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Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

Asian Journal of Andrology 2011年第5期13卷 719-723页

作者： Sung Kyu Hong Jung soo Nam woong Na Jong Jin Oh Cheol Yong Yoon Chang Wook Jeong Hyun June kim Seok-soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy （RP） for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadjuvant or adjuvant therapy at our institution and were followed up for 〉2 years postoperatively. For our analyses, the patients were divided into two groups according to age： younger （〈60 years） and older （≥ 60 years）. Through uni- and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D＇Amico risk classification. Among all subjects, younger （n= 126） and older （n=617） patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival （P=0.288）. For the high-risk group （n= 206）, younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients （P=0.017）, despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group （P=O.O03）. Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

关键词： age factors biochemical outcome prostate prostatic neoplasms prostatectomy

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Accurate Multi-Site Daily-Ahead Multi-Step PM_(2.5)Concentrations Forecasting Using Space-Shared CNN-LSTM

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Computers, Materials & Continua 2022年第3期70卷 5143-5160页

作者： Xiaorui Shao Chang soo kim Department of Information Systems Pukyong National UniversityBusan608737Korea

Accurate multi-step PM_(2.5)(particulate matter with diameters≤2.5 um)concentration prediction is critical for humankinds’health and air populationmanagement because it could provide strong evidence for ***,it is very challenging due to its randomness and *** paper proposed a novel method based on convolutional neural network(CNN)and long-short-term memory(LSTM)with a space-shared mechanism,named space-shared CNN-LSTM(SCNN-LSTM)for multi-site dailyahead multi-step PM_(2.5)forecasting with self-historical *** proposed SCNN-LSTM contains multi-channel inputs,each channel corresponding to one-site historical PM_(2.5)concentration *** which,CNN and LSTM are used to extract each site’s rich hidden feature representations in a stack ***,CNN is to extract the hidden short-time gap PM_(2.5)concentration patterns;LSTM is to mine the hidden features with long-time *** channel extracted features aremerged as the comprehensive features for future multi-step PM_(2.5)concentration ***,the space-shared mechanism is implemented by multi-loss functions to achieve space information ***,the final features are the fusion of short-time gap,long-time dependency,and space information,which enables forecasting more *** validate the proposed method’s effectiveness,the authors designed,trained,and compared it with various leading methods in terms of RMSE,MAE,MAPE,and R^(2)on four real-word PM_(2.5)data sets in Seoul,South *** massive experiments proved that the proposed method could accurately forecast multi-site multi-step PM_(2.5)concentration only using self-historical PM_(2.5)concentration time series and running ***,the proposed method obtained averaged RMSE of 8.05,MAE of 5.04,MAPE of 23.96%,and R^(2)of 0.7 for four-site daily ahead 10-hourPM_(2.5)concentration forecasting.

关键词： PM_(2.5)forecasting CNN-LSTM air quality management multi-site multi-step forecasting

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Game Outlier Behavior Detection System Based on Dynamic Time Warp Algorithm

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 219-237页

作者： Shinjin Kang soo Kyun kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

This paper proposes a methodology for using multi-modal data in gameplay to detect outlier *** proposedmethodology collects,synchronizes,and quantifies time-series data fromwebcams,mouses,and *** expressions are varied on a one-dimensional pleasure axis,and changes in expression in the mouth and eye areas are detected ***,the keyboard and mouse input frequencies are tracked to determine the interaction intensity of ***,we apply a dynamic time warp algorithm to detect outlier *** detected outlier behavior graph patterns were the play patterns that the game designer did not intend or play patterns that differed greatly from those of other *** outlier patterns can provide game designers with feedback on the actual play experiences of users of the *** results can be applied to the game industry as game user experience analysis,enabling a quantitative evaluation of the excitement of a game.

