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Role of GM3 ganglioside in the pathology of some progressive human diseases and prognostic importance of serum anti-GM3 antibodies

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BIOCELL 2021年第6期45卷 1485-1494页

作者： VERA KOLYOVSKA sonya ivanova DESISLAVA DRENSKA DIMITAR MASLAROV RENETA TOSHKOVA Institute of Experimental Morphology Pathology and Anthropology with MuseumBulgarian Academy of SciencesSofia1113Bulgaria University Hospital for Neurology and Psychiatry“St.Naum” Sofia1797Bulgaria University First MHAT-Sofia “St.John Krastitel”Neurology ClinicSofia1142Bulgaria Medical University of Sofia Medical College“Y.Filaretova”Sofia1606Bulgaria

Glycosphingolipids(gangliosides)have been characterized as important biological molecules with a key role as regulators in many physiological processes on cellular,tissue,organ,and organism *** deviations in their normal amounts,production,and metabolism are very often related to the development of many multi-factor socially important ***3 ganglioside,as a small molecule,plays important roles in the cascade regulatory pathways in the pathology of many disorders like neurodegenerative diseases,autoimmune diseases,inflammation,diabetes,malignant transformation,and *** GM3 and its derivatives are membrane-bound glycosphingolipids composed of an oligosaccharide head structure containing one sialic acid *** molecules transduce signals involved in cell surface events,including the phosphorylation of transmembrane *** ganglioside is the most widely distributed among tissues,and it serves as a precursor for most of the more complex ganglioside ***3 inhibits the function of fibroblast growth factor receptor,and cell growth is regulated by GM3-enriched ***3 is thought to inhibit immunologic functions,such as the proliferation and production of cytokines by T *** the other hand,the anti-ganglioside antibodies(AGAs)are important in many acquired demyelinating immunemediated neuropathies,like Multiple sclerosis(MS),Guillain–Barrésyndrome(GBS)and its variation,Miller–Fisher syndrome(MFS)and could be suggested as important diagnostic and prognostic markers about the describe diseases and their *** show that the complexes of anti-ganglioside antibodies to GM3(detected by ELISA)may be useful diagnostic and prognostic tool markers for autoimmune diseases,neurodegenerative disorders,malignancy,diabetes,and *** pilot studies suggest increased serum IgG anti-GM3 antibodies titers in patients with secondary progressive MS(SPMS),throat cancer,elder people with diabetes(89–96 years),old Lewis rat

关键词： Biomarkers Serum GM3 Serum anti-GM3 antibodies ELISA

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