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Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions

Nano-Micro Letters 2021年第12期13卷 452-467页

作者： Guillermo U.Ruiz-Esparza Xichi Wang Xingcai Zhang sofia jimenez-vazquez Liliana Diaz-Gomez Anne-Marie Lavoie Samson Afewerki Andres AFuentes-Baldemar Roberto Parra-Saldivar Nan Jiang Nasim Annabi Bahram Saleh Ali K.Yetisen Amir Sheikhi Thomas H.Jozefiak Su Ryon Shin Nianguo Dong Ali Khademhosseini Biomaterials Innovation Research Center Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Division of Health Sciences and Technology Harvard University-Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering and Science Tecnologico de MonterreyCampus MonterreyMonterreyNuevo Leon 64849Mexico School of Medicine and Health Science Campus GuadalajaraZapopanJalisco 45201Mexico West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Terasaki Institute for Biomedical Innovation 11570 W Olympic BlvdLos AngelesCA 90024USA

More than 90%of surgical patients develop postoper-ative adhesions,and the incidence of hospital re-admissions can be as high as 20%.Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive *** solve thisclinical limitation,we developed an injectable and sprayable shear-thinning hydrogel barrier(STHB)composed of silicate nanoplatelets and poly(ethylene oxide).We optimized this technology to recover mechanical integrity after stress,enabling its delivery though inject-able and sprayable *** also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in *** STHB was then tested in a rodent model of peritoneal injury to determine its e cacy preventing the formation of postoperative *** two weeks,the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions,and STHB formulations presented superior e cacy compared to a commercially available adhesion *** and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB *** technology demonstrated increased e cacy,ease of use in complex anatomies,and compatibility with di erent delivery methods,providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.

关键词： Postoperative adhesions Shear-thinning hydrogel Silicate nanoplatelets Nanotechnology Nanomedicine

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An application of space-filling curves to improve results of turbulent aerodynamics modeling with convolutional neural networks

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Chinese Journal of Aeronautics 2024年第2期37卷 81-92页

作者： Mikhail PETROV sofia ZIMINA Moscow Institute of Physics&Technology Dolgoprudny 141701Russia

When carrying out calculations for turbulent flow simulation,one inevitably has to face the choice between accuracy and speed of *** order to simultaneously obtain both a computationally efficient and more accurate model,a surrogate model can be built on the basis of some fast special model and knowledge of previous calculations obtained by more accurate base models from various test bases or some results of serial *** objective of this work is to construct a surrogate model which allows to improve the accuracy of turbulent calculations obtained by a special model on unstructured *** this purpose,we use 1D Convolutional Neural Network(CNN)of the encoder-decoder architecture and reduce the problem to a single dimension by applying space-filling *** an approach would have the benefit of being applicable to solutions obtained on unstructured *** this work,a non-local approach is applied where entire flow fields obtained by the special and base models are used as input and ground truth output ***-Allmaras(SA)model and Near-wall Domain Decomposition(NDD)method for SA are taken as the base and special models *** efficiency and accuracy of the obtained surrogate model are demonstrated in a case of supersonic flow over a compression corner with different values for angleαand Reynolds number *** conducted an investigation into interpolation and extrapolation by Re and also into interpolation byα.

关键词： Space-filling curves Convolutional neural network Domain decomposition Turbulent flows Unstructured mesh

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Resuspension of spherical particles due to surface vibration

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Particuology 2021年第1期19卷 126-135页

作者： sofia Eirini Chatoutsidou Mihalis Lazaridis School of Environmental Engineering Technical University of Crete73100 ChaniaGreece

In this study,particle resuspension due to surface vibration was investigated.A spherical particle was assumed to rest on top of a thin plate,and an external vibrating force was applied normal on the plate at t=0 and at distance R from the *** external driving force created a displacement field in both time and space domains,where deformations in the body of the plate were considered small elastic oscillations that are perpendicular to the propagation of the *** oscillations were introduced via the theory of elasticity and the creation of waves on thin plates,i.e.,bending *** motion in the vertical direction was initiated through plate displacement,provided that inertia due to particle mass is *** particular,the particle was assumed to oscillate with a force(of oscillation)estimated via Newton’s second law of motion,comprising of two components:the acceleration due to the plate displacement and the particle ***,a simple force balance method was used to determine the conditions for ***,resuspension occurs when the oscillation force exceeds the couple of the adhesive and gravitational *** results suggest that the plate displacement depends on the characteristics of the applied force,material properties,and plate *** addition,it was found that the oscillation force is substantially lower than the applied force and that it depends on plate displacement and particle ***,the particle size significantly influencedthe outcome of ***,resuspension is favorable for large particles,strong applied forces,and high forcing frequencies.

关键词： Particle resuspension Vibration Bending waves

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Agricultural drought severity in NE Italy: Variability, bias, and future scenarios

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International Soil and Water Conservation Research 2024年第2期12卷 403-418页

作者： Giulia sofia Claudio Zaccone Paolo Tarolli Consorzio di Bonifica diⅡGrado Lessinio-Euganeo-Berico Via Tiro a Segno 737044 Cologna VenetaVeronaItaly Department of Land EnvironmentAgriculture and ForestryUniversity of PadovaViale dell’Universita 1635020 LegnaroPadovaItaly Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly

This study investigated the variability of agricultural drought severity,as depicted by vegetation indices,and the bias in identifying drought events when considering a stationary vs nonstationary climate *** work leveraged gridded climate data(NCEP CFSv2,CHIRPS 1981–2022),soil properties(OpenLandMap),satellite imagery(Sentinel2/Landsat,2000–2022),and future climate projections(NEX-GDDP,2050)together with local knowledge of selected farms,to augment drought monitoring techniques and identify potential issues for *** the study domain,significant differences were observed when comparing drought characteristics using stationary and nonstationary drought indexes,with biases being not ubiquitous in either space or time of *** developing sustainable drought mitigation and adaptation strategies,decision-makers should carefully address this uncertainty to avoid a possible underestimation of drought *** showed a drought increase(∼50%)by the mid and late twenty-first *** of future climate highlighted an even more significant impact(∼80%)with a wide variability of risk across the *** drought impact was also related to soil organic carbon(SOC),our results suggest that improving SOC content could be a sustainable strategy for enhancing soil drought resilience,especially in areas commonly characterized by low concentrations of organic carbon and *** analysis highlighted that drought impacts were also modulated by investment in irrigation infrastructure and irrigation *** and land managers could apply the proposed analysis design to address historical,current and future indicators of vegetation conditions within irrigated *** providing spatio-temporal information on the patterns of drought impacts and their bias,this study supports identifying priority regions for targeted drought risk reduction and adaptation options,including water resources and soil management sustainability crite

关键词： Climate impacts Soil organic matter Water management Agricultural systems Remote sensing

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Fluid Structure Interaction Problems:the Necessity of a Well Posed,Stable and Accurate Formulation

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Communications in Computational Physics 2010年第10期8卷 1111-1138页

作者： Jan Nordstrom sofia Eriksson School of Mechanical Industrial and Aeronautical EngineeringUniversity of the WitwatersrandJohannesburgWITS 2050South Africa Department of Aeronautics and Systems Integration FOIThe Swedish Defense Research AgencySE-16490 StockholmSweden Department of Information Technology Division of Scientific ComputingUppsala UniversitySE-75105 UppsalaSweden

We investigate problems of fluid structure interaction type and aim for a formulation that leads to a well posed problem and a stable numerical *** first objective is to investigate if the generally accepted formulations of the fluid structure interaction problem are the only possible *** second objective is to derive a stable numerical *** accomplish that we will use a weak coupling procedure and employ summation-by-parts operators and penalty *** compare the weak coupling with other common *** also study the effect of high order accurate *** multiple dimensions this is a formidable task and we start by investigating the simplest possible model problem *** a flow model we use the linearized Euler equations in one dimension and as the structure model we consider a spring.

关键词： Fluid structure interaction well posed finite difference high accuracy stability

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Argumentative Conversational Agents for Online Discussions

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Journal of Systems Science and Systems Engineering 2021年第4期30卷 450-464页

作者： Rafik Hadfi Jawad Haqbeen sofia Sahab Takayuki Ito Department of Social Informatics Kyoto UniversityYoshidahonmachiSakyo WardKyotoJapan606-8501 Nagoya Institute of Technology Gokiso-choShowa-kuNagoyaAichiJapan466-8555

Artificial Intelligence is revolutionising our communication practices and the ways in which we interact with each other. This revolution does not only impact how we communicate, but it affects the nature of the partners with whom we communicate. Online discussion platforms now allow humans to communicate with artificial agents in the form of socialbots. Such agents have the potential to moderate online discussions and even manipulate and alter public opinions. In this paper, we propose to study this phenomenon using a constructed large-scale agent platform. At the heart of the platform lies an artificial agent that can moderate online discussions using argumentative messages. We investigate the influence of the agent on the evolution of an online debate involving human participants. The agent will dynamically react to their messages by moderating, supporting, or attacking their stances. We conducted two experiments to evaluate the platform while looking at the effects of the conversational agent. The first experiment is a large-scale discussion with 1076 citizens from Afghanistan discussing urban policy-making in the city of Kabul. The goal of the experiment was to increase the citizen involvement in implementing Sustainable Development Goals. The second experiment is a small-scale debate between a group of 16 students about globalisation and taxation in Myanmar. In the first experiment, we found that the agent improved the responsiveness of the participants and increased the number of identified ideas and issues. In the second experiment, we found that the agent polarised the debate by reinforcing the initial stances of the participant.

