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Treat to targ.t in Crohn’s disease:A practical g.ide for clinicians

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World Journal of g.stroenterolog. 2024年第1期30卷 50-69页

作者： Ashish R srinivasan Department of g.stroenterolog. Austin HealthVictoriaMelbourne 3083Australia Department of g.stroenterolog. Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-targ.t(T2T)approach applies the principles of early intervention and tig.t disease control to optimise long.term outcomes in Crohn's *** Selecting.Therapeutic Targ.ts in Inflammatory Bowel Disease(STRIDE)-II g.idelines specify short,intermediate,and long.term treatment g.als,documenting.specific treatment targ.ts to be achieved at each of these *** appraisal of Crohn’s disease activity ag.inst pre-defined treatment targ.ts at these timepoints remains central to determining.whether current therapy should be continued or *** treatment targ.ts in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STRIDE-II g.idelines endorse the pursuit of endoscopic healing.clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to eng.g. patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imag.ng.techniques,particularly intestinal ultrasound,holds g.eat promise;as do emerg.ng.treatment targ.ts such as transmural *** randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving.endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subg.oups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining.to the real-world effectiveness of a T2T approach remains scare,hig.lig.ting.the need for prag.atic real-world *** the obvious promise of a T2T approach,a lack of g.idance to support its integ.ation into real-world clinical practice has the potential to limit its *** hig.lig.ts the need to describe st

关键词： Treat to targ.t Inflammatory bowel disease Crohn’s disease Treatment targ.ts Endoscopic remission Transmural healing Time to response Intestinal ultrasound

Intellig.nt Energ. Utilization Analysis Using.IUA-SMD Model Based Optimization Technique for Smart Metering.Data

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Journal of Harbin Institute of Technolog.(New Series) 2024年第1期31卷 90-98页

作者： K.Rama Devi V.srinivasan g.Clara Barathi Priyadharshini J.g.kulapriya Department of Information Technolog. Panimalar Engineering CollegeChennaiTamil Nadu 600029India Department of Computer Applications Dayananda Sagar College of EngineeringBengaluru 560078KarnatakaIndia Department of Computer Appliations Karpagam Academy of Higher EducationCoimbatoreTamil Nadu 641021India Department of Computer Science Rathinam College of Arts and ScienceCoimbatoreTamil Nadu 641021India

Smart metering.has g.ined considerable attention as a research focus due to its reliability and energ.-efficient nature compared to traditional electromechanical metering.systems. Existing.methods primarily focus on data manag.ment,rather than emphasizing.efficiency. Accurate prediction of electricity consumption is crucial for enabling.intellig.nt g.id operations,including.resource planning.and demandsupply balancing. Smart metering.solutions offer users the benefits of effectively interpreting.their energ. utilization and optimizing.costs. Motivated by this,this paper presents an Intellig.nt Energ. Utilization Analysis using.Smart Metering.Data(IUA-SMD)model to determine energ. consumption patterns. The proposed IUA-SMD model comprises three major processes:data Pre-processing.feature extraction,and classification,with parameter optimization. We employ the extreme learning.machine(ELM)based classification approach within the IUA-SMD model to derive optimal energ. utilization labels. Additionally,we apply the shell g.me optimization(Sg.)alg.rithm to enhance the classification efficiency of the ELM by optimizing.its parameters. The effectiveness of the IUA-SMD model is evaluated using.an extensive dataset of smart metering.data,and the results are analyzed in terms of accuracy and mean square error(MSE). The proposed model demonstrates superior performance,achieving.a maximum accuracy of65.917% and a minimum MSE of0.096. These results hig.lig.t the potential of the IUA-SMD model for enabling.efficient energ. utilization throug. intellig.nt analysis of smart metering.data.

关键词： electricity consumption predictive model data analytics smart metering machine learning

Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 198-213页

作者： Mamatha Rani g. K.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania University

Contact binaries at various stag.s of evolution unveil various operating.mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and Kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q～0.41 and～0.15 with an inclination of i=42°and87°*** solutions sug.est that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing.which sug.ests the mass transfer is occurring.from secondary to *** the case of AH Cnc and based on simulations by randomly varying.the time of minima to fit the LITE solution,we noted the third body orbital period to be around P3=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to g.t an estimate of the final config.ration of the respective systems.

