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Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

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Cellular & Molecular Immunology 2023年第6期20卷 626-650页

作者： Grffn Copp Kevin P.Robb sowmya viswanathan Osteoarthritis Research Program Division of Orthopedic SurgerySchroeder Arthritis InstituteUniversity Health NetworkTorontoONCanada Krembil Research Institute University Health NetworkTorontoONCanada institute of Biomedical Engineering University of TorontoTorontoONCanada Department of Medicine Division of HematologyUniversity of TorontoTorontoONCanada

Osteoarthritis(OA)is a degenerative multifactorial disease with concomitant structural,inflammatory,and metabolic changes that fluctuate in a temporal and patient-specific *** complexity has contributed to refractory responses to various *** have shown promise as multimodal therapeutics in mitigating OA symptoms and disease ***,we evaluated 15 randomized controlled clinical trials(RCTs)and 11 nonrandomized RCTs using culture-expanded MSCs in the treatment of knee OA,and we found net positive effects of MSCs on mitigating pain and symptoms(improving function in 12/15 RCTs relative to baseline and in 11/15 RCTs relative to control groups at study endpoints)and on cartilage protection and/or repair(18/21 clinical studies).We examined MsC dose,tissue of origin,and autologous *** origins as well as patient clinical phenotype,endotype,age,sex and level of OA severity as key parameters in parsing MSC clinical *** relatively small sample size of 610 patients limited the drawing of definitive ***,we noted trends toward moderate to higher doses of MsCs in select OA patient clinical phenotypes mitigating pain and leading to structural improvements or cartilage *** from preclinical studies is supportive of MsC anti-inflammatory and immunomodulatory effects,but additional investigations on immunomodulatory,chondroprotective and other clinical mechanisms of action are *** hypothesize that MsC basal immunomodulatory"fitness"correlates with OA treatment efficacy,but this hypothesis needs to be validated in future *** conclude with a roadmap articulating the need to match an OA patient subset defined by molecular endotype and clinical phenotype with basally immunomodulatory"ft"or engineered-to-be-fit-for-OA MsCs in well-designed,data-intensive clinical trials to advance the field.

关键词： MSC Osteoarthritis Cell therapy mesenchymal stromal cell RCT

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Overcoming the challenges of conducting translational research in cell therapy

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Frontiers of Medicine 2011年第4期5卷 333-335页

作者： sowmya viswanathan Armand Keating Cell Therapy Program Princess Margaret HospitalUniversity Health NetworkTorontoONM5G 2M9Canada Division of Hematology Department of MedicineUniversity of TorontoTorontoONM5G 2M9Canada

Cell therapy holds promise in addressing a number of unmet medical needs but despite its considerable impetus,faces numerous challenges including support for translational research in this ***,we examine the challenges confronting cell therapy research including the limited funding available for translational research partly due to the uncompetitive nature of required validation studies in cell therapy that of necessity are not *** issues include lack of standardization of definitions of cell products,uncertainty regarding optimum preclinical animal models,duplication of efforts to secure regulatory approval and a lack of uniformity of nomenclature for some cell ***,several initiatives to address all of these issues are underway.

关键词： stem cells clinical trials funding animal models standardization common definitions

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan N Vinayakumar Ravi V sowmya Center for Computational Engineering and Networking(CEN) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAN)is used as a standard communication method because of its efficient and reliable ***,CAN is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy C-means(FCM).The proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WNS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UNSW_NB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor CAN traffic in vehicles and proactively alert during attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

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Plasticized Polymer Electrolyte Membranes Based on PEO/PVdF-HFP for Use as an Effective Electrolyte in Lithium-ion Batteries

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Chinese Journal of Polymer Science 2017年第3期35卷 407-421页

作者： pradeepa prabakaran ramesh prabhu manimuthu sowmya gurusamy edwinraj sebasthiyan school of physics alagappa universityKaraikudi-630 004Tamil NaduIndia

