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14-3-3 Proteins Interact with FRMD6 and Regulate Its Subcellular Localization in Breast Cancer Cells

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Chemical Research in Chinese Universities 2015年第4期31卷 558-563页

作者： MENG Fanbo feng wei XIN Hua tian Zhuang zhang yu zhang Liping China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China The First Hospital of Jilin University Changchun 130021 P. R. China The Second Hospital of Jilin University Changchun 130041 P. R. China

The Hippo pathway is evolutionarily conserved from Drosophila to mammals. FRMD6 is one crucial up- stream component of the Hippo pathway while its function and regulatory mechanism are largely elusive. We decided to purify the protein complex of FRMD6 to further explore its regulatory mechanism. We established the MCF7 breast cancer cells that stably expressed FRMD6 by retroviruses infection. And we purified the FRMD6-interacting protein complex for further analysis by high performance liquid chromatography-mass spectrometry/mass spectrometry（HPLC- MS/MS）. Interestingly, we observed that the major binding partner of FRMD6 is 14-3-3 family of proteins. The interac- tion between FRMD6 and 14-3-3 proteins was detected by co-immunoprecipitation（CO-IP）. The disruption of their interaction resulted in the nuclear localization of FRMD6. Importantly, the T28A mutant of FRMD6 showed stronger tumor suppressor function than wild type（WT） FRMD6. Our results indicate that 14-3-3 proteins tightly regulate the subcellular localization of FRMD6 so as to endow FRMD6 with the tumor suppressor function on breast cancer.

关键词： FRMD6 14-3-3 protein Interacting protein complex Nuclear localization

Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina)infected with SIVmac239

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Zoological Research 2018年第1期39卷 42-51页

作者： tian-zhang song ming-xu zhang yu-jie xia yu xiao wei pang yong-tang zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China University of Chinese Academy of Sciences Bejing 100049China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China

Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus （HIV） patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromised hosts during HIV infection Due to the lack of direct evidence from animal experiments, the effects of immunocompromised hosts parasitic infections on remain unclear. Here we detected 14 different parasites in six northern pig-tailed macaques （NPMs） before or at the 50th week of simian immunodeficiency virus （SIV） infection by ELISA. The NPMs all carried parasites before viral injection. At the 50th week after viral injection, the individuals with negative results in parasitic detection （i.e., 08247 and 08287） were characterized as the Parasites Exit （PE） group, with the other individuals （i.e., 09203, 09211, 10205, and 10225） characterized as the Parasites Remain （PR） group. Compared with the PR group, the NPMs in the PE group showed higher viral loads, lower CD4＋ T cells counts, and lower CD4/CD8 rates. Additionally, the PE group had higher immune activation and immune exhaustion of both CD4~ and CD8~ T cells. Pathological observation showed greater injury to the liver, cecum, colon, spleen, and mesenteric lymph nodes in the PE group This study showed more seriously compromised immunity in the PE group, strongly indicating that parasites might exit an immunocompromised host.

关键词： AIDS Immunocompromised Northernpig-tailed macaque Parasite SIVmac239

具身智能研究的关键问题:自主感知、行动与进化

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自动化学报 2025年第1期51卷 43-71页

作者：沈甜雨陶子锐王亚东张庭祯刘宇航王兴霞杨静李志伟陈龙王坤峰王飞跃北京化工大学信息科学与技术学院北京100029 中国科学院自动化研究所复杂系统管理与控制国家重点实验室北京100190 中科慧拓科技有限公司北京100083 青岛智能产业技术研究院青岛266000

具身智能强调大脑、身体及环境三者的相互作用,旨在基于机器与物理世界的交互,创建软硬件结合、可自主学习进化的智能体.当前,机器学习、机器人学、认知科学等多学科技术的快速发展极大地推动了具身智能的研究与应用.已有的具身智能文... 详细信息

具身智能强调大脑、身体及环境三者的相互作用,旨在基于机器与物理世界的交互,创建软硬件结合、可自主学习进化的智能体.当前,机器学习、机器人学、认知科学等多学科技术的快速发展极大地推动了具身智能的研究与应用.已有的具身智能文献更多从技术和方法分类的角度入手,本文以具身智能在研究和应用过程中面临的关键挑战为角度切入,分析具身智能研究的一般性框架,围绕具身感知与执行、具身学习与进化两个方面提出具体的研究思路,并针对其中涉及的关键问题详细梳理相关技术及研究进展.此外,以移动机器人、仿生机器人、平行机器人三方面应用为例,介绍具身智能在感知与理解、控制与决策、交互与学习等方面给实际机器人系统设计带来的启发.最后,对具身智能的发展前景进行展望,探索虚实融合数据智能、基础模型与基础智能、数字孪生与平行智能在其中的重要作用和应用潜力,希望为相关领域学者和从业人员提供新的启示和思路.论文相关项目详见https://***/BUCT-IUSRC/Survey__EmbodiedAI.

