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Characteristics of machined surface controlled by cutting tools and conditions in machining of brittle material

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中国有色金属学会会刊：英文版 2009年第B9期19卷 194-201页

作者： Yong-Woo KIM soo-chang choi Jeung-Woo PARK Deug-Woo LEE Department of Nano Fusion Technology Pusan National University Department of Mechanical Design Engineering Chosun University Department of Nanosystem and Nanoprocess Engineering Pusan National University

One of the ultra-precision machining methods was adapted for brittle material as well as soft material by using multi-arrayed diamond tips and high speed spindle. Conventional machining method is too hard to control surface roughness and surface texture against brittle material because the particles of grinding tools are irregular size and material can be fragile. Therefore, we were able to design tool paths and machine controlled pattern on surface by multi-arrayed diamond tips with uniform size made in MEMS fabrication and high speed spindle, and the maximum speed was about 3×105 r/min. We defined several parameters that can affect the machining surface. Those were multi-array of diamond tips (n×n), speed of air spindle and feeding rate. The surface roughness and surface texture can be controlled by those parameters for micro machining.

关键词：加工表面脆性材料条件控制刀具路径表面粗糙度特征高速主轴加工方法

Clinical usefulness of transpapillary removal of common bile duct stones by frequency doubled double pulse Nd:YAG laser

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World Journal of Gastroenterology 2008年第18期14卷 2863-2866页

作者： Tae Hyeon Kim Hyo Jeong Oh chang-soo choi Dong Han Yeom Suck Chei choi Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Iksan 570180 Korea

AIM: To study the efficacy and the safety of laser lithotripsy without direct visual control by using a balloon catheter in patients with bile duct stones that could not be extracted by standard technique. METHODS: The seventeen patients (7 male and 10 female; mean age 67.8 years) with difficult common bile duct (CBD) stones were not amenable for conventional endoscopic maneuvers such as sphincterotomy and mechanical lithotripsy were included in this study. Laser wavelengths of 532 nm and 1064 nm as a double pulse were applied with pulse energy of 120 mJ. The laser fiber was advanced under fluoroscopic control through the ERCP balloon catheter. Laser lithotripsy was continued until the fragment size seemed to be less than 10 mm. Endoscopic extraction of the stones and fragments was performed with the use of the Dormia basket and balloon catheter. RESULTS: Bile duct clearance was achieved in 15 of 17 patients (88%). The mean number of treatment sessions was 1.7 ± 0.6. Endoscopic stone removal could not be achieved in 2 patients (7%). Adverse effects were noted in three patients (hemobilia, pancreatitis, and cholangitis). CONCLUSION: The Frequency Doubled Double Pulse Nd:YAG (FREDDY) laser may be an effective and safe technique in treatment of difficult bile duct stones.

关键词： Bile duct stones Frequency doubled double pulse Nd:YAG laser Transpapillary removal Mechanical lithotripsy Balloon catheter

Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study

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World Journal of Gastroenterology 2005年第27期11卷 4210-4214页

作者： Yong Sung Kim Tae Hyeon Kim chang soo choi Young Woo Shon Sang Wook Kim Geom Seog Seo Yong Ho Nah Myung Gyu choi Suck Chei choi Department of Internal Medicine

AIM： Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease （GERD） makes it interesting to examine the effect of itopride on esophageal acid ***： The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time （pH〈4） of more than 5% and mild esophagitis （SavaryMiller grades I, II） proven by endoscopy. Ambulatory 24hpH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day （t.i.d.） for 30 d in random order, using an open label *** evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after ***： Total symptom score was significantly decreased after treatment in 150- or 300-mg group. Itopride 300 mg was significantly effective than 150 mg on decreasing the total per cent time with pH〈4, total time with pH〈4 and DeMeester score. No serious adverse effects were observed with administration of itopride in both ***： Itopride 100 mg t.i.d, is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease.

关键词： Gastro-esophageal reflux disease Itopride

Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第30期14卷 4834-4837页

作者： chang soo choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh Suck Chei choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Department of Radiology Wonkwang University School of Medicine

A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred after the third ar... 详细信息

关键词： Transcatheter arterial chemoembolization Cerebral embolism Complication Hepatocellular carcinoma Lipiodol

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Recurrence of gastric cancer in the jejunal stump after radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 74-76页

作者： Jong Han Yoo Sang Hyuk Seo Min Sung An Tae Kwun Ha Kwang Hee Kim Ki Beom Bae chang soo choi Sang Hun Oh Young Kil choi Department of Surgery Busan Paik HospitalInje University College of Medicine

This is a very rare case of the recurrence of gastric cancer in the jejunal stump after radical total gastrectomy with Roux-en-Y *** January 2008,a 65-year-old man underwent radical total gastrectomy with Roux-en-Y reconstruction for stageⅠB gastric cancer of the upper *** a follow-up in December2011,the patient had a recurrence of gastric cancer on gastroduodenal *** gastroduodenal fibroscopic biopsy specimens show a well-differentiated tubular *** tomography showed no lymphadenopathy or hepatic *** laparotomy,there was a tumor in the jejunal stump involving the pancreatic tail and ***,the patient underwent jejunal pouch resection,distal pancreatectomy and *** patient was diagnosed with gastric cancer on histopathological examination.

关键词： Gastric cancer Recurrence Jejunal stump

Neuroendocrine carcinoma of the stomach:A case report

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 77-79页

作者： Sang hyun Kang Kwang hee Kim Sang hyuk Seo Min Sung An Tae Kwun ha ha Kyung Park Ki Beom Bae chang soo choi Sang hun Oh Young Kil choi Department of Surgery Busan Paik HospitalInje University College of Medicine

Neuroendocrine carcinoma(NEC)is a rare tumor,comprising<1%of stomach cancers.A 55-year-old woman was referred to our hospital with biopsy-proven gastric cancer.A shallow ulcerative lesion was detected in the lesser curvature of the lower *** was suspected to be early gastric cancerⅡA+ⅡC ***,endoscopic submucosal dissection was *** was subsequently diagnosed with NEC,which is aggressive and carries a poor *** conducted a radical resection and a laparoscopic-assisted distal *** tumor had infiltrated the subserosal layer and6/42 lymph nodes were *** mitotic index was16/10 high power fields and the Ki-67 labeling index was 26%-50%.The final diagnosis of NEC was made according to the World health Organization 2010 *** was suspected of having jumping metastasis to the proximal *** patient was treated with an oral anticancer drug(5-flurouracil based drug)for2 *** patient has been followed up for 3 years without recurrence.

关键词： Neuroendocrine carcinoma Mitosis Ki-67 Gastrectomy Prognosis

Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

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Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin