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World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-Jae Park hong-Jo Choi Sung-Heun Kim Sang-Young Han sook-hee hong Jin-Han Cho Hyung-Ho Kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

New insights into ATR inhibition in muscle invasive bladder cancer:The role of apolipoprotein B mRNA editing catalytic subunit 3B

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Oncology Research 2024年第6期32卷 1021-1030页

作者： HYUNHO KIM UIJU CHO sook hee hong HYUNG SOON PARK IN-HO KIM HO JUNG AN BYOUNG YONG SHIM JIN HYOUNG KANG Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DNA damage and activates the ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(Chk1)*** cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer(MIBC),it has a poor survival ***,this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with *** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in phosphorylated Chk1(pChk1)expression according to the APOBEC3B *** viability and apoptosis analyses were performed to examine the anti-tumor activity of ATR inhibitors combined with ***:There was a significant association between APOBEC3B and ATR expression in the tumor tissues obtained from patients with *** with higher APOBEC3B expression showed higher pChk1 expression than cells expressing low APOBEC3B *** treatment of ATR inhibitor and cisplatin inhibited cell growth in MIBC cells with a higher APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death in the cells with higher APOBEC3B ***:Our study shows that APOBEC3B’s higher expression status can enhance the sensitivity of MIBC to cisplatin upon ATR *** result provides new insight into appropriate patient selection for the effective application of ATR inhibitors in MIBC.

关键词： Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DNA damage response DNA replication stress

Preparation of Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_2 powders for cathode material in secondary battery by solid-state method

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Rare Metals 2006年第Z2期25卷 184-188页

作者： PARK sook hee KANG Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

Intestinal Behet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis

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World Journal of Gastroenterology 2013年第32期19卷 5389-5392页

作者： sook hee Chung Soo Jung Park Sung Pil hong Jae hee Cheon Tae Il Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

Behet’s disease(BD)is a chronic inflammatory disease affecting multiple organ systems,such as the skin,joints,blood vessels,central nervous system,and gastrointestinal *** BD is characterized by intestinal ulcerations and gastrointestinal *** medical treatment of intestinal BD includes corticosteroids and *** have been several reports of tumor necrosis factor-α (TNF-α)blockers being successful in treatment of refractory intestinal ***,we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker(adalimumab)for underlying ankylosing *** patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen.

关键词： Intestinal Behet's disease Tumor necrosis factor-α Adalimumab

Analysis of interval constants in calendars affiliated with the Shoushili

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Research in Astronomy and Astrophysics 2014年第4期14卷 485-496页

作者： Byeong-hee Mihn Ki-Won Lee Young sook Ahn Advanced Astronomy and Space Science Division Korea Astronomy and Space Science Institute Department of Astronomy and Space Science Chungbuk National University Institute of Liberal Education Catholic University of Daegu

We study interval constants that are related to motions of the Sun and Moon, i.e., the Qi, Intercalation, Revolution and Crossing interval, in calendars affiliated with the Shoushi calendar （Shoushili）, such as Datongli and Chiljeongsannaepyeon. It is known that these interval constants were newly introduced in the Shoushili calendar and revised afterward, except for the Qi interval constant, and the revised values were adopted in later calendars affiliated with the Shoushili. We first investigate the accu- racy of these interval constants and then the accuracy of calendars affiliated with the Shoushili in terms of these constants by comparing times for the new moon and the maximum solar eclipse calculated by each calendar with modem methods of calcula- tion. During our study, we found that the Qi and Intercalation interval constants used in the early Shoushili were well determined, whereas the Revolution and Crossing interval constants were relatively poorly measured. We also found that the interval constants used by the early Shoushili were better than those of the later one, and hence better than those of Datongli and Chiljeongsannaepyeon. On the other hand, we found that the early Shoushili is, in general, a worse calendar than Datongli for use in China but a better one than Chiljeongsannaepyeon for use in Korea in terms of times for the new moon and when a solar eclipse occurs, at least for the period 1281 - 1644. Finally, we verified that the times for sunrise and sunset in the Shoushili-Li-Cheng and Mingshi are those at Beijing and Nanjing, respectively.

关键词： history and philosophy of astronomy: general -- celestial mechanics --ephemerides

Diaphragm disease compared with cryptogenic multifocal ulcerous stenosing enteritis

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World Journal of Gastroenterology 2011年第23期17卷 2873-2876页

作者： sook hee Chung Yunju Jo Sang Ryol Ryu Sang Bong Ahn Byoung Kwan Son Seong Hwan Kim Young sook Park Young Ok hong Department of Internal Medicine Eulji University School of MedicineSeoul 139-711South Korea Department of Pathology Eulji University School of MedicineSeoul 139-711Korea

As the use of drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) increases,so too do gastrointestinal ulcers,bleeding,perforation and *** disease of the small intestine is formed by submucosal fibrosis and destruction of lamina muscularis due to chronic ulceration,which corresponds to the most severe stage of NSAID *** may lead to stricture of the small *** such ulcerations and strictures in the small intestine are multiple,differential diagnosis is between diaphragm disease and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE),because the gross findings of diaphragm disease are similar to those of *** report a rare case of diaphragm disease caused by *** has been finally confirmed by capsule endoscopy and the origin of chronic obscure gastrointestinal bleeding was found to be multiple ulcers and strictures in the small *** operation,we diagnosed the patient with diaphragm disease rather than CMUSE.

