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NAFLD Epidemiology, Emerging Pharmacotherapy, Liver Transplantation Implications and the Trends in the United States

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 215-221页

作者： Chiranjeevi Gadiparthi Moshe Spatz Simi Greenberg Umair Iqbal sowjanya kanna Sanjaya K Satapathy Arkady Broder Aijaz Ahmed Division of Gastroenterology Hepatology and Clinical NutritionSaint Peter’s University HospitalNew BrunswickNJUSA Rutgers Robert Wood Johnson Medical School PiscatawayNJUSA Nova Southeastern University College of Osteopathic Medicine DavieFLUSA Geisinger Commonwealth School of Medicine DanvillePAUSA Division of Gastroenterology Allegheny Health NetworkTarentumPAUSA Northwell Health Division of Hepatology&Sandra Atlas Bass Center for Liver DiseasesManhassetNYUSA Stanford University School of Medicine Division of Gastroenterology and HepatologyStanfordCAUSA

Nonalcoholic fatty liver disease (NAFLD) is a hepatic mani-festation of metabolic syndrome. The spread of obesity worldwide in pandemic proportions has led to a rapid rise of NAFLD in developed and developing countries alike. There are no approved pharmacological agents to treat steatohepatitis or advanced fibrosis but obeticholic acid recently has shown some promise in phase III trial. Currently, NAFLD is the number one etiology for simultaneous liver and kidney trans-plantation in the USA, second most common indication for liver transplantation (LT) and projected to become number one very soon. LT for NAFLD poses unique challenges, as these patients are generally older, obese and more likely to have a number of metabolic risk factors. Bariatric surgery is an option and can be considered if a structured weight loss program does not achieve the sustained weight loss goal. Comprehensive cardiovascular risk assessment and aggres-sive management of comorbid conditions are crucial in the LT evaluation process to improve post-transplant survival. Re-current nonalcoholic steatohepatitis after LT is not uncom-mon, and thus warrants primary and secondary prevention strategies through a multidisciplinary approach. Prevalence of NAFLD in a donor population is a unique and growing concern that limits the access to quality liver grafts.

关键词： NAFLD NAFL NASH Liver transplantation

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