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Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis

World Journal of Psychiatry 2017年第1期7卷 60-76页

作者： sophie e moore Rosana e Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott Child Health Research Centre the University of Queensland Institute of Health and Biomedical Innova-tion Queensland University of Technology School of Public Health and Social Work Queensland University of Technology Queensland Centre for Mental Health Research the Park Centre for Mental Health Faculty of Medicine the University of Queensland the University of Queensland Centre for Clinical Research the University of Queensland Metro North Mental Health Royal Brisbane and Women’s Hospital

AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal *** A systematic review was conducted using Pub Med, eMBASe, eRIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research *** Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for *** significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours.

关键词： Bullying Victimization Systematic review Meta-analysis Child Adolescent

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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;Se=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;Se=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;Se=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics exerkine Mitochondria

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A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic sophie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change exercise Health disparities Oncology Wearable technology

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Optical properties of Weyl semimetals

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National Science Review 2019年第2期6卷 206-208页

作者： Joel e.moore Department of Physics University of California Materials Science Division Lawrence Berkeley National Laboratory

The behavior of electrons in ordinary metals is dominated by physics near the Fermi surface. Indeed, many of the first successes of the quantum theory of solids, such as understanding the large specific heat of metals, followed from applications of the Fermi surface concept. Great effort has been devoted in recent years to semimetals in which the Fermi surface shrinks to a set of Dirac or Weyl points, where four

关键词： As Ta Optical properties of Weyl semimetals

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Choroid plexus tumor necrosis factor receptor 1:a new neuroinflammatory piece of the complex Alzheimer's disease puzzle

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Neural Regeneration Research 2019年第7期14卷 1144-1147页

作者： sophie Steeland Roosmarijn e.Vandenbroucke VIB Center for Inflammation Research Department of Biomedical Molecular Biology Ghent University

Due to the aging of the population and despite the enormous scientific effort,Alzheimer's disease remains one of the biggest medical and pharmaceutical challenges in current *** insights highlight the importance of neuroinflammation as an undeniable player in the onset and progression of Alzheimer's *** necrosis factor is a master inflammatory cytokine that signals via tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2,but that also regulates several brain functions in health and ***,clinical trials investigating drugs that interfere with the tumor necrosis factor pathway in Alzheimer's disease led to inconclusive results,partially because not only the pro-inflammatory tumor necrosis factor/tumor necrosis factor receptor 1,but also the beneficial tumor necrosis factor/tumor necrosis factor receptor 2 signaling was antagonized in these *** recently found that tumor necrosis factor is the main upregulated cytokine in the choroid plexus of Alzheimer's disease patients,signaling via tumor necrosis factor receptor *** agreement with this,choroidal tumor necrosis factor/tumor necrosis factor receptor 1 signaling was also upregulated in different Alzheimer's disease mouse ***,both genetic and nanobody-based pharmacological blockage of tumor necrosis factor receptor 1 signaling was accompanied by favorable effects on Alzheimer's disease-associated inflammation,choroidal morphology and cognitive ***,we briefly summarize the detrimental effects that can be mediated by tumor necrosis factor/tumor necrosis factor receptor 1 signaling in(early) Alzheimer's disease,and the consequences this might have on the disease *** the main hypothesis in Alzheimer's disease clinical trials is still based on the amyloid beta-cascade,the importance of Alzheimer's disease-associated neuroinflammation urge the development of novel therapeutic strategies that might be effective in the early stages

关键词： tumor necrosis factor neuroinflammation blood-cerebrospinal fluid barrier preclinical research drug development neurodegeneration cognitive decline mouse models TNFR

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The importance of non-carbonate mineral weathering as a soil formation mechanism within a karst weathering profile in the SPeCTRA Critical Zone Observatory, Guizhou Province,China

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Acta Geochimica 2017年第3期36卷 566-571页

作者： Oliver W.moore Heather L.Buss sophie M.Green Man Liu Zhaoliang Song School of earth Sciences University of Bristol Geography College of Life and Environmental SciencesUniversity of Exeter School of Water Resources and environment China University of Geosciences (Beijing) Institute of the Surface-earth System Science Research Tianjin University

Soil degradation, including rocky desertification,of the karst regions in China is severe. Karst landscapes are especially sensitive to soil degradation as carbonate rocks are nutrient-poor and easily eroded. Understanding the balance between soil formation and soil erosion is critical for long-term soil sustainability, yet little is known about the initial soil forming processes on karst terrain. Herein we examine the initial weathering processes of several types of carbonate bedrock containing varying amounts of non-carbonate minerals in the SPeCTRA Critical Zone Observatory, Guizhou Province, Southwest China. We compared the weathering mechanisms of the bedrock to the mass transfer of mineral nutrients in a soil profile developed on these rocks and found that soil formation and nutrient contents are strongly dependent upon the weathering of interbedded layers of more silicate-rich bedrock(marls). Atmospheric inputs from dust were also detected.

