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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Applying Job Shop Scheduling to SMEs Manufacturing Platform to Revitalize B2B Relationship

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Computers, Materials & Continua 2023年第3期74卷 4901-4916页

作者： Yeonjee choi Hyun Suk Hwang chang soo Kim Department of Information Systems Pukyong National UniversityBusan608737Korea Research Center Hanyoung DSInc.Seoul07600Korea

A small and medium enterprises(SMEs)manufacturing platform aims to perform as a significant revenue to SMEs and vendors by providing scheduling and monitoring *** optimal job shop scheduling is generated by utilizing the scheduling system of the platform,and a minimum production time,i.e.,makespan decides whether the scheduling is optimal or *** scheduling result allows manufacturers to achieve high productivity,energy savings,and customer *** in Industry 4.0 requires dynamic,uncertain,complex production environments,and customer-centered *** paper proposes a novel method for solving the difficulties of the SMEs manufacturing by applying and implementing the job shop scheduling system on a SMEs manufacturing *** primary purpose of the SMEs manufacturing platform is to improve the B2B relationship between manufacturing companies and *** platform also serves qualified and satisfactory production opportunities for buyers and producers by meeting two key factors:early delivery date and fulfillment of processing as many orders as *** genetic algorithm(GA)-based scheduling method results indicated that the proposed platform enables SME manufacturers to obtain optimized schedules by solving the job shop scheduling problem(JSSP)by comparing with the real-world data from a textile weaving factory in South *** proposed platform will provide producers with an optimal production schedule,introduce new producers to buyers,and eventually foster relationships and mutual economic interests.

关键词： Manufacturing platform job shop scheduling problem(JSSP) genetic algorithm optimization textile process

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Portable nano probe for micro/nano mechanical scratching and measuring

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 205-209页

作者： Woo-Park JEONG chang-choi soo Cho HYUN Woo-Lee DEUG Department of Mechanical Design Engineering Chosun University Department of Nano Fusion Technology Pusan National University Department of Nano-mechatronics Engineering Pusan National University

A nano probe system which can measure precise contact force in mN scale was demonstrated. The nano probe micro parts or optical parts in nanometer range resolution and scratch was originally designed for on-machine measuring applications and one kind of contact type measuring probes was designed for miniaturized or microfactory system. It ideally should be of small size and able to measure surface topography in nanometer scale. A commercial capacitive displacement sensor was proposed. It was a new concept in nano probe systems which can measure the displacement of shaft driven by the variation of surface topography. The nano probe mainly consisted of three parts： a capacitive displacement sensor, a porous type air slide and a contact probe part with various tip radiuses. The porous type air slide assured the shaft slided smoothly with controllable normal force in mN scale and had high positioning accuracy. The probe part which was directly in contact with target surface, can be applied to micro/nanoscale scratching as well as the measurement of sample topography by a simple tip change.

关键词： nano probe displacement sensor air slide PCD tip

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Development of gelatin-sodium caseinate high-oxygen-barrier film containing elderberry(Sambucus nigra L.)extract and its antioxidant capacity on pork

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Food Bioscience 2023年第3期53卷 1192-1199页

作者： Jieun choi Jung-soo Lee Jaejoon Han Yoonjee chang Department of Food and Nutrition College of Science and TechnologyKookmin UniversitySeoul02707Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea

The use of biodegradable polymers and natural additives is a sustainable strategy to prevent oxidation and extend food shelf *** this study,a gelatin-sodium caseinate composite film containing elderberry extract was newly developed and *** film with the most optimal oxygen permeability and water vapor permeability was selected by blending gelatin(G)and sodium caseinate(S)at a 50:50 ratio(w/w).The addition of 0.5%(w/w)elderberry extract(EE)improved the oxygen barrier properties and gave the edible film a high potential for food quality *** was improved(105.82%±9.36%)and DPPH radical scav-enging analysis revealed a significantly strong antioxidant activity(P<0.05).FT-IR spectra and SEM indicated that it is the result of polyphenols and other EE components interacting with the protein *** developed film was applied as a coating and significantly prevented weight loss of pork after 12 h at room temperature(Control,0.18%±0.01%;G50:SC50,0.11%±0.01%;G50:SC50+EE0.5,0.11%±0.02%;P<0.05).The EE-containing G50:SC50-coated pork showed the lowest lipid oxidation as measured by TBARS after 36 h(0.36±0.06 mg MDA/kg sample).This finding suggested that it was related to polymorphic mechanisms,including radical scavenging and oxygen contact ***,protein-based films containing natural extract have the potential for an antioxidant packaging strategy.

