检索结果-南通市图书馆

Oxygen permeability of soft contact lenses in different pH, osmolality and buffering solution

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第5期8卷 1037-1042页

作者： Se Eun Lee so Ra Kim Mijung Park Department of Optometry Seoul National University of Science and Technology

AIMTo determine the effect of pH, osmolality, and buffering system on the oxygen permeability (Dk) of soft contact *** hydrogel lenses (nelfilcon A and etafilcon A) and 2 silicone hydrogel lenses (lotrafilcon A and balafilcon A) were used in the study. These lenses were incubated in phosphate-buffered saline (PBS) and borate-buffered saline (BBS) solutions adjusted by 0.8 pH increments to a pH in the range of 5.8-9.0 or in hypotonic (280 mOsmol/kg), isotonic (310 mOsmol/kg) and hypertonic (380 mOsmol/kg) PBS solutions. Polarographic method was used for measuring the Dk and lenses were stacked as 4 layers to correct the boundary *** values of all contact lenses measured in BBS solutions were more stable than those in PBS solutions. Especially the etafilcon A lens showed a relative big change compared with other types of contact lenses at the same conditions. When the osmolality of PBS solution increased from hypotonic to hypertonic, Dk of all contact lenses decreased. Variations in Dk existed depending on lens materials, etafilcon A lens was the most affected and nelfilcon A was the least affected by *** the result obtained, it is revealed that Dk of contact lenses is changed by the pH, osmolality, and buffering condition of tear. Thus, Dk of contact lens can be varied by the lens wearers' physiological and/or pathological conditions.

关键词： soft contact lens oxygen permeability buffer solutions osmolality pH

RECENT PROGRESS OF NANO-MECHANICAL MAPPING

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2009年第1期27卷 37-47页

作者： Toshio Nishi Sae Nagai so Fujinami Ken Nakajima WPI Advanced Institute for Materials Research Tohoku University 2-I-1KatahiraAoba-kuSendaiMiyagi 980-8577Japan

Nano-mechanical mapping by atomic force microscopy has been developed as an useful application to measure mechanical properties of soft materials at nanometer *** date,the Hertzian theory was used for analyzing force- distance curves as the simplest model among several contact mechanics between elastic ***,the preexisting methods based on this theory do not consider the adhesive interaction in principle,which cannot be neglected in the ambient condition.A new analytical method was introduced...

关键词： Atomic force microscopy Nano-mechanical mapping Force-distance curve JKR theory

中药治疗腰椎椎体间融合术后发热的炎症信号通路

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第21期29卷 4568-4575页

作者：方雨婷彭宏庞玉洁南阳市中医院河南省南阳市473000

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机... 详细信息

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机制,为研究术后发热继续探索新的治疗药物。方法:检索CNKI中国期刊全文数据库、万方数据库和PubMed数据库2006年6月至2023年12月收录的文献,中文检索词为“中药,术后发热,炎症,白细胞介素1,白细胞介素6,白细胞介素8,干扰素γ,肿瘤坏死因子,前列腺素E2,p38丝裂原活化蛋白激酶,核因子κB,Toll样受体,Janus激酶/信号转导和转录激活因子,Notch信号通路”;英文检索词为“medicinal herb,postoperative fever,inflammation,interleukin-1,interleukin-6,interleukin-8,γ-interferon,tumor necrosis factor,Prostaglandin E2,p38 mitogen-activated protein kinase,nuclear factor-κB,toll-like receptor,janus kinases/signal transducer and activator of transcription,notch signaling pathway”。阅读文章剔除研究内容不相关、质量差的文献,纳入100篇文献进行归纳总结。结果与结论:(1)手术造成软组织创伤促使机体释放炎症因子,促炎因子作用于下丘脑前部的体温调节中心,促使发热;(2)术后切口内出血及渗液等的吸收,吞噬细胞吞噬坏死细胞的蛋白分解产物后,产生内生致热原(白细胞介素、肿瘤坏死因子、干扰素等)导致发热;(3)细胞因子通过炎症信号通路发挥致炎作用,促使发热;(4)中药或中药复方可以调控炎症信号通路发挥抗炎解热作用防治术后发热;目前中药作用机制尚无定论,应深入研究阐明中医药防治术后发热的相关信号通路,运用现代技术把细胞分子技术与中医药药理作用机制联系起来,以便指导临床医生用药,促进患者术后恢复;(5)中药联合西药治疗术后发热是未来的研究热点,应充分发挥中医药优势,明确不同证型应用中药单体或有效成分提取物和中药汤剂的靶点作用机制。

关键词：中药腰椎椎体间融合术后发热炎症白细胞介素干扰素γ 肿瘤坏死因子信号通路

NANOMECHANICAL MAPPING OF CARBON BLACK REINFORCED NATURAL RUBBER BY ATOMIC FORCE MICROSCOPY

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2007年第1期25卷 35-41页

作者： Toshio Nishi Hideyuki Nukaga so Fujinami Ken Nakajima Department of Organic and Polymeric Materials Graduate School of Science and EngineeringTokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8552Japan

Atomic force microscopy （AFM） has the advantage of obtaining mechanical properties as well as topographic information at the same time. By analyzing force-distance curves measured over two-dimensional area using Hertzian contact mechanics, Young＇s modulus mapping was obtained with nanometer-scale resolution. Furthermore, the sample deformation by the force exerted was also estimated from the force-distance curve analyses. We could thus reconstruct a real topographic image by incorporating apparent topographic image with deformation image. We applied this method to carbon black reinforced natural rubber to obtain Young＇s modulus distribution image together with reconstructed real topographic image. Then we were able to recognize three regions; rubber matrix, carbon black （or bound rubber） and intermediate regions. Though the existence of these regions had been investigated by pulsed nuclear magnetic resonance, this paper would be the first to report on the quantitative evaluation of the interfacial region in real space.

