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Unraveling the Impact of Direct-Acting Antivirals on Hepatitis-Linked Cirrhosis: A Comprehensive Analysis of Fibrosis, Child Score, and Disease Progression

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Open Journal of Gastroenterology 2024年第6期14卷 203-212页

作者： Hajar Cherkaoui Maryam Elkhayari Maria Lahlali Asmae Lamine Nada Lahmidani Amine Mekkaoui Mounia Elyousfi Dafr Allah Benajah mohammed El Abkari Adil Ibrahimi Hakima Abid Department of Hepato-Gastroenterology Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy of Fez USMBA Fez Morocco

The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).

关键词： Post-Viral Cirrhosis C Pegylated Interferon Direct Acting Antivirals Sustained Viral Response Child Score Fibrosis

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Effects of Transportation Stress during the Hot-Dry Season on Some Haematological and Physiological Parameters in Moroccan Dromedary Camels （Camelus dromedarius）

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Journal of Life Sciences 2013年第1期7卷 13-25页

作者： mohammed El Khasmi Youssef Chakir Fouad Riad Abdallah Safwate E1 hassane Tahri Mohamed Farh Najia E Abbadi Rachid Abouhafs Bernard Faye Laboratory of Physiopathology and Molecular Genetics Faculty of Sciences Ben M'Sik University Hassan II-Mohammedia Casablanca 20000 Morocco Unit of Applied Radioimmunology National Center for Energy Sciences and Techniques and Nuclear Techniques Maamoura Morocco Prefectural Veterinary Service of Casablanca Casablanca 20000 Morocco CIRAD-ES International Campus of Baillarguet Montpellier 34398 Cedex 5 France

The purpose of this study was to determine the effects of road transportation under heat conditions on some haematological [Ht （haematocrit）, blood cells count and EOF （erythrocytes osmotic fragility）] and physiological [Tr （rectal temperature）, HR （heart） and RR （respiratory rates）, and circulating levels of Cor （cortisol）, Glu （glucose） and minerals] parameters in Moroccan dromedary camels. The animals were subjected to road transportation stressor for 2 h by truck during the hot-dry season. Blood samples were collected before loading and transport, and at the end of transport. Transportation induced a significant increase （P 〈 0.05） of erythrocytes count, Ht, EOF, Tr, HR and RR by comparison to values observed before transportation. The same stress conditions induced a significant increase （P 〈 0.05） of plasma Cor （ng/mL） and blood Glu （mM）（220 ± 30 vs. 137 ± 20, 9.7 ± 1.2 vs. 6.4 ± 1. 1 respectively） and a significant decrease （P 〈 0.05） of plasma magnesium （mM）（0.5 ± 0.1 vs. 0.9 ± 0.1） comparatively to pre-transportation values. These results indicate that road transportation associated to heat may be considered as a potent stressor which is able to induce several cellular alterations in camels. Further studies of an eventual protective role of vitamin C against haemolysis induced by transportation stress in camel are needed.

关键词： Cortisol dromedary camel glucose haemolysis hot-dry season minerals transportation stress.

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Superior Mesenteric Arterial Embolism Associated with an Acute Limb Ischemia: A Case Report and Literature Review

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Open Journal of Gastroenterology 2014年第4期4卷 181-186页

作者： Abdesslam Bouassria Elbachir Benjelloun Imane Kamaoui Hicham Elbouhaddouti Ouadii Mouaqit Abdelmalek Ousadden Khalid Mazaz Khalid Ait Taleb Laila Sedreddine mohammed El Abkari SidiAdil Ibrahimi Ihssane Mellouki Department of Hepatology and Gastroenterology School of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University University Hospital HASSAN II Route de SidiHrazem Morocco Department of Radiology School of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University University Hospital HASSAN II Route de SidiHrazem Morocco Department of Surgery School of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University University Hospital HASSAN II Route de SidiHrazem Morocco

Introduction: Acute mesenteric ischemia due to an embolism of the superior mesenteric artery (SMA) is associated with a high mortality rate. Over twenty per cent of acute mesenteric embolism cases consist of multiple emboli. Case Presentation: We present a rare case of a 62-year-old man admitted with acute abdominal pain and signs of intestinal occlusion related to an acute mesenteric ischemia due to superior mesenteric arterial embolism. It was associated with a synchronous acute bilateral lower limb ischemia due to embolic arterial occlusion. He underwent an emergency explorative laparotomy with proximal jejunal resection, and the patient made an excellent recovery. As for the acute limb ischemia, it was treated by efficient anticoagulation allowing limb salvage. Conclusion: When treating a superior mesenteric arterial embolism, the possibility of recurrent or multiple arterial thromboembolic events should be considered. A prompt diagnosis, aggressive surgical treatment and intensive care could improve the prognosis.

