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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 25-26页

作者： Kawakami T. soma y. Kawasaki K. 王琼 Dr.Department of Dermatology St. Marianna University School of Medicine 2-16-1 Sugao Kawasaki Kanagawa 216-8511 Japan

Background: Churg-Strauss sy.drome (CSS), also known as allergic granulomatous angiitis, is a rare entity.that is characterized by.sy.temic vasculitis in patients with a history.of asthma. Patients with CSS show a marked peripheral blood eosinophilia, but the pathogenesis remains unknown. Observations: A retrospective review was performed in 9 cases of CSS in whom cutaneous findings were present as an initial manifestation. All 9 patients had purpura and petechiae as well as severe pain and paresthesias of the lower extremities. Four patients (44%) used leukotriene receptor antagonists to treat their asthma, and 3 (75%) of them developed CSS within 3 months. Five patients (56%) were positive for perinuclear antineutrophil cy.oplasmic antibodies before therapy. but in all 5 the levels of perinuclear antineutrophil cy.oplasmic antibody.normalized. Serum IgE levels were elevated in all patients before treatment but decreased after treatment. Histologically. all patients demonstrated leukocy.oclastic vasculitis and eosinophilic infiltration. Eight biopsy.specimens (73%) revealed marked eosinophilia around the nerve fibers in the dermis. Palisading granulomas in association with vessel-based changes were present in 4 (36%) of 11 biopsy.specimens. Conclusions: These characteristic cutaneous clinical patterns that are consistent with the presence of mononeuropathy.multiplexes in the lower extremities may.help phy.icians establish an earlier diagnosis. Both eosinophils and IgE, as well as perinuclear antineutrophil cy.oplasmic antibodies to some degree, likely.participate in skin lesion development in CSS. Furthermore, there appears to be a correlation between treatment with leukotriene receptor antagonists and the onset of CSS in some cases.

关键词： Strauss 皮肤症状栅栏状肉芽肿系统性血管炎血嗜酸性粒细胞初发症状哮喘病史组织学检查感觉异常活检标本

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对于特应性干性皮肤局部使用烟酰胺后引起皮肤水分增加效应

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 50-51页

作者： soma y. Kashima M. Imaizumi A. 惠海英 Department of Dermatology St. Marianna Univ. Sch. of Medicine2-16-1SugaoMiyamae-kuKawasaki216- 8511 Japan Dr.

Background: Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry.skin is unknown. We examined the effect of topical nicotinamide on atopic dry.skin and compared the results with the effect of white petrolatum in a left-right comparison study. Methods: Twenty.eight patients with atopic dermatitis, with sy.metrical lesions of dry.skin on both forearms, were enrolled, and were instructed to apply.nicotinamide cream containing 2% nicotinamide on the left forearm and white petrolatum on the right forearm, twice daily.over a 4- or 8- week treatment period. Transepidermal water loss and stratum corneum hy.ration were measured by.instrumental devices. The amount of the stratum corneum exfoliated by.tape stripping (desquamation index) was determined by.an image analy.er. Results: Nicotinamide significantly.decreased transepidermal water loss, but white petrolatum did not show any.significant effect. Both nicotinamide and white petrolatum increased stratum corneum hy.ration, but nicotinamide was significantly.more effective than white petrolatum. The desquamation index was positively.correlated with stratum corneum hy.ration at baseline and gradually.increased in the nicotinamide group, but not in the white petrolatum group. Conclusions: Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry.skin, and may.be used as a treatment adjunct in atopic dermatitis.

关键词：干性皮肤特应性烟酰胺白凡士林右前臂水合作用增湿剂左前臂胶带粘贴法丢失率

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特应性皮炎病情进展引发获得性对称性皮肤黑素细胞增生症(霍利痣)发展

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 17-18页

作者： Murakami F. soma y. Mizoguchi M. 李政霄 Dr. Department of Dermatology St Marianna University School of Medicine 2- 16- 1 Sugao Miyamae- ku Kawasaki 2168511 Japan

