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Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

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World Journal of Stem Cells 2024年第6期16卷 708-727页

作者： Lei-Mei Xu xin-xin Yu Ning Zhang Yi-song Chen Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Gynecology Shanghai Key Laboratory of Female Reproductive Endocrine-related DiseasesShanghai 200011China

BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential *** POP,the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and *** intricate etiology of POP and the prohibition of trans-vaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy *** umbilical cord mesenchymal stromal cells(hucMSCs)present limitations,but their exosomes(hucMSC-Exo)are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix *** inflammation in POP group fibroblasts,stimulated primary fibroblast growth,and elevated collagen I(Col1)production in ***-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11(MMP11)*** HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in *** miRNAs in hucMSC-Exo targeted and downregulated MMP11 ***-Exo-based therapy may be ideal for safely and effectively treating POP.

关键词： Pelvic organ prolapse Exosomes Fibroblasts Human umbilical cord mesenchymal stromal cells Extracellular matrix Collagen I

Recent Progress and Regulation Strategies of Layered Materials as Cathode of Aqueous Zinc-Ion Batteries

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Energy & Environmental Materials 2024年第3期7卷 18-35页

作者： Yuan Yuan Si Wu Xiaoxue song Jin yong Lee Baotao Kang School of Chemistry and Chemical Engineering University of Jinan Department of Chemistry Sungkyunkwan University Shandong Hi-Speed Engineering Test Co. Ltd.

Aqueous zinc-ion batteries （ZIBs） have shown great potential in the fields of wearable devices,consumer electronics,and electric vehicles due to their high level of safety,low cost,and multiple electron transfer. The layered cathode materials of ZIBs hold a stable structure during charge and discharge reactions owing to the ultrafast and straightforward （de）intercalation-type storage mechanism of Zn2+ions in their tunable interlayer spacing and their abilities to accommodate other guest ions or ***,the challenges of inadequate energy density,dissolution of active materials,uncontrollable byproducts,increased internal pressure,and a large de-solvation penalty have been deemed an obstacle to the development of ZIBs. In this review,recent strategies on the structure regulation of layered materials for aqueous zinc-ion energy storage devices are systematically summarized. Finally,critical science challenges and future outlooks are proposed to guide and promote the development of advanced cathode materials for ZIBs.

关键词： layered cathode materials modifying strategies structure regulation zinc-ion batteries

Eradication of algae in ships’ ballast water by electrolyzing

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Journal of Marine Science and Application 2006年第4期5卷 58-61页

作者： DANG Kun SUN Pei-ting XIAO Jing-kun song yong-xin Marine Engineering College Dalian Maritime University Dalian 116026China Environmental Science and Technology College Dalian Maritime University. Dalian 116026China

In order to verify the effectiveness of electrolytic treatment on ships’ ballast water, experiments are carried out by a pilot system in laboratory. The raw seawater and seawater with different concentrations of different algae are simulated as ships’ ballast water. The algae in the raw seawater can be killed if it is treated by electrolysis with an initial residual chlorine concentration of 5 mg/L. If the seawater with one kind of algae (Nitzschia closterum, Dicrateria spp., or Pyramidomonnas sp.105cells/mL) is treated by electrolysis with an initial residual chlorine concentration of 5 mg/L, the alga can be sterilized. If the seawater with one kind of algae (Dunaliella sp., Platymonas or Chlorella spp.) is directly treated by electrolyzing with an initial residual chlorine concentration of 4 mg/L, the instant mortality changes with the concentration of different algae. However, after 72 hours, in all treated samples, there are no live algal cells found.

关键词： ships' ballast water electrolysis algae

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Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

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Zoological Research 2024年第4期45卷 747-766页

作者： Hong-Yi Zheng Tian-Zhang song yong-Tang Zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

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Li-ion Battery Failure Warning Methods for Energy-storage Systems

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Chinese Journal of Electrical Engineering 2024年第1期10卷 86-100页

作者： Peihao Wu Nawei Lyu Yuhang song xin Jiang Yang Jin School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China

Energy-storage technologies based on lithium-ion batteries are advancing ***,the occurrence of thermal runaway in batteries under extreme operating conditions poses serious safety concerns and potentially leads to severe *** address the detection and early warning of battery thermal runaway faults,this study conducted a comprehensive review of recent advances in lithium battery fault monitoring and early warning in energy-storage systems from various physical *** focus was electrical,thermal,acoustic,and mechanical aspects,which provide effective insights for energy-storage system safety enhancement.

关键词： Lithium-ion batteries energy-storage systems thermal runaway characteristic signals fault warning

Enhanced Flexoelectricity in Barium Titanate-Cellulose Composite Thin Films

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Acta Mechanica Solida Sinica 2024年第4期37卷 521-527页

作者： Wensi xing Hongyu Cao xin Zhang Xu Liang Jianwei song Shengping Shen Chemomechanics and Intelligent Media Laboratory State Key Laboratory for Strength and Vibration of Mechanical StructuresSchool of Aerospace EngineeringXi’an Jiaotong UniversityXi’an710049China

Biopolymers,the potential flexoelectric materials,are environment-friendly,degradable,lightweight,cost-effective,and possess remarkable processing properties catering to the requirements of advanced ***,the flexoelectric coefficient of biopolymers is normally much weaker than that of ceramic materials,limiting their potential applications for designing high-performance green electromechanical coupling *** improve the flexoelectric response in biopolymers,we composited barium titanate(BTO)with 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized cellulose nanofibrils(TOCNF)to enhance the flexoelectric response of *** to the high permittivity and flexoelectric effect of BTO,the relative dielectric constant and flexoelectric coefficient of 33.3 wt%BTO-TOCNF films reached 30.94@1 kHz and 50.05±1.88 nC/m@1 Hz,which were almost 172 times and 27 times higher than those of TOCNF,*** composite thin film contains high dielectric constant and flexoelectric coefficient,as well as excellent *** study provided a straightforward and efficient method for improving the flexoelectric effect of biopolymers,and demonstrated its great potential applications in flexoelectric-based devices.

