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Acupuncture treatment of a male patient suffering from long-term schizophrenia and sleep disorders

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Journal of Traditional Chinese Medicine 2017年第6期37卷 862-867页

作者： Peggy Bosch Heike Staudte Sujung Yeo sook-Hyun Lee Sabina Lim Maurits van den Noort Donders Centre for Cognition Radboud University NijmegenNijmegen 6525 HRThe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-HauBed-burg-Hau 47551Germany Psychiatric Research Institute LVR-Klinik Bedburg-HauBedburg-Hau 47551Germany Department of Acupuncture&Meridian of Oriental Medicine Sang Ji UniversityWonju 26339Republic ofKorea Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701Republic of Korea Research Group of Pain and Neuro-science Kyung Hee UniversitySeoul 130-701Republic of Korea.Brussels Institute for Applied LinguisticsFree Univer-sity of BrusselsBrussels 1050Belgium

OBJECTIVE: To investigate the effectiveness of acupuncture in the treatment of chronic schizophrenia and co-morbid sleep ***: A 42-year-old German male outpatient,suffering from long-term schizophrenia and sleep disorders, entered the study. Acupuncture was used as a non-pharmacological intervention. In addition to his ongoing Western Medicine(pharmacological) treatment, the patient received 12 weekly(non-standardized) acupuncture treatments in the clinic. The Traditional Chinese Medicine(TCM) diagnosis, the psychological assessment and the actiwatch data were compared before and after the acupuncture ***: The TCM diagnosis revealed a Liver Fire pattern before the acupuncture treatment, which was still present, although to a lesser degree, after the treatment. The psychological assessment revealed no change in the positive symptoms, but a small decrease in the negative symptoms and the general psychopathology of the patient. This was further illustrated by the small decrease in the number of depressive symptoms. The subjective sleep disorders improved markedly after acupuncture treatment, but the daytime sleepiness did not. The actiwatch results showed that after acupuncture treatment, the patient was moving less during sleep, but no significant results were found for the other sleep ***: Acupuncture was found to be an effective non-pharmacological add-on method for treating subjective sleep disorders, and, to a lesser degree, objective sleep disorders and the negative symptoms of chronic schizophrenia. Future larger clinical trials with follow-up measurements are needed in order to replicate the present preliminary beneficial acupuncture findings and in order to determine whether the observed effects can be sustained.

关键词： Actigraphy Acupuncture Schizophre-nia Sleep weak disorders

Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study

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Chinese Journal of Cancer 2017年第2期36卷 63-70页

作者： sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Medical Education Research&Evaluation Department(MERE)Duke-NUS Medical School8 College RoadSingapore 169857Singapore Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSinga-pore 169610Singapore Genetic Cancer Susceptibility Group International Agency for Research on CancerWorld Health Organization150 Cours Albert Thomas69372 Lyon Cedex 08France

Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean ***: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning ***: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.

关键词： Nasopharyngeal carcinoma Diet Smoking Alcohol drinking Case–control study Preserved food

Organic solar cells based on chlorine functionalized benzo[1,2-b:4,5-b′]difuran-benzo[1,2-c:4,5-c′]dithiophene-4,8-dione copolymer with efficiency exceeding 13%

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Science China Chemistry 2020年第4期63卷 483-489页

作者： Linglong Ye Xueshan Li Yunhao Cai Hwa sook Ryu Guangkai Lu Donghui Wei Xiaobo Sun Han Young Woo songting Tan Yanming Sun School of Chemistry Beihang UniversityBeijing 100191China Department of Chemistry College of ScienceKorea UniversityAnam-ro 145Seongbuk-guSeoul 136-713Republic of Korea The College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education College of ChemistryXiangtan UniversityXiangtan 411105China

Benzo[1,2-b:4,5-b′]dithiophene(BDT) has been widely used to construct donor-acceptor(D-A) copolymers in organic solar cells(OSCs). However, benzo[1,2-b:4,5-b′]difuran(BDF), an analogue of BDT, has received less attention than BDT. The photovoltaic performance of BDF copolymers has lagged behind that of BDT copolymers. Here, we designed and synthesized two BDF copolymers, PBF1-C and PBF1-C-2Cl. PBF1-C-2Cl, which is composed of BDF and benzo[1,2-c:4,5-c′]dithiophene-4,8-dione connected by a chlorinated thiophene π-bridge, displays a low-lying highest occupied molecular orbital energy level,which helps in yielding a high open-circuit voltage(Voc) in OSCs. As a result, when blended with Y6, PBF1-C-2Cl-based devices showed a high Voc of 0.83 V and a power conversion efficiency(PCE) of 13.10%. To the best of our knowledge, the PCE of 13.10% is among the highest efficiency values for OSCs based on BDF copolymers.

