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Fauna characteristics and ecological distribution of Carnivora and Artiodactyla in Niubeiliang National Nature Reserve,China

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Frontiers in Biology 2007年第1期2卷 92-99页

作者： ZENG Zhigao song yanling MA Yingtai WANG Xifeng WU Xuntao XIE Zhenfeng SHAO Jianbin LI Chunning Institute of Zoology Chinese Academy of SciencesBeijing 100080China Niubeiliang National Nature Reserve Xi’an 710100China

Niubeiliang National Nature Reserve(NNR,108°45p-109°04p E,33°47p-33°56p N)is located on the east-ern range of the Qinling Mountains in Shaanxi Province,China and spans the southern and northern slopes of ***.A transect survey and investigation were carried out in NNR to determine the fauna characteristics and ecological distribution of carnivora and artiodactyla from May 2003 to August *** NNR has 18 mammals(carnivore and artiodactyl),two of which belong to the first class and seven to the second class of state key protected wildlife in *** results of this study indicated that ungulates were abun-dant in the NNR,as all ungulates that were distributed within *** could be found within the ***,only 45.5%of the carnivores distributed within *** were detected within the *** the mammals,there were 12 oriental species(66.7%),1 palearctic specie(5.5%)and 5 widely-distributed species(27.8%).The NNR is a crossing area of palearctic species and oriental species on the zoogeo-graphical regions,and it is a transitional area from the oriental realm to the palearctic *** results of the analysis on the ecological distribution of carnivore and artiodactyl in the area showed that their elevation ranges had large *** species whose elevation ranges above 1300 m,about 1000 m,and in 450-700 m occupied one third *** results also indicated that species richness for the mam-mals in the NNR peaked at a middle elevation(rising at first,then descending with the increase in elevation).Not only on the southern slope,but also on the northern slope of ***,the number of species distributed in the area at 1800-2200 m *** the largest(more than 80%),while the number of species distributed in the area above 2600 m *** the smallest(about 50%).Elevation gradients of species richness for the mammals in the NNR also embodied the mammal distributions among the vegetation *** number of species distribute

关键词： mammal fauna ecological distribution eleva-tion gradients species richness Niubeiliang National Nature Reserve

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Estimation of Drought Change Trends in Northeast China in 2020-2050 and Its Impact on Maize Yield

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Journal of Geoscience and Environment Protection 2018年第12期6卷 185-201页

作者： Zhulei Dong yanling song Jinfeng Tian Inner Mongolia Climate Centre China Meteorological Administration Hohhot China Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing China Kiel University Kiel Germany

Based on the results of nine Coupled Model Intercomparison Project Phase 5 (CMIP5) coupling models, the temperature and precipitation data of 114 stations in Northeast China were compared and analyzed. The simulation effect of CMIP5 model on precipitation and temperature in Northeast China was evaluated. The research shows that the Geophysical Fluid Dynamics Laboratory Earth System Models (GGFDL-ESM2G) have the best simulation effect on precipitation and temperature in Northeast China. Based on the SPEI index, the relationship between the drought trend of maize growing season and the yield change rate of maize in Northeast China was analyzed, and the future drought (2020-2050) and corn yield in Northeast China were estimated. The cumulative Standardized Precipitation Evapotranspiration Index (SPEI) analysis of the northeast maize growing season (May-September) shows that the drought in the northeastern region showed an intensifying trend from 1980 to 2010, especially in the first ten years of the 21st century. The cumulative SPEI index has a significant positive correlation with the yield of maize in Northeast China, and has a certain indicator effect on the yield of maize in Northeast China. The three scenarios of GFDL-ESM2G model show that under the three scenarios of Representative Concentration Pathways (RCP), the warming in Northeast China is significant;under the RCP4.5 scenario, the precipitation in Northeast China is increasing;in the RCP2.6 and RCP8.5 climate scenarios, precipitation is presented and reduces the trend of drought. Estimates of drought trends in Northeast China show that under the RCP4.5 climate scenario, the drought in Northeast China showed a slowing trend from 2020 to 2050. Under the RCP2.6 and RCP8.5 climate scenarios, the drought in Northeast China showed an increasing trend. Under the RCP2.6 and RCP8.5 climate scenarios, the yield change rate of maize in Northeast China showed a downward trend, indicating that climate warming caused the

