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Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

Neural Regeneration Research 2018年第12期13卷 2044-2049页

作者： Clément Chollat stéphane marret Institut National de la Santé et de la Recherche Médicale U1245 Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University Department of Neonatal Intensive Care Port Royal University Hospital Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics Charles-Nicolle University Hospital

Antenatal administration of magnesium sulfate is an important part of the neuroprotective strategy for preterm infants. strong evidence from five randomized controlled trials and five meta-analyses has demonstrated that magnesium sulfate, when administered before preterm delivery, significantly reduces the risk of cerebral palsy at two years. Through secondary analyses of randomized controlled trials and other original clinical studies, this state-of-the-art review highlights the absence of serious adverse effects in both pregnant women and neonates, as well as the impact of maternal body mass index and preeclamptic status on the maternal and neonatal magnesium levels, which could influence the magnitude of the neuroprotective effect. Although antenatal magnesium sulfate is a cost-effective strategy, some practice surveys have demonstrated that the use of magnesium sulfate is not sufficient and that its use is heterogeneous, differing among different maternity wards. Since 2010, an increasing number of obstetrical societies have recommended its use to improve the neurological outcomes of preterm infants, especially the International Federation of Gynecology and Obstetrics and World Health Organization in 2015, and France in 2017. Considering the neuroprotective impact of magnesium sulfate when administered before delivery, postnatal administration should be considered, and its effects should be assessed using randomized controlled trials.

关键词： magnesium sulfate preterm birth neuroprotection cerebral palsy neurodevelopment international recommendations clinical studies meta-analysis preeclampsia cost-effectiveness

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Development of NK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

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Could near infrared spectroscopy be the new weapon in our understanding of the cerebral and muscle microvascular oxygen demand during exercise?

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Journal of Sport and Health Science 2024年第4期13卷 457-458页

作者： stephane Perrey EuroMov Digital Health in Motion University of MontpellierIMT Mines AlesMontpellier 34090France

Near-infrared spectroscopy(NIRS)has been increasingly utilized in both sport and health sciences to assess various physiological parameters related to exercise performance.1 NIRS methods coupled with the recent development of portable and wearable devices suitable for field-based measurements have revolutionized the study of exercise physiology and the determinants of exercise performance by providing real-time,non-invasive,and spatially localized measurements of tissue oxygenation dynamics.

关键词： cerebral utilized exercise

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大陆俯冲界面之上大规模硅富集流体的地球物理学证据

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中国科学:地球科学 2024年第9期54卷 2848-2863页

作者：毛元彤赵亮 Marco G.MALUSà stefano SOLARINO Silvia PONDRELLI 孙宝璐 Coralie AUBERT Simone SALIMBENI Elena EVA stéphane GUILLOT 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室中国科学院大学地球与行星科学学院 Department of Earth and Environmental Sciences University of Milano-Bicocca Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale Terremoti Istituto Nazionale di Geofisica e Vulcanologia Sezione di Bologna Université Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerre

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地... 详细信息

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地球物理方法分析了西阿尔卑斯造山带地区的VP/VS比值,发现在俯冲区的上盘侧存在高VP/VS（>1.9）带,与部分蛇纹岩化的上覆地幔楔位置一致;而在下盘侧存在异常低的VP/VS（<1.7）带,异常深度浅于30km.本文认为,观测到的低VP/VS比值异常是由地壳内广泛分布的富硅岩脉导致,指示了在俯冲时期大陆俯冲界面之上可能存在的富硅流体流动.本文的结果暗示俯冲时期的流体流动可能降低了俯冲界面的有效应力,从而促进了大陆俯冲.

