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Taxonomic revisionofthegenus Lactarius(Russulales,Basidiomycota)in Korea

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Fungal Diversity 2019年第2期95卷 275-335页

作者： Hyun lee Komsit Wissitrassameewong Myung soo Park Annemieke Verbeken John Eimes young Woon Lim School of Biological Sciences and Institute of Microbiology Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium University College Sungkyunkwan University2066 SeoburoJangan-guSuwon 16419Korea

The genus Lactarius Pers.(Russulales)is a cosmopolitan group of Basidiomycota that forms ectomycorrhizal relationships primarily with both deciduous and coniferous *** the genus has been well-studied in Europe and North America,only fragmentary researches have been carried out on Asian *** particular,the distribution of Lactarius species in South Korea is poorly understood due to insufficient morphological descriptions and a lack of DNA sequence *** addition,the misuse of European and North American names has added to confusion regarding the taxonomy of Asian Lactarius *** this study,the diversity of Lactarius in South Korea was evaluated by employing both morphological and phylogenetic approaches.A multi-locus phylogenetic analysis of 729 Lactarius specimens collected between 1960 and 2017 was performed using the internal transcribed spacer(ITS)region,partial nuclear ribosomal large subunit(nrLSU),partial second largest subunit of RNA polymerase II(rpb2),and minichromosome maintenance complex component 7(mcm7).49 Lactarius species were identified in three Lactarius subgenera:***(17 spp.),***(22 spp.),and ***(10 spp.).Among them,28 Lactarius species were identified as new to science,while just 17 were previously described Lactarius *** of the taxa remain un-named due to paucity of materials.A key to Korean Lactarius species,molecular phylogenies,a summary of diversity,and detailed description are provided.

关键词： Intercontinental conspecificity mcm7 Milkcaps Multi-locus phylogeny Species delimitation

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： young Ju lee Jin-Woo Jung Sangchul lee Sang Wook lee Jeong Hyun Kim Sung Kyu Hong Seok-soo Byun Sang Eun lee Seong Jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

Sojucktang induces apoptosis via loss of mitochondrial membrane potential and caspase-3 activation in KLE human endometrial cancer cells

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Chinese Science Bulletin 2009年第23期54卷 4387-4392页

作者： OH Yeon-Suk KWON Hee-young JEONG soo-Jin PARK Ki-young KIM Sun-young lee Hyo-Jung lee Hyo-Jeong lee Eun-Ok AHN Kwang Seok KIM Sung-Hoon Cancer Preventive Material Development Research Center Oriental Medical CollegeKyunghee University College of Medicine Kyunghee University

Sojucktang (SJT) has long been used for the treatment of endometrial diseases in Korea. However, the mechanisms responsible for the SJT-induced apoptosis in endometrial cancer cells remain unclear. In the present study, SJT was demonstrated to show cytotoxic effect and induce apoptotic cell death via mitochondrial regulation in KLE endometrial cancer cells. Linderae Radix, Glycyrrhizae Radix, Zedoariae Rhizoma, Trogopterorum Faeces and Agelicae Gigantis Radix were found to be the potent constituent herbs of SJT to significantly decrease the viability of KLE cells by a tetra zolium salt (XTT) assay. Apoptotic bodies were observed in SJT-treated KLE cells by 4′-6-diamidino-2-phenylindole (DAPI) and TdT-mediated-dUTP nick-end labeling (TUNEL) assay. SJT also increased sub-G1 DNA contents of the cell cycle undergoing apoptosis in a dose-dependent manner. Furthermore, it was observed that SJT activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), and decreased mitochondrial membrane potential in a dose-dependent manner. Taken together, this study shows that SJT exerts anti-tumor activity against KLE endometrial cancer cells via mitochondrial dependent apoptosis induction.

