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密林·聚落·坝子·桥——云南安宁石江村红砖住宅设计

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建筑学报 2024年第4期 61-62页

作者：饶娆杨雄昆明理工大学建筑与城市规划学院昆明650504 筑象建筑昆明650233

2015年,我们接到一项乡村住宅设计委托。项目位于云南省安宁市石江村,业主出生于此,其父母务农,而她与姐姐在城市发展。尽管她们曾试图将父母接到城市生活,但父母却难以适应。这促使业主考虑在故乡建造一栋房子,不仅为父母,也为自己。... 详细信息

2015年,我们接到一项乡村住宅设计委托。项目位于云南省安宁市石江村,业主出生于此,其父母务农,而她与姐姐在城市发展。尽管她们曾试图将父母接到城市生活,但父母却难以适应。这促使业主考虑在故乡建造一栋房子,不仅为父母,也为自己。设计的起点,是对场地的深刻感受,以及业主对家庭、土地和居住理想之间的情感交融。业主的愿望和故事为建筑赋予了生命,她渴望在城市边缘的乡村中重建一种理想的生活方式,这种愿望深深影响了建筑设计的构思。

关键词：城市边缘建筑设计情感交融乡村住宅住宅设计安宁市云南安宁设计委托

Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1344-1353页

作者： Yu-Hang Diao Si-Qi rao Xin-Peng Shu Yong Cheng Can Tan Li-Juan Wang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer(CRC),but also have been found to have potential prognostic *** To analyze whether preoperative serum tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),affect the prognosis of *** This was a retrospective study conducted in a single *** with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:*** independent prognostic factors were screened by Cox regression analysis,and finally,a prognostic nomogram model was *** newly developed model was tested by internal *** Eventually,3526 postoperative patients with nonmetastatic CRC were included in the *** were 2473 patients at the development site and 1056 patients at the validation ***(P<0.01,HR=1.042,95%CI=1.033-1.051),tumor node metastasis(TNM)classification(P<0.01,HR=1.938,95%CI=1.665-2.255),preoperative CEA(P=0.001,HR=1.393,95%CI=1.137-1.707)and CA19-9(P<0.01,HR=1.948,95%CI=1.614-2.438)levels were considered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram *** areas under the curve of the development and validation sites were 0.655 and 0.658,*** calibration plot also showed the significant performance of the newly established *** We successfully constructed a nomogram model based on age,TNM stage,preoperative CEA,and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.

关键词： Colorectal cancer Prognosis Carcinoembryonic antigen Carbohydrate antigen 19-9 Nomogram

Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia

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Zoological Research 2024年第3期45卷 679-690页

作者： Gao-Lin Qiu Li-Jun Peng Peng Wang Zhi-Lai Yang Ji-Qian Zhang Hu Liu Xiao-Na Zhu Jin rao Xue-Sheng Liu Department of Anesthesiology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

General anesthesia is widely applied in clinical ***,the precise mechanism of loss of consciousness induced by general anesthetics remains ***,we measured the dynamics of five neurotransmitters,includingγ-aminobutyric acid,glutamate,norepinephrine,acetylcholine,and dopamine,in the medial prefrontal cortex and primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from a neurotransmitter *** revealed that the concentrations of γ-aminobutyric acid,glutamate,norepinephrine,and acetylcholine increased in the cortex during propofol-induced loss of *** levels did not change following the hypnotic dose of propofol but increased significantly following surgical doses of propofol ***,the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of ***,the neurotransmitter dynamic networks were not synchronized in the non-anesthesia groups but were highly synchronized in the anesthetic *** findings suggest that neurotransmitter dynamic network synchronization may cause anesthetic-induced loss of consciousness.

