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Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

World Journal of Gastroenterology 2016年第20期22卷 4926-4935页

作者： Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet sophie michalak Antonia Le Gruyer Ludivine Legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand Department of Abdominal Imaging Rennes University Hospital Clinical Inverstigation Center CIC INSERM 1414 Rennes University Hospital Department of Hepatology Rennes University Hospital Department of Pathology Rennes University Hospital Rennes Department of Pathology Angers University Hospital Department of Addictology Rennes University Hospital Department of Research INSERM UMR 991 Rennes 1 Medicine University

AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to ***: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each ***: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/***: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

关键词： Alcoholic liver disease Elastography Noninvasive Acoustic radiation force impulse Fibrosis

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Fluorescence polarization modulation super-resolution imaging provides refined dynamics orientation processes in biological samples sophie Brasselet

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Light(Science & Applications) 2022年第11期11卷 2564-2566页

作者： sophie Brasselet Aix Marseille Univ CNRSCentrale MarseilleInstitut FresnelF-13013 MarseilleFrance

Combining polarization modulation Fourier analysis and spatial information in a joint reconstruction algorithm for polarization-resolved fluorescence imaging provides not only a gain in spatial resolution but also a s... 详细信息

关键词： polarization resolution Fluorescence

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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois sophie michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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New insights into the cell-and tissue-specificity of glucocorticoid actions

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Cellular & Molecular Immunology 2021年第2期18卷 269-278页

作者： Linda Quatrini sophie Ugolini Department of Immunology IRCCS Bambino GesùChildren’s HospitalRomeItaly Aix Marseille Univ CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance

Glucocorticoids(GCs)are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external *** of their anti-inflammatory effects,synthetic GCs are also extensively used in clinical ***,almost all cells in the body are sensitive to GC *** a result,these mediators have pleiotropic effects,which may be undesirable or detrimental to human ***,we summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor *** also discuss the complex role of GCs in infectious diseases such as sepsis and COVID-19,in which the balance between pathogen elimination and protection against excessive inflammation and immunopathology needs to be tightly *** understanding of the cell type-and context-specific actions of GCs from the molecular to the organismal level would help to optimize their therapeutic use.

关键词： Glucocorticoids inflammation immune response

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Actads

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Science China Mathematics 2022年第9期65卷 1909-1952页

作者： sophie Kriz Department of Mathematics College of LiteratureScienceand the ArtsUniversity of MichiganAnn ArborMI 48109USA

In this paper,I introduce a new generalization of the concept of an operad,further generalizing the concept of an opetope introduced by Baez and Dolan(1998),who used this for the definition of their version of non-strict *** arise from iterating a certain construction on operads called the+-construction,starting with *** first step gives rise to plain operads,i.e.,operads without *** permutation axiom in a symmetric operad,however,is an additional structure resulting from permutations of variables,independent of the structure of a *** though we can apply the+-construction to symmetric operads,there is the possibility of introducing a completely different kind of permutations on the higher levels by again permuting variables without regard to the structures on the previous *** and investigating these structures is the main purpose of this *** structures obtained in this way are what I call *** n-actads with n>1,the permutations on the different levels give rise to a certain special kind of n-fold category.I also explore the concept of iterated algebras over an n-actad(generalizing an algebra and a module over an operad),and various types of iterated units.I give some examples of algebras over 2-actads,and show how they can be used to construct certain new interesting homotopy types of operads.I also discuss a connection between actads and ordinal notation.

关键词： operads actads infinite loop spaces universal algebra ordinals

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HOW TO PROVE THE DISCRETE RELIABILITY FOR NONCONFORMING FINITE ELEMENT METHODS

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Journal of Computational Mathematics 2020年第1期38卷 142-175页

作者： Carsten Carstensen sophie Puttkammer Department of Mathematics Humboldt-Universitat zu BerlinUnter den Linden 610099 BerlinGermany

Optimal convergence rates of adaptive finite element methods are well understood in terms of the axioms of *** key ingredient is the discrete reliability of a residualbased a posteriori error estimator,which controls the error of two discrete finite element solutions based on two nested *** the error analysis of nonconforming finite element methods,like the Crouzeix-Raviart or Morley finite element schemes,the difference of the piecewise derivatives of discontinuous approximations to the distributional gradients of global Sobolev functions plays a dominant role and is the object of this *** nonconforming interpolation operator,which comes natural with the definition of the aforementioned nonconforming finite element in the sense of Ciarlet,allows for stability and approximation properties that enable direct proofs of the reliability for the residual that monitors the equilibrium *** novel approach of this paper is the suggestion of a right-inverse of this interpolation operator in conforming piecewise polynomials to design a nonconforming approximation of a given coarse-grid approximation on a refined *** results of this paper allow for simple proofs of the discrete reliability in any space dimension and multiply connected domains on general shape-regular triangulations beyond newest-vertex bisection of *** attention is on optimal constants in some standard discrete estimates listed in the appendices.

