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Advances in Materials Physics and Chemistry 2017年第7期7卷 294-310页

作者： Vincent Claude Hugo Solis Garcia Cédric Wolfs st.phanie D. Lambert Department of Chemical Engineering University of Liege Liege Belgium Chemical Engineering Faculty Central University of Ecuador Quito Ecuador

An aqueous sol-gel method for the synthesis of γ-Al2O3 supports has been developed for the use in tar reforming applications. It was determined the influences of two different aluminum precursors (aluminum sec-butoxide (Al[OCH(CH3)CH2CH3]3) and aluminum nitrate (Al(NO3)3)) on the textural and crystallographic properties of Al2O3 supports. Only the formation of γ-Al2O3 is aimed in order to use these alumina materials as catalytic supports, because it presents high specific surface area and pore volume values. Additionally, the synthesis of γ-Al2O3 was realized with the use of a functionalized silicon precursor, [3-(2-aminoethylamino)propyl]trimethoxysilane, called EDAS. By the presence of an ethylenediamine group in this molecule, it is possible to chelate metallic ions and to highly increase their dispersion at a molecular level during the synthesis of metallic catalysts supported on alumina, which is an asset for catalytic applications. So it was developed a synthesis sol-gel procedure for the cogelation between the functionalized silicon alkoxide EDAS and alumina precursor. The alumina supports synthesized with Al(NO3)3 as precursor presented higher porous values than the ones obtained with aluminium sec-butoxide precursor. Since nitrate salts are much easier to handle than alkoxides, these observations allowed validating Al(NO3)3 as aluminum source for the future synthesis procedures for metallic catalysts supported on alumina.

关键词： Sol-Gel Process γ-Al2O3 Supports Aqueous Synthesis Cogelation Method

估算初级端稳压恒流反激式转换器的输出电流容限(第1部分):分析模型

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中国集成电路 2018年第6期27卷 43-47,51页

作者： st.phanie Cannenterre 安森美半导体

1前言初级端稳压（PSR）反激转换器广泛应用于LED驱动市场以及针对旅行适配器的便携电子市场。初级端稳压包括通过观察转换器初级端的波形来调节反激器的输出电流或输出电压。因此,通过去除光电耦合器、TL431或感测输出电压的运算放大器... 详细信息

1前言初级端稳压（PSR）反激转换器广泛应用于LED驱动市场以及针对旅行适配器的便携电子市场。初级端稳压包括通过观察转换器初级端的波形来调节反激器的输出电流或输出电压。因此,通过去除光电耦合器、TL431或感测输出电压的运算放大器,这种技术有助于减少电源材料清单。此外,它也无需感测输出电流所需的电阻。众所周知,通过观察辅助绕组可获得输出电压的图像。

关键词：输出电流转换器反激式稳压模型容限恒流估算

估算初级端稳压恒流反激式转换器的输出电流容限(第3部分)

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中国集成电路 2018年第8期27卷 48-53页

作者： st.phanie Cannenterre 安森美半导体

1前言在本文的第1部分和第2部分中,我们导出了一个初级端稳压（P SR）恒流（CC）反激分析模型,并使用该模型对转换器进行了蒙特卡罗分析（M CA）。MCA是最差情况下的电路分析（W CCA）技术的一部分,用于评估给定电路设计的风险和极限。... 详细信息

1前言在本文的第1部分和第2部分中,我们导出了一个初级端稳压（P SR）恒流（CC）反激分析模型,并使用该模型对转换器进行了蒙特卡罗分析（M CA）。MCA是最差情况下的电路分析（W CCA）技术的一部分,用于评估给定电路设计的风险和极限。通过该分析可得出转换器使用寿命之初的输出电流变化区间。

关键词：输出电流转换器反激式恒流稳压容限估算蒙特卡罗分析

Jonzac Thermal Spring Water Reinforces Skin Barrier Function of Human Skin and Presents a Soothing and Regenerating Effect

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第4期13卷 247-268页

作者： Valérie Cauche Coralie Martineau Giuseppe Percoco Marie Reynier st.phanie Scalvino Laurent Peno-Mazzarino Laboratoires Léa Avenue Paul Langevin Périgny France Eurofins BIO-EC laboratory 1 chemin de Saulxier Longjumeau France

The skin is a formidable physical and biological barrier which communicates continuously with the outside of the body. And the stratum corneum, the outermost layer of human epidermis, plays a central role in the interaction between the cutaneous tissue and the external environment. The horny layer, and more generally the whole skin layers, avoid the penetration of harmful exogenous agents, produce molecules named anti-microbial peptides which impact the composition of the cutaneous microbiota, regulate the internal corporal temperature, avoid the water loss from the inside of the body and constitute an incredible efficient anti-oxidant network. Nevertheless, nowadays, the skin is more and more solicited by the different elements of the cutaneous exposome, including atmospheric pollution and solar radiations, which can cause a dramatic acceleration of the skin ageing process. As a consequence, due to the multifunctional protective role of the skin, during the recent decade the cosmetic industry invested massively in the development of new raw materials and end-products (dermo-cosmetics) able to preserve an optimal state of the skin regarding the external environment. Based on their physical-chemical properties thermal spring waters, which are extremely rich in inorganics ions, are interesting and powerful candidates to be part, as integral component, of new efficient dermo-cosmetic formulations dedicated to protect the skin from the external stimuli. The aim of the present work was to investigate and characterize the activity of Jonzac thermal spring water on the skin. Using different models, we proved for the first time that Jonzac thermal spring water reinforces the barrier function of the skin by modulating the expression of key markers including filaggrin and human beta defensin 2 on ex vivo human skin. The ex vivo and in vivo hydration activity, by Raman spectroscopy and corneometry respectively, has been also demonstrated. We have also shown that Jonzac thermal

