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建筑节能 2016年第9期44卷 37-37页

作者： eduardo balvís scar sampedro sonia zaragoza angel paredes humberto michinel

Dendritic cell vaccination in glioblastoma after fluorescenceguided resection

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World Journal of Clinical Oncology 2012年第11期3卷 142-149页

作者： Ricardo Diez Valle Ascension Lopez-Diaz de Cerio Susana Inoges sonia Tejada Fernando Pastor Helena Villanueva Jaime Gallego Jaime Espinos Javier Aristu Miguel Angel Idoate Enrique Andreu Maurizio Bendandi Department of Neurosurgery University of Navarra Hospital 31008 Pamplona Navarra Spain Lab of Immunotherapy CIMA 31008 Pamplona Navarra Spain Immunotherapy Program University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Neurology University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Oncology University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Pathology University of Navarra Hospital 31008 Pamplona Navarra Spain Cell Therapy Area University of Navarra Hospital 31008 Pamplona Navarra Spain

AIM: To assess whether the addition of a customized, active immunotherapy to standard of care including fluorescence-guided surgery, may provide hints of an improved survival for patients with poor-prognosis, incurable glioblastoma multiform. METHODS: Preliminary to our ongoing, phase-Ⅱ clinical trial, we conducted a small pilot study enrolling five consecutive patients with resectable glioblastoma. In terms of Recursive Partitioning Analysis, four patientswere class Ⅴ and one was class Ⅳ. In all five cases, fluorescence-guided surgery was employed, followed by rapid steroid discontinuation. Patients were then treated with a combination of standard radio-chemotherapy with temozolomide and tumor lysate-pulsed, mature dendritic cell-based ***: Though all five patients ultimately progressed, with any further treatment left to the sole decision of the treating oncologist, active immunotherapy was very well tolerated and induced specific immune responses in all three patients for whom enough material was available for such an assessment. Median progression-free survival was 16.1 mo. Even more important, median and mean overall survival were 27 mo and 26 mo, respectively. Three patients have died with an overall survival of 9 mo, 27 mo and 27.4 mo, while the other two are still alive at 32 mo and 36 mo, the former receiving treatment with bevacizumab, while the latter has now been off therapy for 12 mo. Four of five patients were alive at two ***: Active immunotherapy with tumor lysate-pulsed, autologous dendritic cells is feasible, safe, well tolerated and biologically efficacious. A phase-Ⅱ study is ongoing to possibly improve further on our very encouraging clinical results.

关键词： Immunotherapy Glioblastoma Fluorescence-guided surgery Dendritic cells Tumor-lysate

One-Step Synthesis and Characterization of a Nanocomposite Based on Carbon Nanotubes/Aluminum and Its Reinforcement Effect on the Metal Matrix

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材料科学与工程（中英文B版） 2015年第7期5卷 311-319页

作者： Marcos Allan Leite dos Reis Elizabeth M. S. Rodrigues Jordan Del Nero sonia Simoes Filomena Viana Manuel F. G. Vieira T. F. Vieira Faculty of Exact Science and Technology Federal University of Para Abaetetuba PA 68440-000 Brazil Institute of Exact Science Federal University of Para Belem PA 68440-000 Brazil CEMUC Faculty of Engineering of the University of Porto (FEUP) University of Porto Rua Dr. Roberto Frias 4200-465 PortoPortugal CEMUC Department of Mechanical Engineering Universidade of Coimbra Pinhal de Marrocos 3030-788 Coimbra Portugal

The nanocomposite based on carbon nanotubes/aluminum (CNT/Al) was one-step prepared by the DC arc discharge method under an argon/acetone mixed atmosphere. Synthesis was performed by arc plasma on a pure graphite rod, filled by aluminum powder as an anode and aluminum plate as a cathode. Discharge conditions of 85 A and 20 V were used at a pressure range of 375 to 750 Torr. The CNT/Al was characterized by Scanning Electron Microscopy with Energy Dispersive Spectroscopy; Transmission Electron Microscopy; Laser Diffraction Particle Size Analysis; X-Ray Diffraction; Raman Spectroscopy; Thermogravimetric Analysis; and, its reinforcement effect of the CNTs on the aluminum matrix was measured by Vickers microhardness test. This nanocomposite shows agglomerates of multiwalled carbon nanotubes filled with Al4C3 and blended with aluminum particles; moreover, in the nanocomposites was found a hardness increase of 40% for nanocomposites with 1.0 wt.% of CNT/Al.

关键词：多壁碳纳米管纳米复合材料一步合成铝板强化作用金属基体扫描电子显微镜透射电子显微镜

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《藏在故事里的听说读写》

全国新书目 2021年第12期 59-59页

作者：王文华陈佳蕙 sonia Ku 蔡侑玲陈志鸿

小学中低年级孩子的语文能力提升书!十二则奇想童话故事,十二种语文能力主题,大语文从听说读写开始!本书是一套面向小学中低年级的语文童话故事集。听说读写是语言能力学习的四个关键要素,也是语文能力的核心所在,在小朋友的成长和学习...

小学中低年级孩子的语文能力提升书!十二则奇想童话故事,十二种语文能力主题,大语文从听说读写开始!本书是一套面向小学中低年级的语文童话故事集。听说读写是语言能力学习的四个关键要素,也是语文能力的核心所在,在小朋友的成长和学习中,特别是在小学中低年级阶段,占据重要地位。作者以巧妙构思,通过童话故事的形式,将其展现出来,引导孩子在潜移默化中学会听说读写,在阅读中培养语文能力,发展大语文思维。

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第11章云物理、气溶胶和气溶胶化学100年进步

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气象科技进展 2019年第S1期9卷 159-171页

作者：索尼娅·克雷登威斯 MARKUS PETTERS ULRIKE LOHMANN 张定媛(编译) 田晓阳(编译) 美国科罗拉多州立大学美国北卡罗来纳州立大学瑞士苏黎世联邦理工学院不详

本章回顾了云核发现的历史及其对云微物理学和气候系统的影响。包括John Aitken、Sir John Mason、Hilding Kohle、Christian Junge、Sean Twomey和Kenneth Whitby在内的先驱为该领域奠定了基础。通过他们和其他很多学者的贡献,近一百年... 详细信息

本章回顾了云核发现的历史及其对云微物理学和气候系统的影响。包括John Aitken、Sir John Mason、Hilding Kohle、Christian Junge、Sean Twomey和Kenneth Whitby在内的先驱为该领域奠定了基础。通过他们和其他很多学者的贡献,近一百年来,在理解大气气溶胶的来源、演变和组成、颗粒物与大气水蒸气的相互作用以及云微物理过程方面取得了快速的进展。测量能力和理论理解方面的重大突破阐明了云凝结核和冰核颗粒的特征,以及它们在塑造云微物理性质和形成降水中所起的作用。尽管取得了这些进步,但对云的形成和演化的影响尚未全部得到解决。在未来的气候预测中,气溶胶-云的相互作用对气候系统产生的辐射强迫仍然是一个无法接受的巨大不确定因素。对气溶胶-云相互作用的过程尺度的理解仍不足以支持技术减缓策略,例如人工影响天气或加速地球系统范围内温度和天气形势变化的地球工程。

关键词：气溶胶化学气候系统人工影响天气测量能力不确定因素气候预测云凝结核

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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阻击朊病毒

环球科学 2020年第7期 44-49页

作者：索尼娅·米尼克尔·瓦拉布埃里克·瓦拉布·米尼克尔祝岸凯(翻译) 张哲(翻译) 师润(翻译) 高振兴(翻译) 李朝阳(审校) 不详李朝阳实验室广州医科大学附属肿瘤医院

朊病毒病作为一种发病速度极快的神经退行性疾病,不仅难以确诊,而且没有特效药,患者发病后数月就会死亡。而想要挽救那些患病风险高的人,最好的办法就是提前阻击朊病毒,预防疾病的发生。

关键词：朊病毒神经退行性疾病患病风险发病速度预防疾病特效药

2019年全球、地区和国家5岁以下儿童呼吸道合胞病毒引发急性下呼吸道感染疾病负担研究的系统分析

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中国病毒病杂志 2023年第2期13卷 81-95页

作者： You Li Xin Wang Dianna M.Blau Mauricio T.Caballero Daniel R.Feikin Christopher J.Gill Shabir A.Madhi Saad B.Omer Eric A.F Simoes Harry Campbell Ana Bermejo Pariente Darmaa Bardach Quique Bassat Jean-Sebastien Casalegno Giorgi Chakhunashvili Nigel Crawford Daria Danilenko Lien Anh Ha Do Marcela Echavarria Angela Gentile Aubree Gordon Terho Heikkinen QSue Huang Sophie Jullien Anand Krishnan Eduardo Luis Lopez Josko Markic Ainara Mira-Iglesias Hannah CMoore Jocelyn Moyes Lawrence Mwananyanda DJames Nokes Faseeha Noordeen Evangeline Obodai Nandhini Palani Candice Romero Vahid Salimi Ashish Satav Euri Seo Zakhar Shchomak Rosalyn Singleton Kirill Stolyarov sonia K Stoszek Anne von Gottberg Danielle Wurzel Lay-Myint Yoshida Chee Fu Yung Heather J Zar Harish Nair 张甜甜从兵兵邓舒予不详南京医科大学公共卫生学院江苏南京211166

