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Extraction and Purification of Depigmenting Agents from Chinese Plants

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Chemical Research in Chinese Universities 2006年第2期22卷 162-167页

作者： AHN so-young ROW Kyung-ho KIM Eun-ki School of Chemical and Biological Engineering Center for Advanced Bioseparation Technology Inha University Nam-Ku Incheon 402-751 Korea

Depigmenting agents were solvent-extracted and purified by preparative and analytical HPLC from three Chinese plants; Chrysanthemum morifolium Ramat（ Xizang Caijuhua）, Rhodiola sachalinensis, and Terminalia chebula Retzius. Four fractions obtained from the ethyl ether layer of C. m. Rama and two fractions from the ethyl acetate layer of Rhodiola salientness show depigmenting effects. At 8 200, the ethyl acetate layers of Chrysanthemum morifolium Ramat, Rhodiola sachalinensis and the methanol extract of Terminalia chebula Retzius, can inhibit the melanin production of mouse B16 melanoma cells by 92%, 60% and 90%, respectively, whereas 46% inhibition was observed by commercially available depigmenting agents（arbutin）. These results show the potential of these three Chinese plants as a novel resource for depigmenting agents in the cosmetic industry.

关键词： Chrysanthemum Morifolium Ramat Rhodiola Sachalinensis Terminalia Chebula Retzius Melanin Inhibitory Effect HPLC

Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients

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World Journal of Gastroenterology 2016年第37期22卷 8314-8321页

作者： hye Won Lee Sang Hoon Ahn Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Institute of Gastroenterology Yonsei University College of Medicine Seoul 03722 South Korea Liver Cirrhosis Clinical Research Center Seoul 03722 South Korea Brain Korea 21 Project for Medical Science Seoul 03722 South Korea

Chronic hepatitis B virus(HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma(HCC). Applying the same strategies for antiviral therapy and HCC surveillance to all chronic hepatitis B(CHB) patients would be a burden worldwide. To properly manage CHB patients, it is necessary to identify and classify the risk for HCC development in such patients. Several HCC risk scores based on risk factors such as cirrhosis, age, male gender, and high viral load have been used, and have negative predictive values of ≥ 95%. Most of these have been derived from, and internally validated in, treatment-na?ve Asian CHB patients. Herein, we summarized various HCC prediction models, including IPM(Individual Prediction Model), CU-HCC(Chinese University-HCC), GAG-HCC(Guide with Age, Gender, HBV DNA, Core Promoter Mutations and Cirrhosis-HCC), NGM-HCC(NomogramHCC), REACH-B(Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B), and Page-B score. To develop a noninvasive test of liver fibrosis, we also introduced a new scoring system that uses liver stiffness values from transient elastography, including an LSM(Liver Stiffness Measurement)-based model, LSM-HCC, and mR EACH-B(modified REACH-B).

关键词： Chronic hepatitis B Hepatocellular carcinoma Development Prediction models

Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 374-379页

作者： Mi-Ja Kim hye Kyung Kim Department of Food and Biotechnology Hanseo UniversitySeosan 356-706Republic of Korea Department of Pharmacology school of MedicineKyunghee UniversitySeoul 130-701Republic of Korea

Objective:To explore the anti-diabetic activity of Ecklonia cava(EC) in streptozotocin(STZ)-induced diabetic ***:Diabetes was induced by a single intraperitoneal injection of STZ(90 mg/kg).Normal and diabetic mice were treated with 0%,3%,and 5%EC diet for 4 weeks. Serum glucose and insulin concentrations,serum lipid profile,oral glucose tolerance test,and liver and pancreaticβ-cell histopathological observations were *** addition,in vitro glucose-induced insulin secretion was determined using pancreaticβ-islet ***:EC supplementation significantly and dose-dependently decreased serum glucose concentration, and improved glucose homeostasis in diabetic mice by preventing loss ofβ-cell mass resulting in increase of insulin *** triglyceride and total cholesterol concentrations in the serum and liver were markedly reduced by EC treatment in STZ-diabetic ***,LDL-,and HDL-cholesterol levels were ameliorated in EC supplemented diabetic *** steatosis induced by STZ was ameliorated by EC ***,in vitro insulinotrophic effect of EC extract was observed in pancreaticβ-***:This study demonstrated that EC is a potent and efficacious hypoglycemic and hypolipidemic agent,and prevents the loss ofβ-cell mass resulting in increase of insulin secretary capacity.

关键词： Diabetes Streptozotocin Insulin Lipid profile Pancreaticβ-cell

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

A Phenomenological Approach to the Korean ＂We＂： A Study in social Intentionality

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Frontiers of Philosophy in China 2017年第4期12卷 612-632页

作者： hye Young Kim Institut Jean Nicod Ecole Normale Superieure Paris 75005 France

This paper explores the phenomenological concept ＂we＂ based on a pre-existing understanding of traditional phenomenology alongside a new aspect of the concept by introducing an analysis of ＂we＂ in Korean. The central questions of this paper are whether the ＂we＂ can be understood as more than a collection of individuals, whether the ＂we＂ can precede both ＂I＂ and ＂thou,＂ and whether the ＂we＂ as an extension of the ＂I＂ or an extended self should necessarily mean the plural of the ＂I.＂

关键词： intersubjectivity subjectivity the "we," phenomenology Korean language

Current guidelines for Helicobacter pylori treatment in East Asia 2022:Differences among China,Japan,and south Korea