关键词： Critical zone Chemical weathering Karst Desertification Guizhou Province

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Amount of polyhydramnios attributable to diabetes may be less than previously reported

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World Journal of Diabetes 2017年第1期8卷 7-10页

作者： Lisa e moore Department of Obstetrics and Gynecology Texas Tech Health Sciences CenterEl PasoTX 79905United States

AIM To evaluate the frequency and the quantity of polyhydramnios attributable to diabetes in *** The charts of patients with a four-quadrant amniotic fluid index(AFI) ≥ 20 cm and either a diagnosis of diabetes or a diabetes screening test during the index pregnancy were retrospectively reviewed. AFI was stratified into 5 categories and the frequency of diabetes was evaluated for each group. The frequency of polyhydramnios attributable to diabetes was compared to the frequency of polyhydramnios in the setting of fetal anomalies or no known cause. ReSULTS One thousand five hundred and forty-five patients were included in the study. eight point five percent(n = 131) had diabetes and no other cause for polyhydramnios. eleven point two percent(173) had antenatally diagnosed anomalies. For all categories of AFI except the largest(> 40.9 cm) the most common cause of polyhydramnios was idiopathic. In patients with diabetes the AFI was most likely to be between 26 cm and 35.9 *** The rate of polyhydramnios in this study is 8.5%. Patients with diabetes most commonly have mild polyhydramnios between 26 and 35.9 cm of fluid on a four-quadrant AFI.

关键词： Gestational diabetes Amniotic fluid index Diabetes in pregnancy Polyhydramnios

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Actads

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Science China Mathematics 2022年第9期65卷 1909-1952页

作者： sophie Kriz Department of Mathematics College of LiteratureScienceand the ArtsUniversity of MichiganAnn ArborMI 48109USA

In this paper,I introduce a new generalization of the concept of an operad,further generalizing the concept of an opetope introduced by Baez and Dolan(1998),who used this for the definition of their version of non-strict *** arise from iterating a certain construction on operads called the+-construction,starting with *** first step gives rise to plain operads,i.e.,operads without *** permutation axiom in a symmetric operad,however,is an additional structure resulting from permutations of variables,independent of the structure of a *** though we can apply the+-construction to symmetric operads,there is the possibility of introducing a completely different kind of permutations on the higher levels by again permuting variables without regard to the structures on the previous *** and investigating these structures is the main purpose of this *** structures obtained in this way are what I call *** n-actads with n>1,the permutations on the different levels give rise to a certain special kind of n-fold category.I also explore the concept of iterated algebras over an n-actad(generalizing an algebra and a module over an operad),and various types of iterated units.I give some examples of algebras over 2-actads,and show how they can be used to construct certain new interesting homotopy types of operads.I also discuss a connection between actads and ordinal notation.

关键词： operads actads infinite loop spaces universal algebra ordinals

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Molecular Modelling and Bonding 1

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丛书名： Molecular world, bk. 6

2002年

作者： e.A. moore

来源：畅想之星图书光盘版（南... 评论

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Microbiological safety of spices and their interaction with antibiotics:implications for antimicrobial resistance and their role as potential antibiotic adjuncts

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Food Quality and Safety 2019年第2期3卷 93-97页

作者： Rachel e.moore B.Cherie Millar Jayachandran R.Panickar John e.moore Department of Bacteriology Northern Ireland Public Health LaboratoryBelfast City HospitalLisburn RoadBelfastNorthern IrelandBT97ADUK School of Biomedical Sciences Ulster UniversityCromore RoadColeraineBT521SANorthern IrelandUK Centre for experimental Medicine Queen’s University97 Lisburn RoadBelfast BT97BLNorthern IrelandUK Department of Paediatrics Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates

Objectives:A study was undertaken to:*** contaminating bacteria on a variety of spices purchased at retail market;*** if spice bacterial enrichments alter the phenotype of 13 bacterial foodborne and clinical pathogens and 1 probiotic organism;and *** if spices can alter antimicrobial activity of seven clinical antibiotics against 16 bacterial foodborne/clinical *** and Methods:Microbiological examination was undertaken employing 27 spice varieties with four antibiotics and 15 bacterial ***:Bacteriological contamination levels varied amongst spice varieties,ranging from Kasmin chilli powder(7.5×10^(6)cfu/g;log10^(6).88 cfu/g)to ginger(1.5×10^(4)cfu/g;log_(10)4.18 cfu/g);mean contamination was 1.38×10^(6)cfu/g(log_(10)6.14 cfu/g).Four species within the genus Bacillus were identified(Bacillus megaterium,Bacillus subtilis,Bacillus licheniformis,and Bacillus cereus).There was no phenotypic difference with the 14 bacteria,with bacterial colony growth/proliferation,pigment production,or with adhesin and mucoid *** of the spice cultures inhibited any of the 14 bacterial species *** the case of doxycycline,amoxicillin,colistin,erythromycin,and piperacillin/tazobactam,the zone of inhibition increased with the inclusion of the 26 spice varieties,suggesting that the spices were interacting synergistically with the antibiotic,thus making the antibiotic more potent against the bacteria ***:This study demonstrates a positive interaction between spices and conventional *** the burden of antimicrobial resistance(AMR)worldwide,but particularly in South Asian countries(India and Pakistan),any food-related innovation that can help maximize the potency of existing antibiotics is to be encouraged and *** specific mechanism as to how spices increase the potency of antibiotics needs to be elucidated,as well as novel food(spice)delivery modalities including novel medicinal foo

关键词： antibiotic resistance antimicrobial resistance Bacillus foodborne pathogen microbiology Pseudomonas aeruginosa spice

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