关键词： Facial expression recognition webcam behavior analysis affective computing

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Outlier Behavior Detection for Indoor Environment Based on t-SNE Clustering

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Computers, Materials & Continua 2021年第9期68卷 3725-3736页

作者： Shinjin Kang soo Kyun kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this study,we propose a low-cost system that can detect the space outlier utilization of residents in an indoor *** focus on the users’app usage to analyze unusual behavior,especially in indoor *** is reflected in the behavioral analysis in that the frequency of using smartphones in personal spaces has recently *** system facilitates autonomous data collection from mobile app logs and Google app servers and generates a high-dimensional dataset that can detect outlier *** density-based spatial clustering of applications with noise(DBSCAN)algorithm was applied for effective singular movement *** analyze high-level mobile phone usage,the t-distributed stochastic neighbor embedding(t-SNE)algorithm was *** two clustering algorithms can effectively detect outlier behaviors in terms of movement and app usage in indoor *** experimental results showed that our system enables effective spatial behavioral analysis at a low cost when applied to logs collected in actual living ***,large volumes of data required for outlier detection can be easily *** system can automatically detect the unusual behavior of a user in an indoor *** particular,this study aims to reflect the recent trend of the increasing use of smartphones in indoor spaces to the behavioral analysis.

关键词： Outlier detection trajectory clustering behavior analysis app data smartphone

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Design of Learning Media in Mixed Reality for Lao Education

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Computers, Materials & Continua 2020年第7期64卷 161-180页

作者： Kalaphath Kounlaxay soo Kyun kim Department of Game Engineering Pai Chai UniversityDaejeon35345Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

To improve and develop education systems,the communication between instructors and learners in a class during the learning process is of utmost *** the presentations of 3D models using mixed reality(MR)technology can be used to avoid misinterpretations of oral and 2D model *** an independent concept and MR applications,MR combines the excellent of each virtual reality(VR)and augmented reality(AR).This work aims to present the descriptions of MR systems,which include its devices,applications,and literature reviews and proposes computer vision tracking using the AR Toolkit Tracking *** focus of this work will be on creating 3D models and implementing in Unity 3D using the Vuforia SDK platform to develop VR and AR applications for architectural presentations.

关键词： Mixed reality virtual reality augmented reality Vuforia head-mounted displays.

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Green Nanocomposites Made With Polyvinyl Alcohol and Cellulose Nanofibers Isolated From Recycled Paper

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Journal of Renewable Materials 2019年第7期7卷 621-629页

作者： Le Van Hai Lindong Zhai Hyun Chan kim Jung woong kim Jaehwan kim Creative Research Center for Nanocellulose Future Composites Inha UniversityIncheonRepublic of Korea Department of Pulp and Paper Technology Phutho College of Industry and TradePhuthoVietnam

This paper reports green nanocomposites made by blending polyvinyl alcohol(PVA)with cellulose nanofiber(CNF)isolated from recycled deinked copy/printing paper(DIP).The reinforcement effect of DIPCNF in the nanocomposites is compared with other CNFs isolated from native cotton and hardwood by means of *** prepared PVA-CNF nanocomposites are characterized in terms of morphology,chemical interaction,structural,thermal and mechanical properties.X-ray diffraction and Fourier transform infrared spectroscopy confirm the reinforcing ability of cellulose nanofibers into *** blending CNFs into PVA matrix,the thermal stability of the nanocomposites is improved and DIPCNF shows similar enhancement effect with COCNF and *** prepared nanocomposites exhibit 50%Young’s modulus improvement by adding 6%of CNF and DIPCNF exhibits similar enhancement of the mechanical properties to COCNF and HWCNF in the *** indicates that the use of DIPCNF is beneficial for environment protection,resource retaining and save energy in comparison with COCNF and HWCNF.

关键词： Green nanocomposite cellulose TEMPO-oxidation recycled paper,polyvinyl alcohol

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Dynamic PIV Measurement of a Compressible Flow Issuing from an Airbag Inflator Nozzle

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Journal of Thermal Science 2006年第4期15卷 377-381页

作者： SangJoonLee YoungGilJang Seokkim Chang soo kim Department of Mechanical Engineering POSTECHSan 31Hyoja DongPohang790-784Korea Safety System R&D Department Hyundai MOBIS80-10Mabook-RiGuseong-EupYongin-ShiGyunggi-Do449-910Korea