关键词： organic solar cells benzo[1,2-b,5-b′]difuran benzo[1,2-c,5-c′]dithiophene-4,8-dione chlorinated thiophene π-bridge

Oxidative degradation of sunflower oil blended with roasted sesame oil during heating at frying temperature

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Grain & Oil Science and Technology 2023年第1期6卷 34-42页

作者： M.Al Amin M.Abbas Ali M.Shamsul Alam Aktarun Nahar sook Chin Chew Department of Chemistry Rajshahi University of Engineering&TechnologyRajshahi 6204Bangladesh Xiamen University Malaysia CampusBandar SereniaSepang 43900SelangorMalaysia

The efficacy of roasted sesame oil(SO)on the oxidation deterioration of sunflower oil(SFO)during heating was *** concentrations of SO in the SFO were 0,10%,20%,and 30%by *** oxidation profile of oil samples was monitored by evaluating the generation of oxidation products and chemical alterations in the oils'composition during heating at frying temperature(180℃).The results showed that the oxidation parameters(free fatty acid,peroxide value,p-anisidine value,total oxidation status,thiobarbituric acid value,and color index)increased significantly in SFO compared to blends or SO during thermal *** heating,the concentration of polyunsaturated fatty acids(PUFA)was reduced with increased level of saturated fatty acids;these results were observed more in SFO than those of SO or blend ***,the presence of SO in SFO reduced the decomposition of *** Fourier-transform infrared spectroscopy,the peak intensities were significantly altered in SFO compared to the blend oils during *** on the most analytical data,it may be agreed that the heating at frying temperature led to the generation of relatively higher contents of oxidative products in SFO compared to blend oils,showing a lower degree of oxidation occurred in *** best frying performance for the SFO was achieved by using 30%SO extracted from the roasted sesame *** study showed the proper blending of high polyunsaturated oil with SO can produce oil blends with high nutritional values and enhanced stability for daily cooking and deep-frying applications.

关键词： Sesame oil Sunflower oil Fatty acids Oxidative stability Blend oil

Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer

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World Journal of Gastroenterology 2009年第48期15卷 6091-6095页

作者： Mi-sook Kim Chul Koo Cho Kwang Mo Yang Dong Han Lee Sun Mi Moon Young Joo Shin Department of RadiationOncology and Surgery Korea Institute of Radiological & Medical Sciences

AIM： To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS： From 2003 to 2009, 7 patients with paraaortic lymph node recurrence （1-3 lesions） from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS： One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION： This pilot study suggests selected paraaortic lymph node recurrence （1-3 closed lesions） that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.

关键词： Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer

Multiple trichoepithelioma improved by intralesional bleomycin injection

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Multiple trichoepithelioma improved by intralesional bleomyc...

Comparison of daily physical activity parameters using objective methods between overweight and normal-weight children

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Hyun Soo Sim Se Won Jung Tae Gwang Kwon Hyun Hwangbo Hyun Ho son sook Kyung Lee Department of Dermatology Maryknoll Medical CenterBusanKorea

＜正＞Trichoepithelioma is a benign adnexal neoplasm arising from hair *** trichoepithelioma（MT） consists of numerous,small,flesh colored papules which located on the nasolabial fold,forehead,nose and upper *** treatments including excision,carbon dioxide laser,cryotherapy,dermabrasion,argon laser,*** been tried for

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Journal of Sport and Health Science 2018年第2期7卷 210-217页

作者： Jonghoon Park Kazuko Ishikawa-Takata Sangjik Lee Eunkyung Kim Kiwon Lim Hyungryul Kim In-sook Lee Shigeho Tanaka Department of Physical Education Korea University Department of Nutritional Education National Institute of Health and Nutrition Division of Physical Education Uiduk University Department of Food and Nutrition Gangneung-Wonju National University Department of Physical Education Konkuk University Division of Food Service Industry Uiduk University Department of Nutritional Science National Institute of Health and Nutrition

