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Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats

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Journal of Animal Science and Biotechnology 2020年第4期11卷 937-949页

作者： Megan Scholtens andrew Jiang Ashley smith Mathew Littlejohn Klaus Lehnert Russell Snell Nicolas Lopez-Villalobos Dorian Garrick Hugh Blair AL Rae Centre for Genetics and Breeding School of AgricultureMassey UniversityPalmerston NorthNew Zealand Applied Translational Genetics Group School of Biological SciencesThe University of AucklandAucklandNew Zealand Research and Development Livestock Improvement CorporationRuakura RoadHamiltonNew Zealand.

Background: Identifying associations between genetic markers and traits of economic importance will provide practical benefits for the dairy goat industry, enabling genomic prediction of the breeding value of individuals, and facilitating discovery of the underlying genes and mutations. Genome-wide association studies were implemented to detect genetic regions that are significantly associated with effects on lactation yields of milk(MY), fat(fY),protein(PY) and somatic cell score(SCS) in New Zealand dairy ***: A total of 4,840 goats were genotyped with the Caprine 50 K SNP chip(Illumina Inc., San Diego, CA).After quality filtering, 3,732 animals and 41,989 SNPs were analysed assuming an additive linear model. four GWAS models were performed, a single-SNP additive linear model and three multi-SNP Bayes C models. for the single-SNP GWAS, SNPs were fitted individually as fixed covariates, while the Bayes C models fit all SNPs simultaneously as random effects. A cluster of significant SNPs were used to define a haplotype block whose alleles were fitted as covariates in a Bayesian model. The corresponding diplotypes of the haplotype block were then fit as class variables in another Bayesian ***: Across all four traits, a total of 43 genome-wide significant SNPs were detected from the SNP GWAS. At a genome-wide significance level, the single-SNP analysis identified a cluster of variants on chromosome 19 associated with MY, fY, PY, and another cluster on chromosome 29 associated with SCS. Significant SNPs mapped in introns of candidate genes(45%), in intergenic regions(36%), were 0–5 kb upstream or downstream of the closest gene(14%) or were synonymous substitutions(5%). The most significant genomic window was located on chromosome 19 explaining up to 9.6% of the phenotypic variation for MY, 8.1% for fY, 9.1% for PY and 1% for ***: The quantitative trait loci for yield traits on chromosome 19 confirms reported findings in other dairy goat p

关键词： Dairy goat GWAS Milk production New Zealand QTL

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The Role of Interleukin-6 in Pemphigus Vulgaris

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International Journal of Dermatology and Venereology 2024年第1期7卷 60-60页

作者： Kashini andrew Dermatology Department Solihull HospitalUniversity Hospital Birmingham NHS TrustSolihull B912JLUnited Kingdom

Dear Editor,Pemphigus vulgaris(PV)is an autoimmune disease characterized by intra-epidermal blistering of the skin and mucosal *** lesions develop when autoantibodies target the desmoglein-1 and desmoglein-3 subunits of desmosomes disrupting the connections between *** the cause of PV is not known,at-risk patients may be genetically predisposed.1-2 I will discuss the possible role of interleukin-6(IL-6)in the pathophysiology of PV.

关键词： Interleukin autoimmune ed.

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用激光寻找外星人

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环球科学 2024年第8期 78-79页

作者：安德鲁·梅不详

60多年来,天文学家一直在寻找外星文明存在的证据,这些工作被统称为“搜寻地外文明”(SETI)。今为止,大部分SETI活动都是在一些局限性较大的假设下开展的。它们把重点放在无线电信号的探测上,假设外星人以高功率发射信号,要么有意宣告... 详细信息

60多年来,天文学家一直在寻找外星文明存在的证据,这些工作被统称为“搜寻地外文明”(SETI)。今为止,大部分SETI活动都是在一些局限性较大的假设下开展的。它们把重点放在无线电信号的探测上,假设外星人以高功率发射信号,要么有意宣告自己的存在,要么是出于其他的一些原因。

关键词：无线电信号外星人地外文明外星文明发射信号局限性高功率

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与机器交流:人机传播领域的未来轨迹

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全球传媒学刊 2024年第1期11卷 71-105页

作者： Jihyun Kim Katrin Etzrodt andrew Prahl Chad Edwards 刘力铭(翻译) 美国中佛罗里达大学科尔森传播与媒体学院国际传播学会人机传播分会德国德累斯顿工业大学媒体与传播研究所新加坡南洋理工大学黄金辉传播与信息学院美国西密歇根大学传播学院清华大学新闻与传播学院

机器行为者(machine actor)融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续... 详细信息

