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Selective Fetal Growth Restriction in Monochorionic Diamniotic Twins: Diagnosis and Management

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Maternal-Fetal Medicine 2022年第4期4卷 268-275页

作者： Alicia Mazer Zumaeta Maria Mar Gil Miguel Rodriguez-Fernandez Pilar Carretero JoséHector Ochoa Maria Cristina Casanova Francisca sonia molina Department of Obstetrics and Gynecology Hospital Universitario Clinico San CecilioGranada 18016Spain Department of Obstetrics and Gynecology Hospital Matemo Provincial Dr.Raul Felipe LuciniCordoba 500oArgentina Diagnus SA Prenatal Diagnosis and Fetal Medicine CenterCordoba 5000Argentina Obstetrics and Gynecology Department Hospital Universitario de TorrejonTorrejon de Ardoz 28223MadridSpain School of Medicine Universidad Francisco de VitoriaPozuelo de Alarcon 28223MadridSpain Instituto de Investigacion Biosanitaria lbs.GRAnADA Granada 18016Spain

Selective fetal growth restriction (sFGR) is a severe condition that complicates 10% to 15% of all monochorionic diamniotic (MCDA) twin pregnancies. Pregnancies complicated with sFGR are at high risk of intrauterine demise or adverse perinatal outcome for the twins. Three clinical types have been described according to the umbilical artery (UA) Doppler pattern observed in the smaller twin: type I, when the UA Doppler is normal;type II, when there is persistent absent or reversed end-diastolic blood flow in the UA Doppler;and type III, when there is intermittent absent and/or reversed end-diastolic blood flow in the UA Doppler. Clinical evolution and management options mainly depend on the type of sFGR. Type I is usually associated with a good prognosis and is managed conservatively. There is no consensus on the management of types II and III, but in earlier and more severe presentations, fetal interventions such as selective laser photocoagulation of placental anastomoses or selective fetal cord occlusion of the smaller twin may be considered. This review aims to provide updated information about the diagnosis, evaluation, follow-up, and management of sFGR in MCDA twin pregnancies.

关键词： Twins Monochorionic diamniotic twins Selective fetal growth restriction Birthweight discordance Fetal therapy Placenta

The road to opportunities： landscape change promotes body-size divergence in a highly mobile species

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Current Zoology 2016年第1期62卷 7-14页

作者： Carlos CAMACHO Pedro SAEZ sonia SAnCHEZ Sebastian PALACIOS Carlos molina Jaime POTTI Department of Evolutionary Ecology Estacion Biologica de Donana--CSIC Av. Americo Vespucio 41092 SevilleSpain Department of Environmental Biology and Public Health. University of Huelva. Av. Andalucia 21071 HuelvaSpain Department of Conservation Biology Estacion Biologica de Donana--CSlC Av. Americo Vespucio 41092Seville Spain Sociedad Espafiola de Ornitologia. Centro Ornitologico Francisco Bernis. Paseo Marismeno sn 21750 Huelva Spain

Landscape change provides a suitable framework for investigating population-level responses to novel ecological pressures. However, relatively little attention has been paid to examine the potential influence of landscape change on the geographic scale of population differentiation. Here, we tested for morphological differentiation of red-necked nightjars breeding in a managed property and a natural reserve situated less than 10 km apart. At both sites, we also estimated site fidelity over 5 years and quantified the potential foraging opportunities for nightjars. Breeding birds in the managed habitat were significantly larger in size-as indexed by keel length-than those in the natural one. However, there were no significant differences in wing or tail length. Immigration from neighboring areas was almost negligible and, furthermore, no individual (out of 1130 captures overall) exchanged habitats between years, indicating strong site fidelity. Food supply for nightjars was equally abundant in both habitats, but the availability of foraging sites was remarkably higher in the managed property. As a result, nightjars-particularly fledglings-in the latter habitat benefited from increased foraging opportunities in relation to those in the natural site. It seems likely that the fine-scale variation in nightjar morphology reflects a phenotypic response to unequal local conditions, since non-random dispersal or differential mortality had been determined not to be influential. High site fidelity appears to contribute to the maintenance of body-size differences between the two habitats. Results from this nightjar population highlight the potential of human-induced landscape change to promote population-level responses at exceedingly small geographic scales.

关键词：动物学演化发展动物分类学

Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue

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Asian Journal of Andrology 2008年第4期10卷 659-666页

作者： Yohani Perez Vivian molina Rosa Mas Roberto Menendez Rosa M. Gonzailez Ambar Oyarzabal sonia Jimenez Laboratory of Biochemistry Center of Natural Products National Center for Scientific Research Havana City 6990 Cuba

Aim： To investigate whether oral treatment with D-004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone （T）-treated rats. Methods： In our first experiment, normal rats were distributed into five groups： one group treated with the vehicle and four groups treated with D-004 （100, 200, 400 or 800 mg/kg）. In our second experiment, rats were randomized into five groups： a negative control group and four T-injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D-004 （200, 400 or 800 mg/kg）. Results： In normal rats, D-004 （100-800 mg/kg） inhibited significantly and dose-dependently iron-initiated malondialdehyde （MDA） accumulation in prostate homogenates （35.7%-80.0%） vs. the controls. D-004 （200-800 mg/kg） significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally （100%） in T-treated rats. Conclusion： Oral treatment with D-004 reduced MDA and carbonyl groups dose-dependently and markedly in normal and T-injected rats. These findings show that D-004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.