关键词：西阿尔卑斯造山带地壳精细结构接收函数 VP/VS波速比硅富集

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Geophysical evidence of large-scale silica-rich fluid flow above the continental subduction interface

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Science China Earth Sciences 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSà stefano SOLARINO Silvia PONDRELLI Baolu SUN Coralie AUBERT Simone SALIMBENI Elena EVA stéphane GUILLOT state Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences Department of Earth and Environmental Sciences University of Milano-Bicocca Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale Terremoti Istituto Nazionale di Geofisica e Vulcanologia Sezione di Bologna Université Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerre

Fluids in subduction zones can have major effects on subduction dynamics. However, geophysical constraints on the scale and impact of fluid flow during continental subduction are still limited. Here we analyze the VP/VSratios in the Western Alpine region, hosting one of the best-preserved fossil continental subduction zones worldwide, to investigate the impact of fluid flow during continental subduction. We found a belt of high VP/VSratios >1.9 on the upper-plate side of the subduction zone,consistent with a partially serpentinized upper-plate mantle, and a belt of unusually low VP/VSratios st fluid flow along the continental subduction interface. Our results suggest that past fluid flow may have reduced the effective stress along the subduction interface thus favoring continental subduction.

关键词： Western Alps Crustal structure Receiver function VP/VS ratio Silica enrichment

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Noninvasive Respiratory strategies in Patients with Acute Hypoxemic Respiratory Failure and COVID-19 in Gabon: A Prospective Observational study

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Open Journal of Emergency Medicine 2024年第1期12卷 18-27页

作者： Ghislain Edjo Nkilly Raphael Okoue Ondo Fernande Manga stéphane Oliveira Jean Marcel Mandji-Lawson Romain Tchoua Department of Emergency Anesthesia Resuscitation Omar Bongo Ondimba Army Training Hospital Libreville Gabon Department of Anesthesia and Resuscitation Libreville University Hospital Center Libreville Gabon Department of Anesthesia and Resuscitation Akanda Army Training Hospital Libreville Gabon

Importance: The best respiratory support technique to reduce intubation and mortality in patients with respiratory failure due to COVID-19 is controversial. Objective: To determine the respiratory support technique that could reduce the need for tracheal intubation and mortality in patients with respiratory failure due to COVID-19 admitted to intensive care units (ICUs) of Military’s Hospital (HIAOBO) in Gabon. Design, Setting, and Participants-Methodology: Prospective observational study over 10 months (January 2021-October 2021). We included patients admitted to intensive care for SARS Cov2 pneumonia who had benefited from available ventilatory support: high concentration face mask, High Flow Nasal cannula (HFNC), NIV (Non Invasive Ventilation), Continuous Positive Airway Pressure (CPAP). The choice was guided by the clinical condition, and the choice of the prescribing physicians. Recourse to mechanical ventilation was decided when faced with a Glasgow score of less than 13, an SpO2/FiO2 ratio ≤ 300, a FR ≥ 35/min, the impossibility of drainage of secretions. Main Outcomes and Measures: The primary outcome was the proportion of patients requiring intubation. The secondary outcomes were mortality in ICU. Results: The sample included 97 patients, the average age was55.6 years, hypertension was the main comorbidity (51.1%). Mean respiratory rate (RR) was 30.8 cycles/min, admission SpO2 was 83%, respiratory alkalosis was present in 63% of patients, mean CT involvement was 51%.Respiratory support was NIV (56.7%), CPAP (21.65%), high concentration face mask (18.55%). Sixteen percent (16%) of patients were intubated, 93% of them following failure of NIV. Mortality was 30%, mechanical ventilation was an independent risk factor for mortality. Conclusions: Non Invasive Ventilation, CPAP, and high-concentration face mask were frequently used in patients with COVID-related acute respiratory failure. The CPAP has reduced the need for intubation. Mechanic

关键词： Respiratory Failure COVID 19-Intensive Care Units Military Hospital Gabon

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Postoperative Analgesia and Cesarean Section under General Anesthesia: Multicenter study

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Open Journal of Anesthesiology 2024年第1期14卷 1-12页

