检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： Han Saem Son Jiae Lee Hye In Lee Narae Kim You-jin Jo Gong-Rak Lee Seong-Eun Hong Minjeong kwon Nam Young Kim Hyun jin Kim jin Ha Park soo Young Lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(BA)has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** reporter assay and the inhibitor study of IL-1βtranscription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β*** also promoted osteoblast ***,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator protein-1

User Interface-Based Repeated Sequence Detection Method for Authentication

在线全文

学校读者我要写书评

暂无评论

Intelligent Automation & Soft Computing 2023年第3期35卷 2573-2588页

作者： Shin jin Kang soo Kyun Kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this paper,we propose an authentication method that use mouse and keystroke dynamics to enhance online privacy and *** proposed method identiﬁes personalized repeated user interface(UI)sequences by analyzing mouse and keyboard *** this end,an Apriori algorithm based on the keystroke-level model(KLM)of the human–computer interface domain was *** proposed system can detect repeated UI sequences based on KLM for authentication in the *** effectiveness of the proposed method is veriﬁed through access test-ing using commercial applications that require intensive UI *** results show using our cognitive mouse-and-keystroke dynamics system can com-plement authentication at the application level.

关键词： Authentication keystroke-level model(KLM) keystroke mouse dynamics

In vitro fungistatic activity of 36 traditional oriental medicines and their synergistic effect against Trichophyton rubrume

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 109-115页

作者： Young soo Kim jin Yeul Ma Korean Medicine Application Center Korea Institute of Oriental Medicine

Objective: To investigate the fungistatic activity and synergistic effects of natural products and their constituents, including traditional oriental medicines(TOMs).Methods: Fungistatic activities of TOMs prepared by hot-water(115 ℃) or ethanol(70%; 40 ℃) extraction were determined by their minimum inhibitory *** assess possible synergistic effects, minimum inhibitory concentrations of various combinations were ***: By evaluating antifungal susceptibility of Trichophyton rubrum, which is a major causative fungus for several types of dermatophytosis, we confirmed that ethanol extracts were more active than hot-water extracts in 25 of the 36 TOMs, suggesting that the constituents with high hydrophobicity tend to contribute significantly to fungistatic *** selected four TOMs with high fungistatic activity, including Aucklandiae radix, Gentianae macrophyllae radix, Scutellariae radix, and Galla rhois, and their synergistic effects were investigated through the combination studies between TOMs or TOM-conventional drug *** combinations between four TOMs, partial synergistic effects were observed in Aucklandiae radix–Galla rhois and Gentianae macrophyllae radix–Galla rhois combinations, as supported by the lowest fractional inhibitory concentration index value of 0.66 for both ***, Galla rhois showed the strongest synergistic effect on growth inhibition of Trichophyton rubrumwith a fractional inhibitory concentration index value of 0.50 in combination with ***: Our findings indicate that the combination of TOMs and TOM-terbinafine may be effective on treatment for chronic and recurrent dermatophytosis by improving fungistatic activity and led to decrease systemic toxicity in clinical practice.

关键词： Fungistatic activity Hot-water and ethanol extracts Traditional oriental medicine Tinea Trichophyton rubrum Synergistic effect

Expression of Ki-67,p53,and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第43期11卷 6765-6769页

作者： Seok Jeong Don Haeng Lee Jung Il Lee jin-Woo Lee Kye sook kwon Pum-soo Kim Hyung Gil Kim Yong Woon Shin Young soo Kim Young Bae Kim Division of Gastroenterology Department of Pathology

AIM： To examine surgical specimens of pancreas with either chronic pancreatitis or pancreatic cancer in order to study whether ductal hyperplasia and dysplasia in pancreas represent precursor lesions for pancreatic cancer. METHODS： We examined expression of Ki-67, CEA, p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas （n = 11） and chronic pancreatitis （n = 12）. Cellular proliferation was assessed by Ki-67 proliferation index using the proliferation marker Ki-67. In specimens with pancreas cancer, we divided pancreas epithelium into normal （n = 7）, ductal hyperplasia （n = 3）, dysplasia （n = 4）, and cancerous lesion （n = 11） after hematoxylin and eosin staining, Ki-67, and CEA immunohistochemical staining. In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal （n = 10）, ductal hyperplasia （n = 4）, or dysplasia （n = 5）. p53 and K-ras expression were also studied by immunohistochemical staining. RESULTS： In pancreatic cancer, the Ki-67 index was 3.73±3.58 in normal site, 6.62±4.39 in ductal hyperplasia, 13.47：1：4.02 in dysplasia and 37.03±10.05 in cancer tissue, respectively. Overall, p53 was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 14 （0%）, 0 of 7 （0%）, 7 of 9 （78%）, and 10 of 11 （91%）, respectively, and K-ras was positive in 0 of 8 （0%）, 1 of 3 （33%）, 4 of 6 （67%）, 4 of 5 （80%）, respectively. CONCLUSION： Our results favorably support the hypothesis that ductal hyperplasia and dysplasia of the pancreas might be precursor lesions for pancreas cancer. Further evaluation of oncogenes by the molecular study is needed.

