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Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

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Neural Regeneration Research 2017年第4期12卷 588-595页

作者： Teresa Neri-Gomez Judith Espinosa-Raya sofia diaz cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian Guerra-Araiza Unidad de Investigación Médica en Farmacología Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Laboratorio de Farmacología Conductual Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Sto. Tomás Ciudad de México México Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Querétaro México Enfermedades Neurológicas (Neurological Diseases) Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Enfermedades Nefrológicas (Kidney Diseases) Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de Mexico Mexico

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles （NFTs）; these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone （TIB） have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB （0.01 mg/kg and 1mg/kg, intragastrically for 12 weeks） on the content of total and hyperphosphorylated Tau （PHF-1） proteins and the regulation of GSK3β/Akt/PI3K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB： it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes.

关键词： nerve regeneration Tibolone hippocampus aged mice sex steroids Akt GSK3β PI3K neuralplasticity Tau neurofibrillary tangles neural regeneration

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Sensory neurons in the spinal cord of nominal female embryos in the marine turtle Lepidochelys olivacea respond to shifts in incubation temperature:implications for temperature dependent sex determination

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Advances in Bioscience and Biotechnology 2011年第1期2卷 1-7页

作者： Francisco Jimenez-Trejo Leonora Olivos-Cisneros Julieta Mendoza-Torreblanca sofia diaz-cintra Esperanza-Melendez-Herrera Armida Baez-Saldana Patricia Padilla Cortes Gabriel Gutierrez-Ospina Alma Lilia Fuentes-Farias Departamento de Biologia Facultad de QuimicaUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico 04510 Departamento de Biologia Celular y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico 04510 Departamento de Neuroquimica Instituto Nacional de PediatriaMexicoDF.Mexico 04530 Departamento de Neurobiologia del Desarrollo y Neurofisiologia Instituto de NeurobiologiaUniversidad Nacional Autonoma de MexicoCampus UNAM-JuriquillaJuriquillaQueretaro Mexico AP.1-1141 Laboratorio de Invertebrados y Ecofisiologia Animal Facultad de BiologiaUniversidad Michoacana de San Nicolas de HidalgoMoreliaMichoacanMexico 58040 Unidad de Cromatografia Liquida de Alta Resolucion Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico 04510

Gonadal determination in marine turtles depends on incubation temperature. The mechanisms that spark off this process remain unclear. Previously, we proposed that sensory nerves reaching the gonadal primordium in nominal female embryos of Lepidochelys (L) olivacea may sense and signal incubation temperature. These nerves could later trigger ovarian determination by releasing neurotransmitters in a code constructed based on the thermal information (Gutierrez-Ospina et al., Acetylcholinesterase-positive innervation is present at the undifferentiated stages of the sea turtle Lepidochelys olivacea embryo gonads: implications for temperature-dependent sex determination, J. Comp. Neurol. 410 (1999) 90-98). The hypothesis briefly described, however, has been recently refuted under weak theoretical grounds and experimental misinterpretations (see introduction). Here, we present preliminary results that show that nominal female embryos have sensory neurons located in the dorsal horn laminae I and II of the lumbar spinal cord that display increased c-Fos-like immuno-staining after being incubated either at 15°C or 50°C. Because these spinal neurons are the primary central target of dorsal root ganglion neurons that innervate the urogential crest, these observations keep open the possibility that gonadal sensory nerves indeed signal thermal information that could later be used to trigger or instruct ovarian specification in marine turtles.

关键词： Reptiles Ovarian Determination c-Fos Incubation Temperature Sensory Neurons

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Lid scrubbing with a gel combining natural extracts for dry eye treatment

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1053-1059页

作者： Blanca diaz-Vega Carlos Rodriguez-Fabuel sofia Vitores-Mate Carlos Carpena-Torres Gran Visión Oftalmología Madrid 28026Spain e-Health Vision Department of OphthalmologyMadrid 28232Spain Gran Óptica Madrid Department of Dry EyeMadrid 28026Spain Ocupharm Research Group Department of Optometry and VisionFaculty of Optics and OptometryComplutense University of MadridMadrid 28037Spain

AIM:To evaluate the effect of lid scrubbing using a gel combining different natural extracts on ocular signs and symptoms of dry eye ***:A retrospective study was performed on 19 dry eye patients(51.1±16.0y).Non-invasive tear break-up time,tear meniscus height,meibomian gland loss,lipid layer thickness,conjunctival redness,corneal staining,ocular surface disease index(OSDI),and ocular pain intensity were measured before(baseline),1wk,and 2mo after lid scrubbing with a gel containing different natural extracts(okra extract,aloe vera leaf juice,hydrolysed soy protein,caffeine,citrus unshiu peel extract,and raspberry seed oil).RESULTS:Compared with the baseline,there was a statistically significant improvement in both first(P=0.048)and average(P=0.026)non-invasive tear break-up time 2mo after treatment,as well as in corneal staining(P=0.043,0.012),OSDI(P<0.001),and ocular pain intensity(P<0.001)after 1wk and *** addition,there was no correlation between ocular signs and ***:The lid scrubbing with a gel combining different natural extracts show beneficial effects on tear film stability,corneal damage,and ocular symptoms,which is the reason why this therapeutic procedure is proposed as an alternative for dry eye ***,it is not possible to attribute this beneficial effect solely to the presence of the natural extracts in the gel,primarily due to the absence of a negative control group.

