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Risk assessment,fitness cost,cross-resistance,and mechanism of tetraniliprole resistance in the rice stem borer,Chilo suppressalis

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Insect Science 2024年第3期31卷 835-846页

作者： Hao Sun Shuai Wang Chong Liu Wen-Kai Hu Jin-Wei Liu Ling-Jun Zheng Meng-Yue Gao Fang-Rui Guo song-Tao qiao Jun-Li Liu Bo Sun Cong-Fen Gao Shun-Fan Wu College of Plant Protection Nanjing Agricultural UniversityState&Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjingChina Bayer Cropscience(China)Co. Ltd.HangzhouChina

The rice stem borer(RSB),Chilo suppressalis,a notorious rice pest in China,has evolved a high resistance level to commonly used insecticides.Tetraniliprole,a new anthranilic diamide insecticide,effectively controls multiple pests,including RSB.However,the potential resistance risk of RSB to tetraniliprole is still unknown.In this study,the tetraniliprole-selection(Tet-R)strain was obtained through 10 continuous generations of selection with tetraniliprole 30%lethal concentration(LC_(30)).The realized heritability(h^(2))of the Tet-R strain was 0.387,indicating that resistance of RSB to tetraniliprole developed rapidly under the continuous selection of tetraniliprole.The Tet-R strain had a high fitness cost(relative fitness=0.53).We established the susceptibility baseline of RSB to tetraniliprole(lethal concentration at LC_(50)=0.727 mg/L)and investigated the resistance level of 6 field populations to tetraniliprole.All tested strains that had resistance to chlorantraniliprole exhibited moderate-to high-level resistance to tetraniliprole(resistance ratio=27.7-806.8).Detection of ryanodine receptor(RyR)mutations showed that the Y4667C,Y4667D,I4758M,and Y4891F mutations were present in tested RSB field populations.RyR mutations were responsible for the cross-resistance between tetraniliprole and chlorantraniliprole.Further,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-mediated genome-modified flies were used to study the contribution of RyR mutations to tetraniliprole resistance.The order of contribution of a single RyR mutation to tetraniliprole resistance was Y4667D>G4915E>Y4667C~~I4758M>Y4891F.In addition,the I4758M and Y4667C double mutations conferred higher tetraniliprole resistance than single Y4667C mutations.These results can guide resistance management practices for diamides in RSB and other arthropods.

关键词： Chilo suppressalis diamide resistance fitness cost cross-resistance RyR target-site mutations

Efficacy and Safety of Iron Isomaltoside Compared with an Oral Iron Supplement in the Management of Patients with Iron Deficiency Anemia

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Open Journal of Blood Diseases 2024年第1期14卷 17-30页

作者： Zhimin Wu Chunxiao Zhou Chunyan Wu qiao song Shilyu Chen Wen Zhang Shaoling Wu Department of Medicine Qingdao University Qingdao China Department of Hematology The Affiliated Hospital of Qingdao University Qingdao China

Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.

关键词： Anemia Iron-Deficiency Drug Therapy Iron Isomaltoside 1000 Treatment Outcome

Chromospheric oscillations observed with BBSO and TRACE

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1718-1722页

作者： song qiao ZHANG Jun Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China

We examine chromospheric oscillations in both a coronal hole (CH) and a quiet Sun (QS) region, by employing Transition Region and Coronal Explorer (TRACE) and Big Bear Solar Observatory (BBSO) data on September 14 and 16, 2004. For the CH, the average oscillation periods of network magnetic field and non-magnetic field (NMF) regions are 257 and 222 s, respectively, and the average period of network field is longer than that of NMF region by 15.8%. In the QS, the average oscillation period is the 225 s for network field and 212 s for the NMF region. The average period of the network field is also longer than that of the NMF region by 6.1%. For the network region, we find that the average period in the CH is longer than that in the QS by 14.2%. This difference between CH and QS is possibly caused by different magnetic configurations i.e. the open magnetic field in the CH and the close field in the QS.