关键词： Flexoelectricity Cellulose BaTiO_(3) Composite Thin films

Identification of FIR systems under difference-driven scheduled quantized observations

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Control Theory and Technology 2024年第2期22卷 163-172页

作者： Dong Liang Ruizhe Jia Fengwei Jing yong song Jin Guo School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Knowledge Automation for Industrial Processes Ministry of EducationBeijing100083China National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China

In networked system identification,how to effectively use communication resources and improve convergence speed is the focus of ***,there is an inherent contradiction between the two *** this paper,the event-driven communication is used to save communication resources for the identification of finite impulse response systems,and the input design is carried out to meet the requirements of convergence ***,a difference-driven communication is ***,the performance of the communication mechanism is analyzed,and the calculation method of its communication rate is *** that,according to the communication rate and the convergence rate of the identification algorithm,the input design problem is transformed into a constrained optimization problem,and the algorithm for finding the optimal solution is *** addition,considering the case that the output is quantized by multiple thresholds,the way to calculate its communication rate is given and the influence of threshold number on communication rate is ***,the effectiveness of the algorithm is verified by simulation.

关键词： System identification FIR system Difference-driven Quantized observation

Self-cleaning SERS sensor based on flexible Ni_(3)S_(2)/MoS_(2)@Ag@PDMS composites for label-free multiplex volatile organic compounds detection

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Nano Research 2024年第6期17卷 5529-5539页

作者： xinyue song yongzheng Zhang Xiaohui Ren Dongyan Tang Xuelin Zhang xin Li MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringState Key Lab of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbin 150090China College of Textile and Clothing Yancheng Institute of TechnologyYancheng 224051China MEMS Center Harbin Institute of TechnologyHarbin 150001China

Flexible self-cleaning surface-enhanced Raman scattering(SERS)sensors are highly desirable for the detection of various environmental pollutants,including volatile organic compounds(VOCs).However,achieving sensitive detection without labeling and ensuring efficient cyclic use remain significant ***,we introduce a direct approach to create a versatile Ni_(3)S_(2)/MoS_(2)@Ag@PDMS(PDMS=polydimethylsiloxane)composite SERS substrate using chemical vapor deposition *** produced substrate shows outstanding performance,offering extremely low detection sensitivity(1.0×10^(−12)M 4-aminobenzenethiol)and high enhancement factors(approximately 107).The interactions between the rod-shaped Ni_(3)S_(2)/MoS_(2)@Ag heterostructure and the molecules facilitate the transfer of charge,resulting in an increased electric field enhancement of the exciton *** has the dual benefit of providing a self-cleaning effect and enhancing SERS ***,the substrate enables sensitive detection of VOCs gas molecules without the need for labels,achieving a minimum detectable concentration as low as 1 ppm for o-dichlorobenzene,due to the preconcentration effect of *** calculations further explain the combined effect of electromagnetic and chemical enhancement in this composite *** utilizing the developed visual SERS barcode,quick multiple detection and analysis of mixtures can be *** flexible and versatile SERS technique has significant potential for on-site detection and analysis of environmental pollutants,opening the doors for the development of a wearable in-situ SERS sensing platform.

关键词： surface-enhanced Raman scattering(SERS) quantitative detection recyclable detection volatile organic compounds(VOCs) chemical vapor deposition(CVD)

A novel multi-state bogie system reliability evaluation approach by extended d-MC model for high-speed trains

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Transportation Safety and Environment 2024年第3期6卷 35-46页

作者： yong Fu Ruoqu Liu Jisheng Dai Wenlong Zhu xin Liu yong Qin Zhuzhou CRRC Times Electric Co. Ltd.Times RoadShifeng DistrictZhuzhouHunan 412001China Department of Statistics University of WarwickCoventry CV47ALUnited Kingdom State Key Lab of Rail Traffic Control&Safety Beijing Jiaotong UniversityHaidian DistrictBeijing 100044China

Bogie is a pivotal system and plays a critical part in the safety and reliability management of high-speed ***,the available bogie system reliability analysis methods lack the consideration of multi-state characteristics,and the common multi-state reliability analysis methods,being an NP-hard problem,lead to low *** order to overcome these drawbacks,this paper proposes a novel multi-state rail train bogie system reliability analysis approach based on the extended d-MC *** different function interactions within the bogie system are considered to build the multi-state bogie system flow network ***,an extended d-MC model is established to remove unnecessary d-MC candidates and duplicates,which greatly enhances the computing *** bogie system reliability is calculated,and examples are *** experiments are carried out for the different operational conditions of the bogie system and are used to test the practicability of the method proposed in this article;it is found that this method outperforms a newly developed method in solving multi-state reliability problems.

关键词： multi-state system reliability bogie flow network extended d-MC model