关键词： lid hygiene natural extracts okra aloe vera soy dry eye

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An application of space-filling curves to improve results of turbulent aerodynamics modeling with convolutional neural networks

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Chinese Journal of Aeronautics 2024年第2期37卷 81-92页

作者： Mikhail PETROV sofia ZIMINA Moscow Institute of Physics&Technology Dolgoprudny 141701Russia

When carrying out calculations for turbulent flow simulation,one inevitably has to face the choice between accuracy and speed of *** order to simultaneously obtain both a computationally efficient and more accurate model,a surrogate model can be built on the basis of some fast special model and knowledge of previous calculations obtained by more accurate base models from various test bases or some results of serial *** objective of this work is to construct a surrogate model which allows to improve the accuracy of turbulent calculations obtained by a special model on unstructured *** this purpose,we use 1D Convolutional Neural Network(CNN)of the encoder-decoder architecture and reduce the problem to a single dimension by applying space-filling *** an approach would have the benefit of being applicable to solutions obtained on unstructured *** this work,a non-local approach is applied where entire flow fields obtained by the special and base models are used as input and ground truth output ***-Allmaras(SA)model and Near-wall Domain Decomposition(NDD)method for SA are taken as the base and special models *** efficiency and accuracy of the obtained surrogate model are demonstrated in a case of supersonic flow over a compression corner with different values for angleαand Reynolds number *** conducted an investigation into interpolation and extrapolation by Re and also into interpolation byα.

关键词： Space-filling curves Convolutional neural network Domain decomposition Turbulent flows Unstructured mesh

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Resuspension of spherical particles due to surface vibration

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Particuology 2021年第1期19卷 126-135页

作者： sofia Eirini Chatoutsidou Mihalis Lazaridis School of Environmental Engineering Technical University of Crete73100 ChaniaGreece

In this study,particle resuspension due to surface vibration was investigated.A spherical particle was assumed to rest on top of a thin plate,and an external vibrating force was applied normal on the plate at t=0 and at distance R from the *** external driving force created a displacement field in both time and space domains,where deformations in the body of the plate were considered small elastic oscillations that are perpendicular to the propagation of the *** oscillations were introduced via the theory of elasticity and the creation of waves on thin plates,i.e.,bending *** motion in the vertical direction was initiated through plate displacement,provided that inertia due to particle mass is *** particular,the particle was assumed to oscillate with a force(of oscillation)estimated via Newton’s second law of motion,comprising of two components:the acceleration due to the plate displacement and the particle ***,a simple force balance method was used to determine the conditions for ***,resuspension occurs when the oscillation force exceeds the couple of the adhesive and gravitational *** results suggest that the plate displacement depends on the characteristics of the applied force,material properties,and plate *** addition,it was found that the oscillation force is substantially lower than the applied force and that it depends on plate displacement and particle ***,the particle size significantly influencedthe outcome of ***,resuspension is favorable for large particles,strong applied forces,and high forcing frequencies.

关键词： Particle resuspension Vibration Bending waves

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Agricultural drought severity in NE Italy: Variability, bias, and future scenarios

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International Soil and Water Conservation Research 2024年第2期12卷 403-418页

作者： Giulia sofia Claudio Zaccone Paolo Tarolli Consorzio di Bonifica diⅡGrado Lessinio-Euganeo-Berico Via Tiro a Segno 737044 Cologna VenetaVeronaItaly Department of Land EnvironmentAgriculture and ForestryUniversity of PadovaViale dell’Universita 1635020 LegnaroPadovaItaly Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly

This study investigated the variability of agricultural drought severity,as depicted by vegetation indices,and the bias in identifying drought events when considering a stationary vs nonstationary climate *** work leveraged gridded climate data(NCEP CFSv2,CHIRPS 1981–2022),soil properties(OpenLandMap),satellite imagery(Sentinel2/Landsat,2000–2022),and future climate projections(NEX-GDDP,2050)together with local knowledge of selected farms,to augment drought monitoring techniques and identify potential issues for *** the study domain,significant differences were observed when comparing drought characteristics using stationary and nonstationary drought indexes,with biases being not ubiquitous in either space or time of *** developing sustainable drought mitigation and adaptation strategies,decision-makers should carefully address this uncertainty to avoid a possible underestimation of drought *** showed a drought increase(∼50%)by the mid and late twenty-first *** of future climate highlighted an even more significant impact(∼80%)with a wide variability of risk across the *** drought impact was also related to soil organic carbon(SOC),our results suggest that improving SOC content could be a sustainable strategy for enhancing soil drought resilience,especially in areas commonly characterized by low concentrations of organic carbon and *** analysis highlighted that drought impacts were also modulated by investment in irrigation infrastructure and irrigation *** and land managers could apply the proposed analysis design to address historical,current and future indicators of vegetation conditions within irrigated *** providing spatio-temporal information on the patterns of drought impacts and their bias,this study supports identifying priority regions for targeted drought risk reduction and adaptation options,including water resources and soil management sustainability crite