作者： Ghislain Edjo Nkilly Raphael Okoue Ondo Pascal Christian Nze Obiang stéphane Oliveira Jean-Marcel Mandji-Lawson Romain Tchoua Department of Anesthesia and Intensive Care Omar Bongo Ondimba Army Training Hospital (HIAOBO) Libreville Gabon Department of Anesthesia and Intensive Care Jeanne Ebori Fondation Libreville Gabon Department of Anesthesia and Intensive Care Akanda Army Training Hospital Libreville Gabon

Background: Neuraxial anesthesia with intrathecal morphine is the reference technique in cesarean section anesthesia for the management of postoperative analgesia. If there is a contraindication to this, general anesthesia is required. The objective of the study was to evaluate the analgesic effectiveness of 4 analgesic techniques performed during cesarean section under general anesthesia in two centers with different anesthetic practices (North Franche Comté Hospital and Omar Bongo Ondimba Army Training Hospital). Method: This is a retrospective and descriptive study over 2 years, from January 1, 2019 to December 31, 2020. It involved evaluating the analgesic effectiveness and tolerance of morphine in the epidural catheter, wound infiltration, intravenous analgesia and Transversus Abdominous Plane block (TAP block) from the post-anesthesia care unit (PACU) until the 4th post-operative day. Results: Of the 354 cesarean sections performed, 84 (11.14%) received general anesthesia. The average age was 32.27 years. Acute fetal distress was the first indication for cesarean section (45.2%), followed by hemorrhagic placenta previa (10.7%) and prolapse of the cord (8.33%). Morphine in the epidural catheter was the most used (47.6%) followed by parietal infiltration (36.9%), intravenous analgesia (13.1%) and TAP block (2.38%). The analgesic effectiveness was comparable between the techniques from postoperative day 0 to day 4. No difference in side effects. Postoperative morphine consumption was significantly reduced (p = 0.011) in the infiltration (9 mg) and TAP block (9mg) groups compared to the epidural catheter (16 mg) and intravenous analgesia (17 mg). No difference in 02 rehabilitation criteria (ambulation, first bowel movement). No difference in the occurrence of chronic pain. Conclusion: In the event of a cesarean section under general anesthesia, there are effective and well-tolerated alternatives to neuraxial anesthesia, particularly regional anesthesia

关键词： Cesarean General Anesthesia Morphine Parietal Infiltration Epidural Catheter Transversus Abdominis Plane Block Intravenous Analgesia

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Distribution and Contamination of Arsenic in Fish, Gastropods and Bivalves in the Aby and Tendo Lagoons in East of Ivory Coast

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Journal of Environmental Protection 2024年第3期15卷 246-264页

作者： Kouakou Serge Kouassi stéphane Jean Claon Kossonou Roland N’Guettia Séri Kipré Laurent Dakouo Guei Jokebed Djaman Allico Joseph Laboratory of Biology and Health University of F&eacutelix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Department of Analytical Sciences and Public Health Faculty of Pharmaceutical and Biological Sciences University of F&eacutelix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Laboratory of Environmental Sciences (LSE) University of Nangui Abrogoua Abidjan C&ocircte d’Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d’Ivoire Abidjan C&ocircte d’Ivoire

Lagoons are ecosystems for biodiversity and the livelihoods of coastal communities. The main objective of the study was to analyze the variability of arsenic concentrations in gastropods and bivalves in the Aby and Tendo lagoons, taking into account spatial, seasonal and hydrological variations. The study was carried out in four stages spread over two successive hydroclimatic cycles, including two seasons during the rainy season and two more during the dry season. The samples were taken in two areas of the Aby and Tendo lagoons. Arsenic levels were measured by ICP-MS. The results showed that mean arsenic concentrations in the muscles of organisms in Aby Lagoon ranged from 0.01 to 1.26 μg As/g, with a mean and median of 0.17 and 0.06 μg As/g, respectively. Fish had the highest levels of arsenic, followed by crustaceans, while molluscs and plants had lower and comparable concentrations of As. Arsenic concentrations in tilapia and jawbones varied significantly between sites and seasons, with higher concentrations at Tendo and during the rainy season. Arsenic concentrations in gastropods and bivalves were significantly higher than those of other species, with averages of 0.74 and 1.03 mg As/kg, respectively.