关键词：具身智能感知与执行学习与进化机器人系统

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厌氧氨氧化工艺处理氧化铁红废水的工程研究

中国环境科学 2025年第1期45卷 158-166页

作者：杨俊锋陈振国郑旭文章裕李嘉懿周松伟汪晓军华南理工大学环境与能源学院广东广州510006 佛山市化尔铵生物科技有限公司广东佛山528300 华南师范大学环境学院广东广州510006

本研究针对物化预处理后的氧化铁红高氨氮废水,构建了工程尺度的厌氧氨氧化系统(CANON).在为期165d的连续运行过程中,CANON系统展现出良好的稳定性和抗冲击能力,其氨氮去除率和总氮去除率(TNRE)分别达90%和80%.Spearman分析和SHAP特征... 详细信息

本研究针对物化预处理后的氧化铁红高氨氮废水,构建了工程尺度的厌氧氨氧化系统(CANON).在为期165d的连续运行过程中,CANON系统展现出良好的稳定性和抗冲击能力,其氨氮去除率和总氮去除率(TNRE)分别达90%和80%.Spearman分析和SHAP特征重要性分析揭示了水质参数及环境参数对TNRE的影响.微生物群落分析揭示了系统中微生物种群结构的显著变化,优势厌氧氨氧化菌从Candidatus Anammoxoglobus过渡到Candidatus Kuenenia(相对丰度13.22%),优势氨氧化细菌为Nitrosomonas(相对丰度1.27%).此外,本研究建立的机器学习模型(XGBoost)对TNRE的预测准确率超过了99.9%,并在实际应用中对新数据点的预测准确度达到98%.本研究为厌氧氨氧化工艺的工程化应用和智能化发展提供了宝贵的实践经验.

关键词：厌氧氨氧化氧化铁红废水微生物群落机器学习模型

Zn/ ZrCl_4 System Induced Reductive Cleavage of Se-Se Bond in Diaryl Diselenides: A Novel Method for the Systhesis of Selenoesters

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Chinese Chemical Letters 2002年第1期13卷 9-12页

作者： song Lin zhang feng Shou tian Gong An LI yu Lu WANG College of Chemistry and Environmental Science Henan Normal University Xinxiang 453002

The Se-Se bond in diaryl diselenides was reduced by Zn/ZrCl4 system to produce selenide anions, which react with acyl chlorides or acid anhydrides to afford selenoesters in THF under mild and neutral conditions.

关键词： Diselenides zinc zirconium (IV) chloride selenoesters.

A review on the structure-performance relationship of the catalysts during propane dehydrogenation reaction

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Petroleum Science 2022年第2期19卷 819-838页

作者： Bohan feng yue-Chang wei wei-yu song Chun-Ming Xu State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing102249People's Republic of China

Dehydrogenation of propane(PDH)technology is one of the most promising on-purpose technologies to solve supply-demand unbalance of *** industrial catalysts for PDH,such as Pt-and Cr-based catalysts,still have their own limitation in expensive price and security ***,a deep understanding into the structure-performance relationship of the catalysts during PDH reaction is necessary to achieve innovation in advanced high-efficient *** this review,we focused on discussion of structure-performance relationship of catalysts in *** on analysis of reaction mechanism and nature of active sites,we detailed interaction mechanism between structure of active sites and catalytic performance in metal catalysts and oxide *** relationship between coke deposition,co-feeding gas,catalytic activity and nanostructure of the catalysts are also *** these discussions on the relationship between structure and performances,we try to provide the insights into microstructure of active sites in PDH and the rational guidance for future design and development of PDH catalysts.

