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Review of plasma exchange and rituximab for prevention of recurrent focal segmental glomerulosclerosis after a prior graft loss

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World Journal of Transplantation 2024年第4期14卷 133-139页

作者： sophie gharaei Hashim Abbas Durga Anil Kanigicherla Manchester Medical School University of ManchesterManchester M139WLUnited Kingdom Department of Renal Medicine Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom

BACKGROUND Focal segmental glomerulosclerosis(FSGS)often recurs after transplantation,leading to graft dysfunction and graft *** who have lost prior grafts due to recurrence are at particularly high risk of re-recurrence in subsequent *** and plasma exchange have been used pre-emptively to prevent post-transplant ***,the efficacy of such preventative measures remains *** To investigate the outcomes of preventative rituximab and plasma exchange for recurrent FSGS in transplant recipients after prior graft *** We conducted a systematic review of 11 studies with 32 patients who had experienced prior graft loss due to post-transplant FSGS recurrence and were treated with either pre-emptive plasma exchange alone,rituximab alone,or a combination of *** Overall,47%of the 32 patients experienced recurrence despite prophylactic ***-recurrence was seen in 25%(1/4)with pre-emptive rituximab alone,and 45%recurrence(9/20)with plasma exchange ***-recurrence was noted in 63%with the use of combined plasma exchange and *** There is a paucity of available evidence in the literature to draw clear conclusions on the benefits of pre-emptive measures to prevent FSGS *** small sample sizes and variations in protocols call for larger and controlled studies to serve this patient population at high risk of recurrence and graft loss.

关键词： Focal segmental glomerulosclerosis Glomerular disease Plasma exchange Rituximab Transplantation

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