关键词： Discrete reliability Nonconforming finite element method Conforming companion Morley Crouzeix-Raviart Explicit constants Axioms of adaptivity

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The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

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Cellular & Molecular Immunology 2022年第9期19卷 1012-1029页

作者： sophie Curio Gabrielle T.Belz The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandWoolloongabbaQLD4102Australia

Cancer is a complex disease,and despite incredible progress over the last decade,it remains the leading cause of death *** cancers,including hepatocellular carcinoma(HCC),and liver metastases are distinct from other cancers in that they typically emerge as a consequence of long-term low-grade *** the mechanisms that underpin inflammation-driven tissue remodeling of the hepatic immune environment is likely to provide new insights into much needed treatments for this devastating *** 1 innate lymphoid cells(ILCs),which include natural killer(NK)cells and ILC1s,are particularly enriched in the liver and thought to contribute to the pathogenesis of a number of liver diseases,including *** cells are an attractive,but underexplored,therapeutic target in hepatic disease due to their role in immunosurveillance and their ability to recognize and eliminate malignant ***1s are closely related to and share many phenotypic features with NK cells but are less well ***,their utility in immunotherapeutic approaches is not yet well ***,we review our current understanding of ILCs in cancer with a particular focus on liver and liver-related diseases.

关键词： Inflammation Tumor ILC subsets Cytokines Progenitors

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Thermoregulatory value of cracking-clay soil shelters for small vertebrates during extreme desert conditions

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Integrative Zoology 2017年第3期12卷 237-249页

作者： Helen P.WAUDBY sophie PETIT Sustainable Environments Research Group School of Natural and Built EnvironmentsUniversity of South AustraliaMawson LakesSouth AustraliaAustralia Institute for Land Water and SocietyCharles Sturt UniversityAlburyNew South WalesAustralia

Deserts exhibit extreme climatic *** desert-dwelling vertebrates have physiological and behavioral adaptations to cope with these conditions,including the ability to seek *** investigated the temperature(T)and relative humidity(RH)regulating properties of the soil cracks that characterize the extensive cracking-clay landscapes of arid Australia,and the extent of their use by 2 small marsupial species:fat-tailed and stripe-faced dunnarts(Sminthopsis crassicaudata and Sminthopsis macroura).We measured hourly(over 24-h periods)the T and RH of randomly-selected soil cracks compared to outside conditions,during 2 summers and 2 *** tracked 17 dunnarts(8 Sminthopsis crassicaudata and 9 Sminthopsis macroura)to quantify their use of *** consistently moderated microclimate,providing more stable conditions than available from non-crack points,which often displayed comparatively dramatic fluctuations in T and *** dunnart species used crack shelters *** constitute important shelter for small animals during extreme conditions by providing a stable microclimate,which is typically cooler than outside conditions in summer and warmer in *** likely play a fundamental sheltering role by sustaining the physiological needs of small mammal ***,cracking-clay areas are dominated by agricultural land uses,including livestock *** of these systems should focus not only on vegetation condition,but also on soil integrity,to maintain shelter resources for ground-dwelling fauna.

关键词： arid zones Dasyuridae livestock grazing refuges survival strategies

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Female mating status affects male mating tactic expression in the wolf spider Rabidosa punctulata

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Current Zoology 2022年第1期68卷 121-127页

作者： sophie BUNCH Dustin J.WILGERS Department of Natural Sciences McPherson College1600 E.EuclidMcPhersonKS 67460USA

Males and females have conflicting interests on the frequency and outcomes of mating *** maximize their fitness by mating with as many females as possible,whereas choosy females often reduce receptivity following *** male mating tactics can be adaptive in their expression to a variety of mating contexts,including interactions with a relatively unreceptive mated *** Rabidosa punctulata wolf spiders can adopt distinctive mating tactics when interacting with a female,a complex courtship display,and/or a more coercive direct mount tactic that often involves grappling with females for *** this study,we set up female mating treatments with initial trials and then paired mated and unmated females with males to observe both female remating frequencies and the male mating tactics used during the *** adopted different mating tactics depending on the mating status of the female they were paired *** were more likely to adopt a direct mount tactic with already-mated females and courtship with unmated ***-mated females were considerably less receptive to males during experimental trials,although they did remate 34%of the time,the majority of which were with males using a direct mount *** males adjusting to these contextual cues were able to gain more copulations,the observation of multiple mating in female *** introduces the potential for sperm *** discuss this sexual conflict in terms of the fitness consequences of these mating outcomes for both males and females.

关键词： alternative mating tactic female multiple mating Lycosidae sexual conflict

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THz Generation by Optical Rectification and Competition with Other Nonlinear Processes

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Chinese Physics Letters 2008年第5期25卷 1868-1870页

作者：赵振宇 HAMEAU sophie TIGNON JerSme Laboratoire Pierre Aigrain Ecole Normale Supdrieure 24 rue Lhomond F-75005 Paris France

We present a study of the competition between tera-hertz （THz） generation by optical rectification in （110） ZnTe crystals, two-photon absorption, second harmonic generation and free-carrier absorption. The two-photon nonlinear absorption coefficient, second harmonic generation efficiency and free-carrier absorption coefficient in the THz range are measured independently. The incident pump field is shown to be depleted by two-photon absorption and the THz radiation is shown to be reduced, upon focusing, by free-carrier absorption. The reduction of the generated THz radiation upon tight focusing is explained, provided that one also takes into account diffraction effects from the sub-wavelength THz source.

关键词： supernova explosion proto-neutron star shock wave

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