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Isolation, identification, Pb(Ⅱ) biosorption isotherms and kinetics of a lead adsorbing Penicillium sp. MRF-1 from South Korean mine soil

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Journal of Environmental Sciences 2010年第7期22卷 1049-1056页

作者： Natarajan Velmurugan Grim Hwang Muthuswamy Sathishkumar Tae Kie choi Kui-Jae Lee Byung-Taek Oh Yang-soo Lee Department of Forest Science and Technology Institute of Agriculture and Life SciencesChonbuk National University College of Agriculture and Life Sciences Seoul National University Singapore-Delft Water Alliance National University of Singapore2 Engineering Drive 2 Division of Biotechnology College of Environment and Bioresources SciencesChonbuk National University

A heavy metal contaminated soil sample collected from a mine in Chonnam Province of South Korea was found to be a source of heavy metal adsorbing biosorbents. Chemical analyses showed high contents of lead （Pb） at 357 mg/kg and cyanide （CN） at 14.6 mg/kg in the soil. The experimental results showed that Penicillium sp. MRF-1 was the best lead resistant fungus among the four individual metal tolerant fungal species isolated from the soil. Molecular characterization of Penicillium sp. MRF-1 was determined using ITS regions sequences. Effects of pH, temperature and contact time on adsorption of Pb（Ⅱ） by Penicillium sp. MRF-1 were studied. Favorable conditions for maximum biosportion were found at pH 4 with 3 hr contact time. Biosorption of Pb（Ⅱ） gradually increased with increasing temperature. Efficient performance of the biosorbent was described using Langmuir and Freundlich isotherms. Adsorption kinetics was studied using pseudo first-order and pseudo second-order models. Biosorbent Penicillium sp. MRF-1 showed the maximum desorption in alkali conditions. Consistent adsorption/desorption potential of the biosorbent in repetitive cycles validated the efficacy of it in large scale. SEM studies given notes on surface modification of fungal biomass under metal stress and FT-IR results showed the presence of amino groups in the surface structure of the biosorbent. In conclusion, the new biosorbent Penicillium sp. MRF- 1 may potentially be used as an inexpensive, easily cultivatable material for the removal of lead from aqueous solution.

关键词： heavy metal resistant fungus Penicillium sp. biosorption isotherms kinetics

Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2727-2738页

作者： Ji Won Han Jong Young choi Eun Sun Jung Ji hoon Kim Hee Sun Cho Jae-Sung Yoo Pil soo Sung Jeong Won Jang Seung Kew Yoon ho Joong choi Young Kyoung You Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea The Catholic University Liver Research Center College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of hospital Pathology The Catholic University of KoreaSeoul 06591South Korea Department of Surgery The Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Clinical factors predicting graft survival(GS)after ABO-incompatible(ABOi)liver transplantation(LT),and differences between recipients with and without hepatocellular carcinoma(HCC)are *** To analyze the impact of serial serum tacrolimus trough concentration in recipients with or without(HCC)in ABOi living-donor liver transplantation(LDLT).METhoDS We analyzed a historical cohort of 89 recipients who underwent ABOi LDLT,including 47 patients with *** The 1-,3-,5-,and 10-year GS rates were 85.9%,73.3%,71.4%,and 71.4%,respectively,and there were no significant differences between HCC and non-HCC *** multivariate Coxregression analyses,tacrolimus trough concentrations below 5.4 ng/mL at 24 wk post-LT,in addition to the antibody-mediated rejection(AMR)were associated with poor-graft *** HCC patients,AMR[hazard ratio(HR)=63.20,P7.3 ng/mL were significant predictive factors for HCC *** propensity score matching,patients with high tacrolimus concentrations at 4 wk had significantly poor recurrence-free *** Elevated tacrolimus levels at 4 wk after ABOi LDLT have been found to correlate with HCC ***,careful monitoring and control of tacrolimus levels are imperative in ABOi LT recipients with HCC.

关键词： ABO-incompatible Liver transplantation Tacrolimus Hepatocellular carcinoma

TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIM HAN NA choi soo JIN KIM SANG DO LEE Department of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest mortality rate among all cancers,in part because it readily *** tumor microenvironment,comprising blood vessels,fibroblasts,immune cells,and macrophages[including tumor-associated macrophages(TAMs)],is closely related to cancer cell growth,migration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer migration and invasion.p21-activated kinase 1(PAK1),an important signaling molecule,induces cell migration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,migration,and ***,the mechanisms by which it increases lung cancer migration remain ***,in this study,we aimed to elucidate the mechanisms by which IL-1βand TonEBP affect lung cancer cell migration and *** found that A549 cocultured-MΦ-secreted IL-1βinduced A549 cell migration and invasion via the PAK1 *** deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1β–induced migration and ***1 phosphorylation,which was promoted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an important role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatment.