关键词： Dehydrogenation of propane Metal catalysts Oxide catalysts Structure-performance relationship Active site Reaction mechanism

Removal of 2-ClBP from soil–water system using activated carbon supported nanoscale zerovalent iron

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Journal of Environmental Sciences 2016年第9期28卷 143-152页

作者： wei zhang tian yu Xiaolin Han weichi Ying State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and Technology

We explored the feasibility and removal mechanism of removing 2-chlorobiphenyl（2-Cl BP）from soil–water system using granular activated carbon（GAC） impregnated with nanoscale zerovalent iron（reactive activated carbon or RAC）.The RAC samples were successfully synthesized by the liquid precipitation *** mesoporous GAC based RAC with low iron content（1.32%） exhibited higher 2-Cl BP removal efficiency（54.6%） in the water *** result of Langmuir–Hinshelwood kinetic model implied that the different molecular structures between 2-Cl BP and trichloroethylene（TCE） resulted in more difference in dechlorination reaction rates on RAC than adsorption *** to removing2-Cl BP in the water phase,RAC removed the 2-Cl BP more slowly in the soil phase due to the significant external mass transfer ***,in the soil phase,a better removal capacity of RAC was observed than its base GAC because the chemical dechlorination played a more important role in total removal process for 2-Cl *** important result verified the effectiveness of RAC for removing 2-Cl BP in the soil *** reducing the total RAC removal rate of 2-Cl BP,soil organic matter（SOM）,especially the soft carbon,also served as an electron transfer medium to promote the dechlorination of 2-Cl BP in the long term.

关键词： Reactive activated carbon nZVI 2-ClBP Dechlorination Soil Soil organic matter

Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool

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World Journal of Gastroenterology 2025年第9期31卷 135-145页

作者： Jia-wei yu Lin-Biao Xiang Xiao-Juan Dong Chen-Xi Yang Lei Wang Xiao-yu Liu Yi-Hong song Xian-Jie Bai jing-Wen Xiao Lu Ren Qin-Hong Xu Gang-Hua Yang Yi Lv Qiang Lu National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of International Medical Center The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Geriatric Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Shortening the recipient warm ischemia time(rWIT)has been proven to be effective for improving the short-and long-term outcomes after liver transplantation(LT)and offsets the negative impact of an extended cold ischemia ***,few studies have been conducted to explore the prognostic effects of shortening the rWIT in transplantations using a liver graft from an extendedcriteria donor(ECD).AIM To investigate whether shortening the rWIT could improve the outcomes of ECD *** Rat ECD autologous orthotopic LT were performed with variable rWITs(0,10,20,and 30 minutes).Near-infrared fluorescence imaging(FI)was used for the real-time assessment of liver graft ischemia-reperfusion injury after the anhepatic *** was assessed,and liver function and histological analyses were performed on the third day after *** The FI curve growth rate and postoperative three-day survival rate significantly increased,and the liver function and Suzuki score of the liver grafts significantly improved when the rWIT was≤10 minutes(P<0.05).CONCLUSION The post-transplant outcomes were significantly better with a shorter rWIT(10 minutes or less)than with a longer rWIT,which could be a strategy for expanding the liver donor pool.

关键词： Extended criteria donor Recipient warm ischemia time Autologous orthotopic liver transplantation Near-infrared fluorescence imaging Outcome

人工智能在结直肠无蒂锯齿状病变中的应用进展

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海军军医大学学报 2025年第1期46卷 24-31页

作者：赵优冬卫佳慧张颂李兆申赵胜兵柏愚海军军医大学(第二军医大学)第一附属医院消化内科国家消化病临床医学研究中心上海200433

结直肠无蒂锯齿状病变(SSL)是一种重要的结直肠癌癌前病变,也是间期结直肠癌的重要原因。结直肠SSL虽然具有独特的组织结构和形态学特征,但内镜下检出率低,组织病理学诊断变异度高,是结直肠癌筛查中最易漏诊的病变之一。近年来,人工智... 详细信息

结直肠无蒂锯齿状病变(SSL)是一种重要的结直肠癌癌前病变,也是间期结直肠癌的重要原因。结直肠SSL虽然具有独特的组织结构和形态学特征,但内镜下检出率低,组织病理学诊断变异度高,是结直肠癌筛查中最易漏诊的病变之一。近年来,人工智能在结直肠疾病诊断中的应用迅速增多,已有研究发现人工智能辅助内镜技术可提高结直肠SSL的检出率和诊断准确性,辅助病理诊断可提高诊断效率和一致性。本文就当前人工智能在结直肠SSL中的应用进展进行综述。

关键词：人工智能结直肠肿瘤无蒂锯齿状病变结肠镜检查病理诊断