检索结果-南通市图书馆

Status and prospects for symmetric organic redox flow batteries

在线全文

学校读者我要写书评

暂无评论

journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to july 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis c serum samples

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2006年第47期12卷 7604-7612页

作者： Thomas Gbel sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt Klinik für Gastroenterologie Hepatologie und InfektiologieHeinrich-Heine-UniversitatDusseldorfMoorenstr.eD-40225 DusseldorfGermany ciphergen Biosystems Neuendorfstr.24aD-16761 Hennigsdorf bei berlinGermany

AIM： To identify a multi serum protein pattern as well as single protein markers using surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry （SELDI-TOF-MS） for detection and differentiation of liver fibrosis （F1-F2）, liver cirrhosis （F4） and hepatocellular carcinoma （Hcc） in patients with chronic hepatitis c virus （HcV）. METHODS： Serum samples of 39 patients with F1/F2 fibrosis, 44 patients with F4 fibrosis, 34 patients with Hcc were applied to cM10 arrays and analyzed using the SELDI-TOF Proteinchip System （PBS-Ⅱc; ciphergen Biosystems） after anion-exchange fractionation. All patients had chronic hepatitis c and histologically confirmed fibrosis stage/Hcc. Data were analyzed for protein patterns by multivariate statistical techniques and artificial neural networks. RESULTS： A 4 peptide/protein multimarker panel （7486, 12843, 44293 and 53598 Da） correctly identified Hccs with a sensitivity of 100% and specificity of 85% in a two way-comparison of HcV-cirrhosis versus HcV-Hcc training samples （AUROc 0.943）. Sensitivity and specificity for identification of Hcc were 68% and 80% for random test samples. cirrhotic patients could be discriminated against patients with F1 or F2 fibrosis using a 5 peptide/protein multimarker pattern （2873, 6646, 7775, 10525 and 67867 Da） with a specificity of 100% and a sensitivity of 85% in training samples （AUROc 0.976） and a sensitivity and specificity of 80% and 67% for random test samples. combination of the biomarker classifiers with APR/score and alfa-fetopotein （AFP） improved the diagnostic performance. The 6646 Da marker protein for liver fibrosis was identified as apolipoprotein c-I. cONcLUSION： SELDI-TOF-MS technology combined with protein pattern analysis seems a valuable approach for the identification of liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis c. Host probably a combination of different serum markers will help to identify liver cirrhosis and early-stage hep

关键词： Hepatocellular carcinoma Hepatitis c virus Apolipoprotein c- I Proteomics Surface-enhanced laser desorption/ionisation

Loss of cD103^+ intestinal dendritic cells during colonic inflammation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2010年第1期16卷 21-29页

作者： Ulrike G Strauch Nicole Grunwald Florian Obermeier sonja Gürster Heiko c Rath Department of Internal Medicine I University of Regensburg

AIM:To investigate possible differences in dendritic cells(Dc)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal Dc derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FAcS) *** of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that Dc derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory *** contrast to Dc from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-Dc produced high levels of the anti-inflammatory cytokine *** induction of mu-rine colitis in a cD4 + cD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated cD80 + Dc could be observed within the inflamed colonic ***,in contrast to splenic Dc,a significant population of Dc within MLN and colonic LP expressed the mucosal integrin cD103 which was lost during colitis. cONcLUSION:The constitutive secretion of antiinflammatory cytokines by immature Dc within the intestinal LP might regulate the homeostatic balance between mucosal immunity and ***103 + Dc could mediate this important function.

关键词： Dendritic cell colitis cytokines Integrin cD103

HYERS—ULAM—RASSIAS STABILITY OF QUADRATIc FUNcTIONAL EQUATIONS IN BANAcH MODULES OVER A c^＊—ALGEBRA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Annals of Mathematics,Series B 2003年第2期24卷 261-266页

作者： c. PARK j. PARK j. SHIN Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.

The authors prove the Hyers-Ulam-Rassias stability of the quadratic mapping in Banachmodules over a unital c*-algebra, and prove the Hyers-Ulam-Rassias stability of the quadraticmapping in Banach modules over a unital... 详细信息

关键词： Stability B-quadratic Functional equation Banach module over Banach algebra

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

c_c(X)Spaces with X Locally compact

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2007年第9期23卷 1593-1600页

作者： j.c.FERRANDO S.MOLL centro de Investigación Operativa Universidad Miquel Hernández Departamento de Matemática Aplicada Universidad Politécnica

In this paper, we show, among other results, that if X is a [separable] locally compact space X [satisfying the first countability axiom] then the space cc （X） has countable tightness [if and only if it has bounding tightness] if and only if it is Frechet-Urysohn, if and only if cc （X） contains a dense （LM） subspace and if and only if X is a-compact.

关键词： Frechet-Urysohn space countable [bounding] tightness (LM)-space

Fabrication and Properties of SiB6-B4c with Phenolic Resin as a carbon Source

在线全文

学校读者我要写书评

暂无评论

journal of Materials Science & Technology 2008年第1期24卷 102-104页

作者： G. c.Hwang j.Matsushita United Graduate School of Science and Engineering Tokai University 1117 Kitakaname Hiratsuka 259-12921 Japan

Si-B-c ceramic composites were synthesized using SiB-6,B-4c,and phenolic resin as a carbon source by pressureless sintering in an Ar ***,the Si-B-c ceramic composites were fabricated to determine their potential for applications as high hardness and high temperature *** X-ray diffraction patterns of sintered bodies of SiB-6-B-4c with carbonized phenolic resin can be seen that SiB-6 and c changed to B-4c and *** this study,it is obtained that carbonized phenolic resin is good addition material as a reaction material comparing to carbon powder at 1683 K for 1 h by pressureless sintering in an Ar atmosphere.

关键词： Silicon boride Boron carbide Phenolic resin