关键词： General anesthesia Loss of consciousness In vivo neurotransmitter imaging Medial prefrontal cortex Primary visual cortex

In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： Jin Liu Yike Gui Jingxin rao Jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu Zhiyi Chene Xia Sheng Yitian Wang Mingyue Zheng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar

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Food Science and Human Wellness 2024年第5期13卷 2765-2778页

作者： Shangong Tong Wenlong Li Yuandong rao Yanqin Xiao Yingyin Yan Weiling Guo Xucong Lü Jinyuan Sun Lianzhong Ai Li Ni Institute of Food Science and Technology College of Biological Science and EngineeringFuzhou UniversityFuzhou 350108China Food Nutrition and Health Research Center School of Advanced ManufacturingFuzhou UniversityJinjiang 362200China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Beijing Laboratory for Food Quality and Safety Beijing Technology and Business UniversityBeijing 100048China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China

This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar,and explore the core functional microbes closely related to the formation of flavor *** analysis demonstrated that Lactobacillus,Acetobacter,Bacillus,Enterobacter,Lactococcus,Leuconostoc and Weissella were the predominant bacterial genera,while Aspergillus piperis,Aspergillus oryzae,Monascus purpureus,Candida athensensis,***,Penicillium ochrosalmoneum and Simplicillium aogashimaense were the predominant fungal *** analysis revealed that Acetobacter was positively correlated with the production of tetramethylpyrazine,acetoin and acetic acid,Lactococcus showed positive correlation with the production of 2-nonanone,2-heptanone,ethyl caprylate,ethyl caprate,1-hexanol,1-octanol and 1-octen-3-ol,*** and *** were positively associated with the production of diethyl malonate,2,3-butanediyl diacetate,acetoin,benzaldehyde and ***,non-volatile metabolites were also detected through ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.A variety of amino acids and functional dipeptides were identified during the traditional brewing of Hongqu aged *** analysis revealed that Lactobacillus was significantly associated with DL-lactate,indolelactic acid,D-(+)-3-phenyllactic acid,pimelic acid,pregabalin and 3-aminobutanoic *** study is useful for understanding flavor formation mechanism and developing effective strategies for the suitable strains selection to improve the flavor quality of Hongqu aged vinegar.

关键词： Hongqu aged vinegar Traditional fermentation Microbial dynamics Flavor components Bidirectional orthogonal partial least squares

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Geochemical characteristics and origins of natural gases in the eastern Cote d'Ivoire Basin,West Africa

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Acta Oceanologica Sinica 2024年第08期 26-36页

作者： Li Li Quan Li Tao Cheng Songling Yang Yong rao Xinyu Liu Wenjing Ding CNOOC International Ltd. School of Natural Sciences Macquarie University CNOOC Research Institute

The gas sources in the eastern Cote d'Ivoire Basin（Tano Basin） are seldom reported and remain controversial due to multiple sets of potential source rocks and poorly documented geochemical characteristics of natural *** marine source rock potential from the Upper Albian to Turonian as well as the molecular composition and the stable carbon isotope composition of natural gases in the eastern Cote d'Ivoire Basin were studied in detail to investigate the origins of natural gases. The total organic carbon（TOC）, hydrogen index（HI）, and generation potential（S1+ S2） of source rocks indicate that both sapropelic source rocks and humic source rocks developed during the late Albian, whereas sapropelic source rocks developed during the Cenomanian and the Turonian. The normal order of δ13CH4< δ13C2H6< δ13C3H8(δ13C1< δ13C2< δ13C3), the relationship between C2/C3molar ratio and δ13C2-δ13C3, and the plot of δ13C1versus C1/（C2+C3） collectively show that the natural gases are thermogenic due to the primary cracking of kerogen, including the typical oil-associated gases from Well D-1, the mixed oil-associated gases and coal-derived gases from Well G-1 and Well L-1. Based on the plot of δ13C1versus δ13C2and the established relationship between δ13C1and equivalent vitrinite reflectance（Ro）, we proposed that the natural gases are in a mature stage（Ro generally varies from 1.0% to 1.3%）. Combined with results of basin modelling and oil-to-source correlation, the transitional to marine source rocks during the late Albian were thought to have made a great contribution to the natural gases. Our study will make a better understanding on petroleum system in the eastern Cote d'Ivoire Basin.

