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流动的艺术Blue Table巧克力店

室内设计与装修 2024年第9期 148-149页

作者： [美国]Arch&Type Kim smith(摄影) 夕阳(编译) Arch&Type

Arch&Type受邀为Blue Table巧克力店打造一处结合制作与销售的综合场所。设计师Seth Amman与Adam McCullough在思考如何透过建筑空间来提升巧克力的制作及消费体验时,巧克力店负责人Ben Johnson向团队提供了一张未经调温程序的巧克力影... 详细信息

Arch&Type受邀为Blue Table巧克力店打造一处结合制作与销售的综合场所。设计师Seth Amman与Adam McCullough在思考如何透过建筑空间来提升巧克力的制作及消费体验时,巧克力店负责人Ben Johnson向团队提供了一张未经调温程序的巧克力影像,其融化、丝滑、流动的样貌,成为设计团队的初始灵感。于是,设计团队以数字建模的方式,打造了一个由CNC铣削、手工组装并经过油漆处理的天花板。

关键词：消费体验数字建模巧克力设计团队天花板

Policy options for Agriculture Green development by farmers in China

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Frontiers of Agricultural Science and Engineering 2020年第1期7卷 90-97页

作者： Laurence E.d.smith Centre for development Environment and PolicySOAS University of LondonLondonWC1H OXGUK

Farmers are the key agents who manage land.a.d *** Green development(AGd)requires a transformation in farming from high resource consumption and environmental cost to sustainable intensification with high productivity,high resource use efficiency and low environmental *** paper analyzes the public policy challenge of AGd.a.d makes the case for a location-sensitive policy mix made up of regulation,advice provision,voluntarism and targeted *** public agricultural extension service in China is a key resource,but one that requires reorientation and reform with the aim of better balancing high farm productivity with environmental protection.

关键词： agriculture environment development incentives policy regulation

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao deng Melissa Walker Chen Chen Heqiao dai Qi Han Ying ding Yongzhi Xia George smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord.a.d Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Ped.a.ric Research Center Temple University School of MedicinePhiladelphiaPAUSA department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food.a.d drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-med.a.ed transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced.a.onal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and.a.onal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

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Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua d.Rieskamp Patricia Sarchet Bryon M.smith Elizabeth d.Kirby Neuroscience Grad.a.e Program The Ohio State UniversityColumbusOHUSA department of Psychology The Ohio State UniversityColumbusOHUSA department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immed.a.e progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by Cd31^(+)endothelia,GFAP-SOX2^(+)intermed.a.e progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)rad.a. glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology

Genotypic diversity of a dominant C_(4) grass across a long-term fire frequency gradient

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Journal of Plant Ecology 2013年第6期6卷 448-458页

作者： Cynthia C.Chang Melinda d.smith department of Ecology and Evolutionary Biology Yale UniversityNew HavenCT 06511USA department of Biology University of WashingtonSeattleWA 98195USA department of Biology Colorado State UniversityFort CollinsCO 80523USA

Aims and Methods diversity-disturbance research has focused on community diversity,but disturbance frequency could impact diversity within species as well,with important consequences for community diversity and ecosystem *** examined patterns of genetic diversity of a dominant grass species,Andropogon gerardii,in native North American tallgrass prairie sites located in eastern Kansas that have been subjected to a gradient of fire frequency treatments(burned every 1,2,4 or 20 years)since the *** addition,we were able to assess the relationships between genetic diversity of ***,species diversity and productivity across this range of fire *** Findings We found no significant relationships between genetic diversity of *** at the local scale(1 m^(2) plot level)and disturbance frequency(burned 2 to 32 times over a 38-year period).However,at the site level(*** all plots sampled within a site,~100 m^(2))there were differences in genotype richness and composition,as well as genomic dissimilarity among individ.a.s of *** richness was greatest for the site burned.a. an intermed.a.e(4-year)frequency and lowest for the infrequently(20-year)burned *** addition,genotypes found in the frequently burned sites were more similar from each other than expected by random chance than those found in the infrequently burned *** composition of *** was not significantly different between the frequently burned sites(annual vs.2 year)but did differ between frequently burned.a.d infrequently burned sites(1 and 2 year vs.4 and 20 year,etc.).Together,these results suggest site-level ecological sorting of genotypes in intact prairie across a broad gradient of disturbance frequencies,likely driven by alterations in environmental *** fire promotes the abundance of dominant grass species,reduces plant community diversity and impacts ecosystem processes such as *** study suggests that

关键词： Andropogon gerardii disturbance frequency genetic relatedness genetic-species diversity relationship genotype richness intermed.a.e disturbance hypothesis productivity tallgrass prairie

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head.a.d Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodney J.Schlosser Thomas S.Ed.a.ds Timothy L.smith Zachary M.Soler department of Otolaryngology-Head.a.d Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA department of Otolaryngology-Head.a.d Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immed.a.e Early Response 3[IER3])had.a. false discovery rate(FdR)correction adjustedP value considered statistically significant(Pd change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(PdR correction)including IL-4 and IL-13 signaling,IL-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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万物皆AI?那自行车运动呢?

中国自行车 2024年第4期 96-99页

作者：尼古拉·史密斯不详

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利... 详细信息

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利用这一新兴技术来提高他们的表现,享受更加舒适的骑行,或者只是为了让骑行更安全,你已经在不知不觉中应用到了AI技术。

关键词：自行车运动人工智能 AI技术快速处理新兴技术骑行预测未来万物

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COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASEd ON THE INTERPRETIVE STRUCTURAL MOdELING METHOdOLOGY： TRANSdISCIPLINARY APPROACH

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.W. smith d. Tate W.d. Lawson T.B. Baturalp department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 department of Industrial design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a d.a.nostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. With the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

Role of granulocyte macrophage colony stimulating factor in regeneration of the central nervous system

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Neural Regeneration Research 2016年第6期11卷 902-903页

作者： Ushananthini Shanmugalingam Nafisa M.Jadavji Patrice d.smith department of Neuroscience Carleton University

Traditionally,it has been thought that the mammalian central nervous system（CNS）does not *** due to the inhibitory extracellular environment post-injury as well as the limited intrinsic characteristics of adult post... 详细信息

关键词： granulocyte macrophage colony regeneration stimulating intrinsic Figure neuronal subunit glial