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甲骨文联合创始人拉里·埃里森的海岛王国

商业周刊（中文版） 2022年第11期 54-61页

作者： sophie alexander Elizabeth Weinberg(摄影) 不详

这位亿万大亨正在将夏威夷拉奈岛变得让富豪们觉得越来越宜人但世代生活在这里的人们正在被他赶走克里斯·安德鲁斯(ChrisAndrus)回忆当年的情形说,事后来看,Nobu餐厅开业不是个好兆头。那是2012年。光头、留着山羊胡子、自称嬉皮士的... 详细信息

这位亿万大亨正在将夏威夷拉奈岛变得让富豪们觉得越来越宜人但世代生活在这里的人们正在被他赶走克里斯·安德鲁斯(ChrisAndrus)回忆当年的情形说,事后来看,Nobu餐厅开业不是个好兆头。那是2012年。光头、留着山羊胡子、自称嬉皮士的安德鲁斯当时住在拉奈岛上,帮一位老朋友创办一家木工厂。这是一个有大约3000人口、面积9万英亩(约合360平方公里)的夏威夷小岛。

关键词：埃里森安德鲁斯嬉皮士夏威夷甲骨文拉里克里斯

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IPO也救不了旧金山楼市

商业周刊（中文版） 2020年第24期 23-24页

作者： sophie alexander Patrick Clark Noah Buhayar 徐安琪(译) 不详

科技股一路飙升,备受瞩目的首次公开发行(IP0)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash... 详细信息

科技股一路飙升,备受瞩目的首次公开发行(IP0)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash Inc上市会导致大量财富流人,但现如今,很多员工已迁往市郊、太浩湖(Lake Tahoe)甚至更远的地方。

关键词：首次公开发行繁荣期 IPO 旧金山

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IPO也救不了旧金山楼市

商业周刊（中文版） 2021年第3期 25-27页

作者： sophie alexander Patrick Clark Noah Buhayar 徐安琪(译) 不详

科技股一路飙升,备受瞩目的首次公幵发行(IPO)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash... 详细信息

科技股一路飙升,备受瞩目的首次公幵发行(IPO)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash Inc上市会导致大量财富流入,但现如今,很多员工已迁往市郊、太浩湖(Lake Tahoe)甚至更远的地方。

关键词： IPO 繁荣期旧金山科技股

Ventilation after pancreaticoduodenectomy increases perioperative mortality: Identification of risk factors and their relevance in Germany that do not apply in England

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 379-388页

作者： Rieke-sophie Homeyer Keith JRoberts Robert P Sutcliffe alexander Kaltenborn Darius Mirza Zhi Qu Jurgen Klempnauer Harald Schrem Core Facility Quality Management Transplantation Integrated Research and Treatment Center Transplantation(IFB-Tx)Hannover Medical SchoolCarl-Neuberg-Str.130625 HannoverGermany General Visceral and Transplant SurgeryHannover Medical SchoolCarl-Neuberg-Str.130625 HannoverGermany Department of HPB Surgery Queen Elizabeth Hospital BirminghamMindelsohn Way EdgbastonBirmingham B15 2GWUnited Kingdom Department of General Visceral and Transplant SurgeryMedical University GrazAuenbrugger Platz 58036 GrazAustria

Background:Pre-operative risk factors for post-operative ventilation and their influence on survival after pancreaticoduodenectomy for malignancy are ***:Totally 391 patients operated in Hannover,Germany were investigated with multivariable logistic regression and Cox regression modeling to identify independent risk factors for post-operative ventilation≥6 h,patient survival and 90-day *** 84 patients operated in Birmingham,United Kingdom were analyzed to assess the external relevance of ***:Longer operations,history of thrombosis,intra-operative blood transfusion,lower estimated glomerular filtration rates(eGFR)and higher values of the age at operation divided by the Horovitz Quotient independently increased the risk of post-operative ventilation≥6 h in German patients(n=108;27.6%)(P75 years,had a history of thrombosis,received blood transfusions,and had significantly worse lung function ***4 tumors were detected in 18 German patients(4.6%),but not in the English ***:Identified risk factors for post-operative ventilation are clinically relevant in Germany but not in England and may be used to lower mortality *** German and the English cohorts displayed significant differences in the approach to patient selection and early post-operative extubation.