机器行为者(machine actor)融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续发展和扩展其研究范式。具体而言,本研究深入探讨人机传播的理论基础和方法论,考量以社会临场感和信任为中心的两个研究前沿,从不同角度探讨人机传播的重要意义并对人机传播未来的研究提出方向。

关键词：人机传播机器人人工智能社会临场感信任

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猛禽送你上火星

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环球科学 2024年第16期 78-79页

作者：安德鲁·梅不详

每个观看SpaceX公司120米高的星舰发射的人,都会震惊于火箭巨大的体型。火箭点火、离开地面、进入太空的画面更是震撼人心。而这一切都要归功于有着特殊设计的猛禽发动机。星舰的上面级星舰飞船里装了6台这种发动机,而它的第一级超重型... 详细信息

每个观看SpaceX公司120米高的星舰发射的人,都会震惊于火箭巨大的体型。火箭点火、离开地面、进入太空的画面更是震撼人心。而这一切都要归功于有着特殊设计的猛禽发动机。星舰的上面级星舰飞船里装了6台这种发动机,而它的第一级超重型火箭里更是装了33台。Spacex与那些采购现成发动机的火箭生产商不同,它会自行设计和制造发动机。这也令它能够灵活地按需定制发动机,像猛禽发动机就采用了划时代的设计。

关键词：火箭点火超重型按需定制上面级猛禽生产商发动机

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Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination

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Molecular Plant 2021年第12期14卷 2088-2103页

作者： Dongsheng Yao Marcus A.Arguez Ping He andrew f.Bent Junqi Song Texas A&M AgriLife Research Center at Dallas Texas A&M University SystemDallasTX 75252USA Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77843USA Department of Plant Pathology University of Wisconsin-MadisonMadisonWI 53706USA Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTX 77843USA

Poly(ADP-ribosyl)ation(PARylation)is a posttranslational modification reversibly catalyzed by poly(ADP-ribose)polymerases(PARPs)and poly(ADP-ribose)glycohydrolases(PARGs)and plays a key role in multi-ple cellular *** molecular mechanisms by which PARylation regulates innate immunity remain largely unknown in *** we show that Arabidopsis UBC13A and UBC13B,the major drivers of lysine 63(K63)-linked polyubiquitination,directly interact with PARPs/*** of pathogen-associated molecular pattern(PAMP)-triggered immunity promotes these interactions and enhances PARylation of *** parp1 parp2 and ubc13a ubc13b mutants are compromised in immune responses with increased accumulation of total pathogenesis-related(PR)proteins but decreased accu-mulation of secreted PR *** disulfide-isomerases(PDIs),essential components of endo-plasmic reticulum quality control(ERQC)that ensure proper folding and maturation of proteins destined for secretion,complex with PARPs/PARGs and are PARylated upon PAMP ***,PARylation of UBC13 regulates K63-linked ubiquitination of PDIs,which may further promote their disulfide isomerase activities for correct protein folding and subsequent *** together,these results indicate that plant immunity is coordinately regulated by PARylation and K63-linked ubiquitination.

关键词： UBC13 PARP1 PARP2 PDI poly(ADP-ribosyl)ation K63-linked ubiquitination secretory pathway PAMP-triggered immunity systemic acquired resistance

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A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 435-441页

作者： Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri andrew M smith Krishna V Menon Department of HPB and Transplant Surgery St James's University Hospital NHS TrustLeeds Teaching Hospitals Beckett street Leeds LS9 7TF United Kingdom Division of Pathology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden Department of Histopathology St James's University Hospital NHS TrustLeeds Teaching Hospitals Beckett street Leeds LS9 7TF United Kingdom

BACKGROUND： Laparoscopic pancreaticoduodenectomy（LPD）is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy（OPD）.METHODS： Between November 2005 and April 2009, 12LPDs（9 ampullary and 3 distal common bile duct tumors）were performed. A cohort of 12 OPDs were matched for age,gender, body mass index（BMI） and American Society of Anesthesiologists（ASA） score and tumor ***： Mean tumor size LPD vs OPD（19.8 vs 19.2 mm,P=0.870）. R0 resection was achieved in 9 LPD vs 8 OPD（P=1.000）. The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1（P=0.140）and 20.7 vs 18.5（P=0.534） respectively. Clavien complications grade I/II（5 vs 8）, III/IV（2 vs 6） and pancreatic leak（2 vs 1）were statistically not significant（LPD vs OPD）. The mean high dependency unit（HDU） stay was longer in OPD（3.7 vs 1.4 days,P〈0.001）. There were 2 recurrences each in LPD and OPD（logrank,P=0.983）. Overall mortality for LPD vs OPD was 3 vs 6（log-rank, P=0.283） and recurrence-related mortality was 2 vs *** was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD ***： Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome.

