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World Journal of Gastroenterology 2014年第45期20卷 17120-17126页

作者： sook hee chung Soo Jung Park Hye Sun Lee Sung Pil Hong Jae hee Cheon Tae Ⅱ Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Internal Medicine and institute of Gastroenterology Ajou University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

关键词： Inflammatory bowel disease Family history Crohn’ s disease Ulcerative colitis Clinical characteristics

Diaphragm disease compared with cryptogenic multifocal ulcerous stenosing enteritis

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World Journal of Gastroenterology 2011年第23期17卷 2873-2876页

作者： sook hee chung Yunju Jo Sang Ryol Ryu Sang Bong Ahn Byoung Kwan Son Seong Hwan Kim Young sook Park Young Ok Hong Department of Internal Medicine Eulji University School of MedicineSeoul 139-711South Korea Department of Pathology Eulji University School of MedicineSeoul 139-711Korea

As the use of drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) increases,so too do gastrointestinal ulcers,bleeding,perforation and *** disease of the small intestine is formed by submucosal fibrosis and destruction of lamina muscularis due to chronic ulceration,which corresponds to the most severe stage of NSAID *** may lead to stricture of the small *** such ulcerations and strictures in the small intestine are multiple,differential diagnosis is between diaphragm disease and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE),because the gross findings of diaphragm disease are similar to those of *** report a rare case of diaphragm disease caused by *** has been finally confirmed by capsule endoscopy and the origin of chronic obscure gastrointestinal bleeding was found to be multiple ulcers and strictures in the small *** operation,we diagnosed the patient with diaphragm disease rather than CMUSE.

关键词： Non-steroidal anti-inflammatory agents Enteritis Gastrointestinal hemorrhage Small intestine Capsule endoscopy

Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

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World Journal of Gastroenterology 2009年第44期15卷 5620-5623页

作者： sook hee chung Young sook Park Yun Ju Jo Seong Hwan Kim Dae Won Jun Byoung Kwan Son Jun Young Jung Dae Hyun Baek Dong hee Kim Yoon Young Jung Won Mi Lee Department of Internal Medicine Eulji General Hospital Eulji University School of MedicineSeoul 139-711South Korea Department of General Surgery Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Radiology Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Pathology Eulji General Hospital Eulji University School of MedicineSeoul 139-711 South Korea

Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography （CT） scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple sepia in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

关键词： Lymphangioma Retroperitoneum Spleen

Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2014年第26期20卷 8631-8637页

作者： Ji Young Yoon Choong Nam Shim sook hee chung Wan Park Hyunsoo chung Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jun Chul Park Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

AIM: To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection (ESD) outcome.

关键词： Endoscopic submucosal dissection Gastric neoplasm Location Complication Outcomes

Comparison of double pants with single pants on satisfaction with colonoscopy

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World Journal of Gastroenterology 2013年第26期19卷 4177-4184页

作者： sook hee chung Soo Jung Park Jong Suk Hong Jee Young Hwang Sin Ae Lee Kyung Ran Kim Hye Sun Lee Sung Pil Hong Jae hee Cheon Tae Il Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Psychiatry Yonsei University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To increase satisfaction and diminish anxiety and shame during colonoscopy, we developed novel double pants (NDP) which consist of doubled fabrics with an inner hole. The aim of study was to compare satisfaction, anxiety and shame between NDP and conventional single pants (CSP). METHODS: Total 160 consecutive examinees were randomly divided into NDP and CSP group. Before colonoscopy, questionnaires identifying state and trait anxiety were completed. After colonoscopy, questionnaires for overall satisfaction (Group Health Association of America 9) and pants-specific satisfaction (5-20), state anxiety (20-80), and shame (6-24) were interviewed. RESULTS: Pants-specific satisfaction scores regarding willingness to repeat colonoscopy using same pants (3.3 ± 0.8 vs 2.1 ± 0.9, P < 0.001) and recommendation of same pants to other people (3.3 ± 0.7 vs 2.0 ± 1.0, P < 0.001) were significantly higher in NDP than CSP groups. State anxiety (33.0 ± 7.0 vs 35.4 ± 6.9, P = 0.028) and shame (6.6 ± 1.5 vs 8.1 ± 3.2, P = 0.001) after colonoscopy was lower in NDP group compared with CSP group. CONCLUSION: The NDP contribute to increase satisfaction and decrease anxiety and shame after colonoscopy.