关键词： chromosphere oscillations UV radiation magnetic fields quiet Sun coronal hole

IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression

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Biomedical and Environmental Sciences 2022年第11期35卷 981-991页

作者： HOU Yu Li WANG Yi Fei song qiao ZHANG Xiao Min LIU Jing WANG Ya Qi CUI Yu Ting FU Jing Xuan FENG Zi Yi ZHANG Chi WANG Pei Chang Department of Clinical Laboratory Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijing 100053China Clinical Laboratory Diagnostics Capital Medical UniversityBeijing 100053China

Objective The individual cascades of the insulin-like growth factor-1(IGF-1)signaling pathway and the molecular mechanism of aging have not been fully clarified.In the current study,we explored the effect of DNA polymerase delta 1(POLD1)on the IGF-1 signaling pathway in cell aging.Methods First,we analyzed the relationship between IGF-1 and POLD1 expression in aging.To investigate the effect of IGF-1 on POLD1 expression and aging,the 2BS cells were incubated with youngage or old-age human serum,IGF-1 protein,or linsitinib.Next,the effect of IGF-1 on aging was examined in the 2BS cells with increased or decreased POLD1 expression to clarify the molecular mechanism.Results In this study,we found that IGF-1 expression increased and POLD1 expression decreased with aging in human serum and hippocampal tissues of SAMP8 mice,and a negative relationship between IGF-1 and POLD1 expression was observed.Furthermore,the cells cultured with old-age human serum or IGF-1 showed lower POLD1 expression and more pronounced senescence characteristics,and the effect could be reversed by treatment with linsitinib or overexpression of POLD1,while the effect of linsitinib on cell aging could be reversed with the knockdown of POLD1.Conclusion Taken collectively,our findings demonstrate that IGF-1 promotes aging by binding to IGF-1R and inhibiting the expression of POLD1.These findings offer a new target for anti-aging strategies.

关键词： Insulin-like growth factor-1 DNA polymerase delta 1 Aging Linsitinib

中国电视剧在“一带一路”国家的地缘传播实践与调适

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编辑之友 2024年第1期32卷 84-91页

作者：刘振东宋巧丽河北大学燕赵文化高等研究院河北保定071002 河北大学管理学院河北保定071002 河北大学新闻传播学院河北保定071002

地缘文化背后潜藏着对于国家观念、价值与信仰体系建构的重要作用。文章从中国电视剧国际传播的文化实践与空间表征出发,结合“一带一路”沿线十国问卷调查,发现其传播现状具有趋同地缘推移的网络传播力度、各国观看体验的圈层集中趋势... 详细信息

地缘文化背后潜藏着对于国家观念、价值与信仰体系建构的重要作用。文章从中国电视剧国际传播的文化实践与空间表征出发,结合“一带一路”沿线十国问卷调查,发现其传播现状具有趋同地缘推移的网络传播力度、各国观看体验的圈层集中趋势、超越国家界限的内凝文化价值、诉诸文化审美成效的实践调整、指向动态外交的地缘文化表征等特点。中国影视作品内蕴的传统文化吸引力,是其展开地缘传播的优势所在,对此,未来中国电视剧创作应把握地缘空间形态展示的渐次推进观念,在实践调适中深耕中国传统文化内核及其外延符号,如饮食文化、传统节日、中式建筑等,实现主题选择、叙事场景、审美升维、地缘传播等层面的内涵创新。

关键词：中国电视剧地缘文化国际传播 “一带一路”

血根碱对腰椎间盘突出症大鼠炎性疼痛的改善作用及机制

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中国药房 2024年第9期35卷 1087-1093页

作者：阮祯何生华龚雪花乔松王超武汉市中医医院推拿科武汉430000 武汉市第七医院中南路街第一社区卫生服务中心武汉430060 湖北省中西医结合医院康复医学中心推拿科武汉430010

目的研究血根碱(SG)对腰椎间盘突出症(LDH)大鼠炎性疼痛的改善作用及机制。方法制备LDH模型大鼠,然后分为模型组和SG低、中、高剂量组(1.00、2.50、6.25 mg/kg)以及SG高剂量+Anisomycin[丝裂原活化蛋白激酶(MAPK)激活剂]组(6.25 mg/kg S... 详细信息