关键词： Lung cancer TonEBP Tumor microenvironment Tumor-associated macrophage IL-1β

Rationally designed graphene channels for real-time sodium ion detection for electronic tongue

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InfoMat 2023年第7期5卷 43-58页

作者： Chung Won Lee Sang Eon Jun Seung Ju Kim Tae Hyung Lee Sol A.Lee Jin Wook Yang Jin Hyuk Cho Shinyoung choi Cheol-joo Kim soo Young Kim ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

Monitoring taste-inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue(E-tongue).Particularly from the five major tastes,the highly selective,sensitive detection of Na^(+)in real-time is *** is due to the saltiness of food is the key ingredient in most ***,existing Na^(+)detecting devices have relatively low performances of selectivity,sensitivity,and lack of on–off ***,conventional devices significantly deteriorate in capac-ity due to repetitive usage or lifetime shortage by degradation of the sensing ***,a graphene-based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this *** act as a receptor and a molecular sieve,respectively,to enhance selectivity and sensitivity and elon-gate the life expectancy of the *** device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off *** fabricated device has highly selective,sensitive Na^(+)detection properties compared to other 10 molecule/ionic *** on–off functions of the device were available,also possesses a long lifespan of at least 220 ***,it can precisely discriminate real beverages containing Na^(+),which can be observed by principal component analysis *** features offer the possibility of ascending to a platform for E-tongues in near future.

关键词： electronic tongue graphene microfluidic channels Na^(+)sensors solution-gated field-effect transistors

Usefulness of transcatheter arterial embolization for eighty-three patients with secondary postpartum hemorrhage:Focusing on difference in angiographic findings

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World Journal of Clinical Cases 2023年第15期11卷 3471-3480页

作者： Bong Man Kim Gyeong Sik Jeon Min Jeong choi Nam-soo hong Department of Radiology Dankook University HospitalDankook University College of MedicineCheonan-si 31116Chungcheongnam-doSouth Korea Department of Radiology CHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Preventive Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Transcatheter arterial embolization(TAE)has been widely used as an effective and a safe treatment method and was often used as an alternative to the surgical management,but there are limited studies on the efficacy and the safety for patients undergoing their secondary postpartum hemorrhage(PPH).AIM To evaluate the usefulness of TAE for secondary PPH focusing on the angiographic *** We conducted a research from January 2008 to July 2022 on all 83 patients(mean:32 years,range:24-43 years)presented with secondary PPH and they were treated with TAE in two university *** medical records and angiography were retrospective reviewed in order to evaluate the patients’characteristics,delivery details,clinical status and peri-embolization management,angiography and embolization details,technical/clinical success and *** group with active bleeding sign and the group without it were also compared and *** On angiography,46(55.4%)patients showed active bleeding signs such as contrast extravasation(n=37)or pseudoaneurysm(n=8)or both(n=1),and 37(44.6%)patients showed non-active bleeding signs such as only spastic uterine artery(n=2)or hyperemia(n=35).In the active bleeding sign group there were more multiparous patients,low platelet count,prothrombin time prolongation,and high transfusion *** technical success rates were 97.8%(45/46)in active bleeding sign group and 91.9%(34/37)in non-active bleeding sign group,and the overall clinical success rates were 95.7%(44/46)and 97.3%(36/37).An uterine rupture with peritonitis and abscess formation occurred to one patient after the embolization,therefore hysterostomy and retained placenta removal were performed which was a major *** TAE is an effective and a safe treatment method for controlling secondary PPH regardless of angiographic findings.

关键词： Postpartum hemorrhage Angiography Transcatheter arterial embolization Pseudoaneurysm Nbutylcyanoacrylate

Impact of statin usage patterns on outcomes after percutaneous coronary in-tervention in acute myocardial infarction：Korea Working Group on Myocar-dial Infarction registry （KorMI） study

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Journal of Geriatric Cardiology 2014年第2期11卷 93-99页

作者： Chan-Hee Lee Sang-Hee Lee Jong-Seon Park Young-Jo Kim Kee-Sik Kim Shung-Chull Chae Hyo-soo Kim Dong-Ju choi Myeong-Chan Cho Seung-Woon Rha Myung-ho Jeong Department of Cardiology Yeungnam University Hospital 170 Hyeonchung-ro Nam-gu Daegu 705-717 South Korea Department of Internal Medicine Daegu Catholic University Hospital 33 Duryugongwon-ro 17-gil Nam-gu Daegu 705-718 South Korea Department of Internal Medicine Kyungpook National University Hospital 130 Dongdeok-ro Jung-gu Daegu 700-721 South Korea Department of Internal Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul 110-744 South Korea Department of Internal Medicine Seoul National University Bundang Hospital 82 Gumi-ro 173-gil Bundang-gu Seongnam 463-707 South Korea Department of Internal Medicine Chungbuk National University Hospital 776 1sunhwan-ro Heungdeok-gu Cheongju 361-711 South Korea Department of Internal Medicine Korea University Guro Hospital 148 Gurodong-ro Guro-gu Seoul 152-703 South Korea Department of Internal Medicine Chonnam National University Hospital 42 Jebong-ro Dong-gu Gwangju 501-757 South Korea