关键词： SMA Limb Embolism Ischemia

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Fasciitis on Abdominal Craniectomy Implantation

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Surgical Science 2014年第10期5卷 479-482页

作者： Pierlesky Elion Ossibi Salima Rezzouk Ibrahima Berete KarimIbn Majdoub Imane Toughrai Said Ait Laalim Abdelmalek Ousadden mohammed Chaoui El Faiz Khalid Mazaz Khalid Ait Taleb Visceral Surgery Department Hassan II University Hospital Fez Morocco Neurosurgery Department Hassan II University Hospital Fez Morocco

Necrotizing fasciitis is an infection of the skin and deep subcutaneous tissue. It is caused by bacteria (group A streptococcus), but may also be idiopathic ora secondary complication of surgery. We report a case of n... 详细信息

关键词： Fasciitis Craniectomy Abdominal Implantation

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A Sensor Web for Real-Time Groundwater Data Monitoring in Morocco

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Journal of Geographic Information System 2014年第6期6卷 613-623页

作者： Aniss Moumen hassane Jarar Oulidi Meryem Agadi Mohamed Nehmadou Mohamed Ben-Daoud Amel Barich Abdelaziz Mridekh Bouabid El Mansouri Said Boutaleb Karim Ben Hachmi mohammed Ali Essahlaoui Samir Eljaafari Geosciences Laboratory of Natural Resources (GeoNaRes) Faculty of Sciences IbnTofial University Kenitra Morocco Department of Mathematics Informatics and Geomatics Hassania School of Public Works (EHTP) Casablanca Morocco Laboratory of Chemical Engineering and Environment Faculty of Science and Technology Hassan II University Mohammedia Morocco Applied Geology and Geo-Environment Laboratory Faculty of Sciences Ibn Zuhr University Agadir Morocco Department of Biology Faculty of Science Moulay Ismail University Meknes Morocco Instituto Andaluz de Ciencias de la Tierra UGR-CSIC Granada Spain Water Sciences and Environmental Engineering Group Department of Geology Faculty of Science Moulay Ismail University Meknes Morocco

This article presents research and development of an interoperable platform to facilitate, monitor and coordinate groundwater data sharing. This system was orchestrated by a number of services described by Open Geospatial Consortium (OGC) such as Sensor Observation Service (SOS) and other services for the use of mapping data, Web Feature Services (WFS), Web Map Service (WMS), and catalogue services (CSW). An important activity for our project was the establishment of a portal for geographic data and services. Geoportal developed for this project will promote and facilitate access to groundwater data and share theme more openly. Otherwise our system has been designed to provide a powerful tool that enhances the ability of regional staff to monitor near real-time groundwater data (i.e.?piezometric level) and as a result will help provide a more effective response to environmental upsets.

关键词： Sensor Web OGC Geoportal Geocatalog Monitoring Groundwater Morocco

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抑郁症的非药物治疗：系统性综述与证据图

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英国医学杂志中文版 2017年第11期20卷 660-667页

作者： Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M hassan Murad Annie LeBlanc Evidence-Based Przctiee Center Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester Minnesota USA Knowledge and Evaluation Research Unit Mayo Clinic Rochester Minnesota USA Division of Preventive. Occupational and Aerospace Medicine Mayo Clinic Rochester Minnesota USA Integrated Behavioral Health Departmenl of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA Mayo GraduateSchool Mayo ClinicRochesterMinnesota USA Center for PharmacyInnovation and Outcomes Geislnger Health System Forty Fort PennsylvaniaUSA Department of Emergency Medicine Mayo ClinicRochesterMinnesota USA Mayo Clinic

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，... 详细信息

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT，纳入了约2000名患者，进行了11种治疗，导出17项独立的头对头比较。通过标准化的量表评估，发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而，这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高，导致证据的质量只是低到中等，限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状，在轻度到重度抑郁症患者中，应当合并抗抑郁药物治疗，一同进行。对于非药物治疗的选择，应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。

关键词：抑郁症非药物治疗系统性综述证据图

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约克圣约翰大学创意中心

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现代装饰 2022年第5期 132-137页

作者： MGACI RLF Eduardo Andreu Gonz a lez Rob Baron Amir Daryoushnezhad Finbarr Duerden Caroline Dunham Rory Harmer Jolene Hor Qaisy Jaslenda laia Loppi Amber McLaren Simon Munashe Dendere Laurence Pinn Ed Rawle mohammed Syafig B hassan Jubri Tristan Searight Jerry Tate Atelier Ten Atelier One Colour Hufton+Crow(摄影) 舒禹(编译) 不详

近期,由Tate+Co Architects设计的约克圣约翰大学创意中心已向学生敞开大门。这座低能耗建筑为约克圣约翰大学的音乐和计算机专业课程提供永久新家,也为表演、创意写作,和媒体制作专业的学生提供空间。项目由三个主要概念构成,首先,这... 详细信息

近期,由Tate+Co Architects设计的约克圣约翰大学创意中心已向学生敞开大门。这座低能耗建筑为约克圣约翰大学的音乐和计算机专业课程提供永久新家,也为表演、创意写作,和媒体制作专业的学生提供空间。项目由三个主要概念构成,首先,这是一座真正的可持续的建筑,它有着坚固的木结构,无论是在运营方面还是在隐含碳方面都是可持续的。其次,主中庭空间的建筑元素体现了高等教育中创造跨学科合作的“第三空间”思想。最后,该中心充分利用靠近约克大教堂的地理位置优势,将大学与周边城市连接起来,在整个中庭、演奏厅和听音室中,为令人惊叹的历史遗址更添如西景色。

关键词：低能耗建筑建筑元素中庭空间圣约翰大学地理位置优势木结构媒体制作第三空间

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad sohaib hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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