关键词： (stars:) binaries (including.multiple): close (stars:) binaries: eclipsing stars: activity

Direct recycling.of Li-ion batteries from cell to pack level:Challeng.s and prospects on technolog.,scalability,sustainability,and economics

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Carbon Energ. 2024年第6期6卷 1-39页

作者： Joseph Jeg.n Roy Do Minh Phuong.Vivek Verma Richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi srinivasan Energ. Research Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore School of Materials Science and Eng.neering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance School of Civil and Environmental Eng.neering Nanyang Technological UniversitySingaporeSingapore

Direct recycling.is a novel approach to overcoming.the drawbacks of conventional lithium-ion battery(LIB)recycling.processes and has g.ined considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling.LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining.electrochemical *** technolog.'s advantag.s over traditional pyrometallurg. and hydrometallurg. are costeffectiveness,energ. efficiency,and sustainability,and it preserves the material structure and morpholog. and can shorten the overall recycling.*** review extensively discusses the advancements in the direct recycling.of LIBs,including.battery sorting.pretreatment processes,separation of cathode and anode materials,and reg.neration and quality enhancement of electrode *** encompasses various approaches to successfully reg.nerate hig.-value electrode materials and streamlining.the recovery process without compromising.their electrochemical ***,we hig.lig.t key challeng.s in direct recycling.when scaled from lab to industries in four perspectives:(1)battery desig.,(2)disassembling.(3)electrode delamination,and(4)commercialization and *** on these challeng.s and chang.ng.market trends,a few strateg.es are discussed to aid direct recycling.efforts,such as binders,electrolyte selection,and alternative battery desig.s;and recent transitions and technolog.cal advancements in the battery industry are presented.

关键词： battery desig. cathode reg.neration direct recycling g.aphite recycling lithium-ion battery,scaling.up

MXene-Based Elastomer Mimetic StretchableSensors: Desig., Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi Sayan g.ng.ly Xiaowu(Shirley)Tang.Bo Wang.Seshasai srinivasan Amin Reza Rajabzadeh Andreas Rosenkranz School of Biomedical Eng.neering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnolog.(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Eng.neering.Practice and Technolog. McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Eng.neering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are hig.ly prospective for next-g.neration wearable electronics used in human-machine *** of the motivating.factors behind the prog.ess of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing.attention since the last decade due to their hig. electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor desig.,their mechanism,and various modes of sensing.platform,but also their future perspective and market throug.out the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting.the swift advancement of flexible MXene-sensors for wearable technolog.es.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

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近海三角张力腿平台钢筋束假定失效研究

哈尔滨工程大学学报（英文版） 2024年第1期23卷 182-200页

作者： srinivasan Chandrasekaran g.nta Shanmukha Rao Department of Ocean Eng.neering Indian Institute of TechnologyMadras 600036India

Offshore triceratops is one of the successful manifestations of the form-dominant desig. approaches deployable in ultra-deepwater oil and g.s *** deck’s g.ometric shape and partial isolation from the leg. counteract lateral *** are position-restrained to the sea bed by taut-moored tendons,while ball joints partially isolate the deck from the buoyant ***,compliance in the horizontal plane imposes larg. displacements,intuiting.the necessity to examine tendon *** analysis of triceratops under wave and wind combined action is carried out under the postulated conditions of a tendon failure.10-yr,100-yr,and 1000-yr post-Katrina hurricane conditions are assumed as loading.to the *** confirm a marg.nal increase in the natural periods of stiff deg.ees of freedom even under postulated failure conditions,ensuring.g.od adaptability to ultra-deep *** postulated failure,the tension of adjacent tendons varies sig.ificantly,causing.a shift to the mean position of the *** life is sig.ificantly reduced under the postulated failure of tendons,making.the platform free-floating.without affecting.its *** also show that the pitch response of the deck is a clear manifestation of the postulated failure,which is otherwise absent due to the presence of ball *** attempted study deliberates on the fatig.e life of tendons,assessing.the platform’s suitability to ultra-deep waters and identifying.the vulnerable leg. for the chosen load combinations.

关键词： Ball joints Tendons Buoyant leg. Fatig.e life Irreg.lar waves Postulated failure

Leaf habit differentiation explains trait tradeoffs across savanna woody plants

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Forest Ecosystems 2024年第3期11卷 287-295页

作者： Yang.iding.Wang.Da Yang.g.rman Varg.s g. g.ang.ou Hao Jennifer S.Powers Yan Ke Qin Wang.Yunbing.Zhang.Jiaolin Zhang CAS Key Laboratory of Tropical Forest Ecolog. Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Beijing 100049China School of Biolog.cal Sciences University of UtahSalt Lake CityUT 84112USA CAS Key Laboratory of Forest Ecolog. and Manag.ment Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Department of Ecolog. Evolution and BehaviorUniversity of MinnesotaSt PaulMN 55108USA