关键词： Pants Colonoscopy Satisfaction Shame Anxiety

Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

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World Journal of Gastroenterology 2016年第33期22卷 7559-7568页

作者： Tae Kyun Kim Young sook Park Haing-Woon Baik Jin Hyun Jun Eun Kyung Kim Jae Woong Sull Ho Joong Sung Jin Woo Choi sook hee chung Myung Chan Gye Ju Yeon Lim Jun Bong Kim Seong Hwan Kim Department of Gastroenterology Eulji University School of MedicineEulji Hospital Department of Biochemistry and Molecular Biology Eulji University School of Medicine Departemnt of Biomedical Laboratory Science Graduate School of Health ScienceEulji University Departemnt of Senior Healthcare BK21 plus ProgramGraduate SchoolEulji University Department of Pathology Eulji University School of Medicine Department of Gastroenterology Ajou University School of Medicine Department of Life Science and Institute of Natural Sciences Hanyang University

AIM To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep *** The following five groups of C57BL/6 mice were used in this study:(1) group Ⅰ,control;(2) group Ⅱ,2% DSS induced colitis for 7 d;(3) group Ⅲ,2% DSS induced colitis and melatonin treatment;(4) group Ⅳ,2% DSS induced colitis with sleep deprivation(SD) using specially designed and modified multiple platform water baths; and(5) group V,2% DSS induced colitis with SD and melatonin treatment. Melatonin(10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures,levels of serum cytokines were measured by ELISA. RESULTS Sleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury,but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis,with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly(P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection. CONCLUSION This study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated antiinflammatory effects on colitis with sleep deprivation.

关键词： Colitis Melatonin Adiponectin Sleep deprivation

Preparation of Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_2 powders for cathode material in secondary battery by solid-state method

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Rare Metals 2006年第Z2期25卷 184-188页

作者： PARK sook hee KANG Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

Laser capture microdissection: from its principle to applications in research on neurodegeneration

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Neural Regeneration Research 2015年第6期10卷 897-898页

作者： sook Hyun chung Weiyong Shen Macula Research Group Save Sight Institutethe University of Sydney

History and the principle of laser capture microdissection （LCM）： LCM, also known as laser microdissection and pressure catapulting, is one of the most powerful and useful techniques in various research areas where isolation of heterogeneous cell population is required. The first use of laser as a cell operation method, was originated in early 1920s （Gilbrich-Wille, 2013）, and it became widely used as a microsurgical tool ill early 1960s. In the need of extremely small tissue isolation, laser beam of LCM has been modified and developed over several decades from Ultraviolet （UV） laser beam to high-energy nitrogen, infrared and carbon dioxide lasers （Gilbrich-Wille,

关键词： cell LCM from its principle to applications in research on neurodegeneration

Expression and regulation of IL-22 in the *** CD4+T lymphocytes

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Cell Research 2006年第11期16卷 902-907页

作者： Yeonseok chung Seon hee Chang Department of lmmunology MD Anderson Cancer CenterHoustonTX 77030USA

IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against *** CD4+helper T lymphocytes(TH)were found as a source of IL-22,the regulation of this cytokine has beenpoorly ***,we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of THcells that also makes ***-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA ***,IL-22 does not regulate TH differentiation; exogenousIL-22 or an IL-22 antagonist had no effect on TH *** data demonstrate a novel cytokine expressed byIL-17-producing T cells,and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflam-mation and autoimmune diseases.

关键词： cytokines helper T cells T cell activation gene regulation