Background The benefit of statin use after acute ST-segment elevation myocardial infarction （STEMI） has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention （PCI）. Methods This analysis of the Korea Working Group on Myocardial Infarction registry （KorMI） study included 3,584 STEMI patients （mean age, 63 ±13 years;male, 2,684, 74.9%） undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events （MACE：all-cause death, recurrent MI, and target lesion revascularization） were compared among patients grouped according to statin therapy timing：I, both during and after hospitalization （n=2,653, 74%）;II, only during hospita-lization （n=309, 8.6%）;III, only after discharge （n=157, 4.4%）;and IV, no statin therapy （n=465, 13%）. Mean follow-up duration was 234 ± 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups Ⅲ and Ⅳ had the highest MACE rates （2.3%, 3.9%, 5.1%, and 4.9%for groups I-IV, respectively, P=0.004）. After adjusting for confounders, groups Ⅱ-Ⅳ had a higher MACE risk than group Ⅰ [hazard ratio （HR）：3.20, 95%confidence interval （95%CI）：1.31-7.86, P=0.011;HR：3.84, 95%CI：1.47-10.02, P=0.006;and HR：3.17, 95%CI：1.59-6.40, P=0.001;respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical prac-tice.

关键词： Statins Acute myocardial infarction Treatment omcome

Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2018年第8期15卷 523-533页

作者： Yong hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol choi Se Yeon choi Jae Kyeong Byun Ju Yeol Baek Woong Gil choi Tae soo Kang Ji hoon Ahn Sang-ho Park Ahmed Mashaly Jin Oh Na Cheol Ung choi hong Euy Lim Eung Ju Kim Chang Gyu Park hong Seog Seo Dong Joo Oh Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuneheon South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Medicine Korea University Graduate School Seoul South Korea Cardiovascular Center Cheong Ju St. Mary hospital Cheong Ju Chung Buk South Korea SCardiology Department Konkuk University Chungju Hospital Chungju South Korea Department of Internal Medicine Cardiovascular Division Dankook University Hospital Cheonan South Korea Department of Cardiology Soonchunhyang University Gumi Hospital G-umi South Korea Cardiology Department Soonchunhyang University Cheonan Hospital Cheonan South Korea

Background There were limited data comparing the major clinical outcomes between first-generation （1G）-drug eluting stentts （DES） and second-generation （2G）-DES in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-, sirolimus-, 1G-zotarolimus-eluting stent （endeavor~ or endeavor sprintS）, n = 554] or 2G-DES [2G-zotarolimus （endeavor resolute~）- or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events （MACE） defined as total death, non-fatal myocardial infarction （MI）, target lesion revascularization （TLR）, target vessel revascularization （TVR）, non-target vessel revascularization （Non-TVR） and the secondary endpoint was stem thrombosis （ST） at 5 years. Results Two propensity score-ma- tched （PSM） groups （232 pairs, n = 464, C-statistic = 0.802） were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio （HR）： 3.133; 95% confidence interval （CI）： 1.539-6.376; P = 0.002], TVR （HR： 3.144; 95% CI： 1.59645.192; P = 0.001） and total revascularization rate （FIR： 1.874; 95% CI： 1.086-3.140; P = 0.023） were significantly higher in 1G-DES compared with 2G-DES after PSM. however, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this single-center and all-comers registry, 2G-DES＇s superiorities for TLR, TVP, and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

关键词： Acute myocardial infarction Clinical outcomes Drug-eluting stem

Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： Sung Hwan choi G. Anoop Dong Wook Suh Kyung Pil Kim Hyun Ju Lee Jae soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

Multi-directionally wrinkle-able textile OLEDs for clothing-type displays

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npj Flexible Electronics 2020年第1期4卷 288-296页

作者： Seungyeop choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun hong Park Hyuncheol Kim ho Seung Lee Minwoo Nam Eun Gyo Jeong Jeong Bin Shin Taek-soo Kim Kyung Cheol choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable *** response to this trend,we demonstrate a textile display that can endure the active movements of a human *** can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and *** a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of *** elastomeric strain buffer for reducing mechanical stress is also inserted into the textile ***,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform.

关键词： OLEDs IoT directional