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Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy

Signal Transduction and Targeted Therapy 2016年第1期1卷 109-118页

作者： Katherine J Wert vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk stephen H Tsang Bernard and Shirlee Brown Glaucoma Laboratory and Barbara&Donald Jonas Laboratory of Regenerative Medicine Columbia UniversityNew YorkNYUSA Edward S.Harkness Eye Institute Columbia UniversityNew YorkNYUSA Institute of Human Nutrition Columbia UniversityNew YorkNYUSA Department of Ophthalmology and Visual Sciences University of IowaIowa CityIAUSA Omics Laboratory University of IowaIowa CityIAUSA Department of Pharmacology and Therapeutics University of FloridaGainesvilleFLUSA Eugene and Marilyn Glick Eye Institute Department of OphthalmologyIndiana University School of MedicineIndianapolisINUSA Department of Pediatrics University of IowaIowa CityIAUSA New York Presbyterian Hospital/Columbia University Medical Center New YorkNYUSA Department of Pathology and Cellular Biology Columbia UniversityNew YorkNYUSA

Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible *** vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory *** recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor *** found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human *** progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding *** addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders.

关键词： HIF1α retinopathy proliferative

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Simultaneous bilateral trochanteric fracturesma report of four cases

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Chinese Journal of Traumatology 2012年第6期15卷 360-363页

作者： vinit Verma Zile Singh Kundu Amit Batra Raj Singh Sukhbir Singh Sangwan Pratyush Gupta Department of Orthopaedic Surgery Paraplegia &Rehabilitation Pt. B.D. Sharma PGIMS Rohtak 124001Haryana India

Simultaneous bilateral intertrochanteric fractures are very rare. There is a paucity of data in current literature documenting patients with such kind of hip fractures. It is severe and potentially life-threatening, associated with a high morbidity. The major determinants of successful outcome are high vigilance, early single stage stabilization and mobilization as well as management of associated comorbid conditions that may influence the longterm rehabilitation of patients. Here we reported 4 cases of concurrent bilateral trochanteric fractures along with review of the literature. Our study aimed to discover its frequency, identify the injury mechanisms as well as factors present in the pathogenesis of these fractures, and outline the available treatment modalities.

关键词：股骨文献记录发病因素治疗方式骨折发病率合并症患者

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非正规美国城市:深化对非正规城市主义的理解

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国际城市规划 2019年第2期34卷 7-14,30页

作者：威尼.穆西贾阿纳斯塔西娅.卢卡图-塞德里斯陈瑞加州大学洛杉矶分校城市规划系重庆大学建筑城规学院

本文来源于我们2014年出版的著作——《非正规美国城市:超越快餐车与计时工》(The Informal American City:Beyond Taco Trucks and Day Labor)中的前言与结论部分。该著作审视了美国城市生活中的"非正规变革"。我们通过一系列案例研究... 详细信息

本文来源于我们2014年出版的著作——《非正规美国城市:超越快餐车与计时工》(The Informal American City:Beyond Taco Trucks and Day Labor)中的前言与结论部分。该著作审视了美国城市生活中的"非正规变革"。我们通过一系列案例研究,从经验和理论两个层面探讨了(美国城市)非正规现象的增长,而这种现象通常被视为更多地存在于发展中国家而非工业化国家。尽管一直以来非正规城市主义被规划者和政策制定者视为边缘甚至是犯罪行为而不加考虑,但是我们通过包括洛杉矶、萨克拉门托、西雅图、波特兰、菲尼克斯、堪萨斯、亚特兰大和纽约在内的一系列案例研究,对这一狭隘的观念提出了质疑。令人惊讶的是,尽管非正规城市主义出现迅猛,规划与城市设计领域的学术文献却甚少提及。因此,我们希望可以抛开传统的观点,审视在美国不同环境与城市中非正规活动的出现、增长与活力。我们倾向于采取更加复杂的方法去认知、理解和处理非正规活动,而非仅仅浪漫化地去赞扬它;我们也将争取对非正规性及其环境有一个明确的空间理解,并讨论规划者、政策制定者、城市设计者和社区应如何应对这种新出现的、蕴含着机会与挑战的城市景观。美国城市中的非正规活动普遍且多样。其中的大多数活动在本质上并非犯罪,也超出了经济上的谋生范畴。虽然非正规性通常与移民相联系,但是非正规活动广泛地存在于不同的社会团体、多样的城市环境和全国不同的地理区域中。正规与非正规活动可能时而冲突、时而交叠或相互依存。非正规活动的案例研究帮助揭示了非正规性的逻辑、潜在合理性,以及非正规活动与城市和法规中更大的政治经济(活动)之间的结构性联系。这些案例通过非正规活动中潜在的获益者与失意者间的联系,展示了这类活动的矛盾本质。近年来出现了一些关于非正规性的迷思和错误观念。迷思之一是非正规性是发展中国家的重要部分,且仅仅出现在发达国家城市中极度贫困和边缘化的社区。然而,不同类型城市的非正规性已经清晰地出现在了发达国家城市的中产阶级和富裕的邻里。第二种迷思认为正规和非正规的活动与环境之间是泾渭分明的,然而在一些城市的正规与非正规环境之间,我们并未发现明显的分界线。第三种迷思是非正规性是一种暂时的现象和短暂的构造,然而非正规活动的空间广泛性与时间延续性所展现出的恰恰相反。最后,非正规活动总是被视为一种美德,或是一种消极的现象,这种认识掩盖了非正规活动并非同质的,而是依赖于具体的背景和环境的事实。在对非正规城市主义的挑战与机遇作出回应之前,规划者和政策制定者与其坚持这些迷思,不如深化对于非正规城市主义的理解,并仔细思考它们的社会和物质背景。

关键词：非正规性非正规城市主义美国误解空间理解

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Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

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