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Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

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Nano-Micro Letters 2022年第6期14卷 248-281页

作者： Arpana Parihar Ayushi singhal Neeraj Kumar Raju Khan MohdAkram Khan Avanish KSrivastava Industrial Waste Utilization Nano and BiomaterialsCSIR-Advanced Materials and Processes Research Institute(AMPRI)Hoshangabad RoadBhopal 462026MPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of ***,2 D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of *** high surface area,surface functional groups availability,and excellent electrical conductivity of MXene make it the 2 D material of choice for the fabrication of advanced electrochemical biosensors for disease ***-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of ***,the stability,ease of synthesis,good reproducibility,and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic *** this review,the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been ***,various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been ***,futuristic sensing applications along with challenges will be deliberated herein.

关键词： MXene Electrochemical devices POCT Aptamer Cancer diagnostics

Fault Coverage-Based Test Case Prioritization and Selection Using African Buffalo Optimization

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Computers, Materials & Continua 2023年第3期74卷 6755-6774页

作者： Shweta singhal Nishtha Jatana Ahmad F Subahi Charu Gupta Osamah Ibrahim Khalaf Youseef Alotaibi Indira Gandhi Delhi Technical University for Women Delhi110006India Maharaja Surajmal Institute of Technology New Delhi110058India Department of Computer Science University College of Al JamoumUmm Al-Qura UniversityMakkah21421Saudi Arabia Bhagwan Parshuram Institute of Technology RohiniNew Delhi110085India Al-Nahrain University Al-Nahrain Nanorenewable Energy Research CenterBaghdad64074Iraq Department of Computer Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkah21955Saudi Arabia

Software needs modifications and requires revisions *** to these revisions,retesting software becomes essential to ensure that the enhancements made,have not affected its bug-free *** time and cost incurred in this process,need to be reduced by the method of test case selection and *** is observed that many nature-inspired techniques are applied in this *** Buffalo Optimization is one such approach,applied to regression test selection and *** this paper,the proposed work explains and proves the applicability of the African Buffalo Optimization approach to test case selection and *** proposed algorithm converges in polynomial time(O(n^(2))).In this paper,the empirical evaluation of applying African Buffalo Optimization for test case prioritization is done on sample data set with multiple *** astounding 62.5%drop in size and a 48.57%drop in the runtime of the original test suite were *** obtained results are compared with Ant Colony *** comparative analysis indicates that African Buffalo Optimization and Ant Colony Optimization exhibit similar fault detection capabilities(80%),and a reduction in the overall execution time and size of the resultant test *** results and analysis,hence,advocate and encourages the use of African Buffalo Optimization in the area of test case selection and prioritization.

关键词： Test case prioritization regression testing test case selection African buffalo optimization nature-inspired meta-heuristic

Autism Spectrum Disorder Prediction by an Explainable Deep Learning Approach

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Computers, Materials & Continua 2022年第4期71卷 1459-1471页

作者： Anupam Garg Anshu Parashar Dipto Barman Sahil Jain Divya singhal Mehedi Masud Mohamed Abouhawwash Computer Science and Engineering Department Thapar Institute of Engineering and TechnologyPatialaIndia School of Computer Science and Statistics Trinity College DublinDublinIreland University Institute of Biotechnology Chandigarh UniversityMohaliIndia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Autism Spectrum Disorder (ASD) is a developmental disorderwhose symptoms become noticeable in early years of the age though it canbe present in any age group. ASD is a mental disorder which affects the communicational, social and non-verbal behaviors. It cannot be cured completelybut can be reduced if detected early. An early diagnosis is hampered by thevariation and severity of ASD symptoms as well as having symptoms commonly seen in other mental disorders as well. Nowadays, with the emergenceof deep learning approaches in various fields, medical experts can be assistedin early diagnosis of ASD. It is very difficult for a practitioner to identifyand concentrate on the major feature’s leading to the accurate prediction ofthe ASD and this arises the need for having an automated approach. Also,presence of different symptoms of ASD traits amongst toddlers directs tothe creation of a large feature dataset. In this study, we propose a hybridapproach comprising of both, deep learning and Explainable Artificial Intelligence (XAI) to find the most contributing features for the early and preciseprediction of ASD. The proposed framework gives more accurate predictionalong with the recommendations of predicted results which will be a vital aidclinically for better and early prediction of ASD traits amongst toddlers.