Plasticized polymer electrolytes were prepared using poly（ethylene oxide）(PEO)/poly（vinylidene fluoridehexafluoro propylene）(PVd F-HFP) with lithium perchlorate（Li Cl O4） and different plasticizers. XRD and FTIR spectroscopic techniques were used to characterize the structure and the complexation of plasticizer with the host polymer matrix. The role of interaction between polymer hosts and plasticizer on conductivity is discussed using the results of alternating current（a.c.） impedance studies. TG-DTA and SEM were used for thermal and physical characterizations. Maximum ionic conductivity(3.26 × 10;S·cm;) has been observed for ethylene carbonate（EC）-based polymer electrolytes. Electrochemical performance of the plasticized polymer electrolyte is evaluated in LiFePO;/plasticized polymer electrolytes（PPEs）/Li coin cell. Good performance with low capacity fading on charge discharge cycling is demonstrated.

关键词： X-ray diffraction Impedance spectroscopy Atomic force microscopy Ionic conductivity Dielectrics

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Effects of stretching/shrinking on the thermal performance of a fully wetted convective-radiative longitudinal fin of exponential profile

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Applied Mathematics and Mechanics(English Edition) 2022年第3期43卷 389-402页

作者： B.J.GIREESHA M.L.KEERTHI G.sowmya Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of PG Mathematics The National College(Auto)Bangalore 560070India

The present investigation focuses on the thermal performance of a fully wet stretching/shrinking longitudinal fin of exponential profile coated with a mechanism like a conveyer *** modeled equation is non-dimensionalized and solved by applying the Runge-Kutta-Fehlberg(RKF)*** effects of parameters such as the wet parameter,the fin shape parameter,and the stretching/shrinking parameter on the heat transfer and thermal characteristics of the fin are graphically analyzed and *** is inferred that the negative effects of motion and internal heat generation on the fin heat transfer rate can be lessened by setting a shrinking mechanism on the fin *** current examination is inclined towards practical applications and is beneficial to the design of fins.

关键词： fully wet longitudinal fin convection exponential profile internal heat generation moving fin

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Investigation of Ti6Al4V and AA7075 alloy embedded nanofluid flow over longitudinal porous fin in the presence of internal heat generation and convective condition

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Communications in Theoretical Physics 2020年第2期72卷 23-29页

作者： G sowmya B J Gireesha S Sindhu B C Prasannakumara Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta-577451KarnatakaIndia Department of Mathematics Davangere UniversityDavangere-577002KarnatakaIndia

The thermal attributes of porous fin due to radiation and natural convection have been carried out in the presence of nanofluid *** geometry of the fin taken for the analysis is rectangular profiled longitudinal *** temperature-dependent internal heat generation condition is also considered along with Darcy’s *** two types of nanofluid containing titanium alloy(Ti6Al4V)and aluminium alloy(AA7075)immersed in water is considered for the *** modelled nonlinear ordinary differential equation is numerically solved by the Runge–Kutta–Fehlberg *** impact of geometric parameter on the heat transfer analysis of the fin due to the flow of both nanofluids is plotted and consequences are physically *** is observed that the presence of the water-based titanium alloy better enhances the fin heat transfer rate.

关键词： alloys nanofluid porous fin heat transfer analysis convective condition internal heat generation

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Consequence of exponential heat generation on non-Darcy- Forchheimer flow of water based carbon nanotubes driven by a curved stretching sheet

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Applied Mathematics and Mechanics(English Edition) 2020年第11期41卷 1723-1734页

作者： B.J.GIREESHA B.NAGARAJA S.SINDHU G.sowmya Department of P.G.Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India

The present article comprises the study on the influence of exponential space based heat generation on the non-Darcy-Forchheimer flow of carbon nanotubes(CNTs).The flow is considered over a curved stretching *** variables are used to reduce the flow descriptive nonlinear partial derivative equations to simple *** equations are then solved by the exploiting Runge-Kutta-Fehlberg fourth-and fifth-order *** numerical solutions are shown in graphs and *** between single and multi-walled CNTs has been established through the tabulated values and plotted *** is concluded that the heat source parameter plays a prime role in enhancement of temperature,and the curvature parameter has adverse impact on velocity and temperature *** the inertial parameter and inverse-Darcy number affect the fluid velocity.

