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Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer

World Journal of Gastroenterology 2012年第10期18卷 1104-1109页

作者： Lee Chun park Ho Sup Lee Seong Hoon Shin Seun Ja park Moo In park Sung Yong Oh Hyuk Chan Kwon jin ho Baek Young jin Choi Myoung Joo Kang Yang soo Kim Department of Internal Medicine Kosin University College of Medicine Busan 602-703 South Korea Department of Internal Medicine Dong-A University Hospital Busan 602-715 South Korea Jin ho Baek Department of Internal Medicine Ulsan University Hospital Ulsan 682-714 South Korea Department of Internal Medicine Busan National University Hospital Busan 626-770 South Korea Department of Internal Medicine Busan Paik Hospital Busan 614-735 South Korea

AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment.

关键词： Colorectal cancer Metastasis Bevacizumab Efficacy Second- or later-line

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Serum prostate-specific antigen as a predictor of prostate volume and lower urinary tract symptoms in acommunity-based cohort： a large-scale Korean screening study

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Asian Journal of Andrology 2013年第2期15卷 249-253,I0008页

作者： Dong soo park Jong jin Oh Jae Yup Hong Young Kwon Hong Don Kyung Choi In Hyuck Gong jin HoHwang Sung Won Kwon Department of Urology CHA Bundang Medical Center CHA University Seongnam 463-712 Korea CHA Cancer Research Center Seou1135-081 Korea Department of Urology CHA Gangnam Medical Center CHA University Seou1135-081 Korea Korea Prostate Health Council Seou1137-070 Korea

The aim of this study is to assess the ability of serum prostate-specific antigen （PSA） to predict prostate volume （PV） and lower urinary tract symptoms （LUTS） represented by the international prostate symptom score （IPSS）. From January 2001 to December 2011, data were collected from men who first enrolled in the Korean Prostate Health Council Screening Program. Patients with a serum PSA level of 10 ng ml^-1 or age 〈40 years were excluded. Accordingly, a total of 34 857 men were included in our study, and serum PSA, PV and the IPSS were estimated in all patients. Linear and age-adjusted multivariate logistic analyses were used to assess the potential association between PSA and PV or IPSS. The predictive value of PSA for estimating PV and IPSS was assessed based on the receiver operating characteristics-derived area under the curve （AUC）. The mean PV was 29.9 ml, mean PSA level was 1.49 ng ml^-1 and mean IPSS was 15.4. A significant relationship was shown between PSA and PV, and the IPSS and PSA were also significantly correlated after adjusting by age. The AUCs of PSA for predicting PV ~20 ml, 〉25 ml and 〉35 ml were 0.722, 0.728 and 0.779, respectively. The AUCs of PSA for predicting IPSS 〉 7, 〉 13 and 〉 19 were 0. 548, 0.536 and 0. 537, respectively. Serum PSA was a strong predictor of PV in a community-based cohort in a large-scale screening study. Although PSA was also significantly correlated with IPSS, predictive values of PSA for IPSS above the cutoff levels were not excellent. Further investigations are required to elucidate the exact interactions between PSA and LUTS and between PSA and PV in prospective controlled studies. Such studies may suggest how PSA can be used to clinically predict PV and the IPSS.

关键词： lower urinary tract symptoms (LUTS) prostate prostate-specific antigen (PSA) prostate volume (PV)

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Effects of nanopores and sulfur doping on hierarchically bunched carbon fibers to protect lithium metal anode

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Carbon Energy 2021年第5期3卷 784-794页

作者： Ji In Jung Sunwoo park Son Ha Se Youn Cho Hyoung-Joon jin Young soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju-gunJeollabuk-doSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSouth Korea

Studies on three-dimensional structured carbon templates have focused on how to guide homogeneous lithium metal nucleation and growth for lithium metal anodes(LMAs).However,there is still insufficient evidence for a key factor to achieve their high electrochemical ***,the effects of nanopores and sulfur doping on carbon-based nanoporous host(CNH)electrode materials for LMAs were investigated using natural polymer-derived *** pore-filling behaviors of lithium metal in the nanopores of the CNH electrode materials were first observed by ex situ scanning electron microscopy analysis,where the protective lithium metal nucleation and growth process led to significantly high Coulombic efficiency(CE)of~99.4%and stable 600 *** addition,a comparison study of CNH and sulfurdoped CNH(S-CNH)electrodes,which differ only in the presence or absence of sulfur,revealed that sulfur doping can cause lower electrochemical series resistance,higher CE value,and better cycling stability in a wide range of current densities and number of ***,S-CNH-based LMAs showed high electrochemical performance in full-cell Li-S battery tests using a sulfur copolymer cathode,where a high energy density of 1370Wh kgelectrode−1 and an excellent power density of 4120Wkgelectrode−1 were obtained.