关键词： Deep learning explainable artificial intelligence autism spectrum disorder machine learning

Intelligent System Application to Monitor the Smart City Building Lighting

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Computers, Materials & Continua 2023年第5期75卷 3159-3169页

作者： Tzu-Chia Chen Ngakan Ketut Acwin Dwijendra Saurabh singhal R.Sivaraman Amr Mamdouh Department of Industrial Engineering and Management Ming Chi University of TechnologyNew Taipei City24301Taiwan Department of Architecture Faculty of EngineeringUdayana UniversityBali80361Indonesia Department of Computer Engineering and Applications GLA UniversityMathuraUttar PradeshIndia Department of Mathematics Dwaraka Doss Goverdhan Doss Vaishnav CollegeArumbakkamUniversity of MadrasChennaiIndia Architectural Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egyp

A smart city incorporates infrastructure methods that are environmentally responsible,such as smart communications,smart grids,smart energy,and smart *** city administration has prioritized the use of cutting-edge technology and informatics as the primary strategy for enhancing service quality,with energy resources taking *** achieve optimal energy management in themultidimensional system of a city tribe,it is necessary not only to identify and study the vast majority of energy elements,but also to define their implicit *** is because optimal energy management is required to reach this *** lighting index is an essential consideration when evaluating the comfort *** order to realize the concept of a smart city,the primary objective of this research is to create a system for managing and monitoring the lighting *** is possible to identify two distinct phaseswithin the intelligent *** data collection concludes,the monitoring system will be *** the second step,the operation of the control system is analyzed and its effect on the performance of the numerical model is *** evaluation is based on the proposed *** optimized resultswere deemed satisfactory because they maintained the brightness index value(79%)while consuming less *** intelligent implementation system generated satisfactory outcomes,which were observed 1.75 times on average.

关键词： Smart city lighting index residential building energy consumption

Pulsed electrolysis of carbon dioxide by large-scale solid oxide electrolytic cells for intermittent renewable energy storage

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Carbon Energy 2023年第4期5卷 2-12页

作者： Anqi Wu Chaolei Li Beibei Han Wu Liu Yang Zhang Svenja Hanson Wanbing Guan Subhash C.singhal Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Faculty of Science and Engineering University of Nottingham Ningbo ChinaNingboZhejiangChina

CO_(2) electrolysis with solid oxide electrolytic cells(SOECs)using intermittently available renewable energy has potential applications for carbon neutrality and energy *** this study,a pulsed current strategy is used to replicate intermittent energy availability,and the stability and conversion rate of the cyclic operation by a large-scale flat-tube SOEC are *** hundred cycles under pulsed current ranging from -100 to -300 mA/cm^(2) with a total operating time of about 800 h were carried *** results show that after 100 cycles,the cell voltage attenuates by 0.041%/cycle in the high current stage of−300 mA/cm^(2),indicating that the lifetime of the cell can reach up to about 500 *** total CO_(2) conversion rate reached 52%,which is close to the theoretical value of 54.3% at -300 mA/cm^(2),and the calculated efficiency approached 98.2%,assuming heat *** study illustrates the significant advantages of SOEC in efficient electrochemical energy conversion,carbon emission mitigation,and seasonal energy storage.

关键词： carbon dioxide cyclic electrolysis pulse current solid oxide electrolytic cells

Secure Watermarking Scheme for Color DICOM Images in Telemedicine Applications

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Computers, Materials & Continua 2022年第2期70卷 2525-2542页

作者： Kamred Udham Singh Hatem Salem Abu-Hamatta Abhishek Kumar Achintya singhal Mamoon Rashid A.K.Bashir Department of Computer Science and Information Engineering National Cheng Kung UniversityTainanTaiwan Department of Applied Sciences Aqaba University CollegeAl Balqa Applied UniversityAqabaJordan School of Computer Science&IT JAIN(to be Deemed University)BangaloreIndia Department of Computer Science Banaras Hindu UniversityVaranasiIndia Department of Computer Engineering Faculty of Science and TechnologyVishwakarma UniversityPune411048India Department of Computing and Mathematics ManchesterMetropolitan UniversityUK

Teleradiology plays a vital role in the medical field,which permits transmitting medical and imaging data over a communication *** ensures data reliability and provides convenient communication for clinical interpretation and diagnostic *** transmission of this medical data over a network raises the problems of legal,ethical issues,privacy,and copyright *** copyright protection of medical images is a significant issue in the medical *** schemes are used to address these issues.A gray-level or binary image is used as a watermark frequently in color image watermarking *** this paper,the authors propose a novel non-blind medical image watermarking scheme based on 2-D LiftingWavelet Transform(LWT),Multiresolution Singular Value Decomposition(MSVD),and LU factorization to improve the robustness and authenticity of medical *** this scheme,multiple color watermarks are embedded into the colored DICOM(Digital Imaging and Communications inMedicine)images obtained from Color Doppler images(DICOM format),and the average results achieved by our proposed scheme is 46.84 db for Peak Signal-to-Noise Ratio(PSNR),37.46 db for Signal-to-Noise Ratio(SNR),0.99 for Quality of Image and 0.998 for Normalized Correlation for various image processing *** results make our watermarking technique an ideal candidate for medical image watermarking.