Among many equipment for passenger safety, the air bag system is the most fundamental and effective device for an automobile. The inflator housing is a main part of the curtain-type air bag system, which supplies high-pressure gases in pumping up the air bag-curtain which is increasingly being adapted in deluxe cars for protecting passengers from the danger of side clash. However, flow information on the inflator housing is very limited. In this study, we measure the instantaneous velocity fields of a high-speed compressible flow issuing from the exit nozzle of an inflator housing using a dynamic PIV system. From the velocity field data measured at a high frame-rate, we evaluate the variation of the mass flow rate with time. The dynamic PIV system consists of a high-repetition Nd：YLF laser, a high-speed CMOS camera, and a delay generator. The flow images are taken at 4000 fps with synchronization of the trigger signal for inflator ignition. From the instantaneous velocity field data of flow ejecting from the airbag inflator housing at the initial stage, we can see a flow pattern of broken shock wave front and its downward propagation. The flow ejecting from the inflator housing is found to have very high velocity fluctuations, with the maximum velocity at about 700 m/s. The time duration of the high-speed flow is very short, and there is no perceptible flow after 100 ms.

关键词： Airbag inflator PIV automobile.

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Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-soo Han Ji-Hyun Kang Eun hye Park Hyo-Jung Lee So-Jeong Jeong Dong-Wook kim Chun-woong Park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying *** amount and the boiling point of the organic acid affected the degree of *** this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder ***175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid *** ACI and PIV results showed a significant increase in aerodynamic performance of corrugated *** FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 *** microparticles also showed better aerosolization,decreased x-axial velocity,and variable *** dissolution of drug formulationswas observed in *** administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered *** modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

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Numerical Study on Air Turbines with Enhanced Techniques for OWC Wave Energy Conversion

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China Ocean Engineering 2017年第5期31卷 517-527页

作者： CUI Ying HYUN Beom-soo kim Kilwon Department of Ocean Engineering College of EngineeringOcean University of China Division of Naval Architecture and Ocean Engineering Korea Maritime and Ocean University

In recent years,the oscillating water column(OWC) wave energy converter,which can capture wave energy from the ocean,has been widely applied all over the *** the essential part of the OWC system,the impulse and Wells turbines are capable of converting the low pressure pneumatic energy into the mechanical shaft *** an enhanced technique,the design of endplate or ring attached to the blade tip is investigated numerically in this paper.3 D numerical models based on a CFD-software FLUENT 12.0 are established and validated by the corresponding experimental results from the reports of Setoguchi et al.(2004) and Takao et al.(2001).Then the flow fields and non-dimensional evaluating coefficients are calculated and analyzed under steady *** show that the efficiency of impulse turbine with ring can reach up to 0.49 when Ф=1,which is 4% higher than that in the cases for the endplate-type and the original *** the ring-type Wells turbine with fixed guide vanes shows the best performance with the maximal efficiency of 0.55,which is 22% higher than that of the original *** addition,the quasi-steady analysis is used to calculate the mean efficiency and output-work of a wave cycle under sinusoidal flow *** all together,this study provides support for structural optimization of impulse turbine and Wells turbine in the future.

关键词： OWC impulse turbine Wells turbine CFD endplate ring quasi-steady analysis

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Connolly Surface on an Atomic Structure via Voronoi Diagram of Atoms

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Journal of Computer Science & Technology 2006年第2期21卷 255-260页

作者： Joonghyun Ryu Rhohun Park Deok-soo kim Voronoi Diagram Research Center Hanyang University Seoul Korea Department of Industrial Engineering Hanyang University Seoul Korea

One of the most important geometric structures of a protein is the Connolly surface of protein since a Connolly surface plays an important role in protein folding, docking, interactions between proteins, amongst other things. This paper presents an algorithm for precisely and efficiently computing the Connolly surface of a protein using a proposed geometric construct called β-shape based on the Voronoi diagram of atoms in the protein. Given the Voronoi diagram of atoms based on the Euclidean distance from the atom surfaces, the proposed algorithm first computes a β-shape with an appropriate probe. Then, the Connolly surface is computed by employing the blending operation on the atomic complex of the protein by the given probe.

关键词： protein Connolly/molecular surface β-shape Voronoi diagram of atoms blending surface

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