关键词： carbon template Li-S batteries lithium metal anode lithium metal batteries nanoporous carbon sulfur doping

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Compressive deformation behavior of an indirect-extruded Mg-8Sn-1Al-1Zn alloy

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International Journal of Minerals,Metallurgy and Materials 2013年第1期20卷 49-56页

作者： Wei-li Cheng Zhong-ping Que jin-shan Zhang Chun-xiang Xu Wei Liang Bong Sun You Sung soo park School of Materials Science and Engineering Taiyuan University of Technology Korea Institute of Materials Science Ulsan National Institute of Science and Technology

The medium and warm deformation behaviors of an indirect-extruded Mg-8Sn-IAI-IZn alloy were investigated by compression tests at temperatures between 298 and 523 K and strain rates of 0.001-10 s-1. It was found that the twinning-slip transition temperature was strain rate dependent, and all the true stress-true strain curves could be divided into two groups： concave and convex curves. Associated microstructural investigations indicated that the dynamic recrystallization （DRX） be- havior of the alloy varied with deformation conditions. At high strain rate and low temperature, dynamically recrystallized grains preferentially nucleated and developed in the twinned regions, indicating that twinning-induced DRX was dominant. While, at low strain rate, DRX developed extensively at grain boundaries and twins, and the process of twinning contributed to both oriented nucleation and selective growth. For the studied alloy, cracks mainly initiated from the shear band and twinning lamellar over the ranges of temperature and strain rate currently applied.

关键词： magnesium alloys compression testing dynamic recrystallization microstructure

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Predictors of pain resolution after varicocelectomy for painful varicocele

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Asian Journal of Andrology 2011年第5期13卷 754-758页

作者： Hyun Jun park Seung soo Lee Nam Cheol park Department of Urology Pusan National University School of MedicineMedical Research InstitutePusan National University.Busan 602-739Korea

Varioocelectomny is a management option for patients with painful varicocele. In this study, we assessed the effectiveness of varicocelectomy for painful varicocele and examined the factors that might be predictive of outcome. All patients who underwent a varicocelectomy for pain between February 2007 and July 2009 were includecL A review of patient medical records was conducted; patient age,body mass index （BMI）, uede, iocatien of the vericocele, tasticular volume, duration and quality of the pain （dull, draaing, throbbing or sharp） and surgical technique （ingulnal versus subinguinal） were documented. All parameters were compared with the rasolution of pain （complete, partial or failure）. We followed up on 53 of 104 patients （51.0%）. Complete postopanntive resolution of pain was reported by 28 patients （52.8%）, whereas 22 （41.5%） reported partial resolution, Only three patients （5.7%） mpaded failure. No relationship was observed between postoperative pain resolution and age, BMI, grade of varicoceio, location of varicocele, ipsilateral testicular, quality of pain or surgical technique. The duration of pain before surllery was the only factor that correlated with postopaative pain resolution （univariate, P=-0.004; multivariate, P=0.002）. Our rasults indicatethat varicocelectomy isan effective treatmentfar painful varicocele in properly selected patients, and that duration of pain before surgery may be predictive of outcome.

关键词： duration pain testis vadcocele vadcocelectemy

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Probability mass first flush evaluation for combined sewer discharges

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Journal of Environmental Sciences 2010年第6期22卷 915-922页

作者： Inhyeok park Hongmyeong Kim soo-Kwon Chae Sungryong Ha Department of Urban Engineering Chungbuk National University Ecowiz Corporation Cheongju School of Human & Environmental Sciences Eulji University

The Korea government has put in a lot of effort to construct sanitation facilities for controlling non-point source pollution. The first flush phenomenon is a prime example of such pollution. However, to date, several serious problems have arisen in the operation and treatment effectiveness of these facilities due to unsuitable design flow volumes and pollution loads. It is difficult to assess the optimal flow volume and pollution mass when considering both monetary and temporal limitations. The objective of this article was to characterize the discharge of storm runoff pollution from urban catchments in Korea and to estimate the probability of mass first flush （MFFn） using the storm water management model and probability density functions. As a result of the review of gauged storms for the representative using probability density function with rainfall volumes during the last two years, all the gauged storms were found to be valid representative precipitation. Both the observed MFFn and probability MFFn in BE-1 denoted similarly large magnitudes of first flush with roughly 40% of the total pollution mass contained in the first 20% of the runoff. In the case of BE-2, however, there were significant difference between the observed MFFn and probability MFFn.