关键词：线粒体膜电位 caspase 子宫内膜癌细胞凋亡活化癌细胞诱导细胞毒作用

Development of genome engineering technologies in cattle: from random to specific

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Journal of Animal Science and Biotechnology 2018年第2期9卷 285-293页

作者： soo-young Yum Ki-young Youn Woo-Jae Choi Goo Jang Department of Veterinary Clinical Science College of Veterinary Medicine and the Research Institute of Veterinary Science Seoul National University Farm Animal Clinical Training and Research Center Institute of Green Bio Science Technology Seoul National University Emergence Center for Food-Medicine Personalized Therapy System Advanced Institutes of Convergence Technology Seoul National University College of Veterinary Medicine Seoul National University

The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the ***, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.

关键词： Cattle CRISPR-Cas9 Genome engineering technologies Transgenesis Transposon

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第23期22卷 5393-5399页

作者： Danbi lee Heather Lyu young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu young Joo lee soo Hyung Ryu Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of MedicineBaltimore Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Hepatobiliary Surgery University of Ulsan College of MedicineAsan Medical Center Department of Internal Medicine Inje Uni-versity College of MedicineSeoul Paik Hospital

AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C ***: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing ***: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV.

关键词： Hepatocellular carcinoma Chronic hepatitis B Genomic change Hepatitis B virus Genotype C

Vaporization reduction characteristics of aqueous ammonia solutions by the addition of ethylene glycol, glycerol and glycine to the CO_2 absorption process

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Journal of Environmental Sciences 2012年第3期24卷 494-498页

作者： Jong-Beom Seo soo-Bin Jeon Je-young Kim Gang-Woo lee Jong-Hyeon Jung Kwang-Joong Oh Department of Environmental Engineering Pusan National University Busan 609735 Korea. Research Institute of Industrial Science & Technology Pohang 790330 Korea Research & Development Institute of Yoosung Co. Ltd. Ulsan 680070 Korea Faculty of Health Science Daegu Haany University Daegu 712715 Korea

Aqueous ammonia （NH3） solution can be used as an alternative absorption for the control of CO2 emitted from flue gases due to its high absorption capacity, fast absorption rate and low corrosion problem. The emission of CO2 from iron and steel plants requires much attention, as they are higher than those emitted from power plants at a single point source. In the present work, low concentration ammonia liquor, 9 wt.%, was used with various additives to obtain the kinetic properties using the blast furnace gas model. Although a solution with a high ammonia concentration enables high CO2 absorption efficiency, ammonium ions are lost as ammonia vapor, resulting in reduced CO2 absorption due to the lower concentration of the ammonia absorbent. To decrease the vaporization of ammonia, ethylene glycol, glycerol and glycine, which contain more than one hydroxyl radical, were chosen. The experiments were conducted at 313 K similar to the CO2 absorption conditions for the blast furnace gas model.

关键词： ammonia vaporization blast furnace gas ethylene glycol glycerol glycine

In vitro fungistatic activity of 36 traditional oriental medicines and their synergistic effect against Trichophyton rubrume

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 109-115页

作者： young soo Kim Jin Yeul Ma Korean Medicine Application Center Korea Institute of Oriental Medicine

Objective: To investigate the fungistatic activity and synergistic effects of natural products and their constituents, including traditional oriental medicines(TOMs).Methods: Fungistatic activities of TOMs prepared by hot-water(115 ℃) or ethanol(70%; 40 ℃) extraction were determined by their minimum inhibitory *** assess possible synergistic effects, minimum inhibitory concentrations of various combinations were ***: By evaluating antifungal susceptibility of Trichophyton rubrum, which is a major causative fungus for several types of dermatophytosis, we confirmed that ethanol extracts were more active than hot-water extracts in 25 of the 36 TOMs, suggesting that the constituents with high hydrophobicity tend to contribute significantly to fungistatic *** selected four TOMs with high fungistatic activity, including Aucklandiae radix, Gentianae macrophyllae radix, Scutellariae radix, and Galla rhois, and their synergistic effects were investigated through the combination studies between TOMs or TOM-conventional drug *** combinations between four TOMs, partial synergistic effects were observed in Aucklandiae radix–Galla rhois and Gentianae macrophyllae radix–Galla rhois combinations, as supported by the lowest fractional inhibitory concentration index value of 0.66 for both ***, Galla rhois showed the strongest synergistic effect on growth inhibition of Trichophyton rubrumwith a fractional inhibitory concentration index value of 0.50 in combination with ***: Our findings indicate that the combination of TOMs and TOM-terbinafine may be effective on treatment for chronic and recurrent dermatophytosis by improving fungistatic activity and led to decrease systemic toxicity in clinical practice.