关键词： Arsenic Pollution Fish Gastropods Lagoons Health Effect

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Intermediate Hip Arthroplasty in Gabon: Blood Loss and Risk Factor for Transfusion

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Open Journal of Anesthesiology 2024年第4期14卷 109-117页

作者： Ghislain Edjo Nkilly Pascal Christian Nze Obiang Raphael Okoue Ondo Arthur Matsanga stéphane Oliveira Léandre Nguiabanda Jean-Marcel Mandji-Lawson Department of Anaesthesia and Intensive Care Omar Bongo Ondimba Army Training Hospital (HIAOBO) Libreville Gabon Department of Anaesthesia and Intensive Care Jeanne Ebori Fondation Libreville Gabon Department of Anaesthesia and Intensive Care Owendo University Hospital (CHUO) Libreville Gabon Department of Anaesthesia and Intensive Care Akanda Army Training Hospital Libreville Gabon Orthopedic Surgery Service Omar Bongo Ondimba Army Training Hospital (HIAOBO) Libreville Gabon

Background: Hip arthroplasty is a surgery with a high risk of bleeding. The main objective of this study was to research risk factors for bleeding and transfusion in patients undergoing hip hemiarthroplasty in Gabon. Method: It was a retrospective, monocentric, descriptive and analytical study carried out from June 2011 to June 2021 at the Omar Bongo Ondimba army training hospital. The variables studied were demographic characteristics, biological variables, transfusion and intraoperative data. The primary outcome was intraoperative transfusion. A univariate and multivariate analysis was conducted to identify the factors associated with the occurrence of a transfusion. Results: Of the 97 patients included, the average age was 74.2 years ± 10, male predominance was 73.2%, the average ASA score was 1.9 ± 0.5, and transfusion incidence was 38.1%. The average number of RBCs transfused was 1.2 ± 0.6. Tranexamic acid was used in 11.3% of patients. The average bleeding was 450 ± 453 ml. Preoperative anemia was predictor of transfusion to be significant. Conclusion: The incidence of transfusion is law compared to total hip arthroplasty. The implementation of a patient blood management protocol is difficult given the urgency of bone repair. However, a better use of tranexamic acid could reduce this transfusion incidence.

关键词： Hip Arthroplasty Risk Factors Patients Hemiarthroplasty Gabon

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中华医学会-欧莱雅中国人健康皮肤/毛发研究项目成果总结——皮肤篇

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中华皮肤科杂志 2024年第5期57卷 464-467页

作者： Michele Verschoore 牛悦青 stéphane Commo Léopold Muller 魏宇昊甄雅贤刘玮欧莱雅研发和创新中心法国克里希92110 欧莱雅研发和创新中心上海201206 欧莱雅研发和创新中心法国欧奈苏布瓦93600 欧莱雅研发和创新中心美国克拉克07066 空军特色医学中心皮肤科北京100142

中华医学会和欧莱雅集团在2003-2018年间联合启动了“中国人健康皮肤/毛发研究项目”,该项目在助力提高中国皮肤科医生科研能力的同时,获得了大量宝贵的基于中国人群样本的临床和基础研究成果,并以期刊论文、会议报告等形式多次参与国... 详细信息

中华医学会和欧莱雅集团在2003-2018年间联合启动了“中国人健康皮肤/毛发研究项目”,该项目在助力提高中国皮肤科医生科研能力的同时,获得了大量宝贵的基于中国人群样本的临床和基础研究成果,并以期刊论文、会议报告等形式多次参与国内和国际学术交流。本文作者通过整理项目资料和已发表文献,对皮肤相关研究项目的主要成果做一总结.

关键词：皮肤生理学过程皮肤衰老皮肤色素沉着皮肤免疫研究报告

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