Background: Acquired sy.metrical dermal melanocy.osis (ASDM) is a pigmentary.disorder characterized by.blue- brown macules most frequently.seen on the face of y.ung and middleaged Asian women. ASDM developing after other skin diseases has not been previously.reported. Objectives: To characterize the clinical and histopathological features of ASDM associated with atopic dermatitis (AD) and to elucidate the differences between AD- associated ASDM and idiopathic ASDM. Methods: Sixteen patients with ASDM associated with AD were examined clinically.and histopathologically.and were compared with 69 patients with idiopathic ASDM. Results: The AD patients associated with ASDM consisted of four men and 12 women with a mean age of 32.8 ± 13.1 y.ars. Most patients remembered that the pigmented macules appeared in places where refractory.eczema had existed for a long time. The marked preponderance in females and the appearance in the early.reproductive period were common features of AD- associated ASDM and idiopathic ASDM. AD- associated ASDM was most commonly.observed on the forehead (68.8% ) and on the backs of the hands (50.0% ), whereas 89.9% of idiopathic ASDM was seen on the cheeks. There was no significant difference in the number of dermal melanocy.es between AD- associated ASDM and idiopathic ASDM. Electron microscopic studies demonstrated many.mature melanocy.es and smaller numbers of immature melanocy.es in the dermis. Some melanocy.es were seen adjacent to mast cells. Conclusions: AD- associated ASDM does not appear to be rare in Japan. ASDM may.be triggered in AD patients by.sunlight exposure, some alterations in sex hormones and/or persistent cutaneous inflammation. Histamine and stem cell factor produced by.mast cells may.play.crucial roles in the pathogenesis of AD- associated ASDM.

关键词：特应性皮炎皮肤黑素细胞霍利色素病色素痣其他皮肤病组织病理学改变电镜检查女性发病率肥大细胞

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微镜下多血管炎患者的皮肤表现:2例报道和少量文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 21-22页

作者： Kawakami T. soma y. Saito C. 冯义国 St.Marianna University.School of Medicine Department of Dermatology2-16-1 SugaoKawasakiKanagawa 216-8511Japan Dr.

Microscopic poly.ngiitis is a sy.temic small vessel vasculitis,which often has cutaneous and musculoskeletal *** poly.ngiitis is a member of the family.of anti-neutrophil cy.oplasmic auto-antibody.ANCA)-associated vasculitides and is strongly.associated with anti-my.loperoxidase(MPO)-*** of MPO-ANCA may.reflect disease activity.and play.a pathogenic *** with microscopic poly.ngiitis usually.present with ery.hematous macules on the extremities as the first cutaneous *** biopsy.specimens from the ery.hema reveal small-sized vessels that are infiltrated with neutrophils,consistent with leukocy.oclastic vasculitis,in the deep dermis to the subcutaneous fat *** cutaneous involvement is present at an early.stage of microscopic poly.ngiitis with other non-specific sy.ptoms,such as arthralgias and *** initial cutaneous manifestations are important in early.diagnosis of possible ANCA-associated vasculitides with elevated ANCA titres.

关键词：血管炎文献回顾微镜 ANCA 关节痛髓过氧化物酶皮下脂肪组织小血管中性粒细胞浸润真皮深

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The Entomological Efficacy.of Piperony. Butoxide (PBO) Combined with a Py.ethroid in Insecticide-Treated Nets for Malaria Prevention: A Village-Based Cohort Study.Prior to Large-Scale Deploy.ent of New Generation Mosquito Nets in Burkina Faso

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Advances in Entomology 2024年第3期12卷 224-248页

作者： Aristide S. Hien Samina Maiga Koama Bay.li Adissa y. Ouattara Dieudonné D. soma Richard Bationo Georges Benson Meda Delphine O. Karama Tiecoura Camara Georges Anicet Ouedraogo Roch K. Dabiré Abdoulay. Diabaté Malaria and Neglected Tropical Disease Department Institut de Recherche en Sciences de la Sant (IRSS) Bobo-Dioulasso Burkina Faso Sciences and Techniques Department Institut du Developpement Rural Universit Nazi Boni Bobo-Dioulasso Burkina Faso Vector Control Department Permanent Secretariat for Malaria Elimination Ouagadougou Burkina Faso

The efficacy.of insecticide-treated nets (ITNs) is increasingly.compromised by.the prevalence of malaria vectors resistant to py.ethroids. In response to this issue, a new generation of ITNs has been developed that incorporate sy.ergistic components, such as piperony. butoxide (PBO). The purpose of this study.is to provide entomological evidence for the efficacy.of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deploy.ent. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly.in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity.in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study.area, as confirmed by.PCR analy.is. Analy.is of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly.greater inhibition than 66.81% permethrin only.ITN. According to the log-time probit regression analy.is, permethrin exhibited a knockdown time of 256 min without sy.ergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for py.ethroids to combat py.ethroid resistance and improve protection against malaria for both individuals and communities, particularly.in areas with high py.ethroid resistance.