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World Journal of Clinical Cases 2022年第19期10卷 6349-6359页

作者： Jun-Hyung Cho so-Young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea

Helicobacter pylori (H. pylori) infection is highly prevalent in East Asia. The overallseroprevalence rate of H. pylori infection is 44.2% in China, 37.6%-43.2% in Japan,and 51.0% in south Korea. H. pylori can cause peptic ulcer disease and gastriccancer. East Asian countries have high rates of gastric cancer (age-standardizedincidence rate: 20-30 per 100000). The Kyoto global consensus report emphasizedthat H. pylori gastritis should be considered the main cause for the development ofgastric cancer. H. pylori treatment guidelines in China, Japan, and south Koreahave recently been revised according to data from each of those ***, emerging antibiotic resistance is an important barrier to H. pylorieradication. The recommended H. pylori treatment regimens differ among thosethree East Asian countries. In this review, recent guidelines and up-to-dateresearch on H. pylori treatment regimens from China, Japan, and south Korea arediscussed.

关键词： Helicobacter pylori Treatment Antibiotic resistance China Japan south Korea

Combined Role of ACC Deaminase Producing Bacteria and Biochar on Cereals Productivity under Drought

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Phyton-International Journal of Experimental Botany 2020年第2期89卷 217-227页

作者： Subhan Danish Muhammad Zafar-ul-hye Department of soil Science Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan soil and Water Testing Laboratory PakArab Fertilizer LimitedPlantsiteMultan60800Pakistan

Most of the cereal crops are widely cultivated to fulfil the humans food *** changing climate scenario,the intensity of drought stress is continuously increasing that is adversely affecting the growth and yield of cereal *** the cereals can tolerate moderate drought to some extent,but mostly they are susceptible to severe drought *** biosynthesis of ethylene under drought stress has been *** scientists observed that inoculation of 1-aminocyclopropane-1-carboxylate(ACC)deaminase producing plant growth promoting rhizobacteria(PGPR)is an efficacious tool to overcome this *** PGPR secrete ACC deaminase which cleavage the ACC into the compounds,other than ***,secretion of growth hormones also play imperative role in enhancing the growth of the cereals under limited availability of *** addition,the use of biochar has also been recognized as another effective amendment to grant resistance against *** application improves the soil physiochemical attributes i.e.,porosity,nutrients retention and water holding capacity which decrease the loss of water and increase its *** recent era,the idea of coapplication of ACC deaminase producing PGPR and biochar is becoming popular which might be more efficient to use water under drought *** aim of current review is to combine the facts and understanding of this novel idea to grant maximum resistance to crops against drought *** scientists have observed significant improvement in yield of cereal crops by combined use of ACC deaminase producing PGPR and ***,more research is suggested for deep understanding of complex synergistic mechanism of ACC deaminase activity in combination with biochar.

关键词： ACC deaminase biochar cereals drought ethylene PGPR yield

Influence of haze pollution on water-soluble chemical species in PM2.5 and size-resolved particles at an urban site during fall

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Journal of Environmental Sciences 2017年第7期29卷 370-382页

作者： Geun-hye Yu Yan Zhang Sung-Yong Cho Seungshik Park Department of Environment and Energy Engineering Chonnam National UniversityGwangju 61186Republic of Korea

To investigate the influence of haze on the chemical composition and formation processes of ambient aerosol particles,PM_（2.5） and size-segregated aerosol particles were collected daily during fall at an urban site of Gwangju,*** the study period,the total concentration of secondary ionic species（SIS） contributed an average of 43.9% to the PM_（2.5） ,whereas the contribution of SIS to the PM_（2.5） during the haze period was 62.3%.The NO_3 and so^（2-）_4 concentrations in PM_（2.5） during the haze period were highly elevated,being 13.4 and 5.0 times higher than those during non-haze period,*** PM,NO^-_3,so^（2-）_4,oxalate,water-soluble organic carbon（WsoC）,and humic-like substances（HULIS） had tri-modal size distributions peaks at 0.32,1.0,and 5.2 μm during the non-haze and haze ***,during the non-haze period they exhibited dominant size distributions at the condensation mode peaking at 0.32 μm,while on October 21 when the heaviest haze event occurred,they had predominant droplet mode size distributions peaking at 1.00 μ***,strong correlations of WsoC and HULIS with so^（2-）_4,oxalate,and K＋at particle sizes of 〈 1.8 μm indicate that secondary processes and emissions from biomass burning could be responsible for WsoC and HULIS *** was found that the factors affecting haze formation could be the local stable synoptic conditions,including the weak surface winds and high surface pressures,the long-range transportation of haze from eastern China and upwind regions of the Korean peninsula,as well as the locally emitted and produced aerosol particles.

关键词： Haze pollution Size distribution Secondary ionic species Humic-like substances Stable synoptic conditions

Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells

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World Journal of Gastroenterology 2014年第1期20卷 175-182页

作者： hye Jin Ku hye Young Kim hyeong Hoe Kim Hee Ju Park Jae Hun Cheong Department of Pediatrics College of MedicinePusan National UniversityBusan 601-721South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 609-735South Korea Department of Experimental Medicine College of MedicinePusan National UniversityBusan 601-721South Korea

AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon coope... 详细信息

关键词： Histamine Histidine decarboxylase Bile acid Farnesoid X receptor