目的研究血根碱(SG)对腰椎间盘突出症(LDH)大鼠炎性疼痛的改善作用及机制。方法制备LDH模型大鼠,然后分为模型组和SG低、中、高剂量组(1.00、2.50、6.25 mg/kg)以及SG高剂量+Anisomycin[丝裂原活化蛋白激酶(MAPK)激活剂]组(6.25 mg/kg SG+5 mg/kg Anisomycin),每组10只;另取10只大鼠作为对照组。各组大鼠腹腔注射相应药物,对照组和模型组大鼠腹腔注射等体积生理盐水,每天1次,连续7 d。观察大鼠一般情况及神经功能变化;测定大鼠疼痛阈值[包括机械刺激缩足反射阈值(PWMT)和热刺激缩足反射潜伏期(PWTL)];观察大鼠背根神经节(DRG)组织病理变化;检测大鼠血清中炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)]和疼痛因子[神经肽Y(NPY)、5羟色胺(5-HT)]水平;观察脊髓小胶质细胞中离子钙接头蛋白1(Iba-1)和星形胶质细胞中胶质原纤维酸性蛋白(GFAP)的阳性表达;检测大鼠DRG组织中MAPK/胞外信号调节激酶(ERK)/核因子κB(NF-κB)信号通路相关蛋白和TNF-α、IL-1β蛋白的表达。结果与对照组相比,模型组大鼠精神食欲不振,后肢运动障碍,DRG椎间盘神经元细胞排列紊乱;神经功能评分,血清中TNF-α、IL-1β、NPY水平,Iba-1、GFAP阳性表达,DRG组织中p38 MAPK、ERK1/2、NF-κB p65蛋白磷酸化水平和TNF-α、IL-1β蛋白表达水平均显著升高(P<0.05);PWMT、PWTL和血清中5-HT水平均显著降低(P<0.05)。与模型组相比,SG各剂量组大鼠精神食欲好转,后肢运动障碍缓解,DRG椎间盘神经元结构改善,上述定量指标水平均显著逆转(P<0.05)。Anisomycin可逆转SG对LDH大鼠炎性疼痛的改善作用。结论SG可通过抑制LDH大鼠DRG组织中小胶质细胞活化,减少炎症因子释放,提高疼痛阈值,从而改善炎性疼痛;其作用机制可能与抑制MAPK/ERK/NF-κB信号通路有关。

关键词：血根碱腰椎间盘突出症炎性疼痛 MAPK/ERK/NF-κB信号通路

橄榄苦苷调节Hippo-YAP/TAZ信号通路对膝骨关节炎大鼠滑膜炎症的影响

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中国骨质疏松杂志 2024年第4期30卷 546-551页

作者：乔松何生华陈忠辉胡冲胡艳平武汉市中医医院推拿科湖北武汉430000 新疆博乐市维吾尔医医院名医堂新疆博乐833499 五峰土家族自治县人民医院康复医学科湖北宜昌443400

目的探讨橄榄苦苷(OL)通过调节Yes相关蛋白(YAP)/转录共激活因子PDZ结合基序(TAZ)信号通路对膝骨关节炎(KOA)大鼠滑膜炎症的影响。方法采用改良的Hulth法构建KOA大鼠模型,并随机分为Model组、低剂量OL组(20 mg/kg)、高剂量OL组(40 mg/kg... 详细信息