关键词： Ki-67 p53 K-ras Chronic pancreatitis Pancreatic ductal adenocarcinoma

Highly Flexible Fabrics/Epoxy Composites with Hybrid Carbon Nanofillers for Absorption-Dominated Electromagnetic Interference Shielding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第11期14卷 307-323页

作者： Jong-Hoon Lee Yoon-Sub Kim Hea-jin Ru Seul-Yi Lee soo-jin Park Department of Chemistry Inha University100 InharoIncheon 22212Korea Korea Architecture Safety Testing and Research Institute(KASTI) 88 Gasan Digital 1-roSeoul 08590Korea

Epoxy-based nano-composites can be ideal electromagnetic interference(EMI)-shielding materials owing to their lightness,chemical inertness,and mechanical ***,poor conductivity and brittleness of the epoxy resin are challenges for fast-growing portable and flexible EMI-shielding applications,such as smart wristband,medical cloth,aerospace,and military *** this study,we explored hybrid nanofillers of single-walled carbon nanotubes(SWCNT)/reduced graphene oxide(rGO)as conductive inks and polyester fabrics(PFs)as a substrate for flexible EMI-shielding *** highest electrical conductivity and fracture toughness of the SWCNT/rGO/PF/epoxy composites were 30.2 S m^(−1)and 38.5 MPa m^(1/2),which are~270 and 65%enhancement over those of the composites without SWCNTs,*** mechanical durability was demonstrated by stable electrical conductivity retention during 1000 cycles of bending *** EMI-shielding effectiveness of~41 dB in the X-band frequency of 8.2-12.4 GHz with a thickness of 0.6 mm was obtained with an EM absorption-dominant behavior over a 0.7 absorption *** results are attributed to the hierarchical architecture of the macroscale PF skeleton and nanoscale SWCNT/rGO networks,leading to superior EMI-shielding *** believe that this approach provides highly flexible and robust EMI-shielding composites for next-generation wearable electronic devices.

关键词： Conductive polymer composites Fracture toughness Flexible composites Absorption-dominated electromagnetic interference shielding

Image Translation Method for Game Character Sprite Drawing

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2022年第5期131卷 747-762页

作者： Jong-In Choi soo-Kyun Kim Shin-jin Kang Department of Digital Media Seoul Women’s UniversitySeoul01797Korea Computer Engineering Jeju National UniversityJeju63243Korea School of Games Hongik UniversitySejong30016Korea

Two-dimensional(2D)character animation is one of the most important visual elements on which users’interest is focused in the game ***,2D character animation works in the game field are mostly performed manually in two dimensions,thus generating high production *** study proposes a generative adversarial network based production tool that can easily and quickly generate the sprite images of 2D ***,we proposed a methodology to create a synthetic dataset for training using images from the real world in the game resource production field where machine learning datasets are *** addition,we have enabled effective sprite generation while minimizing user input in the process of using the *** this end,we proposed a mixed input method with a small number of segmentations and skeletal bone *** proposed image-to-image translation network effectively generated sprite images from the user input images using the skeletal *** conducted an experiment regarding the number of images required and showed that 2D sprite resources can be generated even with a small number of segmentation inputs and one skeletal bone drawing.

关键词： Sprite generation body segmentation pose estimation generative adversarial network deep learning

Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第12期12卷 1511-1528页

作者： Soyoun Um Jueun Ha soo jin Choi Wonil Oh Hye jin jin Research Team for Immune Cell Therapy Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Research Team for Osteoarthritis Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Biomedical Research Institute MEDIPOST Co.Ltd.Seongnam 13494South Korea

Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and *** the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a ***,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue ***,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications.