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Geochemical characteristics and origins of natural gases in the eastern Cote d’Ivoire Basin,West Africa

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Acta Oceanologica Sinica 2024年第8期43卷 26-36页

作者： Li Li Quan Li Tao Cheng Songling Yang Yong rao Xinyu Liu Wenjing Ding CNOOC International Ltd. Beijing 100028China School of Natural Sciences Macquarie UniversitySydneyNSW2109Australia CNOOC Research Institute Beijing 100028China

The gas sources in the eastern Cote d’Ivoire Basin(Tano Basin)are seldom reported and remain controversial due to multiple sets of potential source rocks and poorly documented geochemical characteristics of natural *** marine source rock potential from the Upper Albian to Turonian as well as the molecular composition and the stable carbon isotope composition of natural gases in the eastern Cote d’Ivoire Basin were studied in detail to investigate the origins of natural *** total organic carbon(TOC),hydrogen index(HI),and generation potential(S_(1)+S_(2))of source rocks indicate that both sapropelic source rocks and humic source rocks developed during the late Albian,whereas sapropelic source rocks developed during the Cenomanian and the *** normal order ofδ^(13)CH_(4)<δ^(13)C_(2)H6<δ^(13)C_(3)H_(8)(δ^(13)C_(1)<δ^(13)C_(2)<δ^(13)C_(3)),the relationship between C_(2)/C_(3)molar ratio andδ^(13)C_(2)-δ^(13)C_(3),and the plot ofδ^(13)C_(1)versus C_(1)/(C_(2)+C_(3))collectively show that the natural gases are thermogenic due to the primary cracking of kerogen,including the typical oil-associated gases from Well D-1,the mixed oil-associated gases and coal-derived gases from Well G-1 and Well *** on the plot ofδ^(13)C_(1)versusδ^(13)C_(2)and the established relationship betweenδ^(13)C_(1)and equivalent vitrinite reflectance(Ro),we proposed that the natural gases are in a mature stage(Ro generally varies from 1.0%to 1.3%).Combined with results of basin modelling and oil-to-source correlation,the transitional to marine source rocks during the late Albian were thought to have made a great contribution to the natural *** study will make a better understanding on petroleum system in the eastern Cote d’Ivoire Basin.

关键词： marine source rocks potential molecular composition stable carbon isotopes Upper Albian Tano Basin

明代小说散韵结合体制的形成及诗歌叙事体性化

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南开学报（哲学社会科学版） 2024年第4期 47-59页

作者：饶龙隼四川大学中国俗文化研究所四川成都610207

唐宋以来各类小说的书面化助催散韵结合体制的形成,延至元明时期这种编创观览现象更加凸显并递有新变,从而形成明代小说独特的体制形态,因使其诗性叙事功能有所增强优化。明代小说中羼入的诗歌有多方面叙事功能,但在小说叙事中不占主导... 详细信息

唐宋以来各类小说的书面化助催散韵结合体制的形成,延至元明时期这种编创观览现象更加凸显并递有新变,从而形成明代小说独特的体制形态,因使其诗性叙事功能有所增强优化。明代小说中羼入的诗歌有多方面叙事功能,但在小说叙事中不占主导地位;若脱离散文叙事之主导,其诗性叙事就无所附丽。特别是在小说中羼入诗歌的增聚阶段,其叙事功能非但不能很好地得到发挥,反因非体性成分存在种种弊端。不过随着明代小说书面化,所羼诗歌进入体性化阶段;且因羼入诗歌体性化的增强,其诗性叙事完全融摄散文中。所谓体性化,是指羼入诗歌契入小说的故事情节,而与散文深度融合以修饰辅助叙事。

关键词：明代小说散韵结合体制书面化诗歌叙事体性化