关键词： Digital imaging medicine multiresolution medical image watermarking

Countermeasures for local scour at offshore wind turbine monopile foundations:A review

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Water Science and Engineering 2022年第1期15卷 15-28页

作者： Zi-hao Tang Bruce Melville Naresh singhal Asaad Shamseldin Jin-hai Zheng Da-wei Guan Liang Cheng Department of Civil and Environmental Engineering The University of AucklandAuckland 1010New Zealand State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China

Local scour at monopile foundations of offshore wind turbines is one of the most critical structural stability *** article reviews the contemporary methods of scour countermeasures at monopile *** methods include armouring countermeasures(e.g.,riprap protection)to enhance the anti-scour ability of the bed materials and flow-altering countermeasures(e.g.,collars and sacrificial piles)to reduce downflow or change flow patterns around the *** number and size-selection equations for riprap armour layers are summarised and ***,other alternative methods to riprap are briefly introduced and presented.A typical graph of the scour depth reduction with different collar sizes and elevations under specific test conditions is summarised and compared with a plot for a pile founded on a *** rates for different flow-altering countermeasures,including the collar,are listed and compared.A newly developed soil improvement method,namely microbially induced calcite precipitation(MICP),is also reviewed and introduced as a scour protection *** a popular bio-soil treatment method,MICP has a good potential as a scour countermeasure ***-soil treatment methods and traditional armouring methods are defined as active and passive soil enhancement scour countermeasures,respectively.

关键词： Wind turbine foundation Scour countermeasures Armouring countermeasures Flow-altering countermeasures MICP method

Regression analysis and features of negative activation energy for MHD nanofluid flow model:A comparative study

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Propulsion and Power Research 2023年第2期12卷 273-283页

作者： B.Kumara Prachi Abhinav singhal R.Nandkeolyar Pulkit Kumar Ali J.Chamkha School of Mathematics Thapar Institute of Engineering and TechnologyPatiala 147004PunjabIndia Department of Applied Sciences and Humanities RITRoorkee 247667India School of Sciences Christ(Deemed to be University)Delhi NCR 201003India Department of Mathematics National Institute of TechnologyJamshedpur 831014India Department of Applied Mechanics Indian Institute of TechnologyDelhi 110016India Faculty of Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait

This article elucidates the impact of activation energy on magnetohydrodynamic(MHD)stagnation point nanofluid flow over a slippery surface in a porous regime with thermophoretic and Brownian *** activation energy is scarce in practice,but the impact of negative activation energy could not be neglected as it is noticed in chemical *** rate of some Arrhenius-compliant reactions is retarded by increasing the temperature and is therefore associated with negative activation energies,such as exothermic binding of urea or *** some processes,the temperature dependence of the pressure-induced unfolding and the urea-induced unfolding of proteins at ambient pressure give negative activation *** present mathematical model is solved with successive linearization method(a spectral technique).A comparison of results is made for negative and positive values of activation *** from it,the quadratic multiple regression model is discussed briefly and explained with bar *** is observed that with rise in unsteadiness parameter from 0 to 1(taking positive activation energy),skin friction and Sherwood number are increased by 9.36%and 19%respectively,and Nusselt number is decreased by 26%.However,for negative activation energy,9.36%and 112%enhancement is observed in skin friction and Sherwood number,respectively.

关键词： Negative activation energy Regression analysis Successive linearization method Porous medium

Emerging role of computed tomography coronary angiography in evaluation of children with Kawasaki disease

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World Journal of Clinical Pediatrics 2023年第3期12卷 97-106页

作者： Manphool singhal Rakesh Kumar Pilania Pankaj Gupta Nameirakpam Johnson Surjit Singh Departments of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012ChandigarhIndia Pediatric Allergy Immunology Unit Department of PaediatricsAdvanced Pediatrics CenterPostgraduate Institute of Medical Education and ResearchChandigarh 160012ChandigarhIndia

Coronary artery abnormalities are the most important complications in children with Kawasaki disease(KD).Two-dimensional transthoracic echocardiography currently is the standard of care for initial evaluation and follow-up of children with ***,it has inherent limitations with regard to evaluation of mid and distal coronary arteries and,left circumflex artery and the poor acoustic window in older children often makes evaluation difficult in this age *** angiography(CA)is invasive,has high radiation exposure and fails to demonstrate abnormalities beyond *** limitations of echocardiography and CA necessitate the use of an imaging modality that overcomes these *** recent years advances in computed tomography technology have enabled explicit evaluation of coronary arteries along their entire course including major branches with optimal and acceptable radiation exposure in *** tomography coronary angiography(CTCA)can be performed during acute as well as convalescent phases of *** is likely that CTCA may soon be considered the reference standard imaging modality for evaluation of coronary arteries in children with KD.

关键词： Coronary artery abnormalities Computed tomography coronary angiography 2D-echocardiography Kawasaki disease Imaging modality Acquired heart disease