关键词： Gelatin Sodium caseinate Antioxidant Elderberry extract Oxygen permeability

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Noise reduction effect of airfoil and small-scale rotor using serration trailing edge in a wind tunnel test

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Science China(Technological Sciences) 2017年第2期60卷 325-332页

作者： RYI Jaeha choi Jong-soo Department of Aerospace Engineering Chungnam National University Daejeon 305-764 Korea

This paper discussed a noise reduction effect of airfoil and small-scale model rotor by using attached serration trailing edge in the wind tunnel test condition. In order to analyze the changes in the performance due to the inclusion of a serrated trailing edge designed to reduce noise, a 10 k W wind turbine rotor was equipped with a thin serrated trailing edge. The restrictive condition for the serrated trailing edge equipped with the using of a 2D airfoil was examined through the using of a wind tunnel experiment after studying existing restrictive condition and analyzing prior research on serrated trailing edges. The aerodynamic performance and noise reduction effect of a small-scale model were investigated with the using of a serrated trailing edge. Moreover, the noise levels from the experiment were considered that the noise prediction method could be used for a full-scale rotor. It is confirmed that noise reduction effect is compared with wind tunnel test data at the 2D airfoil and model rotor condition.

关键词： wind turbine rotor wind tunnel experiment wind energy trailing edge serration noise reduction effect

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Structural considerations in friction welding of hybrid Al_2O_3-reinforced aluminum composites

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 42-46页

作者： In-Duck PARK Choon-Tae LEE Hyun-soo KIM Woo-Jin choi Myung-chang KANG Busan Metropolitan City Hall Fundamental Industries Division 2001 Jungang-ro Yeonje-gu Busan 611-735 Korea Department of Automotive & Mechanical Engineering Silla University Research & Development Center Sam-Ho precision 1256-1 Daejeo2-dong Gangseo-gu Busan 618-807 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

Comparative studies on the relationship between the welding parameters and joining efficiency in the friction welding of hybrid Al203-reinforced aluminum composites were conducted. Metal matrix composites （MMCs） with 37% （volume fraction） aluminum particle were joined by friction welding. The results show that the effects of the rotation speed on the reduction rate of particle size are greater than those of the upset pressure, and the area of the MMC weld zone decreases as the joining efficiency increases, while it is considered that the joining efficiency does not increase as the reduction rate of particle size decreases. During the macro-examination of the bonding interlace, a gray discolored region was observed on the bonding interface, and the center of the region was dark gray. After the micro-examination of the bonding interface, base metal made some second particulate formed by condensed alumina particulate but discoloration part distributed minute alumina particulate without second particulate. Consequently, it was also observed that rotational speed of 3 000 r/min and upset pressure of 63.6 MPa showed a very ***.

关键词： friction welding hybrid aluminum composite bonding interface joining efficiency metal matrix composite

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Comparison of the Bright Band Characteristics Measured by Micro Rain Radar (MRR) at a Mountain and a Coastal Site in South Korea

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Advances in Atmospheric Sciences 2009年第2期26卷 211-221页

作者： Joo-Wan CHA Ki-Ho chang Seong soo YUM Young-Jean choi Department of Atmospheric Sciences Yonsei University Global Environment System Research Laboratory NIMR/KMA