关键词： D-004 Roystonea regia Cuban royal palm prostate hyperplasia lipid peroxidation antioxidant

Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

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Asian Journal of Andrology 2009年第3期11卷 385-392页

作者： Emesto Lopez Vivian molina Jose Illnait Ambar Oyarzfibal Lilia C. Femandez Rosa Mas Rafael Gamez Julio C. Fernandez sonia Jimenez Meilis Mesa Ivon Hollands Sarahi Mendoza Medical Surgical Research Centre Havana 6990 Cuba Centre of natural Products from the national Centre for Scientific Research Havana 6880 Cuba

The aim of thisstudy was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine- induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers （20-55 years） in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 （320 mg） capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondialdehyde （MDA）, total hydroxyperoxides （TOH）, sulphydryl （SH） groups and total antioxidant status （TAS）. We assessed treatment compliance and addressed adverse experiences （AEs） at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA （26.7%）, TOH （18.8%） and SH groups （31.6%）, and the mean increase of TAS （35.3%） were significantly different from those of placebo （P 〈 0.001 for plasma TAS, P 〈 0.0001 for all other comparisons）. D-004 did not differ from the placebo in safety indicators. There were two withdrawals （both in the D-004 group）, with one due to dyspepsia （the only AE during the trial）. In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

关键词： antioxidant benign prostate hyperplasia D-004 lipid peroxidation Roystonea regia

Selective Fetal Growth Restriction in MonochorionicDiamniotic Twins: Diagnosis and Management:Erratum

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Maternal-Fetal Medicine 2023年第1期5卷 57-57页

作者： Zumaeta, Alicia Mazer Mar Gil, Maria Rodriguez-Fernandez, Miguel Carretero, Pilar Hector Ochoa, Jose Cristina Casanova, Maria sonia molina, Francisca Hosp Univ Clin San Cecilio Dept Obstet & Gynecol Granada 18016 Spain Hosp Materno Prov Dr Raul Felipe Lucini Dept Obstet & Gynecol RA-5000 Cordoba Argentina Diagnus SA Prenatal Diag & Fetal Med Ctr RA-5000 Cordoba Argentina Inst Invest Biosanitaria Ibs GRAnADA Granada 18016 Spain Hosp Univ Torrejon Obstet & Gynecol Dept Madrid 28223 Spain Univ Francisco Vitoria Sch Med Madrid 28223 Spain

Following the original article’s publication,1the authors identified an error in the published version.The authors and institution section should be corrected as follows:Alicia Mazer Zumaeta1,2,3,MaríaMarGil4,5,*,Miguel Rodríguez-Fernández4,Pilar Carretero1,6,JoséHector Ochoa3,María Cristina Casanova4,Francisca sonia molina1,6.

关键词： institution corrected Management

Linking Climatic Variability with Spatial Performance in Two Varieties of Quinoa Distributed in a Semi-Arid Zone

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American Journal of Plant Sciences 2012年第12期3卷 1682-1687页

作者： sonia Montecinos Pablo Salinas Rómulo Oses Leticia González-Silvestre Marco A. molina-Montenegro Banco Base de Semillas-Instituto de Investigaciones Agropecuarias (InIA) Centro Regional Intihuasi La Serena Chile Centro de Estudios Avanzados en Zonas áridas (CEAZA) Colina El Pino s/n La Serena Chile Centro de Estudios Avanzados en Zonas áridas (CEAZA) Facultad de Ciencias del Mar Universidad Católica del Norte Coquimbo Chile

Different crop varieties can respond in different ways to the climatic variations at local scale. Thus, in order to maximize the yield for a determined crop, the response of different varieties submitted to local climatic conditions should be assessed. The main goal of this study was to evaluate the ecophysiological responses of two varieties of Quinoa (PRP and BO78) submitted to different conditions of thermal amplitude. We performed two experiments in both greenhouse and in 3 sites on experimental-field where were evaluated survival, photochemical efficiency, plant growth and dry biomass in both varieties and compared them with the mean of the thermal conditions recorded during the last 16 years in the Coquimbo Region, Chile. Overall, individuals of BO78 showed higher performance in the sites with lower thermal amplitude than those of PRP. By contrast, in sites with higher thermal amplitude individuals of PRP showed better survival, physiological performance and biomass and therefore higher performance. Our results suggest that while BO78 showed an ecotypic strategy, the PRP showed a plastic strategy to maintain higher performance in sites with moderate and high climatic variability. We consider that under an increase in desertification, semi-arid areas would be available for stress tolerant crops like Quinoa, but the success for the food security in these regions may depend upon the variety used.

关键词： Quinoa Thermal Amplitude Plasticity Ecophysiology Crop Yield

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén Josémolina Aurora Morillo María Dolores navarro-Amuedo Dolores nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain neurology and Clinical neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFn-α).In COVID-19 there is a deficit in DC numbers and IFn-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID