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Brain-derived neurotrophic factor in main neurodegenerative diseases

Neural Regeneration Research 2023年第3期18卷 554-555页

作者： Serena Camuso sonia canterini Division of Neuroscience Department of PsychologyUniversity La SapienzaRomeItaly PhD Program in Behavioral Neuroscience Sapienza University of RomeRomeItaly

Discovered in pig brains in 1982,the brain-derived neurotrophic factor(BDNF)is one of the most studied and characterized neurotrophins in the central nervous system.In recent years,BDNF has received considerable attention for its importance in the development and maintenance of normal brain function.This is because BDNF plays an important role in crucial functions of the nervous system,such as the survival,differentiation,and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions,such as glutamatergic overstimulation,cerebral ischemia,hypoglycemia,and neurotoxicity(Kowiański et al.,2018).

关键词： stimulation diseases

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Sex effect on presenilins expression in post-natal rat brain

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Advances in Bioscience and Biotechnology 2013年第12期4卷 1086-1094页

作者： Paola Piscopo sonia canterini Valentina Carletti Paolo Rosa Alessio Crestini Maria Teresa Fiorenza Annamaria Confaloni Department of Cellular Biology and Neuroscience Section of Clinics Diagnosis and Therapy of Central Nervous System Diseases Istituto Superiore di Sanità Rome Italy Department of Cellular Biology and Neuroscience Section of Clinics Diagnosis and Therapy of Central Nervous System Diseases Istituto Superiore di Sanità Rome Italy Department of Psychology Section of Neuroscience “Sapienza” University of Rome Rome Italy Department of Psychology Section of Neuroscience “Sapienza” University of Rome Rome Italy

Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is regulated by various cellular and extracellular factors, which change with age and sex. Both age and sex are key risk factors for Alzheimer’s disease, but the issue of whether the expression of presenilins is influenced by the sex during early postnatal development of the brain has been poorly investigated so far. In this study, we report that transcript levels of presenilins, and the subset of neurons expressing these proteins in various brain areas of the developing post-natal brain are different in male and female rats, suggesting that their function(s) may contribute to sexual dimorphism in the brain, both at morphological and functional levels.

关键词： Development Sex Presenilins γ-Secretase Rats Sexual Dimorphism

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