关键词： Northeast China CMIP5 Model SPEI Corn Yield Trend Estimation

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Climatic characteristics of summer high temperature and assessment methods in the large cities of North China

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Journal of Geographical Sciences 2006年第1期16卷 13-22页

作者： ZHANG Shangyin ZHANG Dekuan WANG Shourong song yanling Open Laboratory-of the National Climate Center Beijing 100081 China

Based on the high temperature data of June to August in 1961-2000 in North China, the high temperature weather processes are investigated, and a more complete data set for severe high temperature processes is created. The climatic characteristics of adverse high temperature weather in Beijing, Tianjin, Shijiazhuang, Jinan and Taiyuan are analyzed respectively. The major features of the East-Asia Subtropical High and Transformed Continental High are discussed. The outcomes indicate that the influence of both East Asia Subtropical High and Transformed Continental High on these weather events varies, by a larger margin, from one city to another over North China and they are also closely related to the relative humidity. It is found that the behaviours of East-Asia Subtropical High and Transformed Continental High are the major important systems that give rise to the summer high temperature weather over the region. Based on these findings, the 5-day, 10-day and monthly assessment models for such high impact events have been developed. The assessment outcomes prove to be useful in assessing severe high-temperature events in major cities of North China.

关键词： North China urban high temperature climatic characteristics assessment model

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μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway:a comprehensive study including randomized controlled trial

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Cancer Communications 2023年第3期43卷 365-386页

作者： Xiaoqiang Wang song Zhang Di Jin Jiamei Luo Yumiao Shi Yiqi Zhang Lingling Wu yanling song Diansan Su Zhiying Pan Haige Chen Ming Cao Chaoyong Yang Weifeng Yu Jie Tian Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Urology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Institute of Molecular Medicine Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation State Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujianP.R.China

Background:μ-opioid receptor agonists(MORAs)are indispensable for analgesia in bladder cancer(BC)patients,both during surgery and for chronic pain *** MORAs affect BC progression and metastasis remains largely *** study focused on the effects of MORAs on the formation of circulating tumor cells(CTCs)in BC and aimed to provide potential therapeutic targets,which would retain the pain-relieving effects of MORAs in BC patients without sacrificing their long-term ***:Different preclinical models were used to identify the effects of MORAs on the progression of BC.A novel immunocapture microfluidic chip was utilized to analyze whether MORAs affected the number of CTCs in mouse models and clinical BC *** analyses,total transcriptome sequencing,and molecular biology methods were then used to investigate the underlying mechanisms in these models and in BC cell ***:Mouse models of hematogenous metastasis and in situ BC demonstrated that tumor metastasis was significantly increased after MORA treatment.A significant increase in the number of mesenchymal and/or epithelial CTCs was detected after MORA treatment in both the mouse models and clinical trial ***,MORAs facilitated the formation of CTCs by activating the MOR/PI3K/AKT/Slug signaling pathway,hereby promoting the epithelialmesenchymal transition(EMT)of BC cells,as knockdown of MOR,Slug or blockade of PI3K inhibited the EMT process and CTC ***:MORAs promoted BC metastasis by facilitating CTC *** EMT-CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumormetastasis or recurrence in BC patients.

关键词： μ-opioid receptor agonist AKT bladder cancer circulating tumor cell epithelial-mesenchymal transition microfluidic chip MOR PI3K Slug

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Women and Nature: Three Women Talk About Their Experience

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Women of China 1995年第9期 59-61页

作者： song yanling Zhang Haidi Cai Rong

People often think about women’s special relationship to nature. Some say women tend to have a greater appreciation of nature, but what deserves our attention is women’s intimacy and affection for nature. It is as i... 详细信息

