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Phosphorylation of Protein kinase Akt by Mtorc2 in Peripheral Blood Mononuclear Cells of Patients with Cancer and Diabetes

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Journal of Endocrinology Research 2019年第1期1卷 8-12页

作者： Vatseba T.S sokolova l.k Pushkarev V.V kovzun O.I Pushkarev V.M Guda B.B Tronko M.D SI“V.P.komisarenko Institute of endocrinology and metabolism of NAMS of Ukraine” KyivVyshgorodska st6904114Ukraine

Akt/mTOR/p70S6k1 signaling pathway plays an important role in the pathogenesis of cancer and *** and lymphocytes are involved in the pathogenesis of diabetes,diabetic atherosclerosis,formation of insulin resistance as well as immune response to cancer and tumor *** aim of the study was to determine the Akt activation by mTORC2 in peripheral blood mononuclear cell(PBMC)of patients with type 2 diabetes and *** following groups were studied:control group,patients with type 2 diabetes,cancer patients and patients with both cancer and *** amounts of phospho-Akt(р-S473)and phospho-p70S6k1(p-T389)were determined using ElISA *** amount of phosphorylated Akt significantly increases in PBMC of patients with *** was no effect in PBMC from patients with type 2 diabetes and significant decrease in the amount of phospho-Akt in PBMC of the patients group both with cancer and diabetes.p70S6k1 activation was observed in PBMC of the groups 2 and 3 ***,chronic diseases such as type 2 diabetes and cancer can affect the signaling mechanisms in blood *** state of Akt phosphorylation in leukocytes can indicate the activity of mTORC1 and its substrates,which may be important for the evaluation of the pathological process and the efficacy of the drugs.

关键词： Akt,mTORC2 P70S6k1 Peripheral blood mononuclear cell Cancer Diabetes

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Ion-conducting Membranes Based on Bacterial Cellulose Nanofibers Modified by Poly(sodium acrylate-co-2-acrylamido-2-methylpropanesulfonic acid)

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Chinese Journal of Polymer Science 2024年第3期42卷 333-343,I0007页

作者： Elizaveta V.Batishcheva Nikolay N.Smirnov Natalya V.Bobrova Maria P.sokolova Michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

Green method for preparation of ion-conducting membranes(ICM) based on bacterial cellulose nanofibers(CNF) modified by a copolymer of sodium acrylate and 2-acrylamido-2-methylpropanesulfonic acid was elaborated. FTIR and NMR data confirmed grafting of polyacrylate onto cellulose surface. Formation of porous structure of the ICM was controlled by SEM and AFM. The maximal ionic conductivity of the membranes reaches 1.5 and 3.1 mS·cm^(-1)(60 ℃ and 98% relative humidity) when they are saturated with water or H_2SO_4(1 mol·l^(-1)) electrolyte,respectively. Prepared ICM was tested as a separator in a symmetrical supercapacitor with electrodes based on polyaniline hydrogel. The assembled cell demonstrate ability to operate at high current density up to 100 A·g^(-1) maintaining specific capacitance 165 F·g^(-1). Maximal specific capacitance of 289 F·g^(-1) was achieved at current density 1 A·g^(-1). Retaining of 90% of initial capacitance after 10000 of charge-discharge cycles proves high electrochemical stability of prepared ICM.

关键词： Bacterial cellulose Ion conductivity Porous membrane Supercapacitor

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