关键词： Fungistatic activity Hot-water and ethanol extracts Traditional oriental medicine Tinea Trichophyton rubrum Synergistic effect

The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis

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Cellular & Molecular Immunology 2024年第7期21卷 723-737页

作者： Seungwon Ryu Kyung Ah Kim Jinwoo Kim Dong Hun lee Yong-soo Bae Hajeong lee Byoung Choul Kim Hye young Kim Department of Microbiology Gachon University College of MedicineIncheon21999South Korea Department of Nano-Bioengineering Incheon National UniversityIncheon22012South Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of MedicineSeoul03080South Korea Department of Dermatology Seoul National University College of MedicineSeoul03080South Korea Laboratory of Cutaneous Aging Research Biomedical Research InstituteSeoul National University HospitalSeoul03080South Korea Institute of Human–Environment Interface Biology Medical Research CenterSeoul National UniversitySeoul03080South Korea Department of Biological Sciences SRC Center for Immune Research on Non-lymphoid OrgansSungkyunkwan UniversitySuwon16419South Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon16419South Korea Division of Nephrology Department of Internal MedicineSeoul National University Hospital and Seoul National University College of MedicineSeoul03080South Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoul National University College of MedicineSeoul03080South Korea

Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases such as lupus nephritis. However, the mechanisms underlying ILC2 adhesion and migration in the kidney remain poorly understood. Here, we revealed the critical role of integrin α4β7 in mediating renal ILC2 adhesion and function. We found that integrin α4β7 enables the retention of ILC2s in the kidney by binding to VCAM-1, E-cadherin, or fibronectin on structural cells. Moreover, integrin α4β7 knockdown reduced the production of the reparative cytokine amphiregulin (Areg) by ILC2s. In lupus nephritis, TLR7/9 signaling within the kidney microenvironment downregulates integrin α4β7 expression, leading to decreased Areg production and promoting the egress of ILC2s. Notably, IL-33 treatment upregulated integrin α4β7 and Areg expression in ILC2s, thereby enhancing survival and reducing inflammation in lupus nephritis. Together, these findings highlight the potential of targeting ILC2 adhesion as a therapeutic strategy for autoimmune kidney diseases.

关键词： Innate lymphoid cells Tissue residency Adhesion molecules Integrins Kidney Lupus nephritis Amphiregulin

Does intraoperative frozen section really predict significant positive surgical margins after robot-assisted laparoscopic prostatectomy?A retrospective study

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Asian Journal of Andrology 2021年第1期23卷 74-79页

作者： Se young Choi Byung Hoon Chi Tae-Hyoung Kim Bumjin Lim Wonchul lee Dalsan You Choung-soo Kim Department of Urology Chung-Ang University HospitalChung-Ang University College of MedicineDongjak-guSeoul 06973Korea Department of Urology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea

We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate *** study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral *** frozen sections of the periurethra,dorsal vein,and bladder neck were *** ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic *** 271 patients,108(39.9%)had PSM and 163(60.1%)had negative *** Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,P<0.001)were significantly more frequent in the PSM *** analysis showed that Gleason pattern≥4(vs<4;hazard ratio:4.386;P=0.0004)was the only significant predictor of BCR in the PSM *** frozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥*** analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,P<0.0001)were associated with PSM of the *** with Gleason pattern≥4 is significantly predictive of *** frozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could *** examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.

关键词： biochemical recurrence frozen section positive surgical margin robotic-assisted prostatectomy