Purpose: The purpose of the present study was to determine if there were any differences in various aspects of physical activity such as energy expenditure, intensity, and type of activity between normal-weight and overweight ***: Children aged 9—12 years were recruited from 2 elementary schools located in different urban districts in Republic of Korea. The present study included 45 Korean boys, of which 19 were normal-weight and 26 were overweight. Daily physical activity was estimated over the same 1-week study period under free-living conditions using the doubly labeled water(DLW) method and a tri-axial accelerometer. Resting metabolic rate(RMR) was measured using the Douglas bag method and open-circuit indirect calorimetry. We calculated the physical activity level(PAL) as the total energy expenditure(TEE)/***: PAL was not significantly different between the groups. In the accelerometer data, time spent in locomotive moderate-to-vigorous physical activity(MVPA) was significantly lower in overweight boys than in normal-weight subjects, whereas other variables including non-locomotive activity did not differ between groups. In addition, among all participants, time spent in total locomotive activity was significantly associated with PAL. Time spent in locomotive MVPA was significantly associated with ***: Overweight boys may be less physically active based on locomotive MVPA, which was positively related with PAL. Our findings suggest that the contribution of locomotive MVPA to the increase in PAL was relatively significant.

关键词： Accelerometer Doubly labeled water Korean elementary boys Locomotive moderate-to-vigorous physical activity Obesity Physical activity level

Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 896-901页

作者： Ik Soo Byon Dong Hyun Lee Eun sook Jun Min Kyu Shin Sung Who Park Ji Eun Lee Department of Ophthalmology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 Korea College of Medicine Pusan National University Yangsan 50612 Korea Department of Ophthalmology Biomedical Research Institute Pusan National University Hospital Busan 49241 Korea Balgeunsesang Eye Clinic Busan 47286 Korea

AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS： Forty Sprague-Dawley rats were divided into 4 groups： control, diabetes mellitus （DM）, candesartan- treated DM, and enalapril-treated DM （each group, n---10）. After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/（kg · d）] and enalapril [ACEI, 10 mg/（kg · d）] were administered to rats orally for 4Wko Vascular endothelial growth factor （VEGF） and angiotensin II （Ang II） concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor （ATIR） levels were assessed at week 4 by Western blotting. RESULTS： Vitreous Ang II levels were significantly higher in the DM group and candesartan-treated DM group than in the control （P=0.04 and 0.005, respectively）. Vitreous ATIR increased significantly in DM compared to the other three groups （P〈0.007）. Candesartan-treated DM rats showed higher vitreal ATIR concentration than the enalapril-treated DM group and control （P〈0.001 and P=0.005, respectively）. No difference in vitreous Ang II and ATIR concentration was found between the enalapril- treated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups. CONCLUSION： Increased Ang II and ATIR in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB.

关键词： angiotensin converting enzyme inhibitor angiotensin II type 1 receptor blocker diabetic rat intraocularrenin-angiotensin system

Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis

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World Journal of Gastroenterology 2016年第20期22卷 4901-4907页

作者： Ji sook Park Jae Sung Ko Jeong Kee Seo jin Soo Moon Sung Sup Park Department of Pediatrics Seoul National University College of Medicine Department of Pediatrics Gyeongsang National University School of Medicine Department of Laboratory Medicine Seoul National University College of Medicine

AIM: To investigate clinical profiles and mutations of ABCB11 in Koreans with progressive familial intrahepatic cholestasis 2 and review the differences between Koreans and ***: Of 47 patients with neonatal cholestasis, five infants had chronic intrahepatic cholestasis with normal γ-glutamyl transpeptidase. Direct sequencing analyses of ABCB11, including exons and introns, were performed from peripheral ***: Living donor-liver transplantation was performed in four patients because of rapidly progressive hepatic failure and hepatocellular carcinoma. Three missense mutations were found in two patients: compound heterozygous 677C>T(S226L)/3007G>A(G1003R) and heterozygous 2296G>A(G766R). The mutations were located near and in the transmembranous space. CONCLUSION: Alterations in the transmembrane of the bile salt export pump in the Korean infants were different from those previously reported in Chinese, Japanease, Taiwan Residents, and European patients.

关键词： Hepatocellular carcinoma Progressive familial intrahepatic cholestasis ABCB11 Bile salt export pump