关键词： In Three Women Talk About Their Experience Women and Nature

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秦岭羚牛的集群类型

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兽类学报 1999年第2期19卷 81-88页

作者：宋延龄曾治高中国科学院动物研究所

１９９５年７～１１月，１９９６年３～８月在陕西佛坪国家级自然保护区用野外直接观察和无线电跟踪器追踪的方法，对秦岭羚牛（Ｂｕｄｏｒｃａｓｔａｘｉｃｏｌｏｒｂｅｄｆｏｒｄｉ）的集群类型进行了观察。工作期间共记录到羚牛１４... 详细信息

１９９５年７～１１月，１９９６年３～８月在陕西佛坪国家级自然保护区用野外直接观察和无线电跟踪器追踪的方法，对秦岭羚牛（Ｂｕｄｏｒｃａｓｔａｘｉｃｏｌｏｒｂｅｄｆｏｒｄｉ）的集群类型进行了观察。工作期间共记录到羚牛１４６群次，按群体大小和结构可将羚牛群分为家群、混合群、社群、聚集群和独牛５种类型。在野外记录到的家群共３２群次，混合群１５次，社群４７次，聚集群２次，独牛５０次。家群的成员是具有亲缘关系的个体，在羚牛各类型的集群中占据核心的地位，是构成其它类型的羚牛群的基本单位。混合群的成员或是以家群为核心混杂以多只亚成体组成、或全部由亚成体和性成熟不久的年轻成体组成，是介于家群和社群之间的一种集群方式；其形成与羚牛幼仔在成长过程中社会习性的形成和完善有关。社群是由多个家群构成的相对比较稳定的一种群体，在各季节中出现的比例均很稳定，是羚牛群栖的主要形式。聚集群仅见于夏季，是临时聚集的一种不稳定的集群类型，其形成与采食和繁殖活动有关。独牛是羚牛集群的一种特殊形式。

关键词：秦岭羚牛集群习性集群类型

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秦岭羚牛中独栖现象的初步观察

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兽类学报 1999年第3期19卷 169-175页

作者：曾治高宋延龄中国科学院动物研究所

在群栖的秦岭羚牛种群中，存在着少数单独活动的羚牛，称为独牛。野外见到独牛５０只次，占见到羚牛总数的４５９％。独牛中有老年雄性个体、青壮年雄性个体、雌性个体、亚成体和幼仔。在繁殖季节独牛出现的次数最多，其中大部分是雄... 详细信息

在群栖的秦岭羚牛种群中，存在着少数单独活动的羚牛，称为独牛。野外见到独牛５０只次，占见到羚牛总数的４５９％。独牛中有老年雄性个体、青壮年雄性个体、雌性个体、亚成体和幼仔。在繁殖季节独牛出现的次数最多，其中大部分是雄性个体，也有雌性个体。与羚牛的四川亚种不同，在秦岭亚种中很少见到公牛集群的现象。羚牛种群中独牛的形成主要与繁殖有关，同时还与疾病及防御迁移有关。独牛在不同季节、不同生境内均可见到，绝大多数老年独牛活动区域的海拔高度低于集群的羚牛活动的高度。老年独牛在离群活动后，其活动节律与群体中的雄牛有一定的差异，这种差异在夜间的活动时间和活动率方面表现得更加明显。

关键词：羚牛独牛活动节律秦岭

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Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells

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Bioactive Materials 2022年第5期7卷 32-40页

作者： Haicong Shen Rui Su Jiao Peng Lin Zhu Kunyue Deng Qi Niu yanling song Liu Yang Lingling Wu Zhi Zhu Chaoyong Yang MOE Key Laboratory of Spectrochemical Analysis&Instrumentation Collaborative Innovation Center of Chemistry for Energy MaterialsKey Laboratory for Chemical Biology of Fujian ProvinceState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and EngineeringXiamen UniversityXiamen361005China Department of Hematology Clinical LaboratoryThe First Affiliated Hospital of Xiamen UniversityXiamen361005China Institute of Molecular Medicine Department of Gastrointestinal SurgeryRenji HospitalSchool of MedicineShanghai Jiao Tong University Shanghai200127China