关键词： pancreaticoduodenectomy minimally invasive laparoscopic open oncological outcomes resection margins pathology

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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini francesco Giorgianni Mohammad Sikander andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAf-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAfs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAf-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAf-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAf-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAf-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAf) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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History and Progress of the North American Soil Geochemical Landscapes Project,2001-2010

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地学前缘 2012年第3期19卷 19-32页

作者： David B.smith William f.Cannon Laurel G.Woodruff francisco Moreira Rivera andrew N.Rencz Robert G.Garrett US Geological Survey MS 973 Denver CO 80225 USA US Geological Survey MS 9541 Reston VA 20192 USA US Geological Survey 2280 Woodale Drive St. Paul MN 55112 USA Servicio Geologico Mexicano 78280 San Luis Potosl S. L. P. Mexrico Geological Survey of Canada Natural Resources Canada 601 Booth St. Ottawa ON Canada K IA OE8

In 2007,the *** Survey,the Geological Survey of Canada,and the Mexican Geological Survey initiated a low-density(1 site per 1600 km2,13323 sites) geochemical and mineralogical survey of North American soils(North American Soil Geochemical Landscapes Project).Sampling and analytical protocols were developed at a series of workshops in 2003-2004 and pilot studies were conducted from *** ideal sampling protocol at each site includes a sample from 0-5 cm depth,a composite of the soil A horizon,and a sample from the soil C *** fraction of each sample is analyzed for Al,Ca,fe,K,Mg,Na,S,Ti,Ag,Ba,Be,Bi,Cd,Ce,Co,Cr,Cs,Cu,Ga,In,La,Li,Mn,Mo,Nb,Ni,P,Pb,Rb,Sb,Sc,Sn,Sr,Te,Th,Tl,U,V,W,Y,and Zn by inductively coupled plasma-mass spectrometry and inductively coupled plasma-atomic emission spectrometry following a near-total digestion in a mixture of HCl,HNO3,HClO4,and *** methods are used for As,Hg,Se,and total C on this same size *** major mineralogical components are determined by a quantitative X-ray diffraction *** in the conterminous *** completed in 2010(c.4800 sites) with chemical and mineralogical analysis currently *** Mexico,approximately 66% of the sampling(871 sites) had been done by the end of 2010 with completion expected in *** completing sampling in the Maritime provinces and portions of other provinces(472 sites,7.6% of the total),Canada withdrew from the project in *** results for a swath from the central *** florida clearly show the effects of soil parent material and climate on the chemical and mineralogical composition of soils.A sample archive will be established and made available for future investigations.

关键词：墨西哥地质学电感耦合等离子体

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Enhanced dual plasmonic photocatalysis through plasmonic coupling in eccentric noble metal-nonstoichiometric copper chakogenide hetero-nanostructures

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Nano Research 2022年第2期15卷 1579-1586页

作者： Mariia Ivanchenko Vida Nooshnab Alline f.Myers Nicolas Large andrew J.Evangelista Hao Jing Department of Chemistry and Biochemistry George Mason UniversityFairfaxVirginia 22030USA Department of Physics and Astronomy The University of Texas at San AntonioSan AntonioTX 78249USA National Institute of Standards and Technology(NIST) 100 Bureau Dr.GaithersburgMaryland 20899USA

The extension of plasmonics to materials beyond the conventional noble metals opens up a novel and exciting regime after the inspiring discovery of characteristic localized surface plasmon resonances(LSPRs)in doped semiconductor nanocrystals originating from the collective oscillations of free holes in the valence *** herein prepare colloidal monodisperse eccentric dual plasmonic noble metal-nonstoichiometric copper chalcogenide(Au@Cu_(2-x)Se)hybrid hetero-nanostructures with precisely controlled semiconductor shell size and two tunable LSPRs in both visible(VIS)and near-infrared(NIR)regions associated with Au and Cu_(2-x)Se,*** systematic evaluations of the photocatalytic performance of Au@Cu_(2-x)Se upon sole NIR and dual VIS+NIR simultaneous excitations,we are capable of unambiguously elucidating the role of plasmonic coupling between two dissimilar building blocks on the accelerated photocatalytic reactions with greater rate constants from both experimental and computational *** significantly enhanced strength of the electromagnetic field arising from efficient plasmonic coupling under the excitation of two LSPRs results in the superior activities of dual plasmonic Au@Cu_(2-x)Se in *** new physical and chemical insights gained from this work provide the keystone for the rational design and construction of high-quality dual-or even multi-plasmonic nano-systems with optimized properties for widespread applications ranging from photocatalysis to molecular spectroscopies.

关键词： dual plasmonic nonstoichiometric copper chalcogenides time-domain(fDTD) photocatalysis

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