关键词： Umbilical cord blood Mesenchymal stem cell Stem cell therapy Immunomodulation Regenerative medicine Therapeutic cell manufacturing processing

Operational limits of a non-homogeneous dielectric elastomer transducer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Smart and Nano Materials 2017年第4期8卷 214-231页

作者： Anup Teejo Mathew soo jin Adrian Koh Department of Mechanical Engineering National University of SingaporeSingaporeSingapore

Operation of a dielectric elastomer(DE)transducer is limited by the way it fails,and any other limits imposed by the *** example,material rupture and dielectric breakdown are two examples of transducer failure,while tension loss is a user-imposed *** instability may or may not result in transducer failure,but is often considered as a boundary to denote the onset of state *** a DE undergoing homogeneous deformation,constructing operational limits on work-conjugate state diagrams are rather ***,for DE subjected to non-homogeneous deformation,the process is more *** present a method to plot the operational boundaries of a DE subject to non-homogeneous deformation,known commonly as the Universal Muscle Actuator or the loudspeaker *** analysis show that tension loss need not be imposed as a hard operational limit,and that there is further operational space for the transducer,post tension *** plotting the operational limits on work-conjugate planes,we determine an optimal inner-to-outer ring ratio and the required pre-stretches that maximize energy conversion.

关键词： Dielectric elastomer non-homogeneous operational limits loudspeaker configuration

Carbon Dioxide Concentration and Flux in an Urban Residential Area in Seoul,Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2014年第5期31卷 1101-1112页

作者： Moon-soo PARK Seung jin JOO soon-Ung PARK Weather Information Service Engine Center for Atmospheric Science & Earthquake ResearchSeoul 121-835 Korea Center for Atmospheric and Environmental Modeling Seoul 152-775 Korea

The carbon dioxide （CO2） concentrations and fluxes measured at a height of 17.5 m above the ground by a sonic anemometer and an open-path gas analyzer at an urban residential site in Seoul, Korea from February 2011 to January 2012 were analyzed. The annual mean CO2 concentration was found to be 750 mg m-3, with a maximum monthly mean concentration of 827 mg m-3 in January and a minimum value of 679 mg m-3 in August. Meanwhile, the annual mean CO2 flux was found to be 0.45 mg m-2 s-1, with a maximum monthly mean flux of 0.91 mg m-2 s-1 in January and a minimum value of 0.19 mg m-2 s-1 in June. The hourly mean CO2 concentration was found to show a significant diurnal variation; a maximum at 0700-0900 LST and a minimum at 1400-1600 LST, with a large diurnal range in winter and a small one in summer, mainly caused by diurnal changes in mixing height, CO2 flux, and surface complexity. The hourly mean CO2 flux was also found to show a significant diurnal variation, but it showed two maxima at 0700-0900 LST and 2100-2400 LST, and two minima at 1100-1500 LST and 0300-0500 LST, mainly caused by a diurnal pattern in CO2 emissions and sinks from road traffic, domestic heating and cooking by liquefied natural gas use, and the different horizontal distribution of CO2 sources and sinks near the site. Differential advection with respect to wind direction was also found to be a cause of diurnal variations in both the CO2 concentration and flux.

关键词： CO2 concentration CO2 flux liquefied natural gas (LNG) Seoul urban residential area

Effects of an Urban Park and Residential Area on the Atmospheric CO_2 Concentration and Flux in Seoul,Korea

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2013年第2期30卷 503-514页

作者： Moon-soo PARK Seung jin JOO Chang Seok LEE Center for Atmospheric and Environmental Modeling Seoul 151 919Korea Life and Environmental Engineering Seoul Women's UniversitySeoul 139 774Korea

The CO2 concentrations and fluxes over an urban forest site （Namsan） and an urban residential region （Boramae） in Seoul, Korea, during the non-growing season （2 4 March 2011）, the growing season （10-12 June 2011）, and the late-growing season （22-24 September 2011） were analyzed. The CO2 concentrations of two sites showed nearly the same diurnal variation, with a maximum value occurring during the night and a minimum value occurring during daytime, as well as the same seasonal variation, with a maximum value during the non-growing season （early spring） and a minimum value during the growing season （summer）. The CO2 flux over the urban forest did not show any typical diurnal variation during the non-growing season, but did show diurnal variation with a small positive value during the night and a large negative value during daytime in the growing and late-growing seasons due to photosynthesis in the urban forest. The CO2 flux over the urban residential region showed a positive daily mean value for all periods, with large values during the non-growing season and small values during the growing season, and it also showed diurnal variation with two maxima at 0600-1000 LST and 1800-2400 LST, and two minima at 0300-0600 LST and 1100-1500 LST, and was strongly correlated with the use of liquefied natural gas for cooking and heating by surrounding houses.

关键词： C02 concentration C02 flux Seoul urban forest urban residential region