Circulating tumor cells(CTCs),as important liquid biopsy target,can provide valuable information for cancer progress monitoring and individualized ***,current isolation platforms incapable of balancing capture efficiency,specificity,cell viability,and gentle release have restricted the clinical applications of ***,inspired by the structure and functional merits of natural membrane interfaces,we established an antibody-engineered red blood cell(RBC-Ab)affinity interface on microfluidic chip for high-performance isolation and release of *** lateral fluidity,pliability,and anti-adhesion property of the RBC microfluidic interface enabled efficient CTCs capture(96.5%),high CTCs viability(96.1%),and high CTCs purity(average 4.2-log depletion of leukocytes).More importantly,selective lysis of RBCs by simply changing the salt concentration was utilized to destroy the affinity interface for efficient and gentle release of CTCs without nucleic acid *** this chip,CTCs were successfully detected in colon cancer samples with 90%sensitivity and 100%specificity(20 patients and 10 healthy individuals).After the release process,KRAS gene mutations of CTCs were identified from all the 5 cancer samples,which was consistent with the results of tissue *** expect this RBC interface strategy will inspire further biomimetic interface construction for rare cell analysis.

关键词： Red blood cells Circulating tumor cells Colon cancer Biomimetic interface

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全球干旱指数研究进展

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应用气象学报 2022年第5期33卷 513-526页

作者：宋艳玲中国气象科学研究院灾害天气国家重点实验室北京100081 南京信息工程大学气象灾害预报预警与评估协同创新中心南京210044

干旱是世界最严重的气象灾害,是自然灾害中经济损失最重、影响范围最广的灾害。我国深受干旱灾害的影响,近几十年干旱事件频繁发生,给社会造成的不利影响和对人们生存环境的危害日趋严重。因此,讨论全球干旱指数研究进展对于我国干旱研... 详细信息

干旱是世界最严重的气象灾害,是自然灾害中经济损失最重、影响范围最广的灾害。我国深受干旱灾害的影响,近几十年干旱事件频繁发生,给社会造成的不利影响和对人们生存环境的危害日趋严重。因此,讨论全球干旱指数研究进展对于我国干旱研究及防旱抗旱工作具有重要意义。该文系统介绍全球特别是欧美等国气象干旱指数、农业干旱指数、水文干旱指数、遥感干旱指数以及综合干旱指数研究进展,并与我国干旱指数研究情况对比。探讨我国在干旱研究领域存在的主要问题,包括干旱指数适用性比较不足,新的机理性干旱监测指数研究不足,干旱预测预警研究不足。因此加强干旱机理机制研究、开展干旱监测准确性定量评估和加强数值模式在干旱预测预警中的应用是未来研究的重点和难点。

关键词：干旱指数农业定量评估预测预警

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Droplet Microfluidics for Highly Efficient Selection of Recognition Ligands

Droplet Microfluidics for Highly Efficient Selection of Reco...

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第十届全国化学生物学学术会议

作者： Zhi Zhu yanling song Yuyu Tan Chaoyong Yang Department of Chemical Biology College of Chemistry and Chemical EngineeringXiamen University

The acquisition of biochemical information is the key step for human to explore the essence of life phenomena. Biosensing technology is an important tool for biochemical information acquisition. It provides an effective and quick analytical means to the major problems such as environment and food monitoring, disease diagnosis and treatment, biomedical research and biochemical threat *** ligands are the core of biological sensing, as well as the foundation of modern biological analysis and medical diagnosis. The common recognition ligands include small molecules, aptamers, peptides, antibodies, etc. Among them, aptamers and peptides are highly attractive due to their small molecular weight, chemical synthesis with easy modification, high affinity and specificity. However, both the SELEX process for aptamer generation and the phage display process for peptide generation are time-consuming, labor-intensive, inefficient, and expensive. Droplet microfluidic techniques have recently been recognized as powerful tools because thousands of monodisperse microdroplets can be generated in a short time with molecules/cells individually encased, allowing high-throughput analysis and manipulation with precise control of the local environment. The encapsulation of each molecule from the selection library into individual droplets can help isolate the information from the big library and evaluate each binding ligand before sequencing,thus greatly reducing the time-consuming process. Herein, we will present our recent progress of using droplet microfluidics for aptamer and peptide selection.

关键词： Droplet microfluidics aptamer peptide selection

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