关键词： Py.ethroid Resistance Permethrin + PBO ITNs Permethrin ITN Bionomic Data Insecticide Susceptibility.Data Burkina Faso

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Advancements in non-starch poly.accharides research for frozen foods and microencapsulation of probiotics

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Frontiers of Chemical Science and Engineering 2009年第4期3卷 413-426页

作者： Pavan Kumar soma Patrick D.WILLIAMS y.Martin LO Department of Nutrition and Food Science University of MarylandCollege ParkMD 20742USA

Conventionally.used in the food industry.as stabilizing,thickening,gelling,and suspending or dispersing agents,non-starch poly.accharides such as xanthan gum are known to improve the texture of certain frozen *** poly.accharide that has received significant attention in recent y.ars is chitosan,a natural biopoly.er derived from *** the wake of growing interest in finding ideal encapsulating agents for probiotics,non-starch poly.accharides have been *** research can be found on the effect of each individual poly.accharide,but there remains a void in the literature in terms of closely.comparing the characteristics of nonstarch poly.accharides for these applications,especially.when more than one biopoly.er is employ.d.A good understanding of the tools capable of elucidating the underly.ng mechanisms involved is essential in ushering further development of their ***,it is this review’s intention to focus on the selection criteria of non-starch poly.accharides based on their rheological properties,resistance to harsh conditions,and ability.to improve sensory.quality.A variety.of critical tools is also carefully.examined with respect to the attainable information crucial to frozen food and microencapsulation applications.

关键词： microencapsulation xanthan galactomannan chitosan curdlan

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Antibody.delivery.into viable epimastigotes of <i>Try.anosoma cruzi</i>as a tool to study.the parasite biology

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Advances in Bioscience and Biotechnology 2013年第6期4卷 719-726页

作者： Karla y. Acosta-Viana Huchin-Cetz Julio Jimenez-Coello Matilde Guzman-Marin Eugenia Jose L. Rosales-Encina Departamento de Infectomica y.Patogenesis Molecular Centro de Investigación y de Estudios Avanzados del Instituto Politecnico Nacional Unidad Zacatenco México Laboratorio Biologia Celular Centro de Investigaciones Regionales “Dr. Hideyo Noguchi” Universidad Autonoma de Yucatan Merida Mexico

American try.anosomiasis is a zoonosis of worldwide medical importance and currently.there is no effective treatment in chronic patients, hence the importance of the study.of protein function of the parasite with the objective of finding new drug targets and to know better the biology.of the agent causal (Try.ano-soma cruzi). T. cruzi is an RNAi-negative parasite, therefore the silencing genes strategies by.RNAi is not possible;for that reason, antibodies may.be taken as a tool for study.ng the parasite proteins function by.blocking these molecules with specific antibodies. The aim of this work was to establish a methodology.for antibody.delivery.(antibody.transfection) into viable parasites. We used anti-cy.lin-A antibody.(human origin) in western blot assay.with epimastigote of T. cruzi proteins and this recognized a ~55 kDa poly.eptide. Several methods for antibody.transfection (electroporation, saponin permeabilization and a lipid-based formulation) were tested. The first two methods were unsuccessful. In electroporation was impossible to visualize the antibody.inside parasites and with saponin permeabilization, antibodies were successfully.introduced, but with loss of parasites viability. The lipid-based formulation method forms noncovalent complexes with antibodies. These complexes are internalized by.cells and antibodies are released into the cy.oplasm. With this method, a successful antibody.delivery.was achieved. Anti-cy.lin antibodies were visualized in the cy.oplasm from fixed transfected parasites (immunofluorescence assay.). At 24 h post-transfection, parasites maintained their viability.(90%) and were able to arrest the cell cy.le in G0/G1-phase of cultured epimastigotes (cell population increased in G0/G1-phase from 50.5% to 66.2% and decreased in S-phase from 47.2% to 26%). It was also observed that anti-cy.lin-A antibodies inhibit the parasite population doubling (p T. cruzi, with a simple and cheap technique, which will allows carry.ng out further