关键词： Pancreatic cancer Cholangiocellular carcinoma Periampullary carcinoma Comorbidity Outcome

Effects of dietary menthol-rich bioactive lipid compounds on zootechnical traits,blood variables and gastrointestinal function in growing sheep

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Journal of Animal Science and Biotechnology 2020年第1期11卷 227-240页

作者： Amlan K.Patra Sebastian Geiger Katharina T.Schrapers Hannah-sophie Braun Heidrun Gehlen alexander Starke Robert Pieper Adam Cieslak Malgorzata Szumacher-Strabel Jorg R.Aschenbach Institute of Veterinary Physiology Freie Universitat BerlinOertzenweg 19b14163 BerlinGermany Department of Animal Nutrition West Bengal University of Animal and Fishery Sciences37 K.B.SaraniKolkata 700037India PerformaNat GmbH Hohentwielsteig 614163 BerlinGermany Equine Clinic:Surgery and Radiology Freie Universitat BerlinOertzenweg 19b14163 BerlinGermany Clinic for Ruminants and Swine Faculty of Veterinary MedicineUniversity of LeipzigAn den Tierkliniken 1104103 LeipzigGermany Institute of Animal Nutrition Freie Universitat BerlinK?nigin-Luise-Strasse 4914195 BerlinGermany Department of Animal Nutrition Poznan University of Life SciencesWolynska 3360-637 PoznanPoland

Background:The present study aimed at investigating the influence of 90%menthol-containing plant bioactive lipid compounds(PBLC,essential oils)on growth performance,blood haematological and biochemical profile,and nutrient absorption in ***-four growing Suffolk sheep were allotted into three dietary treatments:Control(without PBLC),lower dose of PBLC(PBLC-L;80 mg/d)and higher dose of PBLC(PBLC-H;160 mg/d).Sheep in all groups were fed meadow hay ad libitum plus 600 g/d of concentrate pellets for 28 ***:Average daily gain was not affected by *** of PBLC increased hay and total feed intake per kg body weight(P<0.05).Counts of total leucocytes,lymphocytes and monocytes were not different among ***,neutrophil count decreased(P<0.05)in PBLC-H with a similar trend in PBLC-L(P<0.10).Concentrations of glucose,bilirubin,triglycerides,cholesterol,urea and magnesium in serum were not different among sheep fed different doses of ***,serum calcium concentration tended to increase in PBLC-H(P<0.10)and serum concentrations of aspartate&asparagine(P<0.01)and glutamate&glutamine(P<0.05)increased linearly with increasing PBLC *** ruminal epithelia isolated from the rumen after killing,baseline conductance(Gt;P<0.05)and short-circuit current(Isc;P<0.01)increased in both PBLC *** uptakes of glucose and methionine in the presence of Na+were not affected by the dietary PBLC *** the absence of Na+,however,glucose and methionine uptakes increased(P<0.05)in *** the jejunum,Isc tended to increase in PBLC-H(P<0.10),but baseline Gtwas not *** uptakes of glucose and methionine were not influenced by PBLC in the presence or absence of Na+.Conclusion:The results suggest that menthol-rich PBLC increase feed intake,and passive ion and nutrient transport,the latter specifically in the *** also increased serum concentrations of urea precursor amino acids and tended to increase serum calcium

关键词： Electrophysiology Essential oil Feed intake Growth performance Nutrient uptakes

Radiotherapy for gynecologic cancerin nonagenarian patients：a framework for new paradigms

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Chinese Journal of Cancer 2016年第7期35卷 382-384页

作者： Benoite Mery Sylvie Mengue Ndong Jean-Baptiste Guy Avi Assouline alexander T.Falk Anais Valeille Jane-Chloc Trone Romain Rivoirard Pierre Auberdiac Alexis Vallard sophie Espenel Guillaume Moriceau Olivier Collard Claire Bosacki Jean-Philippe Jacquin Guy de Laroche Pierre Fournel Cyrus Chargari Nicolas Magne Department of Medical Oncology Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Porte De Saint Cloud Clinical Center92100 Boulogne-Billancourt France Department of Radiotherapy Claude Bernard Private Hospital81000 Albi France Department of Radiotherapy Val-De-Grace Military Hospital75230 Paris France Department of Radiation Oncology Antoine Lacassagne Center06100 Nice France

No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian *** retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer(6 endometrial cancers,6 cervical cancers,4 vulvar cancers,and 3 vaginal cancers) who were treated with *** was performed mainly in a palliative setting(n = 12;63.2%),with a median dose of 45 Gy(range,6-76 Gy).Infrequent major acute or late toxicities were *** 19 patients,9(47.4%) experienced tumor progression,5(26.3%) experienced complete response,2(10.5%) experienced stable disease and/or partial *** last follow-up,12 patients(63.2%) had died;most deaths(n = 9) occurred because of the *** results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

关键词：癌症患者妇科放疗放射治疗框架肿瘤患者子宫内膜癌肿瘤治疗

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

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Synthetic and Systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke C.A.van Aalsta sophie C.de Valk Walter M.van Gulik Mickel L.A.Jansen Jack T.Pronka Robert Mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands DSM Biotechnology Centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： Saccharomyces cerevisiae Synthetic biology Metabolic engineering Biofuels Redox metabolism Energy metabolism

