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Segmentation Based Real Time Anomaly Detection and Tracking Model for Pedestrian Walkways

Intelligent Automation & Soft Computing 2023年第6期36卷 2491-2504页

作者： B.sophia D.Chitra Department of Computer Science and Engineering Sri Krishna College of Engineering and TechnologyCoimbatoreTamilnaduIndia Department of Computer Science and Engineering P.A College of Engineering and TechnologyPollachiTamilnaduIndia

Presently,video surveillance is commonly employed to ensure security in public places such as traffic signals,malls,railway stations,etc.A major chal-lenge in video surveillance is the identification of anomalies that exist in it such as crimes,thefts,and so ***,the anomaly detection in pedestrian walkways has gained significant attention among the computer vision communities to enhance pedestrian *** recent advances of Deep Learning(DL)models have received considerable attention in different processes such as object detec-tion,image classification,*** this aspect,this article designs a new Panoptic Feature Pyramid Network based Anomaly Detection and Tracking(PFPN-ADT)model for pedestrian *** proposed model majorly aims to the recognition and classification of different anomalies present in the pedestrian walkway like vehicles,skaters,*** proposed model involves panoptic seg-mentation model,called Panoptic Feature Pyramid Network(PFPN)is employed for the object recognition *** object classification,Compact Bat Algo-rithm(CBA)with Stacked Auto Encoder(SAE)is applied for the classification of recognized *** ensuring the enhanced results better anomaly detection performance of the PFPN-ADT technique,a comparison study is made using Uni-versity of California San Diego(UCSD)Anomaly data and other benchmark data-sets(such as Cityscapes,ADE20K,COCO),and the outcomes are compared with the Mask Recurrent Convolutional Neural Network(RCNN)and Faster Convolu-tional Neural Network(CNN)*** simulation outcome demonstrated the enhanced performance of the PFPN-ADT technique over the other methods.

关键词： Panoptic segmentation object detection deep learning tracking model anomaly detection pedestrian walkway

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ESCRT machinery:role of membrane repair mechanisms in escaping cell death

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2655-2657页

作者： Lisa Gregor sophia Stock Sebastian Kobold Division of Clinical Pharmacology Department of Medicine IVUniversity HospitalLudwig Maximilian University(LMU)of MunichLindwurmstrasse 2a80337 MunichGermany Department of MedicineⅢ University HospitalLudwig Maximilian University(LMU)of MunichMarchioninistrasse 1581377 MunichGermany German Cancer Consortium(DKTK) Partner Site MunichPettenkoferstrasse 8a80336 MunichGermany Einheit für Klinische Pharmakologie(EKLiP) Helmholtz Zentrum MünchenGerman Research Center for Environmental Health(HMGU)Ingolstädter Landstrasse 185764 NeuherbergGermany

A recent research article published in Science by Ritter et *** that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches.

关键词： al. cytotoxicity death

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E2F transcription factors and digestive system malignancies:How much do we know?

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World Journal of Gastroenterology 2014年第29期20卷 10212-10216页

作者： Konstantinos Evangelou sophia Havaki Athanassios Kotsinas Laboratory Histology-Embryology Medical SchoolNational and Kapodistrian University of Athens

The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. Accumulating data suggest that there is no specific role for each individual E2F member. Instead, each E2F can exert a variety of cellular effects, some of which represent opposing ones. For instance, specific E2Fs can activate transcription and repression, promote or hamper cell proliferation, augment or inhibit apoptosis, all being dependent on the cellular context. This complexity reflects the importance that these transcription factors have on a cell’s fate. Thus, delineating the specific role for each E2F member in specific malignancies, although not easy, is a challenging and continuously pursued task, especially in view of potential E2F targeted therapies. Therefore, several reviews are continuously trying to evaluate available data on E2F status in various malignancies. Such reviews have attempted to reach a consensus, often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs. However they frequently miss spatial and temporal alterations of these factors during tumor development, which should also be considered in conjunction with the status of the regulatory networks that these factors participate in. In the current ‘‘Letter to the Editor’’, we comment on the flaws, misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies.

关键词： E2F Hepatocellular carcinoma Pancreatic ductal adenocarcinoma Gastrointestinal tract Digestive system p53 p73 Cancer Apoptosis Proliferation

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Modeling of cognitive brain activity through the information images theory in terms of the bilingual Stroop test

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International Journal of Biomathematics 2017年第7期10卷 19-34页

作者： Alexander Y. Petukhov sophia A. Polevaya Lobachevsky Nizhny Novgorod State University Gagarin Avenue 23 Nizhniy Novgorod 603950 Russia

The paper presents the basic principles of the information image theory and a mathematical model developed using it. The hierarchy of information images in an individual mind, which determines his／her real and virtual activity, is considered. Algo- rithms for describing transfer and distortion of information images by individuals in the communication process are constructed. To corroborate the theory experimentally, the bilingual Stroop test is used. The results of the test are interpreted using the introduced theory, and are then compared with the results of computer modeling based on the theory. It is shown that information images can be used not only to explain a number of cognitive processes of the human mind, but also to predict their dynamics in a number of particular cases.

关键词： Communication field information image information image space virtual particles the bilingual Stroop test.