关键词： Non-steroidal anti-inflammatory agents Enteritis Gastrointestinal hemorrhage Small intestine Capsule endoscopy

Luminescent Properties of Gd_(3)PO_(7):Eu in UV/VUV Region

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Chinese Physics Letters 2001年第5期18卷 690-691页

作者： ZENG Xiao-Qing hong Guang-Yan YOU hong-Peng WU Xue-Yan KIM Chang-hong PYUN Chong-hong YU Byung-Yong BAE Hyun-sook PARK Cheal-hee KWON Il-Eok Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022 Solid State Chemistry Labortory Korea Institute of Science and TechnologyP.O.Box 131CheongryangSeoul 130-650Korea

The luminescent properties of Gd_(3)PO_(7):Eu were investigated in UV and VUV *** phosphor has so strong emissions around 618.5 nm under UV excitation,especially around 209\,nm,so that it has a better colour saturation than that of Y_(2)O_(3):*** would be a new potential red phosphor for lamp and other applications with UV-excitation source or even for displaying *** the VUV excitation spectrum of Eu^(3+)emissions,energy absorptions by Gd^(3+),Gd-O and PO_(4)^(3-) were observed,on which it can be inferred that there are three kinds of energy transferring processes to Eu^(3+)*** energy absorptions of Gd^(3+),Gd-O and PO_(4)^(3-) are induced by 4f→4f transitions,band-gap transition of Gd_(3)PO_(7) and intramolecular(2t_(2)→2a,3t_(2))transition,*** energy transfer efficiency of the PO_(4)^(3-) intramolecular transition is lower compared with that of the band-gap transition(Gd-O).

关键词： excitation intramolecular transition

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World Journal of Gastroenterology 2014年第45期20卷 17120-17126页

作者： sook hee Chung Soo Jung Park Hye Sun Lee Sung Pil hong Jae hee Cheon Tae Ⅱ Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Internal Medicine and institute of Gastroenterology Ajou University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

关键词： Inflammatory bowel disease Family history Crohn’ s disease Ulcerative colitis Clinical characteristics

Glucose-responsive artificial promoter-mediated insulin gene transfer improves glucose control in diabetic mice

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World Journal of Gastroenterology 2012年第44期18卷 6420-6426页

作者： Jaeseok Han Eung-Hwi Kim Woohyuk Choi hee-sook Jun Department of Microbiology and Infectious Diseases University of Calgary3330 Hospital Drive N.W.CalgaryAlberta T2N 4N1Canada Del E.Webb Neuroscience Aging and Stem Cell Research CenterSanford Burnham Medical Research InstituteLa JollaCA 92037United States Lee Gil Ya Cancer and Diabetes Institute Gachon University7-45 SondodongYeonsu-kuIncheon 406-840South Korea College of Pharmacy Gachon University7-45 Sondo-dongYeonsu-kuIncheon 406-840South Korea

AIM:To investigate the effect of insulin gene therapy using a glucose-responsive synthetic promoter in type 2 diabetic obese ***:We employed a recently developed novel insulin gene therapy strategy using a synthetic promoter that regulates insulin gene expression in the liver in response to blood glucose level *** intravenously administered a recombinant adenovirus expressing furin-cleavable rat insulin under the control of the synthetic promoter(rAd-SP-rINSfur) into diabetic Lepr db/db mice.A recombinant adenovirus expressing β-galactosidase under the cytomegalovirus promoter was used as a control(rAd-CMV-βgal).Blood glucose levels and body weights were monitored for 50 *** and insulin tolerance tests were *** staining was performed to investigate islet morphology and insulin ***:Administration of rAd-SP-rINSfur lowered blood glucose levels and normoglycemia was maintained for 50 d,whereas the rAd-CMV-βgal control virus-injected mice remained *** tolerance tests showed that rAd-SP-rINSfur-treated mice cleared exogenous glucose from the blood more efficiently than control virus-injected mice at 4 wk [area under the curve(AUC):21 508.80 ± 2248.18 vs 62 640.00 ± 5014.28,P < 0.01] and at 6 wk(AUC:29 956.60 ± 1757.33 vs 60 016.60 ± 3794.47,P < 0.01).In addition,insulin sensitivity was also significantly improved in mice treated with rAd-SP-rINSfur compared with rAd-CMV-βgal-treated mice(AUC:9150.17 ± 1007.78 vs 11 994.20 ± 474.40,P < 0.05).The islets from rAd-SP-rINSfur-injected mice appeared to be smaller and to contain a higher concentration of insulin than those from rAd-CMV-βgal-injected ***:Based on these results,we suggest that insulin gene therapy might be one therapeutic option for remission of type 2 diabetes.

关键词： Insulin gene therapy Synthetic promoter Glucose-responsive element Liver-specific promoter Type 2 diabetes

Friction and wear of textured surfaces produced by 3D printing

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Science China(Technological Sciences) 2017年第9期60卷 1400-1406页

作者： hong Yi ZHANG Peng LEE Kwang-hee LEE Chul-hee Department of Mechanical Engineering Inha University Incheon 402-751 Korea

Surface texture patterns have great potential for improving tribological performance in terms of reducing friction and wear. The most common methods for surface texatring are laser and injection molding. The 3D printing method is also used to build parts, patterns, and molds that feature fine details for a wide range of applications because texture manufacturing by 3D printing is faster, more flexible, and less expensive than traditional techniques. To date, there has been no research on textured surfaces produced by 3D printing. Therefore, a new fabrication method using 3D printing to improve friction and wear properties is a topic worth exploring. In this study, a reciprocating friction tester was used to evaluate the friction and wear properties of different surface textures produced by 3D printing. The surface of specimens was examined by electron microscope and scanning electron microscope before and after the test. The results show that surface texturing can be applied to 3D printed parts to improve their friction and wear performance.

关键词： three-dimensional (3D) printing texture friction wear