字化转型规模更大。通过抑制管理层短视行为、强化企业社会责任、提高企业内部控制质量,管理层激励能够推动企业数字化转型。研究为因企制宜,建立多样管理层激励机制,以驱动企业数字化转型提供参考。

关键词：管理层激励数字化转型管理层短视企业社会责任企业内部控制

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稀土与间硝基苯甲酸和邻菲罗啉二元、三元固态配合物的合成及荧光光谱

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陕西师大学报（自然科学版） 1995年第3期23卷 44-47,70页

作者：张安运钱博闵杰方秋霞陕西师范大学化学系

采用乙醇－水溶液析出法合成了稀土离子ＲＥ３＋（Ｌａ３＋，Ｎｄ３＋，Ｇｄ３＋，Ｄｙ３＋，Ｙ３＋，Ｙｂ３＋）与间硝基苯甲酸（ＨＡ）和邻菲罗啉（ｐｈｅｎ）的二元及三元固态配合物．通过元素分析、热重分析证实配合物组成为ＮｄＡ... 详细信息

采用乙醇－水溶液析出法合成了稀土离子ＲＥ３＋（Ｌａ３＋，Ｎｄ３＋，Ｇｄ３＋，Ｄｙ３＋，Ｙ３＋，Ｙｂ３＋）与间硝基苯甲酸（ＨＡ）和邻菲罗啉（ｐｈｅｎ）的二元及三元固态配合物．通过元素分析、热重分析证实配合物组成为ＮｄＡ３·３Ｈ２Ｏ，ＲＥＡ３·２Ｈ２Ｏ（ＲＥ＝Ｇｄ，Ｄｙ），ＲＥＡ３（ＲＥ＝Ｙｂ，Ｙ）和ＬａＡ３·ｐｈｅｎ．考察了配合物的红外光谱、紫外光谱、荧光光谱和溶解性．

关键词：配合物间硝基苯甲酸邻菲罗啉荧光光谱稀土族

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High-dose Chemotherapy Combined with Autologous Hematopoietic Stem Cell Transplantation as Frontline Therapy for Intermediate/High-risk Diffuse Large B Cell Lymphoma

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Current Medical Science 2021年第3期41卷 465-473页

作者： Qin WEN Li GAO Jing-kang xiONG Qiong LI San-bin WANG Ji-shi WANG Fang LIU Cheng ZHANG Yao LIU Pei-yan KONG xian-gui PENG Jun RAO Lei GAO xi ZHANG Medical Center of Hematology Xinqiao Hospital Army Medical UniversityChongqing 400037China department of Hematology General Hospital of Kunming Military Region of PLAKunming 650032China department of Hematology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000China department of Hematology General Hospital of Chengdu Military Region of People's Liberation ArmyChengdu 610000China state Key laboratory of Trauma Burns and Combined InjuryArmy Medical UniversityChongqing 400037China

The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphoma(DLBCL).However,its clinical efficacy as frontline therapy remains to be *** study aimed to examine the feasibility of frontline auto-HSCT for newly diagnosed intermediate/high-risk DLBCL *** retrospectively reviewed the data of 223.patients treated with frontline auto-HSCT or chemotherapy alone(year 2008-2014)from four *** median follow-up time was 29.4 *** the two treatment arms among the intermediate/high-risk DLBCL patients,the 3.year overall survival(OS)and progression-free survival(PFS)rates of patients given frontline auto-HSCT were 87.6%and 81.9%,respectively,and the chemotherapy-alone group showed 3.year OS and PFS rates of 64.9%and 59.59%,*** with the chemotherapy-alone group,the frontline auto-HSCT could eliminate the adverse impact of non-germinal center B-cell(GCB)*** addition,in the frontline auto-HSCT group,patients who achieved complete response(CR)at auto-HSCT had a longer survival time than those who did not achieve *** results suggested that frontline auto-HSCT could improve the prognosis of intennediate/high-risk DLBCL patients.

关键词： diffuse large B-cell lymphoma intermediate/high risk autologous hematopoietic stem cell transplantation frontline therapy

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21世纪的人文地理学

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烟台师范学院学报（自然科学版） 2003年第2期19卷 134-139页

作者：孙峰华隋干城王富喜林文杰烟台师范学院地理与资源管理学院山东烟台264025

阐述了人文地理学的发展现状和面临的形势,对21世纪的人文地理学进行了展望。指出21世纪的人文地理学有14个显著特征,从而勾画了21世纪人文地理学的新框架。

关键词： 21世纪人文地理学发展历史发展现状发展趋势可持续发展人地关系

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