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Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 21-33页

作者： Gyokukou You Lu Zeng Hideaki Tanaka Emi Ohta Takahiro Fujii Kazuhiko Ohshima Masakazu Tanaka Nobuyuki Hamajima Chutiwan Viwatthanasittiphong Mantana Muangphot Dhiraphol Chenvidhya Adisorn Jedpiyawongse banchob sripa Masanao Miwa Satoshi Honjo Department of Bioscience Nagahama Institute of Bio-Science and TechnologyNagahama 526-0829ShigaJapan Division of Neuroimmunology Joint Research Center for Human Retrovirus InfectionKagoshima UniversityKagoshima 890-8544KagoshimaJapan Department of Healthcare Administration Nagoya University Graduate School of MedicineNagoya 466-8550AichiJapan Department of Diagnostic and Interventional Radiology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of Pathology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of Surgery Ubon Cancer CentreUbon Ratchathani 34000Thailand Research Division National Cancer InstituteBangkok 10400Thailand Department of Pathology Khon Kaen UniversityKhon Kaen 40002Thailand Department of Paediatirics National Hospital OrganizationFukuoka National HospitalFukuoka 811-1394FukuokaJapan

BACKGROUND Cholangiocarcinoma(CCA)is an intractable cancer,and its incidence in north eastern Thailand is the highest *** with the liver fluke Opisthorchis viverrini(OV)has been associated with CCA ***,animal experiments have suggested that OV alone does not induce CCA,but its combination with a chemical carcinogen like nitrosamine can cause experimentally induced CCA in ***,in humans,other environmental and genetic factors may also be *** To examine relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related *** This hospital-based case-control study enrolled 95 case-control pairs matched by age(±5 years)and *** examined relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related genes,serum anti-OV,alcohol consumption,and *** of CYP2E1,IL-6(-174 and-634),IL-10(-819),and NF-κB(-94)and their cooccurrence with polymorphisms in the drug-metabolizing enzyme gene GSTT1 or GSTM1 were also *** Although CCA risk was not significantly associated with any single polymorphism,persons with the GSTT1 wild-type and CYP2E1 c1/c2+c2/c2 genotype had an increased risk(OR=3.33,95%CI:1.23-9.00)as compared with persons having the GSTT1 wild-type and CYP2E1 c1/c1 wild *** presence of anti-OV in serum was associated with a 7-to 11-fold increased risk,and smoking level was related to an OR of 1.5-1.8 in multivariable analyses adjusted for each of the seven genetic *** In addition to infection with OV,gene-gene interactions may be considered as one of the risk factors for CCA development.

关键词： Opisthorchis Glutathione transferase Cytochrome P-450 CYP2E1 Case-control study

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Association between helminth infections and diabetes mellitus in adults from the Lao People’s Democratic Republic:a crosssectional study

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Infectious Diseases of Poverty 2018年第1期7卷 1110-1120页

作者： Nan Shwe Nwe Htun Peter Odermatt Phimpha Paboriboune Somphou Sayasone Malisa Vongsakid Vilayouth Phimolsarn-Nusith Xuan Duong Tran Phoum-Savath Ounnavong Navalone Andriama-Hefasoa Nilun-Done Senvanpan Anousine Homsana Baocher Lianosay Dalouny Xayavong Dimbitsoa Rakotomalala Robinson Phaivanh Bounsavath Phoy-Phaylinh Prasayasith Seng-Davanh Syphan Yi-Xiao Lu Kanchana Thilakoun Xaipa-Song Xaiyaphet Phout-Tasin Vongngakesone Ikenna C Eze Medea Imboden banchob sripa Daniel Reinharz Nicole Probst-Hensch Department of Epidemiology and Public Health Swiss Tropical and Public Health InstitutePO Box40024051 BaselSwitzerland University of Basel BaselSwitzerland The Francophone Institute for Tropical Medicine(International Program for Health in the Tropics) VientianeLao PDR Lao Tropical and Public Health Institute Ministry of HealthVientianeLao People’s Democratic Republic Tropical Disease Research Laboratory Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Universite Laval Quebec CityCanada

Background:As a result of epidemiological transition,the health systems of low-and middle-income countries are increasingly faced with a dual disease burden of infectious diseases and emerging non-communicable *** is known about the mutual influence of these two disease *** aim of this study was to investigate the cooccurrence of helminth infections and diabetes mellitus in adults in Lao People’s Democratic Republic(Lao PDR).Methods:We conducted a cross-sectional study among 1600 randomly selected adults aged 35 and older from four different socio-economical and ecological *** on socio-demographics,risk factors and health conditions was obtained from personal *** assessments including anthropometry(height,weight,waist and hip circumference)and blood pressure measurements were also *** was classified based on selfreported diagnoses and a point-of-care glycated haemoglobin(HbA1c)test from finger prick blood *** samples for helminth diagnosis were examined with formalin-ether concentration technique for intestinal parasitic *** independent associations of helminth infections with diabetic status and HbA1c were assessed using multiple regression ***:The prevalence of pre-diabetes and diabetes was 37.3%and 22.8%,***-six percent of diabetic cases were undiagnosed and 85%of diagnosed diabetic cases had poor glycemic *** from rural areas and from southern parts of the country had higher infection rates,with Opisthorchis viverrini,being the most common helminth infection(30.5%).We found a positive association between Taenia *** and HbA1c(β=0.117;95%CI:0.042-0.200)and diabetes mellitus risk(OR=2.98;95%CI:1.10-8.05).No other helminth species was associated with glycated ***:Hyperglycaemia and diabetic rates in Lao PDR are alarmingly high,but consistent with other high rates in the *** the high rates of unde

关键词： Dual burden of disease Opisthorchis viverrini Taenia Diabetes mellitus Cross-sectional Epidemiology Adults Lao PDR

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