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中国医疗器械信息 2024年第3期30卷 76-78,143页

作者：李景元郭彬闫鹏伟宋丽霞贺军权缪祥文兰州西脉记忆合金股份有限公司甘肃兰州730105 甘肃省医疗器械检验检测所甘肃兰州730000

镍钛环抱式接骨器是镍钛形状记忆合金医用成功的典范。文章介绍了镍钛环抱式接骨器产品特性,概述了形状恢复率、相变温度和形状恢复力三个记忆性能指标的标准测试方法以及该测试标准在具体产品检验中的使用情况。

关键词：镍钛环抱式接骨器形状记忆效应恢复力

Analysis on characteristics of extreme precipitation indices and atmospheric circulation in Northern Shanxi

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Research in Cold and Arid Regions 2024年第2期16卷 84-97页

作者： xia Cai Yan song Lin Cai Xin Su GuiHua Liang YanMing Xu Shuozhou Meteorological Bureau of Shanxi Province ShuozhouShanxi 036002China China Meteorological Administration Training Center Beijing 100081China Heze University of Shandong Province HezeShandong 274000China Huafeng Meteorological Media Group Beijing 100081China Shuocheng Meteorological Bureau ShuozhouShanxi 036002China

This article utilizes daily precipitation data from 28 national meteorological stations in northern Shanxi Province spanning from 1972 to 2020,and the US NCEP/NCAR monthly average reanalysis and ERA5 monthly average reanalysis *** study employs techniques such as empirical orthogonal function(EOF)decomposition,MannKendall mutation and other methods to investigate the spatiotemporal distribution of extreme precipitation index in northern Shanxi and their correlation with atmospheric *** research results show that:the absolute index,relative index,intensity index and sustained dry period index(CDD)in the continuous index appear from southwest to *** spatial distribution characteristics of the central region decrease,while the continuous wet period(CWD)decreases from the central to the east and *** three indices Rx1day,Rx5day,and CWD mutated in 1978,1975,and 1983 respectively,and other extreme precipitation indices all appeared in a sudden change from a low-value period to a high-value period occurred around *** the high-value years of the summer extreme precipitation index,there is a significant negative anomaly in the height field in the mid-high latitude regions of *** Shanxi is controlled by a broad low-pressure trough in the Lake Baikal *** vapor transported via the east,west,and south routes converges in the northern Shanxi region and encounters cold air from the *** is a strong upward motion anomaly at 500 hPa in the troposphere,and the dynamic conditions of upper-level divergence and lower-level convergence lead to more summer extreme precipitation in the northern Shanxi ***,in the low-value years of the summer extreme precipitation index,northern Shanxi is affected by a strong high-pressure ridge north of Lake *** is a downward motion anomaly at 500 hPa,and the northern Shanxi region lacks water *** cold and warm air cannot converge,and both the water vapor conditions

关键词： Northern Shanxi Extreme precipitation indices Spatio-temporal distribution and evolution Mutations Atmospheric circulation anomaly

外泌体PD-L1在非小细胞肺癌免疫治疗的研究进展

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中国肺癌杂志 2022年第9期25卷 689-695页

作者：王娜宋霞山西医科大学第二临床医学院太原030000 山西省肿瘤医院呼吸二科太原030000

肿瘤免疫疗法在当前癌症治疗领域中愈来愈受瞩目,相关研究也层出不穷。对于非小细胞肺癌(non-small cell lung cancer,NSCLC)患者来说,近些年来,以程序性死亡受体1(programmed cell death 1,PD-1)/程序性死亡配体1(programmed cell deat... 详细信息

肿瘤免疫疗法在当前癌症治疗领域中愈来愈受瞩目,相关研究也层出不穷。对于非小细胞肺癌(non-small cell lung cancer,NSCLC)患者来说,近些年来,以程序性死亡受体1(programmed cell death 1,PD-1)/程序性死亡配体1(programmed cell death ligand 1,PD-L1)免疫抑制剂为代表的免疫检查点抑制剂(immunecheckpoint inhibitors,ICIs)已经成为治疗恶性肿瘤的一种最具前景的治疗方案。免疫检查点阻断治疗包括抗细胞毒T淋巴细胞相关抗原4(cytotoxic T lymphocyte-associated antigen 4,CTLA-4)单抗、抗PD-1单抗和抗PD-L1单抗,其中最被人熟知的为PD-L1免疫疗法。目前ICIs在临床治疗中取得了很不错的治疗效果,但有效率较低,因此我们希望获得更高的治疗有效率。近几年外泌体PD-L1在NSCLC免疫治疗中发挥了重要作用。本文就肿瘤外泌体PD-L1蛋白对肿瘤微环境的影响、预测免疫治疗效果以及作为NSCLC免疫治疗的新型治疗策略作一综述。

关键词：外泌体 PD-L1 肺肿瘤免疫治疗

Lactobacillus plantarum AR495 improves stress-induced irritable bowel syndrome in rats by targeting gut microbiota and Mast cell-PAR2-TRPV1 signaling pathway

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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong Zhuan Liao Yangyan Qian Xin song Li Sui Lianzhong Ai Yongjun xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

Analysis of large-scale UAV images using a multi-scale hierarchical representation

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Geo-Spatial Information Science 2018年第1期21卷 33-44页

作者： Huai Yu Jinwang Wang Yu Bai Wen Yang Gui-song xia School of Electronic Information Wuhan UniversityWuhanChina Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhanChina State Key Laboratory for Information Engineering in Surveying Mapping and Remote Sensing(LIESMARS)Wuhan UniversityWuhanChina

Unmanned aerial vehicle(UAV)-based imaging systems have many superiorities compared with other platforms,such as high flexibility and low cost in collecting images,providing wide application ***,the acquisition of the UAV-based image commonly results in very high resolution and very large-scale images,which poses great challenges for subsequent ***,an efficient representation of large-scale UAV images is necessary for the extraction of the required information in a reasonable *** this work,we proposed a multi-scale hierarchical representation,*** partition tree,for analyzing large-scale UAV *** precisely,we first obtained an initial partition of images by an oversegmentation algorithm,*** simple linear iterative ***,we merged the similar superpixels to build an object-based hierarchical structure by fully considering the spectral and spatial information of the superpixels and their topological ***,objects of interest and optimal segmentation were obtained using object-based analysis methods with the hierarchical *** results on processing the post-seismic UAV images of the 2013 Ya’an earthquake and the mosaic of images in the South-west of Munich demonstrate the effectiveness and efficiency of our proposed method.

关键词： Unmanned aerial vehicle(UAV)image binary partition tree(BPT) object-based image analysis(OBIA) hierarchical segmentation object detection

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鄱阳湖南昌湖区典型断面总磷超标成因

中国环境科学 2024年第3期44卷 1436-1447页

作者：朱利英郑利兵王亚炜张洪束礼敏桂双林夏嵩闫冰刘吉宝胡大洲陶茂梁高婕魏源送中国科学院生态环境研究中心环境模拟与污染控制国家重点联合实验室北京100085 中国科学院生态环境研究中心水污染控制实验室北京100085 中国科学院生态环境研究中心环境水质学国家重点实验室北京100085 中国科学院大学北京100049 江西省科学院能源研究所江西南昌330029 南昌市新建生态环境局江西南昌330100 南昌市生态环境监测中心江西南昌330038

以南矶山国家控制断面及其汇入区域为研究对象,通过水环境因子和沉积物现场调查,分析水体TP超标现象,探究其影响因素.结果表明,研究区域表层水TP超标现象主要发生在枯水期和退水期,超标倍数分别为3.06倍和2.78倍;且TP与溶解性有机物(DOM... 详细信息

以南矶山国家控制断面及其汇入区域为研究对象,通过水环境因子和沉积物现场调查,分析水体TP超标现象,探究其影响因素.结果表明,研究区域表层水TP超标现象主要发生在枯水期和退水期,超标倍数分别为3.06倍和2.78倍;且TP与溶解性有机物(DOM)、浊度显著相关.三维荧光光谱(3D-EEM)区域积分法和平行因子分析(PARAFAC)结果发现,该区域水体DOM为3个组分,其中以富里酸等类腐殖质物质(组分C1和C2、分区Ⅲ)为主,主要来源为湿地植物枯落物降解,在枯水期占比最高(55.47%).涨水期受汇入支流及周边碟形湖等外源输入影响,类蛋白质物质(组分C3和分区I)占比升高至35%以上;TP与腐殖质类有机物呈显著正相关(P<0.05),与蛋白质类有机物呈显著负相关(P<0.05),表明TP与腐殖质类有机物具有共源性.TP与浊度呈显著正相关(P<0.05),枯水期水体浊度最高(均值为320.83NTU),该时期南矶山断面汇入支流及碟形湖来水均断流;调研发现表层沉积物底质为粉砂质,以细组分为主,中值粒径DX(50)属于细粉砂质(2~16μm);分选系数范围为2.11~2.75,分选性差;沉积物样品多位于底边悬浮和均匀悬浮搬运区,搬运能力弱;沉积水动力弱,再悬浮后颗粒物不易沉积,造成浊度较高.0~5cm表层沉积物TP平均含量较高(527.89mg/Kg),泥-水界面P向上覆水释放,其中断面的P释放通量最大(0.21mg/(m2·d));表层沉积物是断面水体TP浓度的重要影响因素之一.

关键词：鄱阳湖表层水溶解性有机物沉积物粒径参数

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具有多个时滞的积分时滞系统的稳定性分析

控制与决策 2023年第2期38卷 562-568页

作者：宋云霞周彬哈尔滨工业大学航天学院哈尔滨150001

首先,针对具有多个时滞的积分时滞系统,建立新的基于线性矩阵不等式的稳定性条件.该条件与正整数k有关,给出k=1时该条件与现有结果间的关系.该关系表明所提出条件在k?2时的保守性比现有结果小;然后,基于所提出的稳定性条件,进一步研究... 详细信息

首先,针对具有多个时滞的积分时滞系统,建立新的基于线性矩阵不等式的稳定性条件.该条件与正整数k有关,给出k=1时该条件与现有结果间的关系.该关系表明所提出条件在k?2时的保守性比现有结果小;然后,基于所提出的稳定性条件,进一步研究具有参数不确定性的积分时滞系统的鲁棒稳定性问题,建立基于线性矩阵不等式的充分条件;最后,利用所提出方法,研究具有多个离散时滞和分布时滞的积分时滞系统的稳定性问题.数值算例结果表明了所提出稳定性判据的有效性.

关键词：积分时滞系统稳定性鲁棒稳定性线性矩阵不等式

Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： song Yun HE Ying LU Xue Xin ZHANG xiao Mei JIANG xiaO Lin song Qing HUANG Xue Yong MA Hong xia YU Peng Cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

Deep-learning-empowered synthetic dimension dynamics:morphing of light into topological modes

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Advanced Photonics 2024年第2期6卷 61-68页

作者： Shiqi xia Sihong Lei Daohong song Luigi Di Lauro Imtiaz Alamgir Liqin Tang Jingjun Xu Roberto Morandotti Hrvoje Buljan Zhigang Chen Nankai University TEDA Institute of Applied PhysicsSchool of PhysicsThe MOE Key Laboratory of Weak-Light Nonlinear PhotonicsTianjinChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina INRS-EMT VarennesQuebecCanada University of Zagreb Department of PhysicsFaculty of ScienceZagrebCroatia

Synthetic dimensions(SDs)opened the door for exploring previously inaccessible phenomena in high-dimensional ***,construction of synthetic lattices with desired coupling properties is a challenging and unintuitive ***,we use deep learning artificial neural networks(ANNs)to construct lattices in real space with a predesigned spectrum of mode eigenvalues,and thus to validly design the dynamics in synthetic mode *** employing judiciously chosen perturbations(wiggling of waveguides at desired frequencies),we show resonant mode coupling and tailored dynamics in *** distinct examples are illustrated:one features uniform synthetic mode coupling,and the other showcases the edge defects that allow for tailored light transport and ***,we demonstrate morphing of light into a topologically protected edge mode with modified Su-Schrieffer-Heeger photonic *** an ANN-assisted construction of SDs may advance toward“utopian networks,”opening new avenues for fundamental research beyond geometric limitations as well as for applications in mode lasing,optical switching,and communication technologies.

关键词： synthetic dimensions deep learning mode manipulation topological mode morphing photonic lattices

Fe_(2)Mn(μ_(3)-O)(COO)_(6) Cluster Based Stable MOF for Oxidative Coupling of Amines via Heterometallic Synergy

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Chinese Journal of Chemistry 2021年第11期39卷 2983-2989页

作者： Ying-xia Wang Hui-Min Wang Pan Meng Dong-xia song Zhikai Qi xian-Ming Zhang Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education) Institute of Chemistry and CultureSchool of Chemistry and Material ScienceShanxi Normal UniversityLinfenShanxi041004 China College of Chemistry&Chemical Engineering Key Laboratory of Interface Science and Engineering in Advanced MaterialMinistry of EducationTaiyuan University of TechnologyNo.79 Yingze WestTaiyuanShanxi030024 China

The direct catalytic oxidative coupling of amines is one of the attracting methods for the synthesis of a variety of pharmaceutical or industrial needed *** earth-abundant manganese based salts,oxides,and complexes have been applied in this ***,these compounds suffered from difficult separation,large catalyst loading,complicated reactivation or indeterminate *** the facts that metal-organic frameworks(MOFs)with crystalline structure,precise composition,and enormous surface area have superior performance in heterogeneous catalytic reactions,herein,we introduced Mn into[Fe_(3)(μ_(3)-O)(CH_(3)COO)_(6)],one of the precursors for the preparation of stable MOFs,and got[Fe_(2)Mn(μ_(3)-O)(CH_(3)COO)_(6)]*** ligand replacement with biphenyl-3,4’,5-tricarboxylic acid(BPTC),heterometallic cluster-based[Fe_(2)Mn(μ_(3)-O)(BPTC)2(DMF)2(H_(2)O)](1)was *** expected,1 is stable and able to catalyze the homo-or cross-coupling of amines effectively and selectively with 0.9 mol%catalyst loading at room *** experiments indicated that the catalytic activity of 1 mainly stems from Mn sites and that Fe synergistically contributes to the ***,1 is recyclable and can be reused easily for at least 8 runs without obvious decrease in catalytic *** our knowledge,1 should be the first heterometallic cluster-based MOF with defined structure suitable for the synthesis of diverse imines from oxidative coupling of amines under mild conditions,which may shed light on the easy preparation of effective heterogeneous catalysts for organic synthesis.

关键词： Amines Metal-organic frameworks Manganese Oxidative coupling Heterometallic synergy