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Dramatic Response to Cabozantinib in a Patient with Refractory Hepatocellular Carcinoma with c-MET Amplification

Journal of Clinical and Translational Hepatology 2023年第3期11卷 747-750页

作者： Yun Beom Sang Gwangil Kim sohyun hwang Haeyoun Kang Hong Jae Chon Department of Medical Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeonggi-doKorea Department of Pathology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeo-nggi-doKorea CHA Future Medicine Research Institute CHA Bundang Medical CenterSeongnam-siGyeonggi-doKorea

We report a case of a patient with c-MET amplified hepato-cellular carcinoma (HCC) who had a dramatic response to cabozantinib despite being refractory to four previous lines of systemic therapy. The patient had previously received re-gorafenib plus nivolumab as first-line treatment, lenvatinib as second-line, sorafenib as third-line, and ipilimumab plus nivolumab as fourth-line treatment in sequence. However, all regimens showed early progression within 2 months. The pa-tient’s HCC was well-controlled, with a partial response (PR) of over 9 months after beginning cabozantinib treatment. Although there were mild adverse events such as diarrhea and elevated liver enzymes, they were tolerable. Next-gen-eration sequencing (NGS) of the patient’s previous surgical specimen indicated amplification of c-MET genes. Although it is well known that cabozantinib has excellent effectiveness for inhibiting c-MET at the preclinical level, to the best of our knowledge this is the first case of dramatic response to cabozantinib in a patient with advanced HCC with c-MET am-plification.

关键词： Hepatocellular carcinoma c-MET amplification Cabozantinib Dra-matic response Next-generation sequencing

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WheatNet： a Genome-Scale Functional Network for Hexaploid Bread Wheat, Triticum aestivum

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Molecular Plant 2017年第8期10卷 1133-1136页

作者： Tak Lee sohyun hwang Chan Yeong Kim Hongseok Shim Hyojin Kim Pamela C. Ronald EdwardM. Marcotte Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Center for Systems and Synthetic Biology Institute for Cellular and Molecular Biology University of Texas at Austin Austin TX 78712 USA Department of Biomedical Science College of Life Science CHA University Seongnam-si 13496 Korea Department of Plant Pathology University of California Davis CA 95616 USA Joint Bioenergy Institute Emeryville CA 94608 USA The Genome Center University of California Davis CA 95616 USA Department of Molecular Bioseiences University of Texas at Austin Austin TX 78712 USA

Dear Editor Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits. Integration of diverse genomics data based on the Bayesian statistics framework has been successfully applied to the construction of genome-scale functional networks for major crop species such as rice （Lee et al., 2011）, soybean （Kim et al., 2017）, and tomato （Kim et al.,

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TomatoNet A Genome-wide Co-functional Network for Unveiling Complex Traits of Tomato, a Model Crop for Fleshy Fruits

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Molecular Plant 2017年第4期10卷 652-655页

作者： Hyojin Kim Bong Suk Kim Jung Eun Shim sohyun hwang Sunmo Yang Eiru Kim Aniafi S. Iver-Pascuzzi2 Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907 USA

Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model c... 详细信息

关键词： Genome-wide Co-functional Network Unveiling Complex Traits Tomato

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Microwave Synthesis of Silver Nanoparticles Using Different Pentose Carbohydrates as Reducing Agents

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Journal of Chemistry and Chemical Engineering 2018年第1期12卷 1-10页

作者： David S. Chung Hanna Kim Jonathan Ko Justine Lee Bryant hwang sohyun Chang ByungJun Kim Sung-Jae Chung Division of Biology and Medicine Brown University Providence R102912 USA Granada Hill Charter High School Granada Hills CA 91344 USA Thomas Jefferson High School for Science and Technology Alexandria VA 22312 USA Langley High School Mclean VA 2210 USA Department of Biology School of Arts & Sciences Johns Hopkins University Baltimore MD 21218 USA Biological Sciences Carnegie Mellon University Pittsburgh PA 15213 USA Marymount University School of Arts and Sciences 2807 N. Glebe Road Arlington VA 22302 USA

A fast, green and readily reproducible microwave-based method for the production of high quality silver nanoparticles （AgNPs） in high yield is presented. Starch is used as a stabilizing agent with few pentose different reducing carbohydrates as D-ribose, D-arabinose and L-arabinose. From the UV-vis peak profile spectra of the solutions of the silver nanoparticles, the authors have investigated the size of the NPs together with the average diameter, shape, and aggregation state of the colloidal AgNPs. TEM measurements and EDX analysis have confirmed the morphology of our AgNPs.

关键词： Microwave synthesis UV-vis spectroscopy Mie theory silver nanoparticles TEM and EDX.

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