Identifying.how leaf habit subdivisions link to the fast–slow and avoidance–tolerance trait tradeoffs can provide new insig.t into diverg.nce in ecophysiolog.cal strateg.es among.plant functional g.oups. Here, we tested a hypothesis that the differentiation across deciduous, semi-deciduous and everg.een woody species contributes to physiolog.cal trait tradeoffs in a dry-hot valley savanna. We investig.ted 11 photosynthetic, morpholog.cal and hydraulic traits of 24 species including.8 deciduous, 10 semi-deciduous and 6 everg.een species. Deciduous species were g.ouped in the fast and avoidance side associated with hig. values of maximum photosynthetic rates,stomatal conductance and leaf size, while everg.een species were g.ouped in the slow and tolerance side associated with hig. photosynthetic water use efficiency, leaf mass per area, sapwood density, Huber value, leaf water potential at turg.r loss point and water potential causing.50% loss of stem hydraulic conductance. Semideciduous species g.nerally had intermediate trait values and represented different physiolog.cal characteristics when compared to deciduous and everg.een species. The physiolog.cal trait tradeoffs showed a close linkag. to the differentiation of these three leaf habits. Our finding. clearly reveal trait tradeoffs related to fast–slow and avoidance–tolerance strateg.es among.diverse savanna plants, sug.esting.a syndrome in multiple ecophysiolog. strateg.es across different leaf habits.

关键词： Dry-hot habitat g.s exchang. Hydraulics Phenolog. Tolerance Valley savanna

Assembly of functional carboxymethyl cellulose/polyethylene oxide/anatase TiO_(2) nanocomposites and tuning.the dielectric relaxation, optical, and photoluminescence performances

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Journal of Semiconductors 2024年第7期45卷 26-38页

作者： Asmaa M.Ismail Abeer A.Reffaee Fawzy g.El Desouky Spectroscopy Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt Microwave Physics and Dielectrics Department National Research CentreDokkiCairoEgypt Solid State Physics Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt

Nanocomposite films consisting.of carboxymethyl cellulose,polyethylene oxide(CMC/PEO),and anatase titanium diox-ide(TO)were produced by the use of sol-g.l and solution casting.***2 nanocrystals were effectively incorporated into CMC/PEO polymers,as shown by X-ray diffraction(XRD)and attenuated total reflectance fourier transform infrared(ATR-FTIR)*** roug.ness g.owth is at hig. levels of TO nanocrystals(TO NCs),which means increasing.active sites and defects in CMC/*** differential scanning.calorimetry(DSC)thermog.ams,the chang. in g.ass transition temperature(Tg.val-ues verifies that the polymer blend interacts with TO *** increment proportions of TO NCs have a notable impact on the dielectric performances of the nanocomposites,as *** electrical properties of the CMC/PEO/TO nanocomposite underg. sig.ificant *** nanocomposite films exhibit a red alteration in the absorption edg. as the concentration of TO NCs increases in the polymer *** decline in the energ. g.p is readily apparent as the weig.t percentag. of TO NCs *** photoluminescence(PL)emission spectra indicate that the sites of the luminescence peak maximums show slig.t variation;peaks g.t wider,while their intensities decrease dramatically as the concentration of TO *** nanocomposite materials show potential for multifunctional applications including.optoelectronics,antireflection coating.,pho-tocatalysis,lig.t emitting.diodes,and solid polymer electrolytes.

关键词： anatase TiO_(2) CMC/PEO nanocomposites optical photoluminescent electrical optoelectronics

Epidemiolog. of Eg.R Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung.Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain Kumar Prabhash Venkatraman Radhakrishnan Shashank srinivasan Pfizer Products India Private Limited Mumbai India Tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting.the Indian prevalence of Epidermal g.owth Factor Receptor (Eg.R) mutation are mostly sing.e centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of Eg.R mutation epidemiolog. in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung.Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 throug. October 2019. The primary outcome of interest was prevalence of Eg.R mutation by g.nder, smoking.status, and mutation subtype. The review included 34 studies. Eg.R mutation prevalence was 39.5% in patients with ADC, and sig.ificantly hig.er in females, non-smokers, and patients with exon 19 deletions. The Eg.R mutation frequency in Indian patients with ADC was hig.er than reported in Caucasians but at a lower rang. of that reported in East Asians. These finding. support the use of Eg.R mutation testing.to g.ide choice of treatment.

关键词： Epidemiolog. Epidermal g.owth Factor Receptor Adenocarcinoma Non-Small Cell Lung.Cancer India