关键词： Jonzac Thermal Spring Water Skin Barrier Function Soothing Effect Regenerating Effect Skin Hydration Isotonicity Dermo-Cosmetics Ex Vivo Explants

Atrial embolism caused by portal vein embolization:Treatment by percutaneous withdrawal and stenting

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World Journal of Hepatology 2012年第12期4卷 412-414页

作者： Ahmed Fouad Bouras st.phanie Truant Jean-Paul Beregi Geraldine Sergent Olivier Delemazure Guido Liddo Gilles Lebuffe Philippe Zerbib Franois-René Pruvot Emmanuel Boleslawski Service de Chirurgie Digestive et Transplantation CHUUniv Nord de FranceF-59000 LilleFrance Service d’imagerie cardiovasculaire diagnostique et interventionnelle Hopital cardiologiqueCHUUniv Nord de FranceF-59000 LilleFrance Service d’imagerie digestive diagnostique et interventionnelle Hopital Claude HuriezCHUUniv Nord de FranceF-59000 LilleFrance Service d’anesthésiologie Hopital Claude HuriezCHUUniv Nord de FranceF-59000 LilleFrance

Hepatectomy remains the only curative treatment for many primary and secondary liver *** vein embolization(PVE) has been used to increase the volume of the future liver remnant and thus lower the risk of small-for-size syndrome and postoperative liver *** technique has proven its safety,with a low post-procedure morbidity ***,we describe a very rare case in which a young patient suffered a glue embolism to the right atrial cavity following PVE in preparation for a major hepatectomy for colorectal *** foreign body was withdrawn from the heart with a femoral,percutaneous device and trapped against the wall of the femoral vein with a self-expanding metal *** report shows that this previously unknown complication of PVE can be resolved without recourse to sternotomy and open heart surgery.

关键词： Liver metastasis Percutaneous endovascular intervention Portal vein Embolization Glue Complications stenting

估算初级端稳压恒流反激式转换器的输出电流容限(第2部分)

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中国集成电路 2018年第7期27卷 60-64页

作者： st.phanie Cannenterre 安森美半导体

1前言本文的第1部分介绍了初级端稳压恒流反激式转换器的分析模型。我们也考虑了通过与实验结果进行对比来验证这个模型的有效性。该模型将使我们能够确定在LED驱动器应用中,在最差的情况下能够实现的反激式输出电流的精度。在第2部分中... 详细信息

1前言本文的第1部分介绍了初级端稳压恒流反激式转换器的分析模型。我们也考虑了通过与实验结果进行对比来验证这个模型的有效性。该模型将使我们能够确定在LED驱动器应用中,在最差的情况下能够实现的反激式输出电流的精度。在第2部分中,我们将通过执行蒙特卡罗分析来估算转换器在最差情况下的输出电流极限。

关键词：输出电流转换器反激式恒流稳压估算容限 LED驱动器

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解决准方波谐振电源的谷底跳频问题

电子设计技术 EDN CHINA 2011年第6期18卷 57-57,59页

作者： st.phanie Cannenterre 安森美半导体

准方波谐振转换器也称作准谐振（QR）转换器,使反激式开关电源（SMPS）设计的信号电磁干扰（EMI）更低及满载能效更高。然而,由于负载下降时开关频率升高,必须限制频率漂移,避免额外的开关损耗。

关键词：准方波谐振转换器谷底锁定安森美

Seaberry (Hippophae rhamnoides L.) and Water Lily (Nymphaeaceae) Extracts Protect Human Skin against Blue Light, Environmental Pollutants and UV-A Irradiations in an Ex VivoModel System

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Journal of Cosmetics, Dermatological Sciences and Applications 2019年第3期9卷 244-262页

作者： Softa Mohamed Percoco Giuseppe Almeida Scalvino st.phanie Peno-Mazzarino Laurent Pauline Bony Lati Elian INDERMA dermatological laboratory Ivry sur SeineFrance BIO-EC laboratory LongjumeauFrance