关键词： Try.anosoma cruzi Antibody Delivery Antibody Transfection Cell Cy.le Anti-Cy.lin-A Antibody

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血管紧张素受体拮抗剂对原发性高血压患者受损的内皮祖细胞功能的作用

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中华高血压杂志 2014年第8期22卷 798-798页

作者： Suzuki R Fukuda N Katakawa M Tsunemi A Tahira y.Matsumoto T Ueno T soma M

内皮祖细胞（endothelial progenitor cells,EPC）可诱导形成新血管和修复损伤血管。业已证明,高血压大鼠的EPC功能受损,表现为氧化应激加重,而血管紧张素受体拮抗剂可改善受损的EPC功能。该研究调查正常血压对照组和高血压患者的EPC功... 详细信息

内皮祖细胞（endothelial progenitor cells,EPC）可诱导形成新血管和修复损伤血管。业已证明,高血压大鼠的EPC功能受损,表现为氧化应激加重,而血管紧张素受体拮抗剂可改善受损的EPC功能。该研究调查正常血压对照组和高血压患者的EPC功能,以及氯沙坦对高血压患者受损的EPC功能的作用。方法：

关键词：血管紧张素受体拮抗剂原发性高血压患者内皮祖细胞细胞功能 cells 高血压大鼠 EPC 损伤血管

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Search for two-neutrino double-beta decay.of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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Chinese Phy.ics C 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Cray.raft T.Daniels L.Darroch S.J.Daugherty.J.Davis S.Delaquis A.Der Mesrobian-Kabakian R.DeVoe J.Dilling A.Dolgolenko M.J.Dolinski J.Echevers W.Fairbank Jr. D.Fairbank J.Farine S.Fey.bakhsh P.Fierlinger y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil C.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi y.H.Lin R.MacLellan T.McElroy.T.Michel B.Mong D.C.Moore K.Murray.O.Njoy. O.Nusair A.Odian I.Ostrovskiy.A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson J.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.y.hne L.y.ng y.-R.y.n O.y..Zeldovich T.Ziegler 无 Phy.ics Department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen Centre for Astroparticle Phy.ics(ECAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Phy.ics Department Carleton UniversityOttawaOntario K1S 5B6Canada Department of Phy.ics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Phy.ics Department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Phy.ics named by.A.I.Alikhanov of National Research Centre“Kurchatov Institute” Moscow 117218Russia Department of Phy.ics University of South DakotaVermillionSouth Dakota 57069USA SLAC National Accelerator Laboratory Menlo ParkCalifornia 94025USA TRIUMF VancouverBritish Columbia V6T 2A3Canada Institute of High Energy.Phy.ics Beijing 100049China Department of Phy.ics Laurentian UniversitySudburyOntario P3E 2C6Canada Phy.ics Department Colorado State UniversityFort CollinsColorado 80523USA Department of Phy.ics and Phy.ical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Phy.ics Department and CEEM Indiana UniversityBloomingtonIndiana 47405USA Phy.ics Department Stanford UniversityStanfordCalifornia 94305USA Department of Phy.ics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst Center for Fundamental Interactions and Phy.ics Department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Phy.ics Department University of MarylandCollege ParkMaryland 20742USA Department of Phy.ics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright Laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS Center for Underground Phy.ics Daejeon 34126Korea Department of Phy.ics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg Lab CaltechPasadenaCalifornia 91125USA LHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay.of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency.is increased relative to previous searches by.EXO-200 by.more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity.of 2νββdecay.to the 0+1 state of 136Ba is 2.9×10^(24)y. using a total^(136)Xe exposure of 234.1 kg *** statistically.significant evidence for 2νββdecay.to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)y. at 90%confidence level,improved by.70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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应用扩散张量MR成像体内分区绘图:图解说明多系统萎缩白质显微结构异常

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国际医学放射学杂志 2010年第4期 377-377页

作者： K.K.Tha S.Terae I.y.be T.Miy.moto H.soma y.Zaitsu 郭丽君 Department of Radiology Hokkaido University Graduate School of MedicineN-15W-7Kita-kuSapporo 060-8638Japan

目的探讨扩散张量成像(DTI)能否显示多系统萎缩(MSA)白质显微结构异常,以及DTI所示影像学征象与临床症状和体征有无相关性。材料与方法本研究经机构审查委员会批准并获

关键词：扩散张量多系统萎缩脑病 MR 白质髓质显微结构

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