关键词： exponential heat generation non-Darcy-Forchheimer flow carbon nanotube(CNT) curved stretching sheet

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Supergranular Fractal Dimension and Solar Rotation

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Research in Astronomy and Astrophysics 2022年第9期22卷 239-244页

作者： G.M.sowmya G.Rajani U.Paniveni R.Srikanth GSSS Institute of Engineering and Technology for Women Mysuru-570016KarmatakaIndia PES College of Engineering Mandya-571401KarnatakaIndia Bangalore University JnanabharathiBengaluru-560056India Poornaprajna Institute of Scientific Research DevanahalliBangalore-562110KamatakaIndia

We present findings from an analysis of the fractal dimension of solar supergranulation as a function of latitude,supergranular cell size and solar rotation, employing spectroheliographic data in the Ca II K line of solar cycle no.23. We find that the fractal dimension tends to decrease from about 1.37 at the equator to about 1 at 20° latitude in either hemisphere, suggesting that solar rotation rate has the effect of augmenting the irregularity of supergranular boundaries. Considering that supergranular cell size is directly correlated with fractal dimension, we conclude that the mechanism behind our observation is that solar rotation influences the cell outflow strength, and thereby cell size, with the latitude dependence of the supergranular fractal dimension being a consequence thereof.

关键词： Sun:chromosphere Sun:rotation Sun:magnetic fields

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The role of deformations and orientations in an alpha ternary fission of Thorium

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Nuclear Science and Techniques 2022年第6期33卷 1-8页

作者： A.V.Mahesh Babu N.sowmya H.C.Manjunatha N.Dhananjaya Department of Physics BMSIT&MAffiliated to VTUBangaloreKarnataka 560064India Department of Physics Government College for WomenKolarKarnataka 563101India

The alpha ternary fission half-lives of thorium isotopes have been studied using the Coulomb and proximity potential *** role of the deformation effects and the angle of orientation were included during the evaluation of the total *** combinations were identified using cold valley plots of the driving *** half-lives and yields were evaluated using the penetration *** dependence of the logarithmic half-lives on different angles of orientation was *** evaluated alpha ternary fission yield was compared with that of the available experiments with and without *** half-lives obtained in the present work were compared with those of the available *** alpha ternary fission fragments were identified in the isotopes of *** alpha ternary fission half-lives were compared to the binary fission *** binary fission half-lives are dominant in the ^(209-225)Th nuclei,and the ternary fission half-lives are dominant in the isotopes of the ^(226-238)Th nuclei.

关键词： Alpha ternary fission Yield Half-lives Driving potential

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Solar Supergranular Fractal Dimension Dependence on the Solar Cycle Phase

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Research in Astronomy and Astrophysics 2022年第4期22卷 55-61页

作者： G.Rajani G.M.sowmya U.Paniveni R.Srikanth PES College of Engineering Mandya-571401KarnatakaIndia GSSS Institute of Engineering and Technology for Women KRS RoadMetagalli Mysuru-570016KarnatakaIndia Bangalore University JnanabharathiBengaluru-560056India Poornaprajna Institute of Scientific Research DevanahalliBangalore-562110KarnatakaIndia

We study the complexity of the supergranular network through fractal dimension by using the Ca II K digitized data archive obtained from the Kodaikanal Solar *** data consist of 326 visually selected supergranular cells spread across the 23rd solar *** cells that were well-defined were chosen for the analysis and we discuss the potential selection effect thereof,mainly that it favors cells of a smaller size(<20 Mm).Within this sample,we analyzed the fractal dimension of supergranules across the solar cycle and find that it is anticorrelated with the activity level.

关键词： Sun:chromosphere Sun:granulation Sun:activity

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