Background: The skin is the outer shell of the mammalian body and it is continuously exposed to a large spectrum of external stimuli including sun irradiation and atmospheric pollutants. These factors present deleterious effects on the cutaneous compartment by altering the skin barrier functions and accelerating the aging of the skin. Objectives: The goal of this study was to investigate the activity of Seaberry and Water Lily extracts, here called Dermina complex, against different external stresses. Methods: Human skin explants were exposed to different stimuli including delipidation by organic solvents, blue light, atmospheric pollutants and UV-A. The activity of the Seaberry and Water Lily extracts was assessed by immunohistochemistry and by biochemical assays. Results: We showed that Dermina complex prevents the delipidation-induced filaggrin decrease, suggesting that these plant extracts exhibited barrier function protecting properties. Also, we observed that Dermina complex showed an antioxidant and DNA protection activity by decreasing the activated form of Nrf2, the oxidized proteins and the formation of γ-H2AX induced upon stress conditions. The Dermina complex also decreased the pro-inflammatory cytokine IL-1 alpha released in the culture medium following atmospheric pollutants and UV-A exposure confirming its anti-inflammatory activity. Moreover, Dermina complex reduced the blue light-induced overexpression of opsin 3, indicating that its skin protection activities may be due, in part, to filter property against environmental stresses. Conclusions: Dermina complex shows a protective activity of the skin against different environmental stresses and these extracts may be able to slow down the aging process of the cutaneous compartment.

关键词： Exposome Environmental Pollution Blue Light Oxidative stress Plant Extracts Skin Explants

Minimally Invaded Sentinel Lymph Node Model for the Development of Intraoperative Infrared Fluorescence Imaging

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Advances in Molecular Imaging 2018年第4期8卷 48-58页

作者： Badiane Serigne Moussa Raes Florian Julien Sobilo Natkunarajah Sharuja Lerondel st.phanie Le Pape Alain UFR des Sciences de la Santé Université Gaston BERGER Saint-Louis Sénégal Centre for Small Animal Imaging PHENOMIN-TAAM CIPA CNRS UPS44 Orléans France

In this study we implemented an axillary SLN invasion model to develop highly sensitive imaging strategies enabling detection of a very small amount of tumor cells. A highly diffusible molecular probe targeting αvβ3 and αvβ5 integrins was investigated either via IV or locoregional injections. We additionally documented the potential interferences of this Near Infrared Fluorescence Probe with Blue Patente V and ICG dyes routinely used to facilitate lymph node detection during surgery. The human mammary adenocarcinoma MDA-MB-231-luc model was injected into the forepaw of nude female rats to obtain a controlled invasion of the axillary LN. Thanks to its high sensitivity, BLI was selected to achieve in vivo quantitation of tumor cells in SLNs and determine eligible animals for the study. NIRF of integrins was performed at 680 nm both in vivo and ex vivo using spectral unmixing to suppress auto-fluorescence signal and preserve sensitivity. In vivo BLI was quite reliable in estimating discrete invasion by cancer cells in the LN with thresholds of detection and quantitation of about 500 and 1500 cells respectively. For fluorescence at 680 nm, in vivo imaging is not suitable to detect micro-invasion, but ex vivo fluorescence with spectral unmixing of SLNs confirmed the presence of a tumor burden as low as 1500 cells expressing αvβ3/αvβ5 integrins. Targeting few tumor cells inside a micro-invaded sentinel lymph node by molecular probes is not sensitive enough to provide direct in vivo or peroperative imaging. At the time NIRF is performed on the excised specimen, high sensitivity imaging associated with spectral unmixing allowed such detection within less than 1 minute of examination.

关键词： Sentinel Lymph Node Near Infrared Fluorescence Imaging Photoacoustic Imaging Molecular Imaging

Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of Retinal Pigment Epithelial Cells

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Advances in Biological Chemistry 2015年第2期5卷 73-82页

作者： Jean-Michel Bourget Mohib Morcos Karine Zaniolo Sylvain L. Guérin st.phanie Proulx Centre de recherche du CHU de Québec and Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX axe médecine régénératrice Hopital du Saint-Sacrement Québec Canada Département d’anatomie et de cytologie pathologiques CHU de Québec Hopital du Saint-Sacrement Québec Canada Département de biologie moléculaire biochimie médicale et pathologie Faculté de médecine Université Laval Québec Canada Département d’Ophtalmologie Faculté de médecine Université Laval Québec Canada

Integrins are a family of transmembrane glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. The integrin α4 subunit is widely expressed by cells from the immune system and its expression by non-hematopoietic cells is scarce. In the present study, gene and protein expression of this integrin subunit was characterized in proliferating and quiescent human RPE cells. Immunofluorescent studies confirm that the α4 subunit is expressed in vitro by RPE cells, a result that has been validated by immunofluorescence and FACS analyses. The accumulation of the α4 integrin at cell-cell junctions in post-confluent RPE cell cultures negatively correlated with the level of expression of the mRNA transcript. Accordingly, transient transfection analyses reveal that the α4 promoter activity is considerably reduced when RPE cells form a confluent monolayer. Moreover, transfection of recombinant constructs bearing 5’-deletions of the α4 promoter segment allows the localization of strong negative regulatory elements on the -76 to -300 region of the α4 gene suggesting that its expression is intimately linked to the proliferative state of primary cultured RPE cells.

关键词： Retinal Pigment Epithelium Integrin Alpha 4 Subunit Cell Culture Confluency Promoter