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Tumour induced osteomalacia due to a sinonasal hemangiopericytoma:A case report

World Journal of Clinical Cases 2013年第1期1卷 59-63页

作者： sophie a jamal Brendan C Dickson Ina Radziunas Division of Endocrinology Department of Medicine University of Toronto Toronto ON M5G 1N8 Canada Department of Pathology Mount Sinai Hospital Toronto ON M5G 1X5 Canada Multidisciplinary Osteoporosis Program Women’s College Hospital Toronto ON M5S 1B1 Canada

Tumour induced osteomalacia(TIO) is a rare and often unrecognized cause of hypophosphatemia. We report on a case of TIO due to a hemangiopericytoma originating from the left nasal sinus. The patient was a 55-year-old male with a 3-year history of left hip pain and an undisplaced left hip fracture. Biochemical testing demonstrated low levels of serum phosphate and serum 1,25-dihydroxyvitamin D, and an elevated level of fibroblast growth factor 23. Octreotide scanning demonstrated uptake in the left nasal sinus area and a computed tomography scan revealed a left nasal sinus mass. The patient underwent surgical resection of the mass and histology was consistent with a sinonasal hemangiopericytoma. His serum phosphate levels normalized almost immediately after surgery and he had complete resolution of hip pain. Our case highlights the importance of considering TIO when assessing patients with low serum phosphate.

关键词： Phosphate Osteomalacia Tumour Fibroblast growth factor 23

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Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema

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World Journal of Diabetes 2013年第6期4卷 303-309页

作者： Ahmadreza Moradi Yasir jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay sophie Diana V Do Quan Dong Nguyen Retinal Imaging Research and Reading Center Wilmer Eye InstituteJohns Hopkins University School of MedicineBaltimoreMD 21287United States Stanley M Truhlsen Eye Institute University of Nebraska Medical CenterOmahaNE 68198United States

Diabetic retinopathy(DR)is the most common cause of visual loss among working age *** macular edema(DME)is an important complication of DR that affects around one third of the patients with *** treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)*** index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of ***-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF *** clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent *** presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular ***,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME.

关键词： Diabetic macular edema Diabetic retinopathy Anti-vascular endothelial growth factor agents Vascular endothelial growth factor trap-eye Aflibercept EYLEA

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