关键词： AFM, Natural rubber Carbon black Young's modulus Force-distance curve.

The progress in optic nerve regeneration, where are we?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第1期11卷 32-36页

作者： Jennifer Wei Huen Shum Kai Liu Kwok-fai so Department of Ophthalmology The University of Hong Kong Division of Life Science State Key Laboratory of Molecular Neuroscience and Center of Systems Biology and Human Health School of Science and Institute for Advance Study The Hong Kong University of Science and Technology GHM Institute of CNS Regeneration Jinan University

Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are many hurdles impeding optic regeneration in mammals. The mammalian central nervous system is non-permissive to regeneration and intrinsically lacks the capacity for axonal regrowth. Any axonal injury also triggers a vicious cycle of apoptosis. Understanding these hurdles provides us with a rough framework to appreciate the essential steps to bring about optic nerve regeneration： enhancing neuronal survival, axon regeneration, remyelination and establishing functional synapses to the original neuronal targets. In this review article, we will go through current potential treatments for optic nerve regeneration, which includes neurotrophic factor provision, inflammatory stimulation, growth inhibition suppression, intracellular signaling modification and modeling of bridging substrates.

关键词： optic nerve regeneration axonal regeneration neurotrophic factor inflammatory stimulation nerve bridging substances

Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第43期23卷 7657-7665页

作者： so young kim yi yi kyaw jaehun cheong department of molecular biology pusan national university

Hepatitis B virus(HBV) is a non-cytopathic virus that causes acute and chronic inflammatory liver diseases,often leading to the pathogenesis of hepatocellular carcinoma(HCC). Although many studies for the roles of HBV on pathogenesis of the liver diseases,such as non-alcoholic fatty liver disease(NAFLD),hepatic inflammation,cirrhosis,and HCC,have been reported,the mechanisms are not fully understood. Endoplasmic reticulum(ER) and mitochondria have the protective mechanisms to restore their damaged function by intrinsic or extrinsic stresses,but their chronic dysfunctions are associated with the pathogenesis of the various diseases. Furthermore,HBV can affect intraor extracellular homeostasis through induction of ER and mitochondrial dysfunctions,leading to liver injury. Therefore,the mechanism by which HBV induces ER or mitochondrial stresses may be a therapeutic target for treatment of liver diseases.

关键词： Liver disease Hepatitis B virus Hepatitis B virus X protein Endoplasmic reticulum stress Unfolded protein response

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Interception time and uncertainty optimization for tangent-impulse orbit interception problem

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2022年第3期18卷 418-440页

作者： Yang hong Li Xin-hong Ding Wen-zhev Department of Aerospace Science and Technology Space Engineering UniversityNo.1 BaYi RoadHuaiRou DistrictBeijing101416China

The traditional tangent impulse interception problem does not consider the influence of actual ***,by taking the actual state deviation of the interceptor into the orbit design process,an interception orbit that is more robust than the nominal orbit can be ***,we study the minimum time interception problem and the minimum terminal interception error problem under tangent impulse conditions and give an orbit optimization method that considers the interception time and the interception ***,we express the interceptor's transfer time equation as a form of flight path angle,establish a global optimization model for solving the minimum time tangent impulse interception and give a hybrid optimization algorithm based on Augmented Lagrange Genetic Algorithm-Sequential Quadratic Programming(ALGA-SQP).Secondly,we use the universal time equation and Bootstrap resampling technology to calculate the interceptor's terminal error distribution and establish the relevant global optimization model by using the circumscribed cuboid volume of the interceptor's terminal position error ellipsoid as the optimization ***,we combined the above two singleobjective optimization models to establish a global multi-objective optimization model that considers interception time and interception uncertainty and gave a hybrid multi-objective optimization algorithm based on Non-dominated sorting Genetic Algorithm Ⅱ-Goal Achievement Method(NSGA2-GAM).The simulation example verifies the effectiveness of this method.

关键词： Tangent impulse interception Minimum time Interception uncertainty Multi-objective optimization Hybrid optimization

Lattice structure adaptive IIR notch filter based on least square kurtosis

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2009年第6期20卷 1188-1192页

作者： Liang hong hong Kang Yang Changsheng Coll. of Marine Northwestern Polytechnical Univ. Xi'an 710072 P. R. China

A new variable step-size algorithm for a second-order lattice form structure adaptive infinite impulse response （IIR） notch filter to detection and estimation frequency of sinusoids in Gaussian noises is proposed. Utilizing least square kurtosis of output signals as a cost function, the new gradient-based algorithm to update frequency of the adaptive IIR notch filter and the new variable step-size algorithm are given. The computer simulation results show that the proposed algorithm has better ability in suppressing colored Gaussian noises and better accuracy in estimating parameters at low SNR than previous algorithms.

关键词： adaptive IIR notch filter least square kurtosis variable step-size colored Gaussian noise.