Data from a long term measurement of Micro Rain Radar （MRR） at a mountain site （Daegwallyeong, DG, one year period of 2005） and a coastal site （Haenam, HN, three years 2004-2006） in South Korea were analyzed to compare the MRR measured bright band characteristics of stratiform precipitation at the two sites. On average, the bright band was somewhat thicker and the sharpness （average gradient of reflectivity above and below the reflectivity peak） was slightly weaker at DG, compared to those values at HN. The peak reflectivity itself was twice as strong and the relative location of the peak reflectivity within the bright band was higher at HN than at DG. Importantly, the variability of these values was much larger at HN than at DG. The key parameter to cause these differences is suggested to be the difference of the snow particle densities at the two sites, which is related to the degree of riming. Therefore, it is speculated that the cloud microphysical processes at HN may have varied significantly from un-rimed snow growth, producing low density snow particles, to the riming of higher density particles, while snow particle growth at DG was more consistently affected by the riming process, and therefore high density snow particles. Forced uplifting of cloudy air over the mountain area around DG might have resulted in an orographic supercooling effect that led to the enhanced riming of supercooled cloud drops.

关键词： Micro Rain Radar bright band thickness and sharpness cloud microphysical processes local characteristics

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changes and development plans in the mountain villages of South Korea:Comparison of the first and second national surveys

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Journal of Mountain Science 2017年第8期14卷 1473-1489页

作者： Hag Mo KANG Hyun KIM chang Heon LEE Chong Kyu LEE soo Im choi Department of Forest Environmental Science Chonbuk National University Jeollabuk-do Forest Environment Research Institute Department of Forest Resources Gyeongnam National University of Science and Technology Department of Forest Resources Sunchon National University

Owing to the geographic disadvantages of mountain villages, the social, cultural, and economic conditions of mountain villagers are inferior to those of urban dwellers in South Korea. Thus, in 1995, the The government of South Korea launched a mountain village development support program to promote agriculture and forestry, balance national land development, and preserve cultural heritage. The program was effectively implemented, improving the income, population size, and living conditions of villagers in addition to setting up a system for stable project implementation. However, concerns were raised about long-term development planning, the creation and marketing of specialty brands, facility management/operation, and follow-up support. The government conducted surveys of mountain villagers in 2003 and 2014, obtaining basic data to address these issues. This study evaluates the outcomes of these two surveys, suggesting areas requiring focusedaction, concentrating on village development projects, forest resource distribution and use, demographic trends, the economy, exchange with urban areas, green tourism, and master planning. We find that despite growth in the forest labor force, forest ownership is diminishing in terms of the number and scale of holdings. Consequently, it is necessary to commercialize forest resources, establish favorable settlement conditions, and expand government support for village-run projects. In addition, systematic forest management for older tree age classes would benefit the public and provide assets for future mountain village development. Our results are expected to provide baseline information for the establishment and efficient implementation of mountain village development policy.

关键词： Forest resources management Mountain village changes Mountain village economy Support for mountain villages Urban-rural exchange

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Recoverable SnO_2-Based Sensors Promoted with MoO_3 and Sb_2O_3 for the Detection of DMMP

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稀有金属材料与工程 2006年第A3期35卷 155-156页

作者： Woo Suk Lee Ho Yun choi soo Chool Lee soo Jae Lee Duk Dong Lee Jeung soo Huh Jae chang Kim Department of Chemical Engineering Kyungpook National UniversityDaegu 702-701Korea School of Electrical Engineering and Computer Science Kyungpook National UniversityDaegu 702-701Korea Department of Materials Science and Metallurgy Kyungpook National UniversityDaegu 702-701Korea

The sensitivity and the recovery behavior of SnO_2-based gas sensor prepared from a commercial SnO_2 powder were tested under the low concentration of DMMP(0.5μg/g) in the flow system at 350℃.In order to improve the sensitivity of the sensor,promoters such as NiO,Nb_2O_5,MoO_3,and Sb_2O_3 were added into SnO_2 *** sensitivities were increased up to 80% from 50% but they were not *** the SnO2-based gas sensor promoted with MoO_3 and Sb_2O_3 was recovered after detection of DMMP,although the recovery rate was *** particular,the SnO_2-based sensor promoted with 5wt% of MoO_3 and 1wt% of Sb_2O_3 simultaneously showed an complete recovery ability,though its sensitivity was 40% which was lower than that of SnO_2 gas sensor without *** ability was discussed in terms of catalytic roles of promoters.

关键词： SnO2 MoO3 Sb2O3 sensor,recovery DMMP

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