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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino M.Reimold E.Beyreuther F.-E.Brack F.Kroll J.Pawelke J.D.Schilz M.schneider U.Schramm M.E.P.Umlandt K.Zeil T.Ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

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Recurrence properties of sequences of integers

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Science China Mathematics 2010年第3期53卷 641-656页

作者： schneider Dominique CNRS LMPA J. Liouville FR 2956 University Lille Nord de France

In order to study the recurrence of sequences of integers, we investigate their L2-exactness and Θ-Hartman property (Θ being a set of rational numbers). Two classes of sequences of integers are well studied, which a... 详细信息

关键词： recurrent set random sequence Wiener-Wintner theorem

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Does Foreign Direct Investment Affect S0_(2) Emissions in the Yangtze River Delta?A Spatial Econometric Analysis

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Chinese Geographical Science 2021年第3期31卷 400-412页

作者： GUO Zheng sophia Shuang CHEN YAO Shimou Anna Charles MKUMBO Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China School of Geography Nanjing University of Information Science&TechnologyNanjing 210000China Faculty of Science&Technology Teofilo Kisanji UniversityMbeya 999132Tanzania

As the major source of air pollution,sulfur dioxide(S0_(2))emissions have become the focus of global ***,existing studies rarely consider spatial effects when discussing the relationship between foreign direct investment(FDI)and S0_(2) *** study took the Yangtze River Delta as the research area and used the spatial panel data of 26 cities in this region for *** study investigated the spatial agglomeration effects and dynamics at work in FDI and S0_(2) emissions by using global and local measures of spatial ***,based on regression analysis using a results of traditional ordinary least squares(OLS)model and a spatial econometric model,the spatial Durbin model(SDM)with spatial-time effects was adopted to quantify the impact of FDI on S0_(2) emissions,so as to avoid the regression results bias caused by ignoring the spatial *** results revealed a significant spatial autocorrelation between FDI and S0_(2) emissions,both of which displayed obvious path dependence characteristics in their geographical distribution.A series of agglomeration regions were observed on the spatial *** estimation results of the SDM showed that FDI inflow promoted S0_(2) emissions,which supports the pollution haven *** findings of this study are significant in the prevention and control of air pollution in the Yangtze River Delta.

关键词： foreign direct investment(FDI) sulfur dioxide(S0_(2))emissions spatial Durbin model(SDM) spatial correlation Yangtze River Delta

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Insights into manganese transport: A matter of phosphorylation

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Molecular Plant 2022年第3期15卷 385-387页

作者： Anja schneider Plant Science Faculty of BiologyLudwig-Maximilians-Universität MünchenMunichGermany

Manganese(Mn)is an essential element required for the growth of all known living *** plants acquire Mn from the rhizosphere,and its translocation into,and distribution within,the plant involves a multitude of transporters(Alejandro et al.,2020).In the aerial part of the green plant,the most prominent reaction that depends on Mn is the water-splitting reaction of photosystem II,which employs a tetra-Mn cluster located in the thylakoid lumen of ***,no less important reactions take place in mitochondria,where a Mn superoxide dismutase acts as a scavenger of reactive oxygen species,and in the Golgi apparatus,where Mn-dependent glycosyltransferases are involved in cell wall biosynthesis.

关键词： manganese apparatus splitting

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Light Induced Inhibition of Protein Phosphatase Calcineurin

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Chinese Journal of Chemistry 2014年第10期32卷 1011-1014页

作者： Andres Quintero Weilin Lin sophia Hermann Yixin Zhang BCUBE Center for Molecular Bioengineering Technische Universität DresdenArnoldstrasse 1801307 DresdenGermany

Light-induced switching of drug activity can be used to realize spatio-temporal control of biological activity in cells and in *** our study of light-switchable derivatives of immunosuppressive drug cyclosporin A(CsA)in their inhibition of protein phosphatase calcineurin(CaN),we have discovered that 7-methyl-6-thioguanosine(MESG)inhibits CaN under light irradiation through a photo-crosslinking *** inhibition has shown selectivity over other enzymes such as phosphatase PP2A,protease chymotrypsin,and cyclophilin 18,the receptor protein for *** discovery could pave the way to discover new covalent inhibitors for protein phosphtase,to design immunophilin-independent CaN inhibitors,and to design new light controlled inhibitors to modulate signal transduction.

关键词： inhibitor photo-switching immunosuppression calcineurin phosphatase

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Idea management revisited:A review of the literature and guide for implementation

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International Journal of Innovation Studies 2017年第2期1卷 144-161页

作者： sophia Gerlach Alexander Brem Friedrich-Alexander-Universit€at Erlangen-Nürnberg Chair of Technology ManagementFürther Str.246c90429 NürnbergGermanyUniversity of Southern DenmarkMads Clausen InstituteAlsion 26400 SonderborgDenmark Detecon International GmbH Sternengasse 14-1650676 CologneGermany

Despite being an established topic in research and practice for many years,the literature on idea management lacks a general model for corporate idea management ***,the purpose of this study is to develop such a conceptual framework based on the findings of an extensive literature *** addition,this paper presents an idea management guide that addresses important aspects of an idea management *** simplify the guide's application for idea managers,it is summarized in a *** paper can serve researchers with a state-of-the-art review and idea managers with a tool for building new idea management programs or reviewing existing ones in companies of different sizes and industries.

关键词： Idea management Employee suggestion scheme Front end innovation

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