关键词： Climate impacts Soil organic matter Water management Agricultural systems Remote sensing

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Fluid Structure Interaction Problems:the Necessity of a Well Posed,Stable and Accurate Formulation

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Communications in Computational Physics 2010年第10期8卷 1111-1138页

作者： Jan Nordstrom sofia Eriksson School of Mechanical Industrial and Aeronautical EngineeringUniversity of the WitwatersrandJohannesburgWITS 2050South Africa Department of Aeronautics and Systems Integration FOIThe Swedish Defense Research AgencySE-16490 StockholmSweden Department of Information Technology Division of Scientific ComputingUppsala UniversitySE-75105 UppsalaSweden

We investigate problems of fluid structure interaction type and aim for a formulation that leads to a well posed problem and a stable numerical *** first objective is to investigate if the generally accepted formulations of the fluid structure interaction problem are the only possible *** second objective is to derive a stable numerical *** accomplish that we will use a weak coupling procedure and employ summation-by-parts operators and penalty *** compare the weak coupling with other common *** also study the effect of high order accurate *** multiple dimensions this is a formidable task and we start by investigating the simplest possible model problem *** a flow model we use the linearized Euler equations in one dimension and as the structure model we consider a spring.

关键词： Fluid structure interaction well posed finite difference high accuracy stability

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Argumentative Conversational Agents for Online Discussions

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Journal of Systems Science and Systems Engineering 2021年第4期30卷 450-464页

作者： Rafik Hadfi Jawad Haqbeen sofia Sahab Takayuki Ito Department of Social Informatics Kyoto UniversityYoshidahonmachiSakyo WardKyotoJapan606-8501 Nagoya Institute of Technology Gokiso-choShowa-kuNagoyaAichiJapan466-8555

Artificial Intelligence is revolutionising our communication practices and the ways in which we interact with each other. This revolution does not only impact how we communicate, but it affects the nature of the partners with whom we communicate. Online discussion platforms now allow humans to communicate with artificial agents in the form of socialbots. Such agents have the potential to moderate online discussions and even manipulate and alter public opinions. In this paper, we propose to study this phenomenon using a constructed large-scale agent platform. At the heart of the platform lies an artificial agent that can moderate online discussions using argumentative messages. We investigate the influence of the agent on the evolution of an online debate involving human participants. The agent will dynamically react to their messages by moderating, supporting, or attacking their stances. We conducted two experiments to evaluate the platform while looking at the effects of the conversational agent. The first experiment is a large-scale discussion with 1076 citizens from Afghanistan discussing urban policy-making in the city of Kabul. The goal of the experiment was to increase the citizen involvement in implementing Sustainable Development Goals. The second experiment is a small-scale debate between a group of 16 students about globalisation and taxation in Myanmar. In the first experiment, we found that the agent improved the responsiveness of the participants and increased the number of identified ideas and issues. In the second experiment, we found that the agent polarised the debate by reinforcing the initial stances of the participant.

关键词： Artificial intelligence conversational agents natural language processing online discussion computational social science

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Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 4-18页

作者： Grant Perry Fernando Cortezon-Tamarit sofia I.Pascu Department of Chemistry University of BathClaverton DownBath BA27AYUK

Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer *** the development of the disease is greatly correlated to age,the identification of novel detection methods reliable,efficient,and cost effective is a matter of significant importance in the ageing population of western *** detection of the prostate specific antigen(PSA)in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past *** the indications against its use in massive population screening,PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate *** latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed *** incorporation of gold nanoparticles,silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity,stability and *** electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

关键词： biosensing immunosensor PSA prostate cancer fluorescence

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An Adaptive Classifier Based Approach for Crowd Anomaly Detection

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Computers, Materials & Continua 2022年第7期72卷 349-364页

作者： sofia Nishath P.S.Nithya Darisini School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India

Crowd Anomaly Detection has become a challenge in intelligent video surveillance system and *** video surveillance systems make extensive use of data mining,machine learning and deep learning *** this paper a novel approach is proposed to identify abnormal occurrences in crowded situations using deep *** this approach,Adaptive GoogleNet Neural Network Classifier with Multi-Objective Whale Optimization Algorithm are applied to predict the abnormal video frames in the crowded *** use multiple instance learning(MIL)to dynamically develop a deep anomalous ranking *** technique predicts higher anomalous values for abnormal video frames by treating regular and irregular video bags and video *** use the multi-objective whale optimization algorithm to optimize the entire process and get the best *** performance parameters such as accuracy,precision,recall,and F-score are considered to evaluate the proposed technique using the Python simulation *** simulation results show that the proposed method performs better than the conventional methods on the public live video dataset.

关键词： Abnormal event detection adaptive GoogleNet neural network classifier multiple instance learning multi-objective whale optimization algorithm

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