关键词： first flush combined sewer overflows (CSOs) probability mass first flush storm water management model best management practices

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Sensitivity analysis for axis rotation diagrid structural systems according to brace angle changes

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Earthquake Engineering and Engineering Vibration 2017年第4期16卷 783-791页

作者： Jae-Kwang Yang Long-Yang Li Sung-soo park Department of Architectural Engineering Pusan National UniversityKorea Department of Architectural Engineering Pusan National UniversityDoctor of EngineeringKorea

General regular shaped diagrid structures can express diverse shapes because braces are installed along the exterior faces of the structures and the structures have no columns. However, since irregular shaped structures have diverse variables, studies to assess behaviors resulting from various variables are continuously required to supplement the imperfections related to such variables. In the present study, materials elastic modulus and yield strength were selected as variables for strength that would be applied to diagrid structural systems in the form of Twisters among the irregular shaped buildings classified by Vollers and that affect the structural design of these structural systems. The purpose of this study is to conduct sensitivity analysis for axial rotation diagrid structural systems according to changes in brace angles in order to identify the design variables that have relatively larger effects and the tendencies of the sensitivity of the structures according to changes in brace angles and axial rotation angles.

关键词： sensitivity analysis axial rotation-diagrid structure lateral behaviors

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Potentiostatic corrosion protection technology under cavitation condition for 5083-H116 Al alloy

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Transactions of Nonferrous Metals Society of China 2013年第11期23卷 3206-3214页

作者： Seung-Jun LEE Young-soo park Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Division of Maritime Transportation Science College of Maritime Sciences Korea Maritime and Ocean University

This study aims to characterize the cavitation damage behavior of aluminum alloys in seawater and thus to enhance its cavitation resistance. Potentiostatic experiments were performed under various potential conditions to determine the optimum protection potentials, at which cavitation damage was suppressed. A potential range was selected for the experiment from -2.2 to -1.4 V, which corresponded to the concentration and activation polarization regions on the cathodic polarization curve of the 5083-H116 alloy. After the experiments, the current density-time behavior was investigated, and the degree of surface damage was observed using three-dimensional microscopy and scanning electron microscopy （SEM）, The optimum protection potential was determined to be in the range of-l.9 to -1.5 V under which the cavitation damage was reduced significantly.

关键词： Al alloy cavitation potentiostatic experiment seawater

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Microstructure and corrosion resistance of a Mg2Sn-dispersed Mg alloy subjected to pulsed electron beam treatment

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Journal of Magnesium and Alloys 2020年第2期8卷 345-351页

作者： Daseul Lee Beomcheol Kim soo-Min Baek Jisoo Kim Hyung Wook park Jung Gu Lee Sung soo park School of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea School of Mechanical Aerospace and Nuclear EngineeringUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea School of Materials Science and Engineering University of UlsanUlsan 44610Republic of Korea

We report that the corrosion resistance of a Mg-Sn-based alloy with MgzSn precipitates can be considerably improved by surface modification using pulsed electron beam *** alloy subjected to a pulse electron beam treatment showed a modified surface layer with a thickness of〜12 μm,appearing more resistant to corrosion attack than the bare surface of the *** 0.6 M NaCl solution,the alloys with and without the surface modification exhibited average corrosion rates of 4.3 and 8.1 mm y^-1,*** improved corrosion resistance was attributed to reduced cathodic activation,resulting from the surficial reduction of relatively noble Mg2Sn precipitates.

关键词： Magnesium alloy Mg2Sn Intermetallic compound Pulsed electron beam treatment Corrosion

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Detection of Apple Marssonina Blotch with PLSR, PCA, and LDA Using Outdoor Hyperspectral Imaging

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光谱学与光谱分析 2020年第4期40卷 1309-1314页

作者： soo Hyun park Youngki Hong Mubarakat Shuaibu Sangcheol Kim Won Suk Lee Department of Agricultural and Biological Engineering University of FloridaGainesvilleFL 32611United States Department of Agricultural Engineering National Academy of Agricultural ScienceRDAJeonju 55365South Korea Smart Farm Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-do 25451South Korea

In this study, hyperspectral images were used to detect a fungal disease in apple leaves called Marssonina blotch(AMB). Estimation models were built to classify healthy, asymptomatic and symptomatic classes using partial least squares regression(PLSR), principal component analysis(PCA), and linear discriminant analysis(LDA) multivariate methods. In general, the LDA estimation model performed the best among the three models in detecting AMB asymptomatic pixels, while all the models were able to detect the symptomatic class. LDA correctly classified asymptomatic pixels and LDA model predicted them with an accuracy of 88.0%. An accuracy of 91.4% was achieved as the total classification accuracy. The results from this work indicate the potential of using the LDA estimation model to identify asymptomatic pixels on leaves infected by AMB.

关键词： Apple Marssonina blotch Hyperspectral imaging PLSR PCA LDA

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