关键词： Artificial intelligence conversational agents natural language processing online discussion computational social science

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Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 4-18页

作者： Grant Perry Fernando Cortezon-Tamarit sofia I.Pascu Department of Chemistry University of BathClaverton DownBath BA27AYUK

Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer *** the development of the disease is greatly correlated to age,the identification of novel detection methods reliable,efficient,and cost effective is a matter of significant importance in the ageing population of western *** detection of the prostate specific antigen(PSA)in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past *** the indications against its use in massive population screening,PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate *** latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed *** incorporation of gold nanoparticles,silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity,stability and *** electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

关键词： biosensing immunosensor PSA prostate cancer fluorescence

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An Adaptive Classifier Based Approach for Crowd Anomaly Detection

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Computers, Materials & Continua 2022年第7期72卷 349-364页

作者： sofia Nishath P.S.Nithya Darisini School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India

Crowd Anomaly Detection has become a challenge in intelligent video surveillance system and *** video surveillance systems make extensive use of data mining,machine learning and deep learning *** this paper a novel approach is proposed to identify abnormal occurrences in crowded situations using deep *** this approach,Adaptive GoogleNet Neural Network Classifier with Multi-Objective Whale Optimization Algorithm are applied to predict the abnormal video frames in the crowded *** use multiple instance learning(MIL)to dynamically develop a deep anomalous ranking *** technique predicts higher anomalous values for abnormal video frames by treating regular and irregular video bags and video *** use the multi-objective whale optimization algorithm to optimize the entire process and get the best *** performance parameters such as accuracy,precision,recall,and F-score are considered to evaluate the proposed technique using the Python simulation *** simulation results show that the proposed method performs better than the conventional methods on the public live video dataset.

关键词： Abnormal event detection adaptive GoogleNet neural network classifier multiple instance learning multi-objective whale optimization algorithm

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Sequential light programs shape kale (Brassica napus) sproutappearance and alter metabolic and nutrient content

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Horticulture Research 2014年第1期1卷 244-256页

作者： sofia D Carvalho Kevin M Folta Horticultural Sciences Department University of FloridaGainesvilleFLUSA Plant Molecular and Cellular Biology Program University of FloridaGainesvilleFLUSA Plant Innovation Program University of FloridaGainesvilleFLUSA

Different light wavelengths have specific effects on plant growth and ***-bandwidth light-emitting diode(LED)lighting may be used to directionally manipulate size,color and metabolites in high-value fruits and *** this report,Red Russian kale(Brassica napus)seedlings were grown under specific light conditions and analyzed for photomorphogenic responses,pigment accumulation and nutraceutical *** results showed that this genotype responds predictably to darkness,blue and red light,with suppression of hypocotyl elongation,development of pigments and changes in specific ***,these seedlings were relatively hypersensitive to far-red light,leading to uncharacteristically short hypocotyls and high pigment accumulation,even after growth under very low fluence rates(,1 mmol m^(-2) s^(-1)).General antioxidant levels and aliphatic glucosinolates are elevated by far-red light *** treatments of darkness,blue light,red light and far-red light were applied throughout sprout development to alter final product *** results indicate that sequential treatment with narrow-bandwidth light may be used to affect key economically important traits in high-value crops.

关键词： treatment content narrow

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Geo-Scape,a Granularity Depended Spatialization Tool for Visualizing Multidimensional Data Sets

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Geo-Spatial Information Science 2010年第4期13卷 275-284页

作者： Kontaxaki sofia Kokla Margarita Kavouras Marinos School of Rural and Surveying Engineering National Technical University of Athens9 H.Polytechniou Str.Zografos Campus15780 AthensGreece

Recently,the expertise accumulated in the field of geovisualization has found application in the visualization of abstract multidimensional data,on the basis of methods called spatialization *** methods aim at visualizing multidimensional data into low-dimensional representational spaces by making use of spatial metaphors and applying dimension reduction *** metaphors are able to provide a metaphoric framework for the visualization of information at different levels of *** present paper makes an investigation on how the issue of granularity is handled in the context of representative examples of spatialization ***,this paper introduces the prototyping tool Geo-Scape,which provides an interactive spatialization environment for representing and exploring multidimensional data at different levels of granularity,by making use of a kernel density estimation technique and on the landscape "smoothness" metaphor.A demonstration scenario is presented next to show how Geo-Scape helps to discover knowledge into a large set of data,by grouping them into meaningful clusters on the basis of a similarity measure and organizing them at different levels of granularity.

关键词： multidimensional data spatial metaphors spatialization graphical interface kernel density estimation

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