Catalyzing Singlet Fission by Transition Metals:Second versus Third Row Effects

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Precision Chemistry 2023年第9期1卷 555-564页

作者： Yuxuan Hou Ilias Papadopoulos Yifan Bo Anna-sophie Wollny Michael J.Ferguson Lukas A.Mai Rik R.Tykwinski Dirk M.Guldi Department of Chemistry University of AlbertaEdmontonAlberta T6G 2G2Canada Department of Chemistry and Pharmacy&Interdisciplinary Center for Molecular Materials(ICMM) Friedrich-Alexander-University Erlangen-Nuremberg91058 ErlangenGermany Department of Applied Chemistry Graduate School of EngineeringCenter for Molecular Systems(CMS)Kyushu University744 Moto-okaNishi-kuFukuoka 819-0395Japan

The synthesis and characterization of platinum(II)and palladium(II)complexes bearing two(dimers Pt(L_(pc))_(2)Cl_(2)and Pd(L_(pc))_(2)Cl_(2)),one(monomers Pt(L_(pc))(L_(ref))Cl_(2)and Pd(L_(pc))(L_(ref))-Cl_(2)),or no(reference compounds Pt(L_(ref))_(2)Cl_(2)and Pd(L_(ref))_(2)Cl_(2))pentacene-based pyridyl ligands are *** properties of the dimers are probed by means of steady-state and time-resolved transient absorption measurements in compar-ison to the monomer and model *** results document that despite enhanced spin−orbit coupling from the presence of heavy atoms,intramolecular singlet fission(iSF)is not challenged by intersystem *** thus yields correlated triplet pairs and even uncorrelated triplet excited states upon ***,significant separation of the two pentacenyl groups facilitates decoupling of the two ***,the mechanism of iSF is altered depending on the respective metal center,that is,Pt(II)versus Pd(II).The dimer based on Pt(II),Pt(L_(pc))2Cl_(2),exhibits a direct pathway for the iSF and forms a correlated triplet pair with singlet−quintet spin-mixing within 10 ns in variable *** the other hand,the dimer based on Pd(II),Pd(L_(pc))_(2)Cl_(2),leads to charge transfer mixing during the population of the correlated triplet pair that is dependent on solvent ***,Pd(L_(pc))_(2)Cl_(2)gives rise to a stable equilibrium between singlet and quintet correlated triplet pairs with lifetimes of up to 170 *** differences in the size and polarizability,when contrasting platinum(II)with palladium(II),are the most likely rationale for the underlying trends.

关键词： metal complexes singlet fission pentacene dimers ultrafast spectroscopy electronic coupling

Targeting stem cells by radiation: From the biological angle to clinical aspects

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World Journal of Stem Cells 2016年第8期8卷 243-250页

作者： Alexis Vallard sophie Espenel Jean-Baptiste Guy Peng Diao Yaoxiong Xia Anis El Meddeb Hamrouni Majed Ben Mrad alexander Tuan Falk Claire Rodriguez-Lafrasse Chloé Rancoule Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute Laboratoire de Radiobiologie Cellulaire et Moléculaire CNRS UMR 5822 Institut de Physique Nucléaire de Lyon Department of Radiation Oncology Sichuan Cancer Hospital Department of Radiotherapy Centre Antoine Lacassagne

Radiotherapy is a cornerstone of anticancer treatment. However in spite of technical evolutions, important rates of failure and of toxicity are still reported. Although numerous pre-clinical data have been published, we address the subject of radiotherapy-stem cells interaction from the clinical efficacy and toxicity perspective. On one side, cancer stem cells(CSCs) have been recently evidenced in most of solid tumor primary locations and are thought to drive radio-resistance phenomena. It is particularly suggested in glioblastoma, where CSCs were showed to be housed in the subventricular zone(SVZ). In recent retrospective studies, the radiation dose to SVZ was identified as an independent factor significantly influencing overall survival. On the other side, healthy tissue stem cells radio-destruction has been recently suggested to cause two of the most quality of life-impacting side effects of radiotherapy, namely memory disorders after brain radiotherapy, and xerostomia after head and neck radiotherapy. Recent publications studying the impact of a radiation dose decrease on healthy brain and salivary stem cells niches suggested significantly reduced long term toxicities. Stem cells comprehension should be a high priority for radiation oncologists, as this particular cell population seems able to widely modulate the efficacy/toxicity ratio of radiotherapy in real life patients.

关键词： Cancer Neoplastic stem cells Radiation therapy Efficacy Toxicity