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RS... 详细信息

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RSV相关社区死亡的更精确估计。本文旨在更新2019年全球、地区和国家层面60月龄以下儿童RSV相关急性下呼吸道感染的发病率和死亡率,重点关注总体死亡率和在研RSV免疫制剂针对的更窄的婴儿年龄组。方法检索获得MEDLINE、Embase、Global Health、CINAHL、Web of Science、LILACS、OpenGrey、中国知网、万方和维普数据库2017—2020年发表文献中的新数据,并纳入RSV GEN合作者提供的未发表数据,以扩展全球RSV疾病负担数据集。纳入的研究符合以下条件:报告了社区中或需要住院治疗的60月龄以下儿童RSV原发性急性下呼吸道感染的数据;报告了至少连续12个月的数据,但院内病死率或RSV季节性定义明确的地区除外;报告了RSV相关急性下呼吸道感染的发病率、住院率、院内病死率或急性下呼吸道感染住院的RSV阳性比例。如果病例定义不明或应用不一致、RSV感染未经实验室确认或仅基于血清学检测、报告的急性下呼吸道感染病例少于50例,则排除该研究。本研究应用广义线性混合效应模型(generalized linear mixed-effects model,GLMM)估计了2019年全球和地区(按国家发展状况和世界银行收入分类)RSV相关急性下呼吸道感染的发病率、住院率和院内病死率;通过基于危险因素的模型估计了国家层面RSV相关急性下呼吸道感染的发病率;通过GLMM开发了新模型,纳入最新的RSV社区死亡率数据,用于估计RSV的总体死亡率。本综述已在PROSPERO注册(CRD42021252400)。结果除了先前综述中纳入的317项研究外,还纳入了113项符合条件的新研究以及51项未发表的研究,共计481项研究。据估计,2019年全球60月龄以下儿童中,共发生3 300万(置信区间为2 540万~4 460万)次RSV相关急性下呼吸道感染,导致360万(290万~460万)例住院、26 300(15 100~49 100)例院内死亡以及101 400(84 500~125 200)例可归因于RSV的总死亡数。在0~6个月的婴儿中,共发生660万(460万~970万)次RSV相关急性下呼吸道感染,导致140万(100万~200万)例住院、13 300(6 800~28 100)例院内死亡以及45 700(38 400~55 900)例可归因于RSV的总死亡数。60月龄以下和28 d~6月龄儿童的死亡中分别有2.0%(置信区间为1.6%~2.4%)和3.6%(3.0%~4.4%)归因于RSV。在各年龄组中,95%以上的RSV相关急性下呼吸道感染事件和97%以上的可归因于RSV的死亡事件都发生在中低收入国家。结论 RSV显著增加了全球60月龄以下儿童的发病和死亡负担,尤其是在出生后前6个月和中低收入国家。本研究强调了全球RSV疾病的总体死亡率负担,60月龄以下儿童中,每50例死亡就有1例可归因于RSV;28 d至6个月大的婴儿中,每28例死亡就有1例可归因于RSV。每1例RSV相关急性下呼吸道感染院内死亡,对应社区中约3例可归因于RSV的死亡。对6月龄内婴儿提供保护的RSV被动免疫计划有望对减轻RSV疾病负担,但实施计划时,仍需要更多数据来了解RSV疾病负担高峰可能向大龄转移的影响。

关键词：呼吸道合胞病毒下呼吸道感染儿童疾病负担住院发病率死亡率病死率模型估计系统分析

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中性理论:完善达尔文演化论

环球科学 2019年第13期 34-41页

作者：安东尼奥·巴瓦迪拉索尼娅·卡米拉斯阿尔弗雷多·鲁伊斯孔娟(译) 巴塞罗那自治大学遗传学和微生物学系不详

经历了半个世纪之后,分子演化的中性理论仍然有效,它很好地解释了自然界中大量存在的遗传变异。然而,这一理论需要进一步发展才能解释新发现的基因组功能。在这篇来自《科学美国人》西班牙版的文章中,巴塞罗那自治大学的三位科学家阐述... 详细信息

经历了半个世纪之后,分子演化的中性理论仍然有效,它很好地解释了自然界中大量存在的遗传变异。然而,这一理论需要进一步发展才能解释新发现的基因组功能。在这篇来自《科学美国人》西班牙版的文章中,巴塞罗那自治大学的三位科学家阐述了中性理论的发展过程。

关键词：中性理论分子演化达尔文《科学美国人》基因组功能遗传变异巴塞罗那自然界