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Natural therapeutics for cancer treatment:success,challenges,and prospect

Journal of Bio-X Research 2023年第2期6卷 61-72页

作者： Debasmita Dubey Shakti Rath Rajesh Kumar Meher Sanghamitra Mishra soumya surath panda Subhashree Ray Subrat Kumar Tripathy Medical Research Laboratory IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Central Research Laboratory Institute of Dental SciencesSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Department of Critical Care Medicine IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Oncology IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Biochemistry IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia.

Cancer is a terrifying disease that has become one of the world’s most challenging health concerns,necessitating a proactive approach to its *** is a rich source of new chemical entities and a promising avenue for cancer *** of their different modes of action on target events in many ways,nature-derived chemicals are considered good possibilities for anticancer drug *** current review article highlights recent breakthroughs in cancer therapeutics,including natural therapeutic molecules and their mechanisms of action against cancer treatment,as well as their limits,challenges,and *** the review,article data have been collected from previously studied and published research reports,clinical evaluations,case studies,and clinical statistical data generated by scientific research organizations of *** chemical structures have been drawn using computational software(chemsketch).The development of promising candidates that can prevent or reduce the proliferation of cancer cells without causing adverse effects from these therapeutics is now ***,nature-derived products are a game-changer because they are simple,safer,environmentally friendly,low-cost,quick,and less toxic than traditional treatment ***,many bioactive chemicals and their analogs have been discovered as possible anticancer treatment *** the review,the potent therapeutics phytochemicals derived from nature with their tremendous anticancer effects with limitations and prospects have been studied and analyzed based on previously published articles and reports.

关键词： cancer treatment chemotherapy drug resistance natural therapy toxicity

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Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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Journal of Bio-X Research 2024年第1期7卷 36-43页

作者： Swati Sucharita Mohanty Sumit Subhadarshi Mohanty soumya surath panda Chita Ranjan Sahoo Prafulla Kumar Mohanty Rabindra Nath Padhy Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital BhubaneswarOdishaIndia Regional Medical Research Centre Bhubaneswar BhubaneswarOdishaIndia Khallikote Unitary University BrahmapurOdishaIndia

There were 2.3 million new cases of breast cancer registered in 2020,establishing it as the world’s leading *** regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages.A literature review was performed by downloading research articles from PubMed Central,with keywords such as breast cancer,hormone exposure in breast cancer,estrogen/progesterone exposure in breast cancer,and breast cancer risk *** breast cancer is a hormone-related disease,several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast ***,an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen *** these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime.A healthy lifestyle,a more extended breastfeeding period,and regular physical activity may help lower one’s *** review summarizes the factors that increase the risk of estrogen/progesterone(hormone receptor)receptor-positive breast cancer due to overall cumulative estrogen exposure,with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

关键词： alterations elevated exposure

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Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

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Journal of Diabetes Mellitus 2017年第3期7卷 195-211页

作者： soumya Ranjan Behera Manoranjan Behera Sidhartha Das Bhabani Prasad panda Saroj Kumar Tripathy Purna Chandra Dash Department of Medicine VSS Institute of Medical Sciences and Research Burla Sambalpur Odisha India PG Department of Medicine Faculty of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India PG Department of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India

Background: Data regarding the prevalence of morbidity and mortality in patients of Type 2 Diabetes Mellitus (T2DM) is scanty in India. Objectives: To determine the prevalence of micro and macro vascular complications, acute metabolic complications, infections, Non Alcoholic Fatty Liver Disease (NAFLD) and cause of mortality in T2DM patients admitted to a tertiary care teaching hospital in Eastern India. Material and Methods: This was a hospital-based prospective study evaluating 150 T2DM patients admitted to a tertiary care institution in Eastern India. Diagnosis of micro and macro vascular complications, infections and NAFLD was made using standard protocols. In case of death, the most probable cause was noted. Results: Out of 150 patients, 14.7% of patients were newly diagnosed T2DM and out of them 41% of patients had vascular complications and 54.5% had infections. Of the total patients, 56% had nephropathy, 20% neuropathy, 17.3% retinopathy, 31.3% CVD, 11.3% CAD, 4.6% acute metabolic complications, 44% infections and 16.6% had NAFLD respectively. Macrovascular events occured earlier than microvascular complications. Multiple logistic regression analysis showed strong association of age, duration of diabetes, serum cholesterol, triglyceride, LDL-C with retinopathy (Regression coefficient β: -0.1086807, 0.4127152, -0.0513393, 0.0146429, 0.0587475;p < 0.05, < 0.001, < 0.05, < 0.05, < 0.05 respectively), while only duration of diabetes was strongly associated with nephropathy and neuropathy (Regression coefficient β: 0.2538751, 0.2261636;p < 0.001 for each). Increasing age was associated with CAD (Regression coefficient β: 0.055392;p β: 0.0055014;p 18.6% patients died due to diabetes related complications. Cardiovascular (CV)-related deaths (CVD+CAD) were most common cause (51.5%: CVD 36.4%, CAD 15.1%) to be followed by infections (27.3%) and then chronic kidney disease (12.1%). Conclusions: This study highlights the high prevalence of vascular complications and in

关键词： Type 2 Diabetes Mellitus Vascular Complications Infections NAFLD Mortality

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