目的探讨橄榄苦苷(OL)通过调节Yes相关蛋白(YAP)/转录共激活因子PDZ结合基序(TAZ)信号通路对膝骨关节炎(KOA)大鼠滑膜炎症的影响。方法采用改良的Hulth法构建KOA大鼠模型,并随机分为Model组、低剂量OL组(20 mg/kg)、高剂量OL组(40 mg/kg)、高剂量OL+VT103组(40 mg/kg+10 mg/kg YAP/TAZ抑制剂),每组12只,另取12只大鼠作为正常对照组(NC组)。观察各组大鼠的情况,Lequesne MG评分对各组大鼠行为学进行评估;ELISA试剂盒检测大鼠血清中肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的表达;苏木精-伊红(HE)染色检测大鼠滑膜组织的病理损伤;qRT-PCR法检测滑膜组织中YAP和TAZ mRNA的表达;Western blot检测大鼠滑膜组织中YAP、磷酸化YAP(p-YAP)、磷酸化TAZ(p-TAZ)、TAZ、B细胞淋巴瘤/白血病-2相关X蛋白(Bax)蛋白表达。结果与NC组比较,Model组大鼠Lequesne MG评分升高、血清中TNF-α和IL-6的表达增加、YAP和TAZ mRNA表达增加、p-YAP/YAP、p-TAZ/TAZ、Bax蛋白表达升高(P<0.05);与Model组比较,低剂量、高剂量OL组大鼠Lequesne MG评分降低、血清中TNF-α和IL-6的表达减少、YAP和TAZ mRNA表达减少、p-YAP/YAP、p-TAZ/TAZ、Bax蛋白表达降低(P<0.05);VT103可明显减弱OL对KOA大鼠滑膜组织的保护作用(P<0.05)。结论OL可能通过激活YAP/TAZ信号通路减轻膝骨关节炎大鼠滑膜炎症。

关键词：橄榄苦苷 Yes相关蛋白转录共激活因子PDZ结合基序膝骨关节炎滑膜炎症

基于经验似然方法对分位数相关系数的区间估计

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高校应用数学学报（A辑） 2024年第1期39卷 1-12页

作者：唐松乔李康强李翔张立新浙江大学数学科学学院浙江杭州310058

分位数相关系数是一种度量两个随机变量之间线性相关关系的非对称相关系数,在统计,金融,化学等领域的特征选择问题中都扮演着重要的作用.同时,经验似然作为一种非参数方法,被广泛应用于各类模型的统计推断问题.对于任意两个随机变量,从... 详细信息

分位数相关系数是一种度量两个随机变量之间线性相关关系的非对称相关系数,在统计,金融,化学等领域的特征选择问题中都扮演着重要的作用.同时,经验似然作为一种非参数方法,被广泛应用于各类模型的统计推断问题.对于任意两个随机变量,从分位数相关系数的定义出发,建立估计方程,引入代入经验似然方法(PEL)和其修正版本(APEL),分别得到渐近规则化的卡方分布和标准卡方分布,从而得到分位数相关系数的区间估计.数值模拟部分从覆盖概率,置信区间长度和基于区间得分的平均损失三方面比较了两种基于经验似然的方法同其他已有方法的效果.实证分析部分将提出的方法应用于一项来自福布斯排行榜的数据集.

关键词：分位数相关系数经验似然区间估计

A heterozygous mutation in GJA1 gene in Chinese family with serious erythrokeratodermia variabilis et progressive

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Chinese Medical Journal 2019年第1期132卷 86-88页

作者： Bi-Rong Guo Hai-Bin Cai Wen-Kai Zong Cong-Sheng Li Li-Zhong Liu song qiao Qi-Ming Zhu Ming Li Department of Dermatology Third Affiliated Hospital of Anhui Medical UniversityFirst People's Hospital of HefeiHefeiAnhui 230061China Department of Dermatology People's Hospital of Pudong New AreaShanghai 201200China Department of Dermatology Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Emergency Third Affiliated Hospital of Anhui Medical UniversityFirst People's Hospital of HefeiHefeiAnhui 230061China Department of Dermatology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

To the Editor:Erythrokeratodermia variabilis (EKV;MIM 133200) is characterized by the coexistence of transient,figurate,erythematous patches,and localized keratotic hyperkeratosis.EKV shows marked phenotypic heterogeneity,even within kindreds bearing the same diseasecausing mutation.[1] The term EKV et progressiva (EKVP) is a severe variant of EKV and has been proposed to encompass the diversity of phenotypes,ranging from limited hyperkeratotic plaques and erythematous patches to severe progressive symmetric erythrokeratodermia which can feature more generalized cutaneous involvement.

关键词： Erythema dermatitis Erythrokeratodermia